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UBE2E3 (ubiquitin conjugating enzyme E2 E3)

Identity

Alias_namesubiquitin-conjugating enzyme E2E 3 (homologous to yeast UBC4/5)
ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)
ubiquitin-conjugating enzyme E2E 3
Alias_symbol (synonym)UbcH9
Other aliasUBCH9
UbcM2
HGNC (Hugo) UBE2E3
LocusID (NCBI) 10477
Atlas_Id 46950
Location 2q31.3  [Link to chromosome band 2q31]
Location_base_pair Starts at 181845851 and ends at 181928154 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
DIS3L2 (2q37.1) / UBE2E3 (2q31.3)P4HB (17q25.3) / UBE2E3 (2q31.3)UBE2E3 (2q31.3) / SREBF1 (17p11.2)
UBE2E3 (2q31.3) / TECPR2 (14q32.31)VGLL4 (3p25.3) / UBE2E3 (2q31.3)DIS3L2 2q37.1 / UBE2E3 2q31.3
UBE2E3 2q31.3 / TECPR2 14q32.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)UBE2E3   12479
Cards
Entrez_Gene (NCBI)UBE2E3  10477  ubiquitin conjugating enzyme E2 E3
AliasesUBCH9; UbcM2
GeneCards (Weizmann)UBE2E3
Ensembl hg19 (Hinxton)ENSG00000170035 [Gene_View]  chr2:181845851-181928154 [Contig_View]  UBE2E3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000170035 [Gene_View]  chr2:181845851-181928154 [Contig_View]  UBE2E3 [Vega]
ICGC DataPortalENSG00000170035
TCGA cBioPortalUBE2E3
AceView (NCBI)UBE2E3
Genatlas (Paris)UBE2E3
WikiGenes10477
SOURCE (Princeton)UBE2E3
Genetics Home Reference (NIH)UBE2E3
Genomic and cartography
GoldenPath hg19 (UCSC)UBE2E3  -     chr2:181845851-181928154 +  2q31.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)UBE2E3  -     2q31.3   [Description]    (hg38-Dec_2013)
EnsemblUBE2E3 - 2q31.3 [CytoView hg19]  UBE2E3 - 2q31.3 [CytoView hg38]
Mapping of homologs : NCBIUBE2E3 [Mapview hg19]  UBE2E3 [Mapview hg38]
OMIM604151   
Gene and transcription
Genbank (Entrez)AB017644 AF085362 AK314145 BC003554 BC003687
RefSeq transcript (Entrez)NM_001278554 NM_001278555 NM_006357 NM_182678
RefSeq genomic (Entrez)NC_000002 NC_018913 NT_005403 NW_004929305
Consensus coding sequences : CCDS (NCBI)UBE2E3
Cluster EST : UnigeneHs.470804 [ NCBI ]
CGAP (NCI)Hs.470804
Alternative Splicing GalleryENSG00000170035
Gene ExpressionUBE2E3 [ NCBI-GEO ]   UBE2E3 [ EBI - ARRAY_EXPRESS ]   UBE2E3 [ SEEK ]   UBE2E3 [ MEM ]
Gene Expression Viewer (FireBrowse)UBE2E3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10477
GTEX Portal (Tissue expression)UBE2E3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ969T4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ969T4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ969T4
Splice isoforms : SwissVarQ969T4
PhosPhoSitePlusQ969T4
Domaine pattern : Prosite (Expaxy)UBIQUITIN_CONJUGAT_1 (PS00183)    UBIQUITIN_CONJUGAT_2 (PS50127)   
Domains : Interpro (EBI)UBQ-conjugat_E2    UBQ-conjugating_AS    UBQ-conjugating_enzyme/RWD   
Domain families : Pfam (Sanger)UQ_con (PF00179)   
Domain families : Pfam (NCBI)pfam00179   
Conserved Domain (NCBI)UBE2E3
DMDM Disease mutations10477
Blocks (Seattle)UBE2E3
SuperfamilyQ969T4
Human Protein AtlasENSG00000170035
Peptide AtlasQ969T4
HPRD05000
IPIIPI00056504   IPI00916628   IPI00916190   IPI00916497   IPI00916788   
Protein Interaction databases
DIP (DOE-UCLA)Q969T4
IntAct (EBI)Q969T4
FunCoupENSG00000170035
BioGRIDUBE2E3
STRING (EMBL)UBE2E3
ZODIACUBE2E3
Ontologies - Pathways
QuickGOQ969T4
Ontology : AmiGOubiquitin-protein transferase activity  protein binding  ATP binding  nucleus  cytoplasm  regulation of growth  ubiquitin conjugating enzyme activity  protein K63-linked ubiquitination  protein K48-linked ubiquitination  protein K11-linked ubiquitination  
Ontology : EGO-EBIubiquitin-protein transferase activity  protein binding  ATP binding  nucleus  cytoplasm  regulation of growth  ubiquitin conjugating enzyme activity  protein K63-linked ubiquitination  protein K48-linked ubiquitination  protein K11-linked ubiquitination  
Pathways : KEGGUbiquitin mediated proteolysis    Protein processing in endoplasmic reticulum   
NDEx NetworkUBE2E3
Atlas of Cancer Signalling NetworkUBE2E3
Wikipedia pathwaysUBE2E3
Orthology - Evolution
OrthoDB10477
GeneTree (enSembl)ENSG00000170035
Phylogenetic Trees/Animal Genes : TreeFamUBE2E3
HOVERGENQ969T4
HOGENOMQ969T4
Homologs : HomoloGeneUBE2E3
Homology/Alignments : Family Browser (UCSC)UBE2E3
Gene fusions - Rearrangements
Fusion : MitelmanDIS3L2/UBE2E3 [2q37.1/2q31.3]  [t(2;2)(q31;q37)]  
Fusion : MitelmanUBE2E3/TECPR2 [2q31.3/14q32.31]  [t(2;14)(q31;q32)]  
Fusion: TCGADIS3L2 2q37.1 UBE2E3 2q31.3 BRCA
Fusion: TCGAUBE2E3 2q31.3 TECPR2 14q32.31 SKCM
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUBE2E3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UBE2E3
dbVarUBE2E3
ClinVarUBE2E3
1000_GenomesUBE2E3 
Exome Variant ServerUBE2E3
ExAC (Exome Aggregation Consortium)UBE2E3 (select the gene name)
Genetic variants : HAPMAP10477
Genomic Variants (DGV)UBE2E3 [DGVbeta]
DECIPHER (Syndromes)2:181845851-181928154  ENSG00000170035
CONAN: Copy Number AnalysisUBE2E3 
Mutations
ICGC Data PortalUBE2E3 
TCGA Data PortalUBE2E3 
Broad Tumor PortalUBE2E3
OASIS PortalUBE2E3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUBE2E3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUBE2E3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch UBE2E3
DgiDB (Drug Gene Interaction Database)UBE2E3
DoCM (Curated mutations)UBE2E3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UBE2E3 (select a term)
intoGenUBE2E3
Cancer3DUBE2E3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604151   
Orphanet
MedgenUBE2E3
Genetic Testing Registry UBE2E3
NextProtQ969T4 [Medical]
TSGene10477
GENETestsUBE2E3
Huge Navigator UBE2E3 [HugePedia]
snp3D : Map Gene to Disease10477
BioCentury BCIQUBE2E3
ClinGenUBE2E3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10477
Chemical/Pharm GKB GenePA37129
Clinical trialUBE2E3
Miscellaneous
canSAR (ICR)UBE2E3 (select the gene name)
Probes
Litterature
PubMed58 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUBE2E3
EVEXUBE2E3
GoPubMedUBE2E3
iHOPUBE2E3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:33:04 CET 2017

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