Identity
HGNC
LOCATION
5q31.1
LOCUSID
ALIAS
E2-17kDa,HHR6B,HR6B,RAD6B,UBC2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 7320
MIM: 179095
HGNC: 12473
Ensembl: ENSG00000119048
Variants:
dbSNP: 7320
ClinVar: 7320
TCGA: ENSG00000119048
COSMIC: UBE2B
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000119048 | ENST00000265339 | P63146 |
| ENSG00000119048 | ENST00000506787 | H0YA80 |
| ENSG00000119048 | ENST00000507277 | H0Y9V2 |
| ENSG00000119048 | ENST00000510021 | D6RDW8 |
Expression (GTEx)
Pathways
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35313791 | 2022 | UBE2B promotes ovarian cancer growth via promoting RAD18 mediated ZMYM2 monoubiquitination and stabilization. | 7 |
| 36162503 | 2022 | Mutations of Rad6 E2 ubiquitin-conjugating enzymes at alanine-126 in helix-3 affect ubiquitination activity and decrease enzyme stability. | 4 |
| 35313791 | 2022 | UBE2B promotes ovarian cancer growth via promoting RAD18 mediated ZMYM2 monoubiquitination and stabilization. | 7 |
| 36162503 | 2022 | Mutations of Rad6 E2 ubiquitin-conjugating enzymes at alanine-126 in helix-3 affect ubiquitination activity and decrease enzyme stability. | 4 |
| 33181138 | 2021 | RAD6B Loss Disrupts Expression of Melanoma Phenotype in Part by Inhibiting WNT/β-Catenin Signaling. | 4 |
| 33181138 | 2021 | RAD6B Loss Disrupts Expression of Melanoma Phenotype in Part by Inhibiting WNT/β-Catenin Signaling. | 4 |
| 31639439 | 2020 | RAD6B is a major mediator of triple negative breast cancer cisplatin resistance: Regulation of translesion synthesis/Fanconi anemia crosstalk and BRCA1 independence. | 15 |
| 33109568 | 2020 | High Expression of UBE2B as a Poor Prognosis Factor in Patients With Rectal Cancer Following Chemoradiotherapy. | 10 |
| 31639439 | 2020 | RAD6B is a major mediator of triple negative breast cancer cisplatin resistance: Regulation of translesion synthesis/Fanconi anemia crosstalk and BRCA1 independence. | 15 |
| 33109568 | 2020 | High Expression of UBE2B as a Poor Prognosis Factor in Patients With Rectal Cancer Following Chemoradiotherapy. | 10 |
| 31683936 | 2019 | Alternative Splicing of RAD6B and Not RAD6A is Selectively Increased in Melanoma: Identification and Functional Characterization. | 6 |
| 31683936 | 2019 | Alternative Splicing of RAD6B and Not RAD6A is Selectively Increased in Melanoma: Identification and Functional Characterization. | 6 |
| 28031328 | 2017 | Interactome Analysis Reveals a Novel Role for RAD6 in the Regulation of Proteasome Activity and Localization in Response to DNA Damage. | 3 |
| 28490629 | 2017 | Pharmacological targeting of RAD6 enzyme-mediated translesion synthesis overcomes resistance to platinum-based drugs. | 22 |
| 28806395 | 2017 | RAD6 promotes DNA repair and stem cell signaling in ovarian cancer and is a promising therapeutic target to prevent and treat acquired chemoresistance. | 38 |
Citation
Dessen P
UBE2B (ubiquitin conjugating enzyme E2 B)
Atlas Genet Cytogenet Oncol Haematol. 2003-11-01
Online version: http://atlasgeneticsoncology.org/gene/42747/ube2b
