UBE2D3 (ubiquitin conjugating enzyme E2 D3)

2003-10-01 Affiliation

Identity

HGNC

UBE2D3

LOCATION

4q24

LOCUSID

7323

ALIAS

E2(17)KB3,UBC4/5,UBCH5C

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 7323
MIM: 602963
HGNC: 12476
Ensembl: ENSG00000109332

Variants:

dbSNP: 7323
ClinVar: 7323
TCGA: ENSG00000109332
COSMIC: UBE2D3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000109332	ENST00000321805	P61077
ENSG00000109332	ENST00000321805	A0A024RDH2
ENSG00000109332	ENST00000338145	P61077
ENSG00000109332	ENST00000338145	A0A024RDH2
ENSG00000109332	ENST00000343106	P61077
ENSG00000109332	ENST00000349311	P61077
ENSG00000109332	ENST00000349311	A0A024RDH2
ENSG00000109332	ENST00000350435	H9KV45
ENSG00000109332	ENST00000357194	P61077
ENSG00000109332	ENST00000394801	P61077
ENSG00000109332	ENST00000394801	A0A024RDH2
ENSG00000109332	ENST00000394803	P61077
ENSG00000109332	ENST00000394803	A0A024RDH2
ENSG00000109332	ENST00000394804	P61077
ENSG00000109332	ENST00000394804	A0A024RDH2
ENSG00000109332	ENST00000453744	P61077
ENSG00000109332	ENST00000453744	A0A024RDH2
ENSG00000109332	ENST00000502404	D6RAH7
ENSG00000109332	ENST00000502563	D6R9F6
ENSG00000109332	ENST00000502690	D6RIZ3
ENSG00000109332	ENST00000503418	D6R933
ENSG00000109332	ENST00000504211	D6RAH7
ENSG00000109332	ENST00000505207	D6RAH7
ENSG00000109332	ENST00000505307	D6R933
ENSG00000109332	ENST00000507845	D6RAH7
ENSG00000109332	ENST00000508238	D6RA11
ENSG00000109332	ENST00000508249	D6RGD0
ENSG00000109332	ENST00000508476	D6RAW0
ENSG00000109332	ENST00000508635	D6RJB3
ENSG00000109332	ENST00000508974	D6R980
ENSG00000109332	ENST00000510129	D6R9F6
ENSG00000109332	ENST00000514755	D6R933
ENSG00000109332	ENST00000618836	A0A087WY85

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Ubiquitin mediated proteolysis	KEGG	ko04120
Ubiquitin mediated proteolysis	KEGG	hsa04120
Protein processing in endoplasmic reticulum	KEGG	ko04141
Protein processing in endoplasmic reticulum	KEGG	hsa04141
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Class I MHC mediated antigen processing & presentation	REACTOME	R-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradation	REACTOME	R-HSA-983168
Innate Immune System	REACTOME	R-HSA-168249
Toll-Like Receptors Cascades	REACTOME	R-HSA-168898
Toll Like Receptor 3 (TLR3) Cascade	REACTOME	R-HSA-168164
MyD88-independent TLR3/TLR4 cascade	REACTOME	R-HSA-166166
TRIF-mediated TLR3/TLR4 signaling	REACTOME	R-HSA-937061
IKK complex recruitment mediated by RIP1	REACTOME	R-HSA-937041
Toll Like Receptor 4 (TLR4) Cascade	REACTOME	R-HSA-166016
Activated TLR4 signalling	REACTOME	R-HSA-166054
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways	REACTOME	R-HSA-168928
Negative regulators of RIG-I/MDA5 signaling	REACTOME	R-HSA-936440
Signal Transduction	REACTOME	R-HSA-162582
Signaling by BMP	REACTOME	R-HSA-201451
Signaling by TGF-beta Receptor Complex	REACTOME	R-HSA-170834
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	REACTOME	R-HSA-2173793
Downregulation of SMAD2/3:SMAD4 transcriptional activity	REACTOME	R-HSA-2173795
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
Cellular responses to stress	REACTOME	R-HSA-2262752
Cellular response to hypoxia	REACTOME	R-HSA-2262749
Regulation of Hypoxia-inducible Factor (HIF) by oxygen	REACTOME	R-HSA-1234174
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	REACTOME	R-HSA-1234176
Protein ubiquitination	REACTOME	R-HSA-8852135
E3 ubiquitin ligases ubiquitinate target proteins	REACTOME	R-HSA-8866654

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
21226485	2011	Ubiquitin in motion: structural studies of the ubiquitin-conjugating enzyme∼ubiquitin conjugate.	62
20347421	2010	Priming and extending: a UbcH5/Cdc34 E2 handoff mechanism for polyubiquitination on a SCF substrate.	54
15280377	2004	Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivo.	51
21772249	2011	Recognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complex.	48
26502057	2015	Systematic E2 screening reveals a UBE2D-RNF138-CtIP axis promoting DNA repair.	35
20051513	2010	Lysine 63-linked polyubiquitination of the dopamine transporter requires WW3 and WW4 domains of Nedd4-2 and UBE2D ubiquitin-conjugating enzymes.	32
24446487	2014	E2~Ub conjugates regulate the kinase activity of Shigella effector OspG during pathogenesis.	31
23550736	2013	Activation of UbcH5c~Ub is the result of a shift in interdomain motions of the conjugate bound to U-box E3 ligase E4B.	26
12215439	2002	Ubiquitylation of the transducin betagamma subunit complex. Regulation by phosducin.	21
17420285	2007	RNAi screen identifies UBE2D3 as a mediator of all-trans retinoic acid-induced cell growth arrest in human acute promyelocytic NB4 cells.	19

Citation

Dessen P

UBE2D3 (ubiquitin conjugating enzyme E2 D3)

Atlas Genet Cytogenet Oncol Haematol. 2003-10-01

Online version: http://atlasgeneticsoncology.org/gene/42750/ube2d3