UBE2T (ubiquitin conjugating enzyme E2 T)

2008-10-01  

Identity

HGNC
UBE2T
LOCATION
1q32.1
LOCUSID
29089
ALIAS
FANCT,HSPC150,PIG50
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 29089
MIM: 610538
HGNC: 25009
Ensembl: ENSG00000077152

Variants:

dbSNP: 29089
ClinVar: 29089
TCGA: ENSG00000077152
COSMIC: UBE2T

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000077152ENST00000643045A0A2R8Y812
ENSG00000077152ENST00000646651Q9NPD8
ENSG00000077152ENST00000646651A0A024R9A9

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Fanconi anemia pathwayKEGGko03460
Fanconi anemia pathwayKEGGhsa03460
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DNA RepairREACTOMER-HSA-73894
Fanconi Anemia PathwayREACTOMER-HSA-6783310
Protein ubiquitinationREACTOMER-HSA-8852135
Synthesis of active ubiquitin: roles of E1 and E2 enzymesREACTOMER-HSA-8866652

References

Pubmed IDYearTitleCitations
169166452006UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation.113
191116572008Mechanistic insight into site-restricted monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI.94
260463682015Mutations in the gene encoding the E2 conjugating enzyme UBE2T cause Fanconi anemia.52
261197372015Deficiency of UBE2T, the E2 Ubiquitin Ligase Necessary for FANCD2 and FANCI Ubiquitination, Causes FA-T Subtype of Fanconi Anemia.50
195897842009FANCI binds branched DNA and is monoubiquitinated by UBE2T-FANCL.41
198876022009Ubiquitination and downregulation of BRCA1 by ubiquitin-conjugating enzyme E2T overexpression in human breast cancer cells.30
260855752015AluY-mediated germline deletion, duplication and somatic stem cell reversion in UBE2T defines a new subtype of Fanconi anemia.28
263080722015Elevated expression of UBE2T exhibits oncogenic properties in human prostate cancer.23
269430302016UBE2T promotes nasopharyngeal carcinoma cell proliferation, invasion, and metastasis by activating the AKT/GSK3β/β-catenin pathway.19
186678442008Elevated expression of UBE2T in lung cancer tumors and cell lines.16

Citation

Dessen P

UBE2T (ubiquitin conjugating enzyme E2 T)

Atlas Genet Cytogenet Oncol Haematol. 2008-10-01

Online version: http://atlasgeneticsoncology.org/gene/50427/ube2t