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UBE2D3 (ubiquitin conjugating enzyme E2 D3)

Identity

Alias_namesubiquitin-conjugating enzyme E2D 3 (homologous to yeast UBC4/5)
ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)
ubiquitin-conjugating enzyme E2D 3
Alias_symbol (synonym)UbcH5C
Other aliasE2(17)KB3
UBC4/5
UBCH5C
HGNC (Hugo) UBE2D3
LocusID (NCBI) 7323
Atlas_Id 42750
Location 4q24  [Link to chromosome band 4q24]
Location_base_pair Starts at 103715540 and ends at 103747017 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
AFF1 (4q21.3) / UBE2D3 (4q24)CISD2 (4q24) / UBE2D3 (4q24)CLCN3 (4q33) / UBE2D3 (4q24)
MANBA (4q24) / UBE2D3 (4q24)RHOB (2p24.1) / UBE2D3 (4q24)UBE2D3 (4q24) / ARPC5 (1q25.3)
UBE2D3 (4q24) / NRF1 (7q32.2)UBE2D3 (4q24) / SHTN1 (10q25.3)UBE2D3 (4q24) / SLC9B1 (4q24)
CLCN3 4q33 / UBE2D3 4q24UBE2D3 4q24 / SLC9B1 4q24

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)UBE2D3   12476
Cards
Entrez_Gene (NCBI)UBE2D3  7323  ubiquitin conjugating enzyme E2 D3
AliasesE2(17)KB3; UBC4/5; UBCH5C
GeneCards (Weizmann)UBE2D3
Ensembl hg19 (Hinxton)ENSG00000109332 [Gene_View]  chr4:103715540-103747017 [Contig_View]  UBE2D3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000109332 [Gene_View]  chr4:103715540-103747017 [Contig_View]  UBE2D3 [Vega]
ICGC DataPortalENSG00000109332
TCGA cBioPortalUBE2D3
AceView (NCBI)UBE2D3
Genatlas (Paris)UBE2D3
WikiGenes7323
SOURCE (Princeton)UBE2D3
Genetics Home Reference (NIH)UBE2D3
Genomic and cartography
GoldenPath hg19 (UCSC)UBE2D3  -     chr4:103715540-103747017 -  4q24   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)UBE2D3  -     4q24   [Description]    (hg38-Dec_2013)
EnsemblUBE2D3 - 4q24 [CytoView hg19]  UBE2D3 - 4q24 [CytoView hg38]
Mapping of homologs : NCBIUBE2D3 [Mapview hg19]  UBE2D3 [Mapview hg38]
OMIM602963   
Gene and transcription
Genbank (Entrez)AF116686 AI651378 AK095822 AK127304 AK315775
RefSeq transcript (Entrez)NM_001300795 NM_003340 NM_181886 NM_181887 NM_181888 NM_181889 NM_181890 NM_181891 NM_181892 NM_181893
RefSeq genomic (Entrez)NC_000004 NC_018915 NT_016354 NW_004929320
Consensus coding sequences : CCDS (NCBI)UBE2D3
Cluster EST : UnigeneHs.621366 [ NCBI ]
CGAP (NCI)Hs.621366
Alternative Splicing GalleryENSG00000109332
Gene ExpressionUBE2D3 [ NCBI-GEO ]   UBE2D3 [ EBI - ARRAY_EXPRESS ]   UBE2D3 [ SEEK ]   UBE2D3 [ MEM ]
Gene Expression Viewer (FireBrowse)UBE2D3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7323
GTEX Portal (Tissue expression)UBE2D3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP61077   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP61077  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP61077
Splice isoforms : SwissVarP61077
PhosPhoSitePlusP61077
Domaine pattern : Prosite (Expaxy)UBIQUITIN_CONJUGAT_1 (PS00183)    UBIQUITIN_CONJUGAT_2 (PS50127)   
Domains : Interpro (EBI)UBQ-conjugat_E2    UBQ-conjugating_AS    UBQ-conjugating_enzyme/RWD   
Domain families : Pfam (Sanger)UQ_con (PF00179)   
Domain families : Pfam (NCBI)pfam00179   
Conserved Domain (NCBI)UBE2D3
DMDM Disease mutations7323
Blocks (Seattle)UBE2D3
PDB (SRS)1X23    2FUH    3L1Z    3RPG    3UGB    4BVU    4R8P    4S3O   
PDB (PDBSum)1X23    2FUH    3L1Z    3RPG    3UGB    4BVU    4R8P    4S3O   
PDB (IMB)1X23    2FUH    3L1Z    3RPG    3UGB    4BVU    4R8P    4S3O   
PDB (RSDB)1X23    2FUH    3L1Z    3RPG    3UGB    4BVU    4R8P    4S3O   
Structural Biology KnowledgeBase1X23    2FUH    3L1Z    3RPG    3UGB    4BVU    4R8P    4S3O   
SCOP (Structural Classification of Proteins)1X23    2FUH    3L1Z    3RPG    3UGB    4BVU    4R8P    4S3O   
CATH (Classification of proteins structures)1X23    2FUH    3L1Z    3RPG    3UGB    4BVU    4R8P    4S3O   
SuperfamilyP61077
Human Protein AtlasENSG00000109332
Peptide AtlasP61077
HPRD04269
IPIIPI00966744   
Protein Interaction databases
DIP (DOE-UCLA)P61077
IntAct (EBI)P61077
FunCoupENSG00000109332
BioGRIDUBE2D3
STRING (EMBL)UBE2D3
ZODIACUBE2D3
Ontologies - Pathways
QuickGOP61077
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  protein polyubiquitination  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  ATP binding  nucleoplasm  cytosol  plasma membrane  DNA repair  cellular protein modification process  ubiquitin-dependent protein catabolic process  protein monoubiquitination  apoptotic process  endosome membrane  protein ubiquitination  BMP signaling pathway  TRIF-dependent toll-like receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  protein autoubiquitination  regulation of transcription from RNA polymerase II promoter in response to hypoxia  ubiquitin conjugating enzyme activity  extracellular exosome  protein K48-linked ubiquitination  protein K11-linked ubiquitination  positive regulation of protein targeting to mitochondrion  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  protein polyubiquitination  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  ATP binding  nucleoplasm  cytosol  plasma membrane  DNA repair  cellular protein modification process  ubiquitin-dependent protein catabolic process  protein monoubiquitination  apoptotic process  endosome membrane  protein ubiquitination  BMP signaling pathway  TRIF-dependent toll-like receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  protein autoubiquitination  regulation of transcription from RNA polymerase II promoter in response to hypoxia  ubiquitin conjugating enzyme activity  extracellular exosome  protein K48-linked ubiquitination  protein K11-linked ubiquitination  positive regulation of protein targeting to mitochondrion  
Pathways : KEGGUbiquitin mediated proteolysis    Protein processing in endoplasmic reticulum   
NDEx NetworkUBE2D3
Atlas of Cancer Signalling NetworkUBE2D3
Wikipedia pathwaysUBE2D3
Orthology - Evolution
OrthoDB7323
GeneTree (enSembl)ENSG00000109332
Phylogenetic Trees/Animal Genes : TreeFamUBE2D3
HOVERGENP61077
HOGENOMP61077
Homologs : HomoloGeneUBE2D3
Homology/Alignments : Family Browser (UCSC)UBE2D3
Gene fusions - Rearrangements
Fusion: TCGACLCN3 4q33 UBE2D3 4q24 BRCA
Fusion: TCGAUBE2D3 4q24 SLC9B1 4q24 BRCA LUSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUBE2D3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UBE2D3
dbVarUBE2D3
ClinVarUBE2D3
1000_GenomesUBE2D3 
Exome Variant ServerUBE2D3
ExAC (Exome Aggregation Consortium)UBE2D3 (select the gene name)
Genetic variants : HAPMAP7323
Genomic Variants (DGV)UBE2D3 [DGVbeta]
DECIPHER (Syndromes)4:103715540-103747017  ENSG00000109332
CONAN: Copy Number AnalysisUBE2D3 
Mutations
ICGC Data PortalUBE2D3 
TCGA Data PortalUBE2D3 
Broad Tumor PortalUBE2D3
OASIS PortalUBE2D3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUBE2D3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUBE2D3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch UBE2D3
DgiDB (Drug Gene Interaction Database)UBE2D3
DoCM (Curated mutations)UBE2D3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UBE2D3 (select a term)
intoGenUBE2D3
Cancer3DUBE2D3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602963   
Orphanet
MedgenUBE2D3
Genetic Testing Registry UBE2D3
NextProtP61077 [Medical]
TSGene7323
GENETestsUBE2D3
Huge Navigator UBE2D3 [HugePedia]
snp3D : Map Gene to Disease7323
BioCentury BCIQUBE2D3
ClinGenUBE2D3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7323
Chemical/Pharm GKB GenePA37126
Clinical trialUBE2D3
Miscellaneous
canSAR (ICR)UBE2D3 (select the gene name)
Probes
Litterature
PubMed269 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUBE2D3
EVEXUBE2D3
GoPubMedUBE2D3
iHOPUBE2D3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:24:03 CEST 2017

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