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UBE2O (ubiquitin conjugating enzyme E2 O)

Identity

Alias_namesubiquitin-conjugating enzyme E2O
Alias_symbol (synonym)E2-230K
Other alias
HGNC (Hugo) UBE2O
LocusID (NCBI) 63893
Atlas_Id 46667
Location 17q25.1  [Link to chromosome band 17q25]
Location_base_pair Starts at 76389532 and ends at 76453206 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
BSDC1 (1p35.1) / UBE2O (17q25.1)MAT2A (2p11.2) / UBE2O (17q25.1)UBE2O (17q25.1) / RNF213 (17q25.3)
UBE2O (17q25.1) / UBE2O (17q25.1)USP32 (17q23.1) / UBE2O (17q25.1)UBE2O 17q25.1 / RNF213 17q25.3
USP32 17q23.1 / UBE2O 17q25.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)UBE2O   29554
Cards
Entrez_Gene (NCBI)UBE2O  63893  ubiquitin conjugating enzyme E2 O
AliasesE2-230K
GeneCards (Weizmann)UBE2O
Ensembl hg19 (Hinxton)ENSG00000175931 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000175931 [Gene_View]  chr17:76389532-76453206 [Contig_View]  UBE2O [Vega]
ICGC DataPortalENSG00000175931
TCGA cBioPortalUBE2O
AceView (NCBI)UBE2O
Genatlas (Paris)UBE2O
WikiGenes63893
SOURCE (Princeton)UBE2O
Genetics Home Reference (NIH)UBE2O
Genomic and cartography
GoldenPath hg38 (UCSC)UBE2O  -     chr17:76389532-76453206 -  17q25.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)UBE2O  -     17q25.1   [Description]    (hg19-Feb_2009)
EnsemblUBE2O - 17q25.1 [CytoView hg19]  UBE2O - 17q25.1 [CytoView hg38]
Mapping of homologs : NCBIUBE2O [Mapview hg19]  UBE2O [Mapview hg38]
Gene and transcription
Genbank (Entrez)AB051521 AK000926 AK022940 AK024657 AK025999
RefSeq transcript (Entrez)NM_022066
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)UBE2O
Cluster EST : UnigeneHs.16130 [ NCBI ]
CGAP (NCI)Hs.16130
Alternative Splicing GalleryENSG00000175931
Gene ExpressionUBE2O [ NCBI-GEO ]   UBE2O [ EBI - ARRAY_EXPRESS ]   UBE2O [ SEEK ]   UBE2O [ MEM ]
Gene Expression Viewer (FireBrowse)UBE2O [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)63893
GTEX Portal (Tissue expression)UBE2O
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9C0C9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9C0C9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9C0C9
Splice isoforms : SwissVarQ9C0C9
PhosPhoSitePlusQ9C0C9
Domaine pattern : Prosite (Expaxy)UBIQUITIN_CONJUGAT_2 (PS50127)   
Domains : Interpro (EBI)UBQ-conjugat_E2    UBQ-conjugating_enzyme/RWD   
Domain families : Pfam (Sanger)UQ_con (PF00179)   
Domain families : Pfam (NCBI)pfam00179   
Conserved Domain (NCBI)UBE2O
DMDM Disease mutations63893
Blocks (Seattle)UBE2O
SuperfamilyQ9C0C9
Human Protein AtlasENSG00000175931
Peptide AtlasQ9C0C9
HPRD10928
IPIIPI00783378   
Protein Interaction databases
DIP (DOE-UCLA)Q9C0C9
IntAct (EBI)Q9C0C9
FunCoupENSG00000175931
BioGRIDUBE2O
STRING (EMBL)UBE2O
ZODIACUBE2O
Ontologies - Pathways
QuickGOQ9C0C9
Ontology : AmiGORNA binding  ubiquitin-protein transferase activity  protein binding  ATP binding  nucleus  cytoplasm  cytosol  protein monoubiquitination  nuclear body  positive regulation of BMP signaling pathway  ubiquitin protein ligase binding  retrograde transport, endosome to Golgi  ubiquitin protein ligase activity  ubiquitin conjugating enzyme activity  protein K63-linked ubiquitination  
Ontology : EGO-EBIRNA binding  ubiquitin-protein transferase activity  protein binding  ATP binding  nucleus  cytoplasm  cytosol  protein monoubiquitination  nuclear body  positive regulation of BMP signaling pathway  ubiquitin protein ligase binding  retrograde transport, endosome to Golgi  ubiquitin protein ligase activity  ubiquitin conjugating enzyme activity  protein K63-linked ubiquitination  
Pathways : KEGGUbiquitin mediated proteolysis   
NDEx NetworkUBE2O
Atlas of Cancer Signalling NetworkUBE2O
Wikipedia pathwaysUBE2O
Orthology - Evolution
OrthoDB63893
GeneTree (enSembl)ENSG00000175931
Phylogenetic Trees/Animal Genes : TreeFamUBE2O
HOVERGENQ9C0C9
HOGENOMQ9C0C9
Homologs : HomoloGeneUBE2O
Homology/Alignments : Family Browser (UCSC)UBE2O
Gene fusions - Rearrangements
Fusion : MitelmanUBE2O/RNF213 [17q25.1/17q25.3]  
Fusion : MitelmanUSP32/UBE2O [17q23.1/17q25.1]  [t(17;17)(q23;q25)]  
Fusion: TCGAUBE2O 17q25.1 RNF213 17q25.3 BRCA
Fusion: TCGAUSP32 17q23.1 UBE2O 17q25.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUBE2O [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UBE2O
dbVarUBE2O
ClinVarUBE2O
1000_GenomesUBE2O 
Exome Variant ServerUBE2O
ExAC (Exome Aggregation Consortium)UBE2O (select the gene name)
Genetic variants : HAPMAP63893
Genomic Variants (DGV)UBE2O [DGVbeta]
DECIPHERUBE2O [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUBE2O 
Mutations
ICGC Data PortalUBE2O 
TCGA Data PortalUBE2O 
Broad Tumor PortalUBE2O
OASIS PortalUBE2O [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUBE2O  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUBE2O
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch UBE2O
DgiDB (Drug Gene Interaction Database)UBE2O
DoCM (Curated mutations)UBE2O (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UBE2O (select a term)
intoGenUBE2O
Cancer3DUBE2O(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenUBE2O
Genetic Testing Registry UBE2O
NextProtQ9C0C9 [Medical]
TSGene63893
GENETestsUBE2O
Target ValidationUBE2O
Huge Navigator UBE2O [HugePedia]
snp3D : Map Gene to Disease63893
BioCentury BCIQUBE2O
ClinGenUBE2O
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD63893
Chemical/Pharm GKB GenePA142670651
Clinical trialUBE2O
Miscellaneous
canSAR (ICR)UBE2O (select the gene name)
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUBE2O
EVEXUBE2O
GoPubMedUBE2O
iHOPUBE2O
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 13:01:40 CEST 2017

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