Atlas of Genetics and Cytogenetics in Oncology and Haematology

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UBE2Z (ubiquitin conjugating enzyme E2 Z)

Identity

Other aliasHOYS7
USE1
HGNC (Hugo) UBE2Z
LocusID (NCBI) 65264
Atlas_Id 57024
Location 17q21.32  [Link to chromosome band 17q21]
Location_base_pair Starts at 48908369 and ends at 48929060 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
UBE2Z (17q21.32) / EPS15 (1p32.3)UBE2Z (17q21.32) / UBE2Z (17q21.32)UBE2Z (17q21.32) / UTP18 (17q21.33)
UBE2Z (17q21.32) / ZNF652 (17q21.32)YPEL2 (17q22) / UBE2Z (17q21.32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  UBE2Z/UTP18 (17q21)
UBE2Z/ZNF652 (17q21)
t(17;17)(q21;q22) YPEL2/UBE2Z

External links

Nomenclature
HGNC (Hugo)UBE2Z   25847
Cards
Entrez_Gene (NCBI)UBE2Z  65264  ubiquitin conjugating enzyme E2 Z
AliasesHOYS7; USE1
GeneCards (Weizmann)UBE2Z
Ensembl hg19 (Hinxton)ENSG00000159202 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000159202 [Gene_View]  ENSG00000159202 [Sequence]  chr17:48908369-48929060 [Contig_View]  UBE2Z [Vega]
ICGC DataPortalENSG00000159202
TCGA cBioPortalUBE2Z
AceView (NCBI)UBE2Z
Genatlas (Paris)UBE2Z
WikiGenes65264
SOURCE (Princeton)UBE2Z
Genetics Home Reference (NIH)UBE2Z
Genomic and cartography
GoldenPath hg38 (UCSC)UBE2Z  -     chr17:48908369-48929060 +  17q21.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)UBE2Z  -     17q21.32   [Description]    (hg19-Feb_2009)
EnsemblUBE2Z - 17q21.32 [CytoView hg19]  UBE2Z - 17q21.32 [CytoView hg38]
Mapping of homologs : NCBIUBE2Z [Mapview hg19]  UBE2Z [Mapview hg38]
OMIM611362   
Gene and transcription
Genbank (Entrez)AA843379 AA845421 AB025426 AK023917 AK024030
RefSeq transcript (Entrez)NM_023079
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)UBE2Z
Cluster EST : UnigeneHs.514297 [ NCBI ]
CGAP (NCI)Hs.514297
Alternative Splicing GalleryENSG00000159202
Gene ExpressionUBE2Z [ NCBI-GEO ]   UBE2Z [ EBI - ARRAY_EXPRESS ]   UBE2Z [ SEEK ]   UBE2Z [ MEM ]
Gene Expression Viewer (FireBrowse)UBE2Z [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)65264
GTEX Portal (Tissue expression)UBE2Z
Human Protein AtlasENSG00000159202-UBE2Z [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H832   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H832  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H832
Splice isoforms : SwissVarQ9H832
Catalytic activity : Enzyme2.3.2.23 [ Enzyme-Expasy ]   2.3.2.232.3.2.23 [ IntEnz-EBI ]   2.3.2.23 [ BRENDA ]   2.3.2.23 [ KEGG ]   
PhosPhoSitePlusQ9H832
Domaine pattern : Prosite (Expaxy)UBIQUITIN_CONJUGAT_2 (PS50127)   
Domains : Interpro (EBI)UBQ-conjugat_E2    UBQ-conjugating_enzyme/RWD   
Domain families : Pfam (Sanger)UQ_con (PF00179)   
Domain families : Pfam (NCBI)pfam00179   
Conserved Domain (NCBI)UBE2Z
DMDM Disease mutations65264
Blocks (Seattle)UBE2Z
PDB (RSDB)5A4P   
PDB Europe5A4P   
PDB (PDBSum)5A4P   
PDB (IMB)5A4P   
Structural Biology KnowledgeBase5A4P   
SCOP (Structural Classification of Proteins)5A4P   
CATH (Classification of proteins structures)5A4P   
SuperfamilyQ9H832
Human Protein Atlas [tissue]ENSG00000159202-UBE2Z [tissue]
Peptide AtlasQ9H832
IPIIPI00011996   IPI00829749   IPI00965499   IPI00965124   
Protein Interaction databases
DIP (DOE-UCLA)Q9H832
IntAct (EBI)Q9H832
FunCoupENSG00000159202
BioGRIDUBE2Z
STRING (EMBL)UBE2Z
ZODIACUBE2Z
Ontologies - Pathways
QuickGOQ9H832
Ontology : AmiGOcysteine-type endopeptidase inhibitor activity  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  cytosol  cytosol  ubiquitin-dependent protein catabolic process  apoptotic process  negative regulation of endopeptidase activity  protein ubiquitination  protein ubiquitination  positive regulation of apoptotic process  negative regulation of apoptotic process  ubiquitin conjugating enzyme activity  
Ontology : EGO-EBIcysteine-type endopeptidase inhibitor activity  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  cytosol  cytosol  ubiquitin-dependent protein catabolic process  apoptotic process  negative regulation of endopeptidase activity  protein ubiquitination  protein ubiquitination  positive regulation of apoptotic process  negative regulation of apoptotic process  ubiquitin conjugating enzyme activity  
Pathways : KEGGUbiquitin mediated proteolysis   
NDEx NetworkUBE2Z
Atlas of Cancer Signalling NetworkUBE2Z
Wikipedia pathwaysUBE2Z
Orthology - Evolution
OrthoDB65264
GeneTree (enSembl)ENSG00000159202
Phylogenetic Trees/Animal Genes : TreeFamUBE2Z
HOGENOMQ9H832
Homologs : HomoloGeneUBE2Z
Homology/Alignments : Family Browser (UCSC)UBE2Z
Gene fusions - Rearrangements
Fusion : QuiverUBE2Z
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUBE2Z [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UBE2Z
dbVarUBE2Z
ClinVarUBE2Z
1000_GenomesUBE2Z 
Exome Variant ServerUBE2Z
ExAC (Exome Aggregation Consortium)ENSG00000159202
GNOMAD BrowserENSG00000159202
Varsome BrowserUBE2Z
Genetic variants : HAPMAP65264
Genomic Variants (DGV)UBE2Z [DGVbeta]
DECIPHERUBE2Z [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUBE2Z 
Mutations
ICGC Data PortalUBE2Z 
TCGA Data PortalUBE2Z 
Broad Tumor PortalUBE2Z
OASIS PortalUBE2Z [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUBE2Z  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUBE2Z
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch UBE2Z
DgiDB (Drug Gene Interaction Database)UBE2Z
DoCM (Curated mutations)UBE2Z (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UBE2Z (select a term)
intoGenUBE2Z
Cancer3DUBE2Z(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611362   
Orphanet
DisGeNETUBE2Z
MedgenUBE2Z
Genetic Testing Registry UBE2Z
NextProtQ9H832 [Medical]
TSGene65264
GENETestsUBE2Z
Target ValidationUBE2Z
Huge Navigator UBE2Z [HugePedia]
snp3D : Map Gene to Disease65264
BioCentury BCIQUBE2Z
ClinGenUBE2Z
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD65264
Chemical/Pharm GKB GenePA142670659
Clinical trialUBE2Z
Miscellaneous
canSAR (ICR)UBE2Z (select the gene name)
DataMed IndexUBE2Z
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUBE2Z
EVEXUBE2Z
GoPubMedUBE2Z
iHOPUBE2Z
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Feb 14 17:04:23 CET 2019
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