UBE2J1 (ubiquitin conjugating enzyme E2 J1)

2007-04-01  

Identity

HGNC
LOCATION
6q15
LOCUSID
ALIAS
CGI-76,HSPC153,HSPC205,HSU93243,NCUBE-1,NCUBE1,UBC6,UBC6E,Ubc6p
FUSION GENES

Other Information

Locus ID:

NCBI: 51465
MIM: 616175
HGNC: 17598
Ensembl: ENSG00000198833

Variants:

dbSNP: 51465
ClinVar: 51465
TCGA: ENSG00000198833
COSMIC: UBE2J1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198833ENST00000435041Q9Y385

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Ubiquitin mediated proteolysisKEGGhsa04120
Parkinson's diseaseKEGGhsa05012
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
212452962011HRD1 and UBE2J1 target misfolded MHC class I heavy chains for endoplasmic reticulum-associated degradation.59
202229552010A meta-analysis of genome-wide data from five European isolates reveals an association of COL22A1, SYT1, and GABRR2 with serum creatinine level.19
167205812006Human homologs of Ubc6p ubiquitin-conjugating enzyme and phosphorylation of HsUbc6e in response to endoplasmic reticulum stress.16
275700742016Posttranscriptional Regulation of Glycoprotein Quality Control in the Endoplasmic Reticulum Is Controlled by the E2 Ub-Conjugating Enzyme UBC6e.11
301578862018Ubiquitin-conjugating enzyme UBE2J1 negatively modulates interferon pathway and promotes RNA virus infection.2

Citation

Dessen P

UBE2J1 (ubiquitin conjugating enzyme E2 J1)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47111/ube2j1