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UBE2J2 (ubiquitin conjugating enzyme E2 J2)

Identity

Alias_namesubiquitin-conjugating enzyme E2, J2 (UBC6 homolog, yeast)
ubiquitin-conjugating enzyme E2, J2
Alias_symbol (synonym)Ubc6p
NCUBE2
Other aliasNCUBE-2
PRO2121
HGNC (Hugo) UBE2J2
LocusID (NCBI) 118424
Atlas_Id 54744
Location 1p36.33  [Link to chromosome band 1p36]
Location_base_pair Starts at 1189292 and ends at 1209234 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
AGRN (1p36.33) / UBE2J2 (1p36.33)CMTM3 (16q21) / UBE2J2 (1p36.33)DNAH1 (3p21.1) / UBE2J2 (1p36.33)
MDM2 (12q15) / UBE2J2 (1p36.33)RLF (1p34.2) / UBE2J2 (1p36.33)RPL38 (17q25.1) / UBE2J2 (1p36.33)
UBE2J2 (1p36.33) / ACAP3 (1p36.33)UBE2J2 (1p36.33) / GNB1 (1p36.33)UBE2J2 (1p36.33) / PKD1 (16p13.3)
UBE2J2 (1p36.33) / PRKAR1B (7p22.3)UBE2J2 (1p36.33) / RPL38 (17q25.1)UBE2J2 (1p36.33) / TKT (3p21.1)
UBE2J2 1p36.33 / ACAP3 1p36.33UBE2J2 1p36.33 / GNB1 1p36.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Small Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)UBE2J2   19268
Cards
Entrez_Gene (NCBI)UBE2J2  118424  ubiquitin conjugating enzyme E2 J2
AliasesNCUBE-2; NCUBE2; PRO2121
GeneCards (Weizmann)UBE2J2
Ensembl hg19 (Hinxton)ENSG00000160087 [Gene_View]  chr1:1189292-1209234 [Contig_View]  UBE2J2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000160087 [Gene_View]  chr1:1189292-1209234 [Contig_View]  UBE2J2 [Vega]
ICGC DataPortalENSG00000160087
TCGA cBioPortalUBE2J2
AceView (NCBI)UBE2J2
Genatlas (Paris)UBE2J2
WikiGenes118424
SOURCE (Princeton)UBE2J2
Genetics Home Reference (NIH)UBE2J2
Genomic and cartography
GoldenPath hg19 (UCSC)UBE2J2  -     chr1:1189292-1209234 -  1p36.33   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)UBE2J2  -     1p36.33   [Description]    (hg38-Dec_2013)
EnsemblUBE2J2 - 1p36.33 [CytoView hg19]  UBE2J2 - 1p36.33 [CytoView hg38]
Mapping of homologs : NCBIUBE2J2 [Mapview hg19]  UBE2J2 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AF116687 AF296658 AK056065 AK075017 AK098803
RefSeq transcript (Entrez)NM_058167 NM_194315 NM_194316 NM_194457 NM_194458
RefSeq genomic (Entrez)NC_000001 NC_018912 NT_032977 NW_004929288
Consensus coding sequences : CCDS (NCBI)UBE2J2
Cluster EST : UnigeneHs.191987 [ NCBI ]
CGAP (NCI)Hs.191987
Alternative Splicing GalleryENSG00000160087
Gene ExpressionUBE2J2 [ NCBI-GEO ]   UBE2J2 [ EBI - ARRAY_EXPRESS ]   UBE2J2 [ SEEK ]   UBE2J2 [ MEM ]
Gene Expression Viewer (FireBrowse)UBE2J2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)118424
GTEX Portal (Tissue expression)UBE2J2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N2K1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N2K1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N2K1
Splice isoforms : SwissVarQ8N2K1
Catalytic activity : Enzyme2.3.2.23 [ Enzyme-Expasy ]   2.3.2.232.3.2.23 [ IntEnz-EBI ]   2.3.2.23 [ BRENDA ]   2.3.2.23 [ KEGG ]   
PhosPhoSitePlusQ8N2K1
Domaine pattern : Prosite (Expaxy)UBIQUITIN_CONJUGAT_2 (PS50127)   
Domains : Interpro (EBI)UBQ-conjugat_E2    UBQ-conjugating_enzyme/RWD   
Domain families : Pfam (Sanger)UQ_con (PF00179)   
Domain families : Pfam (NCBI)pfam00179   
Conserved Domain (NCBI)UBE2J2
DMDM Disease mutations118424
Blocks (Seattle)UBE2J2
PDB (SRS)2F4W   
PDB (PDBSum)2F4W   
PDB (IMB)2F4W   
PDB (RSDB)2F4W   
Structural Biology KnowledgeBase2F4W   
SCOP (Structural Classification of Proteins)2F4W   
CATH (Classification of proteins structures)2F4W   
SuperfamilyQ8N2K1
Human Protein AtlasENSG00000160087
Peptide AtlasQ8N2K1
HPRD15600
IPIIPI00455911   IPI00873186   IPI01013764   IPI00383350   IPI00967802   IPI00335071   IPI00966281   IPI00514050   IPI00375728   IPI01014819   IPI01012785   IPI00967793   IPI00967274   IPI00963927   
Protein Interaction databases
DIP (DOE-UCLA)Q8N2K1
IntAct (EBI)Q8N2K1
FunCoupENSG00000160087
BioGRIDUBE2J2
STRING (EMBL)UBE2J2
ZODIACUBE2J2
Ontologies - Pathways
QuickGOQ8N2K1
Ontology : AmiGOubiquitin ligase complex  protein polyubiquitination  ATP binding  endoplasmic reticulum  endoplasmic reticulum membrane  response to unfolded protein  integral component of membrane  ER-associated ubiquitin-dependent protein catabolic process  ubiquitin protein ligase binding  ubiquitin protein ligase activity  ubiquitin conjugating enzyme activity  positive regulation of protein targeting to mitochondrion  
Ontology : EGO-EBIubiquitin ligase complex  protein polyubiquitination  ATP binding  endoplasmic reticulum  endoplasmic reticulum membrane  response to unfolded protein  integral component of membrane  ER-associated ubiquitin-dependent protein catabolic process  ubiquitin protein ligase binding  ubiquitin protein ligase activity  ubiquitin conjugating enzyme activity  positive regulation of protein targeting to mitochondrion  
Pathways : KEGGUbiquitin mediated proteolysis    Protein processing in endoplasmic reticulum    Parkinson's disease   
NDEx NetworkUBE2J2
Atlas of Cancer Signalling NetworkUBE2J2
Wikipedia pathwaysUBE2J2
Orthology - Evolution
OrthoDB118424
GeneTree (enSembl)ENSG00000160087
Phylogenetic Trees/Animal Genes : TreeFamUBE2J2
HOVERGENQ8N2K1
HOGENOMQ8N2K1
Homologs : HomoloGeneUBE2J2
Homology/Alignments : Family Browser (UCSC)UBE2J2
Gene fusions - Rearrangements
Fusion : MitelmanRLF/UBE2J2 [1p34.2/1p36.33]  [t(1;1)(p34;p36)]  
Fusion : MitelmanUBE2J2/ACAP3 [1p36.33/1p36.33]  [t(1;1)(p36;p36)]  
Fusion : MitelmanUBE2J2/GNB1 [1p36.33/1p36.33]  [t(1;1)(p36;p36)]  
Fusion : MitelmanUBE2J2/PKD1 [1p36.33/16p13.3]  [t(1;16)(p36;p13)]  
Fusion: TCGAUBE2J2 1p36.33 ACAP3 1p36.33 BRCA
Fusion: TCGAUBE2J2 1p36.33 GNB1 1p36.33 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUBE2J2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UBE2J2
dbVarUBE2J2
ClinVarUBE2J2
1000_GenomesUBE2J2 
Exome Variant ServerUBE2J2
ExAC (Exome Aggregation Consortium)UBE2J2 (select the gene name)
Genetic variants : HAPMAP118424
Genomic Variants (DGV)UBE2J2 [DGVbeta]
DECIPHER (Syndromes)1:1189292-1209234  ENSG00000160087
CONAN: Copy Number AnalysisUBE2J2 
Mutations
ICGC Data PortalUBE2J2 
TCGA Data PortalUBE2J2 
Broad Tumor PortalUBE2J2
OASIS PortalUBE2J2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUBE2J2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUBE2J2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch UBE2J2
DgiDB (Drug Gene Interaction Database)UBE2J2
DoCM (Curated mutations)UBE2J2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UBE2J2 (select a term)
intoGenUBE2J2
Cancer3DUBE2J2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenUBE2J2
Genetic Testing Registry UBE2J2
NextProtQ8N2K1 [Medical]
TSGene118424
GENETestsUBE2J2
Huge Navigator UBE2J2 [HugePedia]
snp3D : Map Gene to Disease118424
BioCentury BCIQUBE2J2
ClinGenUBE2J2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD118424
Chemical/Pharm GKB GenePA134882268
Clinical trialUBE2J2
Miscellaneous
canSAR (ICR)UBE2J2 (select the gene name)
Probes
Litterature
PubMed15 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUBE2J2
EVEXUBE2J2
GoPubMedUBE2J2
iHOPUBE2J2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 15:24:05 CEST 2017

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