Identity
HGNC
LOCATION
19q13.43
LOCUSID
ALIAS
UBC-RS2,UBC12,hUbc12
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 9040
MIM: 603173
HGNC: 12491
Ensembl: ENSG00000130725
Variants:
dbSNP: 9040
ClinVar: 9040
TCGA: ENSG00000130725
COSMIC: UBE2M
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000130725 | ENST00000253023 | P61081 |
| ENSG00000130725 | ENST00000253023 | A0A024R4T4 |
| ENSG00000130725 | ENST00000595957 | M0QX69 |
| ENSG00000130725 | ENST00000596985 | M0QYI6 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38126621 | 2024 | NNMT/1-MNA Promote Cell-Cycle Progression of Breast Cancer by Targeting UBC12/Cullin-1-Mediated Degradation of P27 Proteins. | 3 |
| 38126621 | 2024 | NNMT/1-MNA Promote Cell-Cycle Progression of Breast Cancer by Targeting UBC12/Cullin-1-Mediated Degradation of P27 Proteins. | 3 |
| 33905671 | 2021 | NPRL2 reduces the niraparib sensitivity of castration-resistant prostate cancer via interacting with UBE2M and enhancing neddylation. | 4 |
| 33905671 | 2021 | NPRL2 reduces the niraparib sensitivity of castration-resistant prostate cancer via interacting with UBE2M and enhancing neddylation. | 4 |
| 31898237 | 2020 | Targeting DCN1-UBC12 Protein-Protein Interaction for Regulation of Neddylation Pathway. | 5 |
| 32012120 | 2020 | UBE2M promotes cell proliferation via the β-catenin/cyclin D1 signaling in hepatocellular carcinoma. | 13 |
| 32449166 | 2020 | UBC12-mediated SREBP-1 neddylation worsens metastatic tumor prognosis. | 23 |
| 32651357 | 2020 | NEDD8-conjugating enzyme UBC12 as a novel therapeutic target in esophageal squamous cell carcinoma. | 13 |
| 32819607 | 2020 | Ubiquitin conjugating enzyme E2 M promotes apoptosis in osteoarthritis chondrocytes via Wnt/β-catenin signaling. | 8 |
| 31898237 | 2020 | Targeting DCN1-UBC12 Protein-Protein Interaction for Regulation of Neddylation Pathway. | 5 |
| 32012120 | 2020 | UBE2M promotes cell proliferation via the β-catenin/cyclin D1 signaling in hepatocellular carcinoma. | 13 |
| 32449166 | 2020 | UBC12-mediated SREBP-1 neddylation worsens metastatic tumor prognosis. | 23 |
| 32651357 | 2020 | NEDD8-conjugating enzyme UBC12 as a novel therapeutic target in esophageal squamous cell carcinoma. | 13 |
| 32819607 | 2020 | Ubiquitin conjugating enzyme E2 M promotes apoptosis in osteoarthritis chondrocytes via Wnt/β-catenin signaling. | 8 |
| 31208947 | 2019 | Validation of NEDD8-conjugating enzyme UBC12 as a new therapeutic target in lung cancer. | 33 |
Citation
Dessen P
UBE2M (ubiquitin conjugating enzyme E2 M)
Atlas Genet Cytogenet Oncol Haematol. 2007-04-01
Online version: http://atlasgeneticsoncology.org/gene/47166/ube2m
