Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

UBE2M (ubiquitin conjugating enzyme E2 M)

Identity

Alias_namesubiquitin-conjugating enzyme E2M (homologous to yeast UBC12)
ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)
ubiquitin-conjugating enzyme E2M
Alias_symbol (synonym)hUbc12
UBC12
Other aliasUBC-RS2
HGNC (Hugo) UBE2M
LocusID (NCBI) 9040
Atlas_Id 47166
Location 19q13.43  [Link to chromosome band 19q13]
Location_base_pair Starts at 58555712 and ends at 58558976 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
HSPB1 (7q11.23) / UBE2M (19q13.43)UBE2M (19q13.43) / HSF1 (8q24.3)UBE2M (19q13.43) / PKDCC (2p21)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)UBE2M   12491
Cards
Entrez_Gene (NCBI)UBE2M  9040  ubiquitin conjugating enzyme E2 M
AliasesUBC-RS2; UBC12; hUbc12
GeneCards (Weizmann)UBE2M
Ensembl hg19 (Hinxton)ENSG00000130725 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000130725 [Gene_View]  chr19:58555712-58558976 [Contig_View]  UBE2M [Vega]
ICGC DataPortalENSG00000130725
TCGA cBioPortalUBE2M
AceView (NCBI)UBE2M
Genatlas (Paris)UBE2M
WikiGenes9040
SOURCE (Princeton)UBE2M
Genetics Home Reference (NIH)UBE2M
Genomic and cartography
GoldenPath hg38 (UCSC)UBE2M  -     chr19:58555712-58558976 -  19q13.43   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)UBE2M  -     19q13.43   [Description]    (hg19-Feb_2009)
EnsemblUBE2M - 19q13.43 [CytoView hg19]  UBE2M - 19q13.43 [CytoView hg38]
Mapping of homologs : NCBIUBE2M [Mapview hg19]  UBE2M [Mapview hg38]
OMIM603173   
Gene and transcription
Genbank (Entrez)AB012191 AF075599 AL569047 BC058924 BM559596
RefSeq transcript (Entrez)NM_003969
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)UBE2M
Cluster EST : UnigeneHs.406068 [ NCBI ]
CGAP (NCI)Hs.406068
Alternative Splicing GalleryENSG00000130725
Gene ExpressionUBE2M [ NCBI-GEO ]   UBE2M [ EBI - ARRAY_EXPRESS ]   UBE2M [ SEEK ]   UBE2M [ MEM ]
Gene Expression Viewer (FireBrowse)UBE2M [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9040
GTEX Portal (Tissue expression)UBE2M
Protein : pattern, domain, 3D structure
UniProt/SwissProtP61081   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP61081  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP61081
Splice isoforms : SwissVarP61081
Catalytic activity : Enzyme6.3.2.- [ Enzyme-Expasy ]   6.3.2.-6.3.2.- [ IntEnz-EBI ]   6.3.2.- [ BRENDA ]   6.3.2.- [ KEGG ]   
PhosPhoSitePlusP61081
Domaine pattern : Prosite (Expaxy)UBIQUITIN_CONJUGAT_1 (PS00183)    UBIQUITIN_CONJUGAT_2 (PS50127)   
Domains : Interpro (EBI)UBQ-conjugat_E2    UBQ-conjugating_AS    UBQ-conjugating_enzyme/RWD   
Domain families : Pfam (Sanger)UQ_con (PF00179)   
Domain families : Pfam (NCBI)pfam00179   
Conserved Domain (NCBI)UBE2M
DMDM Disease mutations9040
Blocks (Seattle)UBE2M
PDB (SRS)1TT5    1Y8X    2NVU    3TDU    3TDZ    4GAO    4P5O   
PDB (PDBSum)1TT5    1Y8X    2NVU    3TDU    3TDZ    4GAO    4P5O   
PDB (IMB)1TT5    1Y8X    2NVU    3TDU    3TDZ    4GAO    4P5O   
PDB (RSDB)1TT5    1Y8X    2NVU    3TDU    3TDZ    4GAO    4P5O   
Structural Biology KnowledgeBase1TT5    1Y8X    2NVU    3TDU    3TDZ    4GAO    4P5O   
SCOP (Structural Classification of Proteins)1TT5    1Y8X    2NVU    3TDU    3TDZ    4GAO    4P5O   
CATH (Classification of proteins structures)1TT5    1Y8X    2NVU    3TDU    3TDZ    4GAO    4P5O   
SuperfamilyP61081
Human Protein AtlasENSG00000130725
Peptide AtlasP61081
HPRD04414
IPIIPI00022597   
Protein Interaction databases
DIP (DOE-UCLA)P61081
IntAct (EBI)P61081
FunCoupENSG00000130725
BioGRIDUBE2M
STRING (EMBL)UBE2M
ZODIACUBE2M
Ontologies - Pathways
QuickGOP61081
Ontology : AmiGOubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  ATP binding  cytoplasm  cytosol  cellular protein modification process  cellular protein modification process  transforming growth factor beta receptor signaling pathway  protein ubiquitination  ribosomal S6-glutamic acid ligase activity  NEDD8 transferase activity  ubiquitin protein ligase binding  NIK/NF-kappaB signaling  positive regulation of neuron apoptotic process  protein neddylation  protein neddylation  ubiquitin protein ligase activity  extracellular exosome  
Ontology : EGO-EBIubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  ATP binding  cytoplasm  cytosol  cellular protein modification process  cellular protein modification process  transforming growth factor beta receptor signaling pathway  protein ubiquitination  ribosomal S6-glutamic acid ligase activity  NEDD8 transferase activity  ubiquitin protein ligase binding  NIK/NF-kappaB signaling  positive regulation of neuron apoptotic process  protein neddylation  protein neddylation  ubiquitin protein ligase activity  extracellular exosome  
Pathways : BIOCARTARegulation of p27 Phosphorylation during Cell Cycle Progression [Genes]   
Pathways : KEGGUbiquitin mediated proteolysis   
NDEx NetworkUBE2M
Atlas of Cancer Signalling NetworkUBE2M
Wikipedia pathwaysUBE2M
Orthology - Evolution
OrthoDB9040
GeneTree (enSembl)ENSG00000130725
Phylogenetic Trees/Animal Genes : TreeFamUBE2M
HOVERGENP61081
HOGENOMP61081
Homologs : HomoloGeneUBE2M
Homology/Alignments : Family Browser (UCSC)UBE2M
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUBE2M [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UBE2M
dbVarUBE2M
ClinVarUBE2M
1000_GenomesUBE2M 
Exome Variant ServerUBE2M
ExAC (Exome Aggregation Consortium)UBE2M (select the gene name)
Genetic variants : HAPMAP9040
Genomic Variants (DGV)UBE2M [DGVbeta]
DECIPHERUBE2M [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUBE2M 
Mutations
ICGC Data PortalUBE2M 
TCGA Data PortalUBE2M 
Broad Tumor PortalUBE2M
OASIS PortalUBE2M [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUBE2M  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUBE2M
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch UBE2M
DgiDB (Drug Gene Interaction Database)UBE2M
DoCM (Curated mutations)UBE2M (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UBE2M (select a term)
intoGenUBE2M
Cancer3DUBE2M(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603173   
Orphanet
MedgenUBE2M
Genetic Testing Registry UBE2M
NextProtP61081 [Medical]
TSGene9040
GENETestsUBE2M
Target ValidationUBE2M
Huge Navigator UBE2M [HugePedia]
snp3D : Map Gene to Disease9040
BioCentury BCIQUBE2M
ClinGenUBE2M
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9040
Chemical/Pharm GKB GenePA37140
Clinical trialUBE2M
Miscellaneous
canSAR (ICR)UBE2M (select the gene name)
Probes
Litterature
PubMed71 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUBE2M
EVEXUBE2M
GoPubMedUBE2M
iHOPUBE2M
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 1 17:18:11 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.