Atlas of Genetics and Cytogenetics in Oncology and Haematology


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UBE2B (ubiquitin conjugating enzyme E2 B)

Identity

Other namesE2-17kDa
HHR6B
HR6B
RAD6B
UBC2
HGNC (Hugo) UBE2B
LocusID (NCBI) 7320
Atlas_Id 42747
Location 5q31.1  [Link to chromosome band 5q31]
Location_base_pair Starts at 133706867 and ends at 133727799 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
JADE2 (5q31.1) / UBE2B (5q31.1)PPP6R2 (22q13.33) / UBE2B (5q31.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 0 ]
  Lung: Translocations in Small Cell Carcinoma

External links

Nomenclature
HGNC (Hugo)UBE2B   12473
Cards
Entrez_Gene (NCBI)UBE2B  7320  ubiquitin conjugating enzyme E2 B
AliasesE2-17kDa; HHR6B; HR6B; RAD6B; 
UBC2
GeneCards (Weizmann)UBE2B
Ensembl hg19 (Hinxton)ENSG00000119048 [Gene_View]  chr5:133706867-133727799 [Contig_View]  UBE2B [Vega]
Ensembl hg38 (Hinxton)ENSG00000119048 [Gene_View]  chr5:133706867-133727799 [Contig_View]  UBE2B [Vega]
ICGC DataPortalENSG00000119048
TCGA cBioPortalUBE2B
AceView (NCBI)UBE2B
Genatlas (Paris)UBE2B
WikiGenes7320
SOURCE (Princeton)UBE2B
Genomic and cartography
GoldenPath hg19 (UCSC)UBE2B  -     chr5:133706867-133727799 +  5q31.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)UBE2B  -     5q31.1   [Description]    (hg38-Dec_2013)
EnsemblUBE2B - 5q31.1 [CytoView hg19]  UBE2B - 5q31.1 [CytoView hg38]
Mapping of homologs : NCBIUBE2B [Mapview hg19]  UBE2B [Mapview hg38]
OMIM179095   
Gene and transcription
Genbank (Entrez)AK312012 BC001694 BC005979 BC008404 BC008470
RefSeq transcript (Entrez)NM_003337
RefSeq genomic (Entrez)NC_000005 NC_018916 NT_034772 NW_004929323
Consensus coding sequences : CCDS (NCBI)UBE2B
Cluster EST : UnigeneHs.730071 [ NCBI ]
CGAP (NCI)Hs.730071
Alternative Splicing GalleryENSG00000119048
Gene ExpressionUBE2B [ NCBI-GEO ]   UBE2B [ EBI - ARRAY_EXPRESS ]   UBE2B [ SEEK ]   UBE2B [ MEM ]
Gene Expression Viewer (FireBrowse)UBE2B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7320
GTEX Portal (Tissue expression)UBE2B
Protein : pattern, domain, 3D structure
UniProt/SwissProtP63146 (Uniprot)
NextProtP63146  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP63146
Splice isoforms : SwissVarP63146 (Swissvar)
PhosPhoSitePlusP63146
Domaine pattern : Prosite (Expaxy)UBIQUITIN_CONJUGAT_1 (PS00183)    UBIQUITIN_CONJUGAT_2 (PS50127)   
Domains : Interpro (EBI)UBQ-conjugat_E2    UBQ-conjugating_AS    UBQ-conjugating_enzyme/RWD   
Domain families : Pfam (Sanger)UQ_con (PF00179)   
Domain families : Pfam (NCBI)pfam00179   
DMDM Disease mutations7320
Blocks (Seattle)UBE2B
PDB (SRS)1JAS    1NXA    2Y4W    2YB6    2YBF   
PDB (PDBSum)1JAS    1NXA    2Y4W    2YB6    2YBF   
PDB (IMB)1JAS    1NXA    2Y4W    2YB6    2YBF   
PDB (RSDB)1JAS    1NXA    2Y4W    2YB6    2YBF   
Structural Biology KnowledgeBase1JAS    1NXA    2Y4W    2YB6    2YBF   
SCOP (Structural Classification of Proteins)1JAS    1NXA    2Y4W    2YB6    2YBF   
CATH (Classification of proteins structures)1JAS    1NXA    2Y4W    2YB6    2YBF   
SuperfamilyP63146
Human Protein AtlasENSG00000119048
Peptide AtlasP63146
HPRD01533
IPIIPI00012060   IPI00964819   IPI00964509   IPI00963978   
Protein Interaction databases
DIP (DOE-UCLA)P63146
IntAct (EBI)P63146
FunCoupENSG00000119048
BioGRIDUBE2B
STRING (EMBL)UBE2B
ZODIACUBE2B
Ontologies - Pathways
QuickGOP63146
Ontology : AmiGOprotein polyubiquitination  chromatin  nuclear chromatin  in utero embryonic development  XY body  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  ATP binding  nucleus  nucleoplasm  replication fork  cytoplasm  plasma membrane  DNA repair  postreplication repair  postreplication repair  maintenance of chromatin silencing  ubiquitin-dependent protein catabolic process  ubiquitin-dependent protein catabolic process  protein monoubiquitination  cellular response to DNA damage stimulus  spermatogenesis  sperm axoneme assembly  response to UV  positive regulation of reciprocal meiotic recombination  protein ubiquitination  ubiquitin protein ligase binding  negative regulation of histone phosphorylation  HULC complex  histone H2A ubiquitination  response to drug  DNA damage response, detection of DNA damage  negative regulation of apoptotic process  proteasome-mediated ubiquitin-dependent protein catabolic process  negative regulation of cAMP-mediated signaling  meiotic telomere clustering  protein stabilization  chiasma assembly  protein autoubiquitination  canonical Wnt signaling pathway  ubiquitin protein ligase activity  ubiquitin conjugating enzyme activity  histone lysine demethylation  synaptonemal complex organization  protein K63-linked ubiquitination  protein K48-linked ubiquitination  protein K11-linked ubiquitination  
Ontology : EGO-EBIprotein polyubiquitination  chromatin  nuclear chromatin  in utero embryonic development  XY body  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  ATP binding  nucleus  nucleoplasm  replication fork  cytoplasm  plasma membrane  DNA repair  postreplication repair  postreplication repair  maintenance of chromatin silencing  ubiquitin-dependent protein catabolic process  ubiquitin-dependent protein catabolic process  protein monoubiquitination  cellular response to DNA damage stimulus  spermatogenesis  sperm axoneme assembly  response to UV  positive regulation of reciprocal meiotic recombination  protein ubiquitination  ubiquitin protein ligase binding  negative regulation of histone phosphorylation  HULC complex  histone H2A ubiquitination  response to drug  DNA damage response, detection of DNA damage  negative regulation of apoptotic process  proteasome-mediated ubiquitin-dependent protein catabolic process  negative regulation of cAMP-mediated signaling  meiotic telomere clustering  protein stabilization  chiasma assembly  protein autoubiquitination  canonical Wnt signaling pathway  ubiquitin protein ligase activity  ubiquitin conjugating enzyme activity  histone lysine demethylation  synaptonemal complex organization  protein K63-linked ubiquitination  protein K48-linked ubiquitination  protein K11-linked ubiquitination  
Pathways : KEGGUbiquitin mediated proteolysis   
NDEx Network
Atlas of Cancer Signalling NetworkUBE2B
Wikipedia pathwaysUBE2B
Orthology - Evolution
OrthoDB7320
GeneTree (enSembl)ENSG00000119048
Phylogenetic Trees/Animal Genes : TreeFamUBE2B
Homologs : HomoloGeneUBE2B
Homology/Alignments : Family Browser (UCSC)UBE2B
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerUBE2B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UBE2B
dbVarUBE2B
ClinVarUBE2B
1000_GenomesUBE2B 
Exome Variant ServerUBE2B
ExAC (Exome Aggregation Consortium)UBE2B (select the gene name)
Genetic variants : HAPMAP7320
Genomic Variants (DGV)UBE2B [DGVbeta]
Mutations
ICGC Data PortalUBE2B 
TCGA Data PortalUBE2B 
Broad Tumor PortalUBE2B
OASIS PortalUBE2B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUBE2B 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch UBE2B
DgiDB (Drug Gene Interaction Database)UBE2B
DoCM (Curated mutations)UBE2B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UBE2B (select a term)
intoGenUBE2B
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)5:133706867-133727799  ENSG00000119048
CONAN: Copy Number AnalysisUBE2B 
Mutations and Diseases : HGMDUBE2B
OMIM179095   
MedgenUBE2B
Genetic Testing Registry UBE2B
NextProtP63146 [Medical]
TSGene7320
GENETestsUBE2B
Huge Navigator UBE2B [HugePedia]
snp3D : Map Gene to Disease7320
BioCentury BCIQUBE2B
ClinGenUBE2B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7320
Chemical/Pharm GKB GenePA37123
Clinical trialUBE2B
Miscellaneous
canSAR (ICR)UBE2B (select the gene name)
Probes
Litterature
PubMed68 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUBE2B
EVEXUBE2B
GoPubMedUBE2B
iHOPUBE2B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 9 19:10:58 CEST 2016

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