UBE2O (ubiquitin conjugating enzyme E2 O)

2007-04-01  

Identity

HGNC
LOCATION
17q25.1
LOCUSID
ALIAS
E2-230K
FUSION GENES

Other Information

Locus ID:

NCBI: 63893
MIM: 617649
HGNC: 29554
Ensembl: ENSG00000175931

Variants:

dbSNP: 63893
ClinVar: 63893
TCGA: ENSG00000175931
COSMIC: UBE2O

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000175931ENST00000319380Q9C0C9
ENSG00000175931ENST00000587127K7ES11
ENSG00000175931ENST00000590658K7EQ12

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Ubiquitin mediated proteolysisKEGGhsa04120
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
247039502014Autodeubiquitination protects the tumor suppressor BAP1 from cytoplasmic sequestration mediated by the atypical ubiquitin ligase UBE2O.55
234551532013Fine-tuning BMP7 signalling in adipogenesis by UBE2O/E2-230K-mediated monoubiquitination of SMAD6.37
281629742017A UBE2O-AMPKα2 Axis that Promotes Tumor Initiation and Progression Offers Opportunities for Therapy.29
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
233811382013UBE2O negatively regulates TRAF6-mediated NF-κB activation by inhibiting TRAF6 polyubiquitination.26
287749222017UBE2O is a quality control factor for orphans of multiprotein complexes.21
286733172017The ubiquitin-conjugating enzyme UBE2O modulates c-Maf stability and induces myeloma cell apoptosis.8
298459342018The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.7
298719232018Ubiquitin-conjugating enzyme UBE2O regulates cellular clock function by promoting the degradation of the transcription factor BMAL1.6
304685562019Diverse roles of the E2/E3 hybrid enzyme UBE2O in the regulation of protein ubiquitination, cellular functions, and disease onset.1

Citation

Dessen P

UBE2O (ubiquitin conjugating enzyme E2 O)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46667/ube2o