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UBE2E2 (ubiquitin conjugating enzyme E2 E2)

Identity

Alias_namesubiquitin-conjugating enzyme E2E 2 (homologous to yeast UBC4/5)
ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast)
ubiquitin-conjugating enzyme E2E 2
Alias_symbol (synonym)UbcH8
FLJ25157
Other aliasUBCH8
HGNC (Hugo) UBE2E2
LocusID (NCBI) 7325
Atlas_Id 47212
Location 3p24.3  [Link to chromosome band 3p24]
Location_base_pair Starts at 23203293 and ends at 23590805 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
AAK1 (2p13.3) / UBE2E2 (3p24.3)ITGA4 (2q31.3) / UBE2E2 (3p24.3)ST7 (7q31.2) / UBE2E2 (3p24.3)
UBE2E2 (3p24.3) / BRPF3 (6p21.31)UBE2E2 (3p24.3) / FAM179B (14q21.2)UBE2E2 (3p24.3) / NUP210 (3p25.1)
UBE2E2 (3p24.3) / SRSF3 (6p21.31)UBE2E2 (3p24.3) / UBE2E2 (3p24.3)ITGA4 2q31.3 / UBE2E2 3p24.3
UBE2E2 3p24.3 / FAM179B 14q21.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)UBE2E2   12478
Cards
Entrez_Gene (NCBI)UBE2E2  7325  ubiquitin conjugating enzyme E2 E2
AliasesUBCH8
GeneCards (Weizmann)UBE2E2
Ensembl hg19 (Hinxton)ENSG00000182247 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000182247 [Gene_View]  chr3:23203293-23590805 [Contig_View]  UBE2E2 [Vega]
ICGC DataPortalENSG00000182247
TCGA cBioPortalUBE2E2
AceView (NCBI)UBE2E2
Genatlas (Paris)UBE2E2
WikiGenes7325
SOURCE (Princeton)UBE2E2
Genetics Home Reference (NIH)UBE2E2
Genomic and cartography
GoldenPath hg38 (UCSC)UBE2E2  -     chr3:23203293-23590805 +  3p24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)UBE2E2  -     3p24.3   [Description]    (hg19-Feb_2009)
EnsemblUBE2E2 - 3p24.3 [CytoView hg19]  UBE2E2 - 3p24.3 [CytoView hg38]
Mapping of homologs : NCBIUBE2E2 [Mapview hg19]  UBE2E2 [Mapview hg38]
OMIM602163   
Gene and transcription
Genbank (Entrez)AK057886 AK307075 BC022332 CB851345
RefSeq transcript (Entrez)NM_152653
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)UBE2E2
Cluster EST : UnigeneHs.595802 [ NCBI ]
CGAP (NCI)Hs.595802
Alternative Splicing GalleryENSG00000182247
Gene ExpressionUBE2E2 [ NCBI-GEO ]   UBE2E2 [ EBI - ARRAY_EXPRESS ]   UBE2E2 [ SEEK ]   UBE2E2 [ MEM ]
Gene Expression Viewer (FireBrowse)UBE2E2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7325
GTEX Portal (Tissue expression)UBE2E2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96LR5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96LR5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96LR5
Splice isoforms : SwissVarQ96LR5
PhosPhoSitePlusQ96LR5
Domaine pattern : Prosite (Expaxy)UBIQUITIN_CONJUGAT_1 (PS00183)    UBIQUITIN_CONJUGAT_2 (PS50127)   
Domains : Interpro (EBI)UBQ-conjugat_E2    UBQ-conjugating_AS    UBQ-conjugating_enzyme/RWD   
Domain families : Pfam (Sanger)UQ_con (PF00179)   
Domain families : Pfam (NCBI)pfam00179   
Conserved Domain (NCBI)UBE2E2
DMDM Disease mutations7325
Blocks (Seattle)UBE2E2
PDB (SRS)1Y6L   
PDB (PDBSum)1Y6L   
PDB (IMB)1Y6L   
PDB (RSDB)1Y6L   
Structural Biology KnowledgeBase1Y6L   
SCOP (Structural Classification of Proteins)1Y6L   
CATH (Classification of proteins structures)1Y6L   
SuperfamilyQ96LR5
Human Protein AtlasENSG00000182247
Peptide AtlasQ96LR5
HPRD06779
IPIIPI00102173   IPI00927417   IPI00926860   IPI00926642   
Protein Interaction databases
DIP (DOE-UCLA)Q96LR5
IntAct (EBI)Q96LR5
FunCoupENSG00000182247
BioGRIDUBE2E2
STRING (EMBL)UBE2E2
ZODIACUBE2E2
Ontologies - Pathways
QuickGOQ96LR5
Ontology : AmiGOubiquitin-protein transferase activity  protein binding  ATP binding  cellular response to DNA damage stimulus  ISG15-protein conjugation  ISG15 transferase activity  ubiquitin conjugating enzyme activity  protein K63-linked ubiquitination  protein K48-linked ubiquitination  protein K11-linked ubiquitination  positive regulation of G1/S transition of mitotic cell cycle  
Ontology : EGO-EBIubiquitin-protein transferase activity  protein binding  ATP binding  cellular response to DNA damage stimulus  ISG15-protein conjugation  ISG15 transferase activity  ubiquitin conjugating enzyme activity  protein K63-linked ubiquitination  protein K48-linked ubiquitination  protein K11-linked ubiquitination  positive regulation of G1/S transition of mitotic cell cycle  
Pathways : KEGGUbiquitin mediated proteolysis    Protein processing in endoplasmic reticulum   
NDEx NetworkUBE2E2
Atlas of Cancer Signalling NetworkUBE2E2
Wikipedia pathwaysUBE2E2
Orthology - Evolution
OrthoDB7325
GeneTree (enSembl)ENSG00000182247
Phylogenetic Trees/Animal Genes : TreeFamUBE2E2
HOVERGENQ96LR5
HOGENOMQ96LR5
Homologs : HomoloGeneUBE2E2
Homology/Alignments : Family Browser (UCSC)UBE2E2
Gene fusions - Rearrangements
Fusion : MitelmanITGA4/UBE2E2 [2q31.3/3p24.3]  [t(2;3)(q31;p24)]  
Fusion : MitelmanUBE2E2/FAM179B [3p24.3/14q21.2]  [t(3;14)(p24;q21)]  
Fusion: TCGAITGA4 2q31.3 UBE2E2 3p24.3 LGG
Fusion: TCGAUBE2E2 3p24.3 FAM179B 14q21.2 LUSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUBE2E2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UBE2E2
dbVarUBE2E2
ClinVarUBE2E2
1000_GenomesUBE2E2 
Exome Variant ServerUBE2E2
ExAC (Exome Aggregation Consortium)UBE2E2 (select the gene name)
Genetic variants : HAPMAP7325
Genomic Variants (DGV)UBE2E2 [DGVbeta]
DECIPHERUBE2E2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUBE2E2 
Mutations
ICGC Data PortalUBE2E2 
TCGA Data PortalUBE2E2 
Broad Tumor PortalUBE2E2
OASIS PortalUBE2E2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUBE2E2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUBE2E2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch UBE2E2
DgiDB (Drug Gene Interaction Database)UBE2E2
DoCM (Curated mutations)UBE2E2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UBE2E2 (select a term)
intoGenUBE2E2
Cancer3DUBE2E2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602163   
Orphanet
MedgenUBE2E2
Genetic Testing Registry UBE2E2
NextProtQ96LR5 [Medical]
TSGene7325
GENETestsUBE2E2
Target ValidationUBE2E2
Huge Navigator UBE2E2 [HugePedia]
snp3D : Map Gene to Disease7325
BioCentury BCIQUBE2E2
ClinGenUBE2E2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7325
Chemical/Pharm GKB GenePA37128
Clinical trialUBE2E2
Miscellaneous
canSAR (ICR)UBE2E2 (select the gene name)
Probes
Litterature
PubMed62 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUBE2E2
EVEXUBE2E2
GoPubMedUBE2E2
iHOPUBE2E2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:37:05 CEST 2017

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