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UBE2E1 (ubiquitin conjugating enzyme E2 E1)

Identity

Alias_namesubiquitin-conjugating enzyme E2E 1 (homologous to yeast UBC4/5)
ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)
ubiquitin-conjugating enzyme E2E 1
Alias_symbol (synonym)UbcH6
Other aliasUBCH6
HGNC (Hugo) UBE2E1
LocusID (NCBI) 7324
Atlas_Id 47517
Location 3p24.2  [Link to chromosome band 3p24]
Location_base_pair Starts at 23810443 and ends at 23891640 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
UBE2E1 (3p24.3) / ASCC3 (6q16.3)UBE2E1 (3p24.3) / COL24A1 (1p22.3)UBE2E1 (3p24.3) / RABGAP1L (1q25.1)
UBE2E1 (3p24.3) / UBE2E1 (3p24.3)UBE2E1 (3p24.3) / WNT7A (3p25.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Adenocarcinoma


External links

Nomenclature
HGNC (Hugo)UBE2E1   12477
Cards
Entrez_Gene (NCBI)UBE2E1  7324  ubiquitin conjugating enzyme E2 E1
AliasesUBCH6
GeneCards (Weizmann)UBE2E1
Ensembl hg19 (Hinxton)ENSG00000170142 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000170142 [Gene_View]  chr3:23810443-23891640 [Contig_View]  UBE2E1 [Vega]
ICGC DataPortalENSG00000170142
TCGA cBioPortalUBE2E1
AceView (NCBI)UBE2E1
Genatlas (Paris)UBE2E1
WikiGenes7324
SOURCE (Princeton)UBE2E1
Genetics Home Reference (NIH)UBE2E1
Genomic and cartography
GoldenPath hg38 (UCSC)UBE2E1  -     chr3:23810443-23891640 +  3p24.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)UBE2E1  -     3p24.2   [Description]    (hg19-Feb_2009)
EnsemblUBE2E1 - 3p24.2 [CytoView hg19]  UBE2E1 - 3p24.2 [CytoView hg38]
Mapping of homologs : NCBIUBE2E1 [Mapview hg19]  UBE2E1 [Mapview hg38]
OMIM602916   
Gene and transcription
Genbank (Entrez)AK295354 AK314854 BC009139 BF698653 BI223271
RefSeq transcript (Entrez)NM_001202476 NM_003341 NM_182666
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)UBE2E1
Cluster EST : UnigeneHs.164853 [ NCBI ]
CGAP (NCI)Hs.164853
Alternative Splicing GalleryENSG00000170142
Gene ExpressionUBE2E1 [ NCBI-GEO ]   UBE2E1 [ EBI - ARRAY_EXPRESS ]   UBE2E1 [ SEEK ]   UBE2E1 [ MEM ]
Gene Expression Viewer (FireBrowse)UBE2E1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7324
GTEX Portal (Tissue expression)UBE2E1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP51965   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP51965  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP51965
Splice isoforms : SwissVarP51965
PhosPhoSitePlusP51965
Domaine pattern : Prosite (Expaxy)UBIQUITIN_CONJUGAT_1 (PS00183)    UBIQUITIN_CONJUGAT_2 (PS50127)   
Domains : Interpro (EBI)UBQ-conjugat_E2    UBQ-conjugating_AS    UBQ-conjugating_enzyme/RWD   
Domain families : Pfam (Sanger)UQ_con (PF00179)   
Domain families : Pfam (NCBI)pfam00179   
Conserved Domain (NCBI)UBE2E1
DMDM Disease mutations7324
Blocks (Seattle)UBE2E1
PDB (SRS)1XR9    3BZH    4JJQ   
PDB (PDBSum)1XR9    3BZH    4JJQ   
PDB (IMB)1XR9    3BZH    4JJQ   
PDB (RSDB)1XR9    3BZH    4JJQ   
Structural Biology KnowledgeBase1XR9    3BZH    4JJQ   
SCOP (Structural Classification of Proteins)1XR9    3BZH    4JJQ   
CATH (Classification of proteins structures)1XR9    3BZH    4JJQ   
SuperfamilyP51965
Human Protein AtlasENSG00000170142
Peptide AtlasP51965
HPRD04225
IPIIPI00021346   IPI00377011   IPI00797418   IPI00925368   IPI00926893   
Protein Interaction databases
DIP (DOE-UCLA)P51965
IntAct (EBI)P51965
FunCoupENSG00000170142
BioGRIDUBE2E1
STRING (EMBL)UBE2E1
ZODIACUBE2E1
Ontologies - Pathways
QuickGOP51965
Ontology : AmiGOubiquitin ligase complex  protein polyubiquitination  ubiquitin-protein transferase activity  protein binding  ATP binding  nucleus  nucleoplasm  cytosol  ubiquitin-dependent protein catabolic process  histone monoubiquitination  protein ubiquitination  protein ubiquitination  anaphase-promoting complex-dependent catabolic process  ISG15-protein conjugation  histone H2B ubiquitination  ISG15 transferase activity  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  proteasome-mediated ubiquitin-dependent protein catabolic process  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  ubiquitin conjugating enzyme activity  protein K48-linked ubiquitination  
Ontology : EGO-EBIubiquitin ligase complex  protein polyubiquitination  ubiquitin-protein transferase activity  protein binding  ATP binding  nucleus  nucleoplasm  cytosol  ubiquitin-dependent protein catabolic process  histone monoubiquitination  protein ubiquitination  protein ubiquitination  anaphase-promoting complex-dependent catabolic process  ISG15-protein conjugation  histone H2B ubiquitination  ISG15 transferase activity  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  proteasome-mediated ubiquitin-dependent protein catabolic process  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  ubiquitin conjugating enzyme activity  protein K48-linked ubiquitination  
Pathways : KEGGUbiquitin mediated proteolysis    Protein processing in endoplasmic reticulum   
NDEx NetworkUBE2E1
Atlas of Cancer Signalling NetworkUBE2E1
Wikipedia pathwaysUBE2E1
Orthology - Evolution
OrthoDB7324
GeneTree (enSembl)ENSG00000170142
Phylogenetic Trees/Animal Genes : TreeFamUBE2E1
HOVERGENP51965
HOGENOMP51965
Homologs : HomoloGeneUBE2E1
Homology/Alignments : Family Browser (UCSC)UBE2E1
Gene fusions - Rearrangements
Fusion : MitelmanUBE2E1/ASCC3 [3p24.3/6q16.3]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUBE2E1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UBE2E1
dbVarUBE2E1
ClinVarUBE2E1
1000_GenomesUBE2E1 
Exome Variant ServerUBE2E1
ExAC (Exome Aggregation Consortium)UBE2E1 (select the gene name)
Genetic variants : HAPMAP7324
Genomic Variants (DGV)UBE2E1 [DGVbeta]
DECIPHERUBE2E1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUBE2E1 
Mutations
ICGC Data PortalUBE2E1 
TCGA Data PortalUBE2E1 
Broad Tumor PortalUBE2E1
OASIS PortalUBE2E1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUBE2E1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUBE2E1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch UBE2E1
DgiDB (Drug Gene Interaction Database)UBE2E1
DoCM (Curated mutations)UBE2E1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UBE2E1 (select a term)
intoGenUBE2E1
Cancer3DUBE2E1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602916   
Orphanet
MedgenUBE2E1
Genetic Testing Registry UBE2E1
NextProtP51965 [Medical]
TSGene7324
GENETestsUBE2E1
Target ValidationUBE2E1
Huge Navigator UBE2E1 [HugePedia]
snp3D : Map Gene to Disease7324
BioCentury BCIQUBE2E1
ClinGenUBE2E1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7324
Chemical/Pharm GKB GenePA37127
Clinical trialUBE2E1
Miscellaneous
canSAR (ICR)UBE2E1 (select the gene name)
Probes
Litterature
PubMed99 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUBE2E1
EVEXUBE2E1
GoPubMedUBE2E1
iHOPUBE2E1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 13:01:36 CEST 2017

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