UBE2W (ubiquitin conjugating enzyme E2 W)

2012-06-01  

Identity

HGNC
LOCATION
8q21.11
LOCUSID
ALIAS
UBC-16,UBC16
FUSION GENES

Other Information

Locus ID:

NCBI: 55284
MIM: 614277
HGNC: 25616
Ensembl: ENSG00000104343

Variants:

dbSNP: 55284
ClinVar: 55284
TCGA: ENSG00000104343
COSMIC: UBE2W

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104343ENST00000419880X6REH9
ENSG00000104343ENST00000422906E5RG25
ENSG00000104343ENST00000517608Q96B02
ENSG00000104343ENST00000519255E5RG25
ENSG00000104343ENST00000519277E5RG25
ENSG00000104343ENST00000523278H0YB73
ENSG00000104343ENST00000602593Q96B02
ENSG00000104343ENST00000650817X6REH9
ENSG00000104343ENST00000651945Q96B02
ENSG00000104343ENST00000651945A0A024R7X9

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Ubiquitin mediated proteolysisKEGGhsa04120
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168
Protein ubiquitinationREACTOMER-HSA-8852135
Synthesis of active ubiquitin: roles of E1 and E2 enzymesREACTOMER-HSA-8866652

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
261013722015TRIM5α requires Ube2W to anchor Lys63-linked ubiquitin chains and restrict reverse transcription.38
236966362013The ubiquitin-conjugating enzyme (E2) Ube2w ubiquitinates the N terminus of substrates.35
254365192015Intrinsic disorder drives N-terminal ubiquitination by Ube2w.25
212293262011UBE2W interacts with FANCL and regulates the monoubiquitination of Fanconi anemia protein FANCD2.18
163685322006Cloning, characterization and subcellular localization of a gene encoding a human Ubiquitin-conjugating enzyme (E2) homologous to the Arabidopsis thaliana UBC-16 gene product.4
271855772016Loss of ubiquitin E2 Ube2w rescues hypersensitivity of Rnf4 mutant cells to DNA damage.3
315186132020N-Terminal Ubiquitination of Amyloidogenic Proteins Triggers Removal of Their Oligomers by the Proteasome Holoenzyme.2

Citation

Dessen P

UBE2W (ubiquitin conjugating enzyme E2 W)

Atlas Genet Cytogenet Oncol Haematol. 2012-06-01

Online version: http://atlasgeneticsoncology.org/gene/52739/ube2w