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UBE2N (ubiquitin conjugating enzyme E2 N)

Identity

Alias (NCBI)HEL-S-71
UBC13
UBCHBEN
UBC13
UbcH-ben
UbcH13
HGNC (Hugo) UBE2N
HGNC Alias symbUbcH-ben
UBC13
MGC8489
HGNC Previous nameubiquitin-conjugating enzyme E2N (homologous to yeast UBC13)
 ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)
 ubiquitin-conjugating enzyme E2N
LocusID (NCBI) 7334
Atlas_Id 42752
Location 12q22  [Link to chromosome band 12q22]
Location_base_pair Starts at 93405684 and ends at 93441947 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
EEA1 (12q22) / UBE2N (12q22)PDCD4 (10q25.2) / UBE2N (12q22)UBE2N (12q22) / UBE2N (12q22)
EEA1 12q22 / UBE2N 12q22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)UBE2N   12492
Cards
Entrez_Gene (NCBI)UBE2N    ubiquitin conjugating enzyme E2 N
AliasesHEL-S-71; UBC13; UBCHBEN; UBC13; 
UbcH-ben; UbcH13
GeneCards (Weizmann)UBE2N
Ensembl hg19 (Hinxton)ENSG00000177889 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000177889 [Gene_View]  ENSG00000177889 [Sequence]  chr12:93405684-93441947 [Contig_View]  UBE2N [Vega]
ICGC DataPortalENSG00000177889
TCGA cBioPortalUBE2N
AceView (NCBI)UBE2N
Genatlas (Paris)UBE2N
SOURCE (Princeton)UBE2N
Genetics Home Reference (NIH)UBE2N
Genomic and cartography
GoldenPath hg38 (UCSC)UBE2N  -     chr12:93405684-93441947 -  12q22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)UBE2N  -     12q22   [Description]    (hg19-Feb_2009)
GoldenPathUBE2N - 12q22 [CytoView hg19]  UBE2N - 12q22 [CytoView hg38]
ImmunoBaseENSG00000177889
Genome Data Viewer NCBIUBE2N [Mapview hg19]  
OMIM603679   
Gene and transcription
Genbank (Entrez)AK098233 AL110140 BC000396 BC003365 BC108704
RefSeq transcript (Entrez)NM_003348
Consensus coding sequences : CCDS (NCBI)UBE2N
Gene ExpressionUBE2N [ NCBI-GEO ]   UBE2N [ EBI - ARRAY_EXPRESS ]   UBE2N [ SEEK ]   UBE2N [ MEM ]
Gene Expression Viewer (FireBrowse)UBE2N [ Firebrowse - Broad ]
GenevisibleExpression of UBE2N in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7334
GTEX Portal (Tissue expression)UBE2N
Human Protein AtlasENSG00000177889-UBE2N [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP61088   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP61088  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP61088
PhosPhoSitePlusP61088
Domaine pattern : Prosite (Expaxy)UBC_1 (PS00183)    UBC_2 (PS50127)   
Domains : Interpro (EBI)UBQ-conjugat_E2    UBQ-conjugating_AS    UBQ-conjugating_enzyme/RWD   
Domain families : Pfam (Sanger)UQ_con (PF00179)   
Domain families : Pfam (NCBI)pfam00179   
Conserved Domain (NCBI)UBE2N
PDB (RSDB)1J7D    2C2V    3HCT    3HCU    3VON    3W31    4DHI    4DHJ    4DHZ    4IP3    4NR3    4NRG    4NRI    4ONL    4ONM    4ONN    4ORH    4TKP    4WHV    5AIT    5AIU    5EYA    5H7S    5VNZ    5VO0    5YWR    6D6I    6JKY    6KFP    6KG6    6KL4    6P5B    6S53    6ULH    6UMP    6UMS    7BXG   
PDB Europe1J7D    2C2V    3HCT    3HCU    3VON    3W31    4DHI    4DHJ    4DHZ    4IP3    4NR3    4NRG    4NRI    4ONL    4ONM    4ONN    4ORH    4TKP    4WHV    5AIT    5AIU    5EYA    5H7S    5VNZ    5VO0    5YWR    6D6I    6JKY    6KFP    6KG6    6KL4    6P5B    6S53    6ULH    6UMP    6UMS    7BXG   
PDB (PDBSum)1J7D    2C2V    3HCT    3HCU    3VON    3W31    4DHI    4DHJ    4DHZ    4IP3    4NR3    4NRG    4NRI    4ONL    4ONM    4ONN    4ORH    4TKP    4WHV    5AIT    5AIU    5EYA    5H7S    5VNZ    5VO0    5YWR    6D6I    6JKY    6KFP    6KG6    6KL4    6P5B    6S53    6ULH    6UMP    6UMS    7BXG   
PDB (IMB)1J7D    2C2V    3HCT    3HCU    3VON    3W31    4DHI    4DHJ    4DHZ    4IP3    4NR3    4NRG    4NRI    4ONL    4ONM    4ONN    4ORH    4TKP    4WHV    5AIT    5AIU    5EYA    5H7S    5VNZ    5VO0    5YWR    6D6I    6JKY    6KFP    6KG6    6KL4    6P5B    6S53    6ULH    6UMP    6UMS    7BXG   
Structural Biology KnowledgeBase1J7D    2C2V    3HCT    3HCU    3VON    3W31    4DHI    4DHJ    4DHZ    4IP3    4NR3    4NRG    4NRI    4ONL    4ONM    4ONN    4ORH    4TKP    4WHV    5AIT    5AIU    5EYA    5H7S    5VNZ    5VO0    5YWR    6D6I    6JKY    6KFP    6KG6    6KL4    6P5B    6S53    6ULH    6UMP    6UMS    7BXG   
SCOP (Structural Classification of Proteins)1J7D    2C2V    3HCT    3HCU    3VON    3W31    4DHI    4DHJ    4DHZ    4IP3    4NR3    4NRG    4NRI    4ONL    4ONM    4ONN    4ORH    4TKP    4WHV    5AIT    5AIU    5EYA    5H7S    5VNZ    5VO0    5YWR    6D6I    6JKY    6KFP    6KG6    6KL4    6P5B    6S53    6ULH    6UMP    6UMS    7BXG   
CATH (Classification of proteins structures)1J7D    2C2V    3HCT    3HCU    3VON    3W31    4DHI    4DHJ    4DHZ    4IP3    4NR3    4NRG    4NRI    4ONL    4ONM    4ONN    4ORH    4TKP    4WHV    5AIT    5AIU    5EYA    5H7S    5VNZ    5VO0    5YWR    6D6I    6JKY    6KFP    6KG6    6KL4    6P5B    6S53    6ULH    6UMP    6UMS    7BXG   
SuperfamilyP61088
AlphaFold pdb e-kbP61088   
Human Protein Atlas [tissue]ENSG00000177889-UBE2N [tissue]
HPRD04725
Protein Interaction databases
DIP (DOE-UCLA)P61088
IntAct (EBI)P61088
BioGRIDUBE2N
STRING (EMBL)UBE2N
ZODIACUBE2N
Ontologies - Pathways
QuickGOP61088
Ontology : AmiGOubiquitin ligase complex  activation of MAPK activity  protein polyubiquitination  double-strand break repair via homologous recombination  DNA double-strand break processing  fibrillar center  RNA binding  ubiquitin-protein transferase activity  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytoplasm  cytosol  regulation of DNA repair  postreplication repair  postreplication repair  double-strand break repair  double-strand break repair via nonhomologous end joining  ubiquitin-dependent protein catabolic process  JNK cascade  protein ubiquitination  protein ubiquitination  histone ubiquitination  positive regulation of histone modification  UBC13-MMS2 complex  ubiquitin protein ligase binding  protein-containing complex  regulation of histone ubiquitination  UBC13-UEV1A complex  aggrephagy  positive regulation of I-kappaB kinase/NF-kappaB signaling  ubiquitin binding  positive regulation of DNA repair  T cell receptor signaling pathway  positive regulation of NF-kappaB transcription factor activity  positive regulation of NF-kappaB transcription factor activity  positive regulation of ubiquitin-protein transferase activity  ubiquitin conjugating enzyme activity  ubiquitin conjugating enzyme activity  ubiquitin conjugating enzyme activity  extracellular exosome  nucleotide-binding oligomerization domain containing signaling pathway  interleukin-1-mediated signaling pathway  protein K63-linked ubiquitination  protein K63-linked ubiquitination  protein K63-linked ubiquitination  
Ontology : EGO-EBIubiquitin ligase complex  activation of MAPK activity  protein polyubiquitination  double-strand break repair via homologous recombination  DNA double-strand break processing  fibrillar center  RNA binding  ubiquitin-protein transferase activity  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytoplasm  cytosol  regulation of DNA repair  postreplication repair  postreplication repair  double-strand break repair  double-strand break repair via nonhomologous end joining  ubiquitin-dependent protein catabolic process  JNK cascade  protein ubiquitination  protein ubiquitination  histone ubiquitination  positive regulation of histone modification  UBC13-MMS2 complex  ubiquitin protein ligase binding  protein-containing complex  regulation of histone ubiquitination  UBC13-UEV1A complex  aggrephagy  positive regulation of I-kappaB kinase/NF-kappaB signaling  ubiquitin binding  positive regulation of DNA repair  T cell receptor signaling pathway  positive regulation of NF-kappaB transcription factor activity  positive regulation of NF-kappaB transcription factor activity  positive regulation of ubiquitin-protein transferase activity  ubiquitin conjugating enzyme activity  ubiquitin conjugating enzyme activity  ubiquitin conjugating enzyme activity  extracellular exosome  nucleotide-binding oligomerization domain containing signaling pathway  interleukin-1-mediated signaling pathway  protein K63-linked ubiquitination  protein K63-linked ubiquitination  protein K63-linked ubiquitination  
Pathways : KEGGUbiquitin mediated proteolysis   
NDEx NetworkUBE2N
Atlas of Cancer Signalling NetworkUBE2N
Wikipedia pathwaysUBE2N
Orthology - Evolution
OrthoDB7334
GeneTree (enSembl)ENSG00000177889
Phylogenetic Trees/Animal Genes : TreeFamUBE2N
Homologs : HomoloGeneUBE2N
Homology/Alignments : Family Browser (UCSC)UBE2N
Gene fusions - Rearrangements
Fusion : QuiverUBE2N
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUBE2N [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UBE2N
dbVarUBE2N
ClinVarUBE2N
MonarchUBE2N
1000_GenomesUBE2N 
Exome Variant ServerUBE2N
GNOMAD BrowserENSG00000177889
Varsome BrowserUBE2N
ACMGUBE2N variants
VarityP61088
Genomic Variants (DGV)UBE2N [DGVbeta]
DECIPHERUBE2N [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUBE2N 
Mutations
ICGC Data PortalUBE2N 
TCGA Data PortalUBE2N 
Broad Tumor PortalUBE2N
OASIS PortalUBE2N [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUBE2N  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DUBE2N
Mutations and Diseases : HGMDUBE2N
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaUBE2N
DgiDB (Drug Gene Interaction Database)UBE2N
DoCM (Curated mutations)UBE2N
CIViC (Clinical Interpretations of Variants in Cancer)UBE2N
Cancer3DUBE2N
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603679   
Orphanet
DisGeNETUBE2N
MedgenUBE2N
Genetic Testing Registry UBE2N
NextProtP61088 [Medical]
GENETestsUBE2N
Target ValidationUBE2N
Huge Navigator UBE2N [HugePedia]
ClinGenUBE2N
Clinical trials, drugs, therapy
MyCancerGenomeUBE2N
Protein Interactions : CTDUBE2N
Pharm GKB GenePA37141
PharosP61088
Clinical trialUBE2N
Miscellaneous
canSAR (ICR)UBE2N
HarmonizomeUBE2N
DataMed IndexUBE2N
Probes
Litterature
PubMed271 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXUBE2N
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:37:09 CEST 2021

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