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UBE2N (ubiquitin conjugating enzyme E2 N)

Identity

Other namesHEL-S-71
UBC13
UBCHBEN
UBC13
UbcH-ben
UbcH13
HGNC (Hugo) UBE2N
LocusID (NCBI) 7334
Atlas_Id 42752
Location 12q22
Location_base_pair Starts at 93802088 and ends at 93836026 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
EEA1 (12q22) / UBE2N (12q22)PDCD4 (10q25.2) / UBE2N (12q22)UBE2N (12q22) / UBE2N (12q22)
EEA1 12q22 / UBE2N 12q22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)UBE2N   12492
Cards
Entrez_Gene (NCBI)UBE2N  7334  ubiquitin conjugating enzyme E2 N
GeneCards (Weizmann)UBE2N
Ensembl hg19 (Hinxton)ENSG00000177889 [Gene_View]  chr12:93802088-93836026 [Contig_View]  UBE2N [Vega]
Ensembl hg38 (Hinxton)ENSG00000177889 [Gene_View]  chr12:93802088-93836026 [Contig_View]  UBE2N [Vega]
ICGC DataPortalENSG00000177889
TCGA cBioPortalUBE2N
AceView (NCBI)UBE2N
Genatlas (Paris)UBE2N
WikiGenes7334
SOURCE (Princeton)UBE2N
Genomic and cartography
GoldenPath hg19 (UCSC)UBE2N  -     chr12:93802088-93836026 -  12q22   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)UBE2N  -     12q22   [Description]    (hg38-Dec_2013)
EnsemblUBE2N - 12q22 [CytoView hg19]  UBE2N - 12q22 [CytoView hg38]
Mapping of homologs : NCBIUBE2N [Mapview hg19]  UBE2N [Mapview hg38]
OMIM603679   
Gene and transcription
Genbank (Entrez)AK098233 AL110140 BC000396 BC003365 BC108704
RefSeq transcript (Entrez)NM_003348
RefSeq genomic (Entrez)NC_000012 NC_018923 NT_029419 NW_004929384
Consensus coding sequences : CCDS (NCBI)UBE2N
Cluster EST : UnigeneHs.524630 [ NCBI ]
CGAP (NCI)Hs.524630
Alternative Splicing GalleryENSG00000177889
Gene ExpressionUBE2N [ NCBI-GEO ]   UBE2N [ EBI - ARRAY_EXPRESS ]   UBE2N [ SEEK ]   UBE2N [ MEM ]
Gene Expression Viewer (FireBrowse)UBE2N [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7334
GTEX Portal (Tissue expression)UBE2N
Protein : pattern, domain, 3D structure
UniProt/SwissProtP61088 (Uniprot)
NextProtP61088  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP61088
Splice isoforms : SwissVarP61088 (Swissvar)
PhosPhoSitePlusP61088
Domaine pattern : Prosite (Expaxy)UBIQUITIN_CONJUGAT_1 (PS00183)    UBIQUITIN_CONJUGAT_2 (PS50127)   
Domains : Interpro (EBI)UBQ-conjugat_E2    UBQ-conjugating_AS    UBQ-conjugating_enzyme/RWD   
Domain families : Pfam (Sanger)UQ_con (PF00179)   
Domain families : Pfam (NCBI)pfam00179   
DMDM Disease mutations7334
Blocks (Seattle)UBE2N
PDB (SRS)1J7D    2C2V    3HCT    3HCU    3VON    3W31    4DHI    4DHJ    4DHZ    4IP3    4NR3    4NRG    4NRI    4ONL    4ONM    4ONN    4ORH    4TKP    4WHV    5AIT    5AIU   
PDB (PDBSum)1J7D    2C2V    3HCT    3HCU    3VON    3W31    4DHI    4DHJ    4DHZ    4IP3    4NR3    4NRG    4NRI    4ONL    4ONM    4ONN    4ORH    4TKP    4WHV    5AIT    5AIU   
PDB (IMB)1J7D    2C2V    3HCT    3HCU    3VON    3W31    4DHI    4DHJ    4DHZ    4IP3    4NR3    4NRG    4NRI    4ONL    4ONM    4ONN    4ORH    4TKP    4WHV    5AIT    5AIU   
PDB (RSDB)1J7D    2C2V    3HCT    3HCU    3VON    3W31    4DHI    4DHJ    4DHZ    4IP3    4NR3    4NRG    4NRI    4ONL    4ONM    4ONN    4ORH    4TKP    4WHV    5AIT    5AIU   
Structural Biology KnowledgeBase1J7D    2C2V    3HCT    3HCU    3VON    3W31    4DHI    4DHJ    4DHZ    4IP3    4NR3    4NRG    4NRI    4ONL    4ONM    4ONN    4ORH    4TKP    4WHV    5AIT    5AIU   
SCOP (Structural Classification of Proteins)1J7D    2C2V    3HCT    3HCU    3VON    3W31    4DHI    4DHJ    4DHZ    4IP3    4NR3    4NRG    4NRI    4ONL    4ONM    4ONN    4ORH    4TKP    4WHV    5AIT    5AIU   
CATH (Classification of proteins structures)1J7D    2C2V    3HCT    3HCU    3VON    3W31    4DHI    4DHJ    4DHZ    4IP3    4NR3    4NRG    4NRI    4ONL    4ONM    4ONN    4ORH    4TKP    4WHV    5AIT    5AIU   
SuperfamilyP61088
Human Protein AtlasENSG00000177889
Peptide AtlasP61088
HPRD04725
IPIIPI00003949   IPI01021398   IPI01021220   IPI01020774   IPI01020921   
Protein Interaction databases
DIP (DOE-UCLA)P61088
IntAct (EBI)P61088
FunCoupENSG00000177889
BioGRIDUBE2N
STRING (EMBL)UBE2N
ZODIACUBE2N
Ontologies - Pathways
QuickGOP61088
Ontology : AmiGOubiquitin ligase complex  double-strand break repair via homologous recombination  DNA double-strand break processing  stimulatory C-type lectin receptor signaling pathway  ubiquitin-protein transferase activity  protein binding  ATP binding  nucleus  nucleoplasm  nucleolus  cytoplasm  cytoplasm  cytosol  regulation of DNA repair  postreplication repair  double-strand break repair via nonhomologous end joining  cellular protein modification process  proteolysis  ubiquitin-dependent protein catabolic process  protein ubiquitination  protein ubiquitination  histone ubiquitination  positive regulation of histone modification  UBC13-MMS2 complex  ubiquitin protein ligase binding  regulation of histone ubiquitination  UBC13-UEV1A complex  Fc-epsilon receptor signaling pathway  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of I-kappaB kinase/NF-kappaB signaling  ubiquitin binding  protein complex  poly(A) RNA binding  positive regulation of DNA repair  T cell receptor signaling pathway  T cell receptor signaling pathway  positive regulation of NF-kappaB transcription factor activity  positive regulation of ubiquitin-protein transferase activity  ubiquitin protein ligase activity  ubiquitin conjugating enzyme activity  extracellular exosome  nucleotide-binding oligomerization domain containing signaling pathway  protein K63-linked ubiquitination  protein K63-linked ubiquitination  global genome nucleotide-excision repair  
Ontology : EGO-EBIubiquitin ligase complex  double-strand break repair via homologous recombination  DNA double-strand break processing  stimulatory C-type lectin receptor signaling pathway  ubiquitin-protein transferase activity  protein binding  ATP binding  nucleus  nucleoplasm  nucleolus  cytoplasm  cytoplasm  cytosol  regulation of DNA repair  postreplication repair  double-strand break repair via nonhomologous end joining  cellular protein modification process  proteolysis  ubiquitin-dependent protein catabolic process  protein ubiquitination  protein ubiquitination  histone ubiquitination  positive regulation of histone modification  UBC13-MMS2 complex  ubiquitin protein ligase binding  regulation of histone ubiquitination  UBC13-UEV1A complex  Fc-epsilon receptor signaling pathway  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of I-kappaB kinase/NF-kappaB signaling  ubiquitin binding  protein complex  poly(A) RNA binding  positive regulation of DNA repair  T cell receptor signaling pathway  T cell receptor signaling pathway  positive regulation of NF-kappaB transcription factor activity  positive regulation of ubiquitin-protein transferase activity  ubiquitin protein ligase activity  ubiquitin conjugating enzyme activity  extracellular exosome  nucleotide-binding oligomerization domain containing signaling pathway  protein K63-linked ubiquitination  protein K63-linked ubiquitination  global genome nucleotide-excision repair  
Pathways : KEGGUbiquitin mediated proteolysis   
NDEx Network
Atlas of Cancer Signalling NetworkUBE2N
Wikipedia pathwaysUBE2N
Orthology - Evolution
OrthoDB7334
GeneTree (enSembl)ENSG00000177889
Phylogenetic Trees/Animal Genes : TreeFamUBE2N
Homologs : HomoloGeneUBE2N
Homology/Alignments : Family Browser (UCSC)UBE2N
Gene fusions - Rearrangements
Fusion: TCGAEEA1 12q22 UBE2N 12q22 LUAD
Polymorphisms : SNP, variants
NCBI Variation ViewerUBE2N [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UBE2N
dbVarUBE2N
ClinVarUBE2N
1000_GenomesUBE2N 
Exome Variant ServerUBE2N
ExAC (Exome Aggregation Consortium)UBE2N (select the gene name)
Genetic variants : HAPMAP7334
Genomic Variants (DGV)UBE2N [DGVbeta]
Mutations
ICGC Data PortalUBE2N 
TCGA Data PortalUBE2N 
Broad Tumor PortalUBE2N
OASIS PortalUBE2N [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUBE2N 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch UBE2N
DgiDB (Drug Gene Interaction Database)UBE2N
DoCM (Curated mutations)UBE2N (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UBE2N (select a term)
intoGenUBE2N
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)12:93802088-93836026  ENSG00000177889
CONAN: Copy Number AnalysisUBE2N 
Mutations and Diseases : HGMDUBE2N
OMIM603679   
MedgenUBE2N
Genetic Testing Registry UBE2N
NextProtP61088 [Medical]
TSGene7334
GENETestsUBE2N
Huge Navigator UBE2N [HugePedia]
snp3D : Map Gene to Disease7334
BioCentury BCIQUBE2N
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7334
Chemical/Pharm GKB GenePA37141
Clinical trialUBE2N
Miscellaneous
canSAR (ICR)UBE2N (select the gene name)
Probes
Litterature
PubMed175 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUBE2N
EVEXUBE2N
GoPubMedUBE2N
iHOPUBE2N
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sun May 8 19:10:37 CEST 2016

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