UBE2L3 (ubiquitin conjugating enzyme E2 L3)

2007-02-01 Affiliation

Identity

HGNC

UBE2L3

LOCATION

22q11.21

LOCUSID

7332

ALIAS

E2-F1,L-UBC,UBCH7,UbcM4

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 7332
MIM: 603721
HGNC: 12488
Ensembl: ENSG00000185651

Variants:

dbSNP: 7332
ClinVar: 7332
TCGA: ENSG00000185651
COSMIC: UBE2L3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000185651	ENST00000342192	P68036
ENSG00000185651	ENST00000342192	A0A024R1A4
ENSG00000185651	ENST00000458578	P68036
ENSG00000185651	ENST00000545681	P68036

Expression (GTEx)

100

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Ubiquitin mediated proteolysis	KEGG	ko04120
Ubiquitin mediated proteolysis	KEGG	hsa04120
Parkinson's disease	KEGG	hsa05012
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Class I MHC mediated antigen processing & presentation	REACTOME	R-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradation	REACTOME	R-HSA-983168
Protein ubiquitination	REACTOME	R-HSA-8852135
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	REACTOME	R-HSA-8866652
E3 ubiquitin ligases ubiquitinate target proteins	REACTOME	R-HSA-8866654

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
21532592	2011	UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids.	192
21068098	2011	Study of the common genetic background for rheumatoid arthritis and systemic lupus erythematosus.	51
20601676	2010	Analysis of SNPs with an effect on gene expression identifies UBE2L3 and BCL3 as potential new risk genes for Crohn's disease.	50
20601676	2010	Analysis of SNPs with an effect on gene expression identifies UBE2L3 and BCL3 as potential new risk genes for Crohn's disease.	50
24162738	2013	New loci associated with chronic hepatitis B virus infection in Han Chinese.	47
24906799	2014	The ubiquitin-conjugating enzymes UBE2N, UBE2L3 and UBE2D2/3 are essential for Parkin-dependent mitophagy.	36
25640675	2015	UBE2L3 polymorphism amplifies NF-κB activation and promotes plasma cell development, linking linear ubiquitination to multiple autoimmune diseases.	27
22308380	2012	Crystal structures of two bacterial HECT-like E3 ligases in complex with a human E2 reveal atomic details of pathogen-host interactions.	23
12215439	2002	Ubiquitylation of the transducin betagamma subunit complex. Regulation by phosducin.	21
20962850	2011	A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles.	21

Citation

Dessen P

UBE2L3 (ubiquitin conjugating enzyme E2 L3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46591/ube2l3