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UBE2G2 (ubiquitin conjugating enzyme E2 G2)

Identity

Alias_namesubiquitin-conjugating enzyme E2G 2 (homologous to yeast UBC7)
ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast)
ubiquitin-conjugating enzyme E2G 2
Alias_symbol (synonym)UBC7
Other alias
HGNC (Hugo) UBE2G2
LocusID (NCBI) 7327
Atlas_Id 46647
Location 21q22.3  [Link to chromosome band 21q22]
Location_base_pair Starts at 46188495 and ends at 46221751 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ATG5 (6q21) / UBE2G2 (21q22.3)SUMO3 (21q22.3) / UBE2G2 (21q22.3)TAX1BP3 (17p13.2) / UBE2G2 (21q22.3)
UBE2G2 (21q22.3) / C1orf61 (1q22)UBE2G2 (21q22.3) / GART (21q22.11)UBE2G2 (21q22.3) / TNFRSF1A (12p13.31)
UBE2G2 21q22.3 / GART 21q22.11

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)UBE2G2   12483
Cards
Entrez_Gene (NCBI)UBE2G2  7327  ubiquitin conjugating enzyme E2 G2
AliasesUBC7
GeneCards (Weizmann)UBE2G2
Ensembl hg19 (Hinxton)ENSG00000184787 [Gene_View]  chr21:46188495-46221751 [Contig_View]  UBE2G2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000184787 [Gene_View]  chr21:46188495-46221751 [Contig_View]  UBE2G2 [Vega]
ICGC DataPortalENSG00000184787
TCGA cBioPortalUBE2G2
AceView (NCBI)UBE2G2
Genatlas (Paris)UBE2G2
WikiGenes7327
SOURCE (Princeton)UBE2G2
Genetics Home Reference (NIH)UBE2G2
Genomic and cartography
GoldenPath hg19 (UCSC)UBE2G2  -     chr21:46188495-46221751 -  21q22.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)UBE2G2  -     21q22.3   [Description]    (hg38-Dec_2013)
EnsemblUBE2G2 - 21q22.3 [CytoView hg19]  UBE2G2 - 21q22.3 [CytoView hg38]
Mapping of homologs : NCBIUBE2G2 [Mapview hg19]  UBE2G2 [Mapview hg38]
OMIM603124   
Gene and transcription
Genbank (Entrez)AF032456 AK075143 AK122700 AK290629 AL355686
RefSeq transcript (Entrez)NM_001202489 NM_003343 NM_182688
RefSeq genomic (Entrez)NC_000021 NC_018932 NT_011512 NW_004929427
Consensus coding sequences : CCDS (NCBI)UBE2G2
Cluster EST : UnigeneHs.701398 [ NCBI ]
CGAP (NCI)Hs.701398
Alternative Splicing GalleryENSG00000184787
Gene ExpressionUBE2G2 [ NCBI-GEO ]   UBE2G2 [ EBI - ARRAY_EXPRESS ]   UBE2G2 [ SEEK ]   UBE2G2 [ MEM ]
Gene Expression Viewer (FireBrowse)UBE2G2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7327
GTEX Portal (Tissue expression)UBE2G2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP60604   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP60604  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP60604
Splice isoforms : SwissVarP60604
PhosPhoSitePlusP60604
Domaine pattern : Prosite (Expaxy)UBIQUITIN_CONJUGAT_1 (PS00183)    UBIQUITIN_CONJUGAT_2 (PS50127)   
Domains : Interpro (EBI)UBQ-conjugat_E2    UBQ-conjugating_AS    UBQ-conjugating_enzyme/RWD   
Domain families : Pfam (Sanger)UQ_con (PF00179)   
Domain families : Pfam (NCBI)pfam00179   
Conserved Domain (NCBI)UBE2G2
DMDM Disease mutations7327
Blocks (Seattle)UBE2G2
PDB (SRS)2CYX    2KLY    2LXP    3H8K    4LAD   
PDB (PDBSum)2CYX    2KLY    2LXP    3H8K    4LAD   
PDB (IMB)2CYX    2KLY    2LXP    3H8K    4LAD   
PDB (RSDB)2CYX    2KLY    2LXP    3H8K    4LAD   
Structural Biology KnowledgeBase2CYX    2KLY    2LXP    3H8K    4LAD   
SCOP (Structural Classification of Proteins)2CYX    2KLY    2LXP    3H8K    4LAD   
CATH (Classification of proteins structures)2CYX    2KLY    2LXP    3H8K    4LAD   
SuperfamilyP60604
Human Protein AtlasENSG00000184787
Peptide AtlasP60604
HPRD04387
IPIIPI00010142   IPI00168518   IPI00982719   IPI00945463   IPI00945979   IPI00337747   
Protein Interaction databases
DIP (DOE-UCLA)P60604
IntAct (EBI)P60604
FunCoupENSG00000184787
BioGRIDUBE2G2
STRING (EMBL)UBE2G2
ZODIACUBE2G2
Ontologies - Pathways
QuickGOP60604
Ontology : AmiGOubiquitin-protein transferase activity  protein binding  ATP binding  endoplasmic reticulum  cytosol  ubiquitin-dependent protein catabolic process  protein N-linked glycosylation via asparagine  ER-associated ubiquitin-dependent protein catabolic process  ubiquitin protein ligase binding  cellular response to interferon-beta  identical protein binding  cellular protein catabolic process  ubiquitin protein ligase activity  ubiquitin conjugating enzyme activity  protein K48-linked ubiquitination  negative regulation of retrograde protein transport, ER to cytosol  
Ontology : EGO-EBIubiquitin-protein transferase activity  protein binding  ATP binding  endoplasmic reticulum  cytosol  ubiquitin-dependent protein catabolic process  protein N-linked glycosylation via asparagine  ER-associated ubiquitin-dependent protein catabolic process  ubiquitin protein ligase binding  cellular response to interferon-beta  identical protein binding  cellular protein catabolic process  ubiquitin protein ligase activity  ubiquitin conjugating enzyme activity  protein K48-linked ubiquitination  negative regulation of retrograde protein transport, ER to cytosol  
Pathways : BIOCARTARole of Parkin in the Ubiquitin-Proteasomal Pathway [Genes]   
Pathways : KEGGUbiquitin mediated proteolysis    Protein processing in endoplasmic reticulum    Parkinson's disease   
NDEx NetworkUBE2G2
Atlas of Cancer Signalling NetworkUBE2G2
Wikipedia pathwaysUBE2G2
Orthology - Evolution
OrthoDB7327
GeneTree (enSembl)ENSG00000184787
Phylogenetic Trees/Animal Genes : TreeFamUBE2G2
HOVERGENP60604
HOGENOMP60604
Homologs : HomoloGeneUBE2G2
Homology/Alignments : Family Browser (UCSC)UBE2G2
Gene fusions - Rearrangements
Fusion : MitelmanUBE2G2/GART [21q22.3/21q22.11]  
Fusion: TCGAUBE2G2 21q22.3 GART 21q22.11 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUBE2G2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UBE2G2
dbVarUBE2G2
ClinVarUBE2G2
1000_GenomesUBE2G2 
Exome Variant ServerUBE2G2
ExAC (Exome Aggregation Consortium)UBE2G2 (select the gene name)
Genetic variants : HAPMAP7327
Genomic Variants (DGV)UBE2G2 [DGVbeta]
DECIPHER (Syndromes)21:46188495-46221751  ENSG00000184787
CONAN: Copy Number AnalysisUBE2G2 
Mutations
ICGC Data PortalUBE2G2 
TCGA Data PortalUBE2G2 
Broad Tumor PortalUBE2G2
OASIS PortalUBE2G2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUBE2G2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUBE2G2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch UBE2G2
DgiDB (Drug Gene Interaction Database)UBE2G2
DoCM (Curated mutations)UBE2G2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UBE2G2 (select a term)
intoGenUBE2G2
Cancer3DUBE2G2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603124   
Orphanet
MedgenUBE2G2
Genetic Testing Registry UBE2G2
NextProtP60604 [Medical]
TSGene7327
GENETestsUBE2G2
Huge Navigator UBE2G2 [HugePedia]
snp3D : Map Gene to Disease7327
BioCentury BCIQUBE2G2
ClinGenUBE2G2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7327
Chemical/Pharm GKB GenePA37132
Clinical trialUBE2G2
Miscellaneous
canSAR (ICR)UBE2G2 (select the gene name)
Probes
Litterature
PubMed63 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUBE2G2
EVEXUBE2G2
GoPubMedUBE2G2
iHOPUBE2G2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:24:05 CEST 2017

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