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UBE2B (ubiquitin-conjugating enzyme E2B)

Identity

Other namesE2-17kDa
HHR6B
HR6B
RAD6B
UBC2
HGNC (Hugo) UBE2B
LocusID (NCBI) 7320
Location 5q31.1
Location_base_pair Starts at 133706870 and ends at 133727799 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)UBE2B   12473
Entrez_Gene (NCBI)UBE2B  7320  ubiquitin-conjugating enzyme E2B
Cards
GeneCards (Weizmann)UBE2B
Ensembl (Hinxton)ENSG00000119048 [Gene_View]  chr5:133706870-133727799 [Contig_View]  UBE2B [Vega]
AceView (NCBI)UBE2B
Genatlas (Paris)UBE2B
SOURCE (Stanford)NM_003337
Genomic and cartography
GoldenPath (UCSC)UBE2B  -  5q31.1   chr5:133706870-133727799 +  5q31.1   [Description]    (hg19-Feb_2009)
EnsemblUBE2B - 5q31.1 [CytoView]
Mapping of homologs : NCBIUBE2B [Mapview]
OMIM179095   
Gene and transcription
Genbank (Entrez)AK312012 BC001694 BC005979 BC008404 BC008470
RefSeq transcript (SRS)NM_003337
RefSeq transcript (Entrez)NM_003337
RefSeq genomic (SRS)AC_000137 NC_000005 NC_018916 NT_034772 NW_001838952 NW_004078024
RefSeq genomic (Entrez)AC_000137 NC_000005 NC_018916 NT_034772 NW_001838952 NW_004078024
Consensus coding sequences : CCDS (NCBI)UBE2B
Cluster EST : UnigeneHs.730071 [ SRS ] Hs.730071 [ NCBI ]
CGAP (NCI)Hs.730071
Alternative Splicing : Fast-db (Paris)GSHG0024241
Alternative Splicing GalleryENSG00000119048
Gene ExpressionUBE2B [ NCBI-GEO ]   UBE2B [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP63146 (SRS) P63146 (Uniprot)
NextProtP63146
With graphics : InterProP63146
Splice isoforms : SwissVarP63146(Swissvar)
Domaine pattern : Prosite (SRS)UBIQUITIN_CONJUGAT_1 (PS00183)    UBIQUITIN_CONJUGAT_2 (PS50127)   
Domaine pattern : Prosite (Expaxy)UBIQUITIN_CONJUGAT_1 (PS00183)    UBIQUITIN_CONJUGAT_2 (PS50127)   
Domains : Interpro (SRS)UBQ-conjugat_E2    UBQ-conjugating_AS    UBQ-conjugating_enzyme/RWD   
Domains : Interpro (EBI)UBQ-conjugat_E2    UBQ-conjugating_AS    UBQ-conjugating_enzyme/RWD   
Related proteins : CluSTrP63146
Domain families : Pfam (SRS)UQ_con (PF00179)   
Domain families : Pfam (Sanger)UQ_con (PF00179)   
Domain families : Pfam (NCBI)pfam00179   
DMDM7320
Blocks (Seattle)P63146
PDB (SRS)1JAS    1NXA    2Y4W    2YB6    2YBF   
PDB (PDBSum)1JAS    1NXA    2Y4W    2YB6    2YBF   
PDB (IMB)1JAS    1NXA    2Y4W    2YB6    2YBF   
PDB (RSDB)1JAS    1NXA    2Y4W    2YB6    2YBF   
Human Protein AtlasENSG00000119048
HPRD01533
IPIIPI00012060   IPI00964819   IPI00964509   IPI00963978   
Protein Interaction databases
DIP (DOE-UCLA)P63146
IntAct (EBI)P63146
FunCoupENSG00000119048
REACTOMEUBE2B
Protein Interaction Database7320
BioGRIDUBE2B
InParanoidP63146
Interologous Interaction database P63146
IntegromeDBUBE2B
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)UBE2B
SNP (GeneSNP Utah)UBE2B
SNP : HGBaseUBE2B
Genetic variants : HAPMAPUBE2B
Somatic Mutations in Cancer : COSMICUBE2B 
CONAN: Copy Number AnalysisUBE2B 
Mutations and Diseases : HGMDUBE2B
OMIM179095   
GENETests179095   
Disease Genetic AssociationUBE2B
Huge Navigator UBE2B [HugePedia]  UBE2B [HugeCancerGEM]
Genomic VariantsUBE2B  UBE2B [DGVbeta]
snp3D : Map Gene to Disease7320
General knowledge
Homologs : HomoloGeneUBE2B
Homology/Alignments : Family Browser (UCSC)UBE2B
Phylogenetic Trees/Animal Genes : TreeFamUBE2B
Catalytic activity : Enzyme6.3.2.19 [ Enzyme-Expasy ]   6.3.2.19 [ Enzyme-SRS ]   6.3.2.19 [ IntEnz-EBI ]   6.3.2.19 [ BRENDA ]   6.3.2.19 [ KEGG ]   
Chemical/Protein Interactions : CTD7320
Chemical/Pharm GKB GenePA37123
Clinical trialUBE2B
Cancer Resource (Charite)ENSG00000119048
Ontology : AmiGOprotein polyubiquitination  chromatin  nuclear chromatin  response to hypoxia  in utero embryonic development  XY body  ubiquitin-protein ligase activity  ubiquitin-protein ligase activity  protein binding  ATP binding  nucleus  replication fork  cytoplasm  plasma membrane  DNA repair  postreplication repair  postreplication repair  maintenance of chromatin silencing  ubiquitin-dependent protein catabolic process  ubiquitin-dependent protein catabolic process  protein monoubiquitination  response to DNA damage stimulus  spermatogenesis  sperm axoneme assembly  response to UV  positive regulation of reciprocal meiotic recombination  protein ubiquitination  ubiquitin protein ligase binding  cellular response to insulin stimulus  negative regulation of histone phosphorylation  HULC complex  histone H2A ubiquitination  response to drug  negative regulation of apoptotic process  proteasomal ubiquitin-dependent protein catabolic process  negative regulation of cAMP-mediated signaling  protein stabilization  chiasma assembly  protein autoubiquitination  canonical Wnt receptor signaling pathway  histone lysine demethylation  synaptonemal complex organization  protein K63-linked ubiquitination  protein K48-linked ubiquitination  protein K11-linked ubiquitination  
Ontology : EGO-EBIprotein polyubiquitination  chromatin  nuclear chromatin  response to hypoxia  in utero embryonic development  XY body  ubiquitin-protein ligase activity  ubiquitin-protein ligase activity  protein binding  ATP binding  nucleus  replication fork  cytoplasm  plasma membrane  DNA repair  postreplication repair  postreplication repair  maintenance of chromatin silencing  ubiquitin-dependent protein catabolic process  ubiquitin-dependent protein catabolic process  protein monoubiquitination  response to DNA damage stimulus  spermatogenesis  sperm axoneme assembly  response to UV  positive regulation of reciprocal meiotic recombination  protein ubiquitination  ubiquitin protein ligase binding  cellular response to insulin stimulus  negative regulation of histone phosphorylation  HULC complex  histone H2A ubiquitination  response to drug  negative regulation of apoptotic process  proteasomal ubiquitin-dependent protein catabolic process  negative regulation of cAMP-mediated signaling  protein stabilization  chiasma assembly  protein autoubiquitination  canonical Wnt receptor signaling pathway  histone lysine demethylation  synaptonemal complex organization  protein K63-linked ubiquitination  protein K48-linked ubiquitination  protein K11-linked ubiquitination  
Other databases
Probes
Litterature
PubMed52 Pubmed reference(s) in Entrez
PubGeneUBE2B
iHOPUBE2B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:22:20 CEST 2013
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