Atlas of Genetics and Cytogenetics in Oncology and Haematology


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UBE2D2 (ubiquitin conjugating enzyme E2 D2)

Identity

Alias_namesubiquitin-conjugating enzyme E2D 2 (homologous to yeast UBC4/5)
ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)
ubiquitin-conjugating enzyme E2D 2
Alias_symbol (synonym)UbcH5B
UBC4
Other aliasE2(17)KB2
PUBC1
UBC4/5
UBCH4
UBCH5B
HGNC (Hugo) UBE2D2
LocusID (NCBI) 7322
Atlas_Id 42749
Location 5q31.2  [Link to chromosome band 5q31]
Location_base_pair Starts at 139561166 and ends at 139628433 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
HARS (5q31.3) / UBE2D2 (5q31.2)HEXIM2 (17q21.31) / UBE2D2 (5q31.2)NDUFS4 (5q11.2) / UBE2D2 (5q31.2)
NRG2 (5q31.2) / UBE2D2 (5q31.2)RCC1 (1p35.3) / UBE2D2 (5q31.2)UBE2D2 (5q31.2) / MATR3 (5q31.2)
UBE2D2 (5q31.2) / PAIP2 (5q31.2)UBE2D2 (5q31.2) / SND1 (7q32.1)UBE2D2 (5q31.2) / UBE2D2 (5q31.2)
NDUFS4 5q11.2 / UBE2D2 5q31.2UBE2D2 5q31.2 / PAIP2 5q31.2UBE2D2 5q31.2 / SND1 7q32.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Adenocarcinoma


External links

Nomenclature
HGNC (Hugo)UBE2D2   12475
Cards
Entrez_Gene (NCBI)UBE2D2  7322  ubiquitin conjugating enzyme E2 D2
AliasesE2(17)KB2; PUBC1; UBC4; UBC4/5; 
UBCH4; UBCH5B
GeneCards (Weizmann)UBE2D2
Ensembl hg19 (Hinxton)ENSG00000131508 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000131508 [Gene_View]  chr5:139561166-139628433 [Contig_View]  UBE2D2 [Vega]
ICGC DataPortalENSG00000131508
TCGA cBioPortalUBE2D2
AceView (NCBI)UBE2D2
Genatlas (Paris)UBE2D2
WikiGenes7322
SOURCE (Princeton)UBE2D2
Genetics Home Reference (NIH)UBE2D2
Genomic and cartography
GoldenPath hg38 (UCSC)UBE2D2  -     chr5:139561166-139628433 +  5q31.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)UBE2D2  -     5q31.2   [Description]    (hg19-Feb_2009)
EnsemblUBE2D2 - 5q31.2 [CytoView hg19]  UBE2D2 - 5q31.2 [CytoView hg38]
Mapping of homologs : NCBIUBE2D2 [Mapview hg19]  UBE2D2 [Mapview hg38]
OMIM602962   
Gene and transcription
Genbank (Entrez)AF317220 AK001311 AK001428 AK310273 AY651263
RefSeq transcript (Entrez)NM_003339 NM_181838
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)UBE2D2
Cluster EST : UnigeneHs.108332 [ NCBI ]
CGAP (NCI)Hs.108332
Alternative Splicing GalleryENSG00000131508
Gene ExpressionUBE2D2 [ NCBI-GEO ]   UBE2D2 [ EBI - ARRAY_EXPRESS ]   UBE2D2 [ SEEK ]   UBE2D2 [ MEM ]
Gene Expression Viewer (FireBrowse)UBE2D2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7322
GTEX Portal (Tissue expression)UBE2D2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP62837   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP62837  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP62837
Splice isoforms : SwissVarP62837
PhosPhoSitePlusP62837
Domaine pattern : Prosite (Expaxy)UBIQUITIN_CONJUGAT_1 (PS00183)    UBIQUITIN_CONJUGAT_2 (PS50127)   
Domains : Interpro (EBI)UBQ-conjugat_E2    UBQ-conjugating_AS    UBQ-conjugating_enzyme/RWD   
Domain families : Pfam (Sanger)UQ_con (PF00179)   
Domain families : Pfam (NCBI)pfam00179   
Conserved Domain (NCBI)UBE2D2
DMDM Disease mutations7322
Blocks (Seattle)UBE2D2
PDB (SRS)1UR6    1W4U    2CLW    2ESK    2ESO    2ESP    2ESQ    3A33    3JVZ    3JW0    3L1Y    3TGD    3ZNI    4A49    4A4B    4A4C    4AUQ    4DDG    4LDT    4V3K    4V3L    4WZ3    5D0K    5D0M    5D1K    5D1L    5D1M    5EDV   
PDB (PDBSum)1UR6    1W4U    2CLW    2ESK    2ESO    2ESP    2ESQ    3A33    3JVZ    3JW0    3L1Y    3TGD    3ZNI    4A49    4A4B    4A4C    4AUQ    4DDG    4LDT    4V3K    4V3L    4WZ3    5D0K    5D0M    5D1K    5D1L    5D1M    5EDV   
PDB (IMB)1UR6    1W4U    2CLW    2ESK    2ESO    2ESP    2ESQ    3A33    3JVZ    3JW0    3L1Y    3TGD    3ZNI    4A49    4A4B    4A4C    4AUQ    4DDG    4LDT    4V3K    4V3L    4WZ3    5D0K    5D0M    5D1K    5D1L    5D1M    5EDV   
PDB (RSDB)1UR6    1W4U    2CLW    2ESK    2ESO    2ESP    2ESQ    3A33    3JVZ    3JW0    3L1Y    3TGD    3ZNI    4A49    4A4B    4A4C    4AUQ    4DDG    4LDT    4V3K    4V3L    4WZ3    5D0K    5D0M    5D1K    5D1L    5D1M    5EDV   
Structural Biology KnowledgeBase1UR6    1W4U    2CLW    2ESK    2ESO    2ESP    2ESQ    3A33    3JVZ    3JW0    3L1Y    3TGD    3ZNI    4A49    4A4B    4A4C    4AUQ    4DDG    4LDT    4V3K    4V3L    4WZ3    5D0K    5D0M    5D1K    5D1L    5D1M    5EDV   
SCOP (Structural Classification of Proteins)1UR6    1W4U    2CLW    2ESK    2ESO    2ESP    2ESQ    3A33    3JVZ    3JW0    3L1Y    3TGD    3ZNI    4A49    4A4B    4A4C    4AUQ    4DDG    4LDT    4V3K    4V3L    4WZ3    5D0K    5D0M    5D1K    5D1L    5D1M    5EDV   
CATH (Classification of proteins structures)1UR6    1W4U    2CLW    2ESK    2ESO    2ESP    2ESQ    3A33    3JVZ    3JW0    3L1Y    3TGD    3ZNI    4A49    4A4B    4A4C    4AUQ    4DDG    4LDT    4V3K    4V3L    4WZ3    5D0K    5D0M    5D1K    5D1L    5D1M    5EDV   
SuperfamilyP62837
Human Protein AtlasENSG00000131508
Peptide AtlasP62837
HPRD04268
IPIIPI00332376   IPI00019932   IPI00967041   
Protein Interaction databases
DIP (DOE-UCLA)P62837
IntAct (EBI)P62837
FunCoupENSG00000131508
BioGRIDUBE2D2
STRING (EMBL)UBE2D2
ZODIACUBE2D2
Ontologies - Pathways
QuickGOP62837
Ontology : AmiGOubiquitin ligase complex  protein polyubiquitination  stimulatory C-type lectin receptor signaling pathway  ubiquitin-protein transferase activity  protein binding  ATP binding  nucleoplasm  cytosol  cellular protein modification process  ubiquitin-dependent protein catabolic process  protein ubiquitination  protein ubiquitination  TRIF-dependent toll-like receptor signaling pathway  Fc-epsilon receptor signaling pathway  protein complex  T cell receptor signaling pathway  protein autoubiquitination  regulation of transcription from RNA polymerase II promoter in response to hypoxia  ubiquitin conjugating enzyme activity  extracellular exosome  protein K48-linked ubiquitination  
Ontology : EGO-EBIubiquitin ligase complex  protein polyubiquitination  stimulatory C-type lectin receptor signaling pathway  ubiquitin-protein transferase activity  protein binding  ATP binding  nucleoplasm  cytosol  cellular protein modification process  ubiquitin-dependent protein catabolic process  protein ubiquitination  protein ubiquitination  TRIF-dependent toll-like receptor signaling pathway  Fc-epsilon receptor signaling pathway  protein complex  T cell receptor signaling pathway  protein autoubiquitination  regulation of transcription from RNA polymerase II promoter in response to hypoxia  ubiquitin conjugating enzyme activity  extracellular exosome  protein K48-linked ubiquitination  
Pathways : KEGGUbiquitin mediated proteolysis    Protein processing in endoplasmic reticulum    Shigellosis   
NDEx NetworkUBE2D2
Atlas of Cancer Signalling NetworkUBE2D2
Wikipedia pathwaysUBE2D2
Orthology - Evolution
OrthoDB7322
GeneTree (enSembl)ENSG00000131508
Phylogenetic Trees/Animal Genes : TreeFamUBE2D2
HOVERGENP62837
HOGENOMP62837
Homologs : HomoloGeneUBE2D2
Homology/Alignments : Family Browser (UCSC)UBE2D2
Gene fusions - Rearrangements
Fusion : MitelmanNDUFS4/UBE2D2 [5q11.2/5q31.2]  [t(5;5)(q11;q31)]  
Fusion : MitelmanRCC1/UBE2D2 [1p35.3/5q31.2]  [t(1;5)(p35;q31)]  
Fusion : MitelmanUBE2D2/MATR3 [5q31.2/5q31.2]  [t(5;5)(q31;q31)]  
Fusion : MitelmanUBE2D2/PAIP2 [5q31.2/5q31.2]  [t(5;5)(q31;q31)]  
Fusion : MitelmanUBE2D2/SND1 [5q31.2/7q32.1]  [t(5;7)(q31;q32)]  
Fusion: TCGANDUFS4 5q11.2 UBE2D2 5q31.2 LUAD
Fusion: TCGAUBE2D2 5q31.2 PAIP2 5q31.2 OV
Fusion: TCGAUBE2D2 5q31.2 SND1 7q32.1 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUBE2D2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UBE2D2
dbVarUBE2D2
ClinVarUBE2D2
1000_GenomesUBE2D2 
Exome Variant ServerUBE2D2
ExAC (Exome Aggregation Consortium)UBE2D2 (select the gene name)
Genetic variants : HAPMAP7322
Genomic Variants (DGV)UBE2D2 [DGVbeta]
DECIPHERUBE2D2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUBE2D2 
Mutations
ICGC Data PortalUBE2D2 
TCGA Data PortalUBE2D2 
Broad Tumor PortalUBE2D2
OASIS PortalUBE2D2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUBE2D2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUBE2D2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch UBE2D2
DgiDB (Drug Gene Interaction Database)UBE2D2
DoCM (Curated mutations)UBE2D2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UBE2D2 (select a term)
intoGenUBE2D2
Cancer3DUBE2D2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602962   
Orphanet
MedgenUBE2D2
Genetic Testing Registry UBE2D2
NextProtP62837 [Medical]
TSGene7322
GENETestsUBE2D2
Target ValidationUBE2D2
Huge Navigator UBE2D2 [HugePedia]
snp3D : Map Gene to Disease7322
BioCentury BCIQUBE2D2
ClinGenUBE2D2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7322
Chemical/Pharm GKB GenePA37125
Clinical trialUBE2D2
Miscellaneous
canSAR (ICR)UBE2D2 (select the gene name)
Probes
Litterature
PubMed321 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUBE2D2
EVEXUBE2D2
GoPubMedUBE2D2
iHOPUBE2D2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 13:01:36 CEST 2017

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