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UBE2L6 (ubiquitin conjugating enzyme E2 L6)

Identity

Alias_namesubiquitin-conjugating enzyme E2L 6
Alias_symbol (synonym)UBCH8
Other aliasRIG-B
HGNC (Hugo) UBE2L6
LocusID (NCBI) 9246
Atlas_Id 46868
Location 11q12.1  [Link to chromosome band 11q12]
Location_base_pair Starts at 57551655 and ends at 57567707 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
UBE2L6 (11q12.1) / INTS6L (Xq26.3)UBE2L6 (11q12.1) / UBE2L6 (11q12.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)UBE2L6   12490
Cards
Entrez_Gene (NCBI)UBE2L6  9246  ubiquitin conjugating enzyme E2 L6
AliasesRIG-B; UBCH8
GeneCards (Weizmann)UBE2L6
Ensembl hg19 (Hinxton)ENSG00000156587 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000156587 [Gene_View]  chr11:57551655-57567707 [Contig_View]  UBE2L6 [Vega]
ICGC DataPortalENSG00000156587
TCGA cBioPortalUBE2L6
AceView (NCBI)UBE2L6
Genatlas (Paris)UBE2L6
WikiGenes9246
SOURCE (Princeton)UBE2L6
Genetics Home Reference (NIH)UBE2L6
Genomic and cartography
GoldenPath hg38 (UCSC)UBE2L6  -     chr11:57551655-57567707 -  11q12.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)UBE2L6  -     11q12.1   [Description]    (hg19-Feb_2009)
EnsemblUBE2L6 - 11q12.1 [CytoView hg19]  UBE2L6 - 11q12.1 [CytoView hg38]
Mapping of homologs : NCBIUBE2L6 [Mapview hg19]  UBE2L6 [Mapview hg38]
OMIM603890   
Gene and transcription
Genbank (Entrez)AF031141 AF061736 AK093462 AK129621 AK226165
RefSeq transcript (Entrez)NM_004223 NM_198183
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)UBE2L6
Cluster EST : UnigeneHs.425777 [ NCBI ]
CGAP (NCI)Hs.425777
Alternative Splicing GalleryENSG00000156587
Gene ExpressionUBE2L6 [ NCBI-GEO ]   UBE2L6 [ EBI - ARRAY_EXPRESS ]   UBE2L6 [ SEEK ]   UBE2L6 [ MEM ]
Gene Expression Viewer (FireBrowse)UBE2L6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9246
GTEX Portal (Tissue expression)UBE2L6
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14933   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14933  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14933
Splice isoforms : SwissVarO14933
Catalytic activity : Enzyme2.3.2.23 [ Enzyme-Expasy ]   2.3.2.232.3.2.23 [ IntEnz-EBI ]   2.3.2.23 [ BRENDA ]   2.3.2.23 [ KEGG ]   
PhosPhoSitePlusO14933
Domaine pattern : Prosite (Expaxy)UBIQUITIN_CONJUGAT_1 (PS00183)    UBIQUITIN_CONJUGAT_2 (PS50127)   
Domains : Interpro (EBI)UBQ-conjugat_E2    UBQ-conjugating_AS    UBQ-conjugating_enzyme/RWD   
Domain families : Pfam (Sanger)UQ_con (PF00179)   
Domain families : Pfam (NCBI)pfam00179   
Conserved Domain (NCBI)UBE2L6
DMDM Disease mutations9246
Blocks (Seattle)UBE2L6
PDB (SRS)1WZV    1WZW    2KJH   
PDB (PDBSum)1WZV    1WZW    2KJH   
PDB (IMB)1WZV    1WZW    2KJH   
PDB (RSDB)1WZV    1WZW    2KJH   
Structural Biology KnowledgeBase1WZV    1WZW    2KJH   
SCOP (Structural Classification of Proteins)1WZV    1WZW    2KJH   
CATH (Classification of proteins structures)1WZV    1WZW    2KJH   
SuperfamilyO14933
Human Protein AtlasENSG00000156587
Peptide AtlasO14933
HPRD04867
IPIIPI00329563   IPI00386520   IPI00980266   IPI00979677   
Protein Interaction databases
DIP (DOE-UCLA)O14933
IntAct (EBI)O14933
FunCoupENSG00000156587
BioGRIDUBE2L6
STRING (EMBL)UBE2L6
ZODIACUBE2L6
Ontologies - Pathways
QuickGOO14933
Ontology : AmiGOubiquitin-protein transferase activity  protein binding  nucleoplasm  cytosol  cellular protein modification process  protein ubiquitination  modification-dependent protein catabolic process  translesion synthesis  ISG15-protein conjugation  negative regulation of type I interferon production  ISG15 transferase activity  ubiquitin binding  cellular protein metabolic process  
Ontology : EGO-EBIubiquitin-protein transferase activity  protein binding  nucleoplasm  cytosol  cellular protein modification process  protein ubiquitination  modification-dependent protein catabolic process  translesion synthesis  ISG15-protein conjugation  negative regulation of type I interferon production  ISG15 transferase activity  ubiquitin binding  cellular protein metabolic process  
Pathways : KEGGUbiquitin mediated proteolysis    Parkinson's disease   
NDEx NetworkUBE2L6
Atlas of Cancer Signalling NetworkUBE2L6
Wikipedia pathwaysUBE2L6
Orthology - Evolution
OrthoDB9246
GeneTree (enSembl)ENSG00000156587
Phylogenetic Trees/Animal Genes : TreeFamUBE2L6
HOVERGENO14933
HOGENOMO14933
Homologs : HomoloGeneUBE2L6
Homology/Alignments : Family Browser (UCSC)UBE2L6
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUBE2L6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UBE2L6
dbVarUBE2L6
ClinVarUBE2L6
1000_GenomesUBE2L6 
Exome Variant ServerUBE2L6
ExAC (Exome Aggregation Consortium)UBE2L6 (select the gene name)
Genetic variants : HAPMAP9246
Genomic Variants (DGV)UBE2L6 [DGVbeta]
DECIPHERUBE2L6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUBE2L6 
Mutations
ICGC Data PortalUBE2L6 
TCGA Data PortalUBE2L6 
Broad Tumor PortalUBE2L6
OASIS PortalUBE2L6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUBE2L6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUBE2L6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch UBE2L6
DgiDB (Drug Gene Interaction Database)UBE2L6
DoCM (Curated mutations)UBE2L6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UBE2L6 (select a term)
intoGenUBE2L6
Cancer3DUBE2L6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603890   
Orphanet
MedgenUBE2L6
Genetic Testing Registry UBE2L6
NextProtO14933 [Medical]
TSGene9246
GENETestsUBE2L6
Target ValidationUBE2L6
Huge Navigator UBE2L6 [HugePedia]
snp3D : Map Gene to Disease9246
BioCentury BCIQUBE2L6
ClinGenUBE2L6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9246
Chemical/Pharm GKB GenePA37139
Clinical trialUBE2L6
Miscellaneous
canSAR (ICR)UBE2L6 (select the gene name)
Probes
Litterature
PubMed49 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUBE2L6
EVEXUBE2L6
GoPubMedUBE2L6
iHOPUBE2L6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 14:10:59 CEST 2017

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