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UBE2N (ubiquitin-conjugating enzyme E2N)

Identity

Other namesHEL-S-71
UBC13
UBCHBEN
UBC13
UbcH-ben
UbcH13
HGNC (Hugo) UBE2N
LocusID (NCBI) 7334
Atlas_Id 42752
Location 12q22
Location_base_pair Starts at 93802088 and ends at 93836026 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)UBE2N   12492
Cards
Entrez_Gene (NCBI)UBE2N  7334  ubiquitin-conjugating enzyme E2N
GeneCards (Weizmann)UBE2N
Ensembl hg19 (Hinxton) [Gene_View]  chr12:93802088-93836026 [Contig_View]  UBE2N [Vega]
Ensembl hg38 (Hinxton) [Gene_View]  chr12:93802088-93836026 [Contig_View]  UBE2N [Vega]
TCGA cBioPortalUBE2N
AceView (NCBI)UBE2N
Genatlas (Paris)UBE2N
WikiGenes7334
SOURCE (Princeton)UBE2N
Genomic and cartography
GoldenPath hg19 (UCSC)UBE2N  -     chr12:93802088-93836026 -  12q22   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)UBE2N  -     12q22   [Description]    (hg38-Dec_2013)
EnsemblUBE2N - 12q22 [CytoView hg19]  UBE2N - 12q22 [CytoView hg38]
Mapping of homologs : NCBIUBE2N [Mapview hg19]  UBE2N [Mapview hg38]
OMIM603679   
Gene and transcription
Genbank (Entrez)AK098233 AL110140 BC000396 BC003365 BC108704
RefSeq transcript (Entrez)NM_003348
RefSeq genomic (Entrez)NC_000012 NC_018923 NT_029419 NW_004929384
Consensus coding sequences : CCDS (NCBI)UBE2N
Cluster EST : UnigeneHs.524630 [ NCBI ]
CGAP (NCI)Hs.524630
Alternative Splicing : Fast-db (Paris)GSHG0007683
Gene ExpressionUBE2N [ NCBI-GEO ]     UBE2N [ SEEK ]   UBE2N [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP61088 (Uniprot)
NextProtP61088  [Medical]  [Publications]
With graphics : InterProP61088
Splice isoforms : SwissVarP61088 (Swissvar)
Catalytic activity : Enzyme6.3.2.19 [ Enzyme-Expasy ]   6.3.2.196.3.2.19 [ IntEnz-EBI ]   6.3.2.19 [ BRENDA ]   6.3.2.19 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)UBIQUITIN_CONJUGAT_1 (PS00183)    UBIQUITIN_CONJUGAT_2 (PS50127)   
Domains : Interpro (EBI)UBQ-conjugat_E2    UBQ-conjugating_AS    UBQ-conjugating_enzyme/RWD   
Related proteins : CluSTrP61088
Domain families : Pfam (Sanger)UQ_con (PF00179)   
Domain families : Pfam (NCBI)pfam00179   
DMDM Disease mutations7334
Blocks (Seattle)P61088
PDB (SRS)1J7D    2C2V    3HCT    3HCU    3VON    3W31    4DHI    4DHJ    4DHZ    4IP3    4NR3    4NRG    4NRI    4ORH   
PDB (PDBSum)1J7D    2C2V    3HCT    3HCU    3VON    3W31    4DHI    4DHJ    4DHZ    4IP3    4NR3    4NRG    4NRI    4ORH   
PDB (IMB)1J7D    2C2V    3HCT    3HCU    3VON    3W31    4DHI    4DHJ    4DHZ    4IP3    4NR3    4NRG    4NRI    4ORH   
PDB (RSDB)1J7D    2C2V    3HCT    3HCU    3VON    3W31    4DHI    4DHJ    4DHZ    4IP3    4NR3    4NRG    4NRI    4ORH   
Peptide AtlasP61088
HPRD04725
IPIIPI00003949   IPI01021398   IPI01021220   IPI01020774   IPI01020921   
Protein Interaction databases
DIP (DOE-UCLA)P61088
IntAct (EBI)P61088
BioGRIDUBE2N
IntegromeDBUBE2N
STRING (EMBL)UBE2N
Ontologies - Pathways
QuickGOP61088
Ontology : AmiGOubiquitin ligase complex  double-strand break repair via homologous recombination  DNA double-strand break processing  stimulatory C-type lectin receptor signaling pathway  toll-like receptor signaling pathway  MyD88-dependent toll-like receptor signaling pathway  ubiquitin-protein transferase activity  protein binding  ATP binding  nucleus  cytoplasm  cytoplasm  cytosol  regulation of DNA repair  postreplication repair  cellular protein modification process  proteolysis  ubiquitin-dependent protein catabolic process  protein ubiquitination  protein ubiquitination  histone ubiquitination  ligase activity  cytokine-mediated signaling pathway  positive regulation of histone modification  UBC13-MMS2 complex  ubiquitin protein ligase binding  regulation of histone ubiquitination  toll-like receptor 2 signaling pathway  toll-like receptor 4 signaling pathway  toll-like receptor 5 signaling pathway  toll-like receptor 9 signaling pathway  toll-like receptor 10 signaling pathway  UBC13-UEV1A complex  nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway  Fc-epsilon receptor signaling pathway  toll-like receptor TLR1:TLR2 signaling pathway  toll-like receptor TLR6:TLR2 signaling pathway  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of I-kappaB kinase/NF-kappaB signaling  ubiquitin binding  protein complex  poly(A) RNA binding  innate immune response  positive regulation of DNA repair  T cell receptor signaling pathway  T cell receptor signaling pathway  positive regulation of NF-kappaB transcription factor activity  positive regulation of ubiquitin-protein transferase activity  ubiquitin protein ligase activity  extracellular exosome  nucleotide-binding oligomerization domain containing signaling pathway  protein K63-linked ubiquitination  
Ontology : EGO-EBIubiquitin ligase complex  double-strand break repair via homologous recombination  DNA double-strand break processing  stimulatory C-type lectin receptor signaling pathway  toll-like receptor signaling pathway  MyD88-dependent toll-like receptor signaling pathway  ubiquitin-protein transferase activity  protein binding  ATP binding  nucleus  cytoplasm  cytoplasm  cytosol  regulation of DNA repair  postreplication repair  cellular protein modification process  proteolysis  ubiquitin-dependent protein catabolic process  protein ubiquitination  protein ubiquitination  histone ubiquitination  ligase activity  cytokine-mediated signaling pathway  positive regulation of histone modification  UBC13-MMS2 complex  ubiquitin protein ligase binding  regulation of histone ubiquitination  toll-like receptor 2 signaling pathway  toll-like receptor 4 signaling pathway  toll-like receptor 5 signaling pathway  toll-like receptor 9 signaling pathway  toll-like receptor 10 signaling pathway  UBC13-UEV1A complex  nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway  Fc-epsilon receptor signaling pathway  toll-like receptor TLR1:TLR2 signaling pathway  toll-like receptor TLR6:TLR2 signaling pathway  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of I-kappaB kinase/NF-kappaB signaling  ubiquitin binding  protein complex  poly(A) RNA binding  innate immune response  positive regulation of DNA repair  T cell receptor signaling pathway  T cell receptor signaling pathway  positive regulation of NF-kappaB transcription factor activity  positive regulation of ubiquitin-protein transferase activity  ubiquitin protein ligase activity  extracellular exosome  nucleotide-binding oligomerization domain containing signaling pathway  protein K63-linked ubiquitination  
Pathways : KEGGUbiquitin mediated proteolysis   
Protein Interaction DatabaseUBE2N
DoCM (Curated mutations)UBE2N
Wikipedia pathwaysUBE2N
Gene fusion - Rearrangements
Gene fusion: TCGA
Polymorphisms : SNP, variants
NCBI Variation ViewerUBE2N [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UBE2N
dbVarUBE2N
ClinVarUBE2N
1000_GenomesUBE2N 
Exome Variant ServerUBE2N
SNP (GeneSNP Utah)UBE2N
SNP : HGBaseUBE2N
Genetic variants : HAPMAPUBE2N
Genomic Variants (DGV)UBE2N [DGVbeta]
Mutations
ICGC Data PortalUBE2N 
TCGA Data PortalUBE2N 
Tumor PortalUBE2N
Somatic Mutations in Cancer : COSMICUBE2N 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)12:93802088-93836026
CONAN: Copy Number AnalysisUBE2N 
Mutations and Diseases : HGMDUBE2N
OMIM603679   
MedgenUBE2N
NextProtP61088 [Medical]
GENETestsUBE2N
Disease Genetic AssociationUBE2N
Huge Navigator UBE2N [HugePedia]  UBE2N [HugeCancerGEM]
snp3D : Map Gene to Disease7334
DGIdb (Drug Gene Interaction db)UBE2N
BioCentury BCIQUBE2N
General knowledge
Homologs : HomoloGeneUBE2N
Homology/Alignments : Family Browser (UCSC)UBE2N
Phylogenetic Trees/Animal Genes : TreeFamUBE2N
Chemical/Protein Interactions : CTD7334
Chemical/Pharm GKB GenePA37141
Clinical trialUBE2N
Other databases
Probes
Litterature
PubMed167 Pubmed reference(s) in Entrez
CoreMineUBE2N
GoPubMedUBE2N
iHOPUBE2N
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Jun 27 12:28:32 CEST 2015

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