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UBE3D (ubiquitin protein ligase E3D)

Identity

Alias_namesC6orf157
UBE2CBP
chromosome 6 open reading frame 157
ubiquitin-conjugating enzyme E2C binding protein
Alias_symbol (synonym)DKFZp434A1520
H10BH
YJR141W
Other alias
HGNC (Hugo) UBE3D
LocusID (NCBI) 90025
Atlas_Id 75426
Location 6q14.1  [Link to chromosome band 6q14]
Location_base_pair Starts at 82892398 and ends at 83065841 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
UBE3D (6q14.1) / SERPINB1 (6p25.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;6)(p25;q14) UBE3D/SERPINB1


External links

Nomenclature
HGNC (Hugo)UBE3D   21381
Cards
Entrez_Gene (NCBI)UBE3D  90025  ubiquitin protein ligase E3D
AliasesC6orf157; H10BH; UBE2CBP; YJR141W
GeneCards (Weizmann)UBE3D
Ensembl hg19 (Hinxton)ENSG00000118420 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000118420 [Gene_View]  chr6:82892398-83065841 [Contig_View]  UBE3D [Vega]
ICGC DataPortalENSG00000118420
TCGA cBioPortalUBE3D
AceView (NCBI)UBE3D
Genatlas (Paris)UBE3D
WikiGenes90025
SOURCE (Princeton)UBE3D
Genetics Home Reference (NIH)UBE3D
Genomic and cartography
GoldenPath hg38 (UCSC)UBE3D  -     chr6:82892398-83065841 -  6q14.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)UBE3D  -     6q14.1   [Description]    (hg19-Feb_2009)
EnsemblUBE3D - 6q14.1 [CytoView hg19]  UBE3D - 6q14.1 [CytoView hg38]
Mapping of homologs : NCBIUBE3D [Mapview hg19]  UBE3D [Mapview hg38]
OMIM612495   
Gene and transcription
Genbank (Entrez)AB126062 AF026526 AK298205 AL137544 BC036049
RefSeq transcript (Entrez)NM_001304437 NM_001350602 NM_001350603 NM_001350604 NM_198920
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)UBE3D
Cluster EST : UnigeneHs.148609 [ NCBI ]
CGAP (NCI)Hs.148609
Alternative Splicing GalleryENSG00000118420
Gene ExpressionUBE3D [ NCBI-GEO ]   UBE3D [ EBI - ARRAY_EXPRESS ]   UBE3D [ SEEK ]   UBE3D [ MEM ]
Gene Expression Viewer (FireBrowse)UBE3D [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)90025
GTEX Portal (Tissue expression)UBE3D
Human Protein AtlasENSG00000118420-UBE3D [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z6J8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z6J8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z6J8
Splice isoforms : SwissVarQ7Z6J8
Catalytic activity : Enzyme2.3.2.26 [ Enzyme-Expasy ]   2.3.2.262.3.2.26 [ IntEnz-EBI ]   2.3.2.26 [ BRENDA ]   2.3.2.26 [ KEGG ]   
PhosPhoSitePlusQ7Z6J8
Domains : Interpro (EBI)UBQ-conj_enz_E2-bd_prot   
Domain families : Pfam (Sanger)HECT_2 (PF09814)   
Domain families : Pfam (NCBI)pfam09814   
Conserved Domain (NCBI)UBE3D
DMDM Disease mutations90025
Blocks (Seattle)UBE3D
SuperfamilyQ7Z6J8
Human Protein Atlas [tissue]ENSG00000118420-UBE3D [tissue]
Peptide AtlasQ7Z6J8
HPRD12861
IPIIPI00376330   IPI00644099   IPI00514727   IPI00967171   IPI00642582   IPI00964115   IPI00644577   
Protein Interaction databases
DIP (DOE-UCLA)Q7Z6J8
IntAct (EBI)Q7Z6J8
FunCoupENSG00000118420
BioGRIDUBE3D
STRING (EMBL)UBE3D
ZODIACUBE3D
Ontologies - Pathways
QuickGOQ7Z6J8
Ontology : AmiGOcytoplasm  protein ubiquitination  transferase activity  
Ontology : EGO-EBIcytoplasm  protein ubiquitination  transferase activity  
NDEx NetworkUBE3D
Atlas of Cancer Signalling NetworkUBE3D
Wikipedia pathwaysUBE3D
Orthology - Evolution
OrthoDB90025
GeneTree (enSembl)ENSG00000118420
Phylogenetic Trees/Animal Genes : TreeFamUBE3D
HOVERGENQ7Z6J8
HOGENOMQ7Z6J8
Homologs : HomoloGeneUBE3D
Homology/Alignments : Family Browser (UCSC)UBE3D
Gene fusions - Rearrangements
Fusion : QuiverUBE3D
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUBE3D [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UBE3D
dbVarUBE3D
ClinVarUBE3D
1000_GenomesUBE3D 
Exome Variant ServerUBE3D
ExAC (Exome Aggregation Consortium)ENSG00000118420
GNOMAD BrowserENSG00000118420
Genetic variants : HAPMAP90025
Genomic Variants (DGV)UBE3D [DGVbeta]
DECIPHERUBE3D [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUBE3D 
Mutations
ICGC Data PortalUBE3D 
TCGA Data PortalUBE3D 
Broad Tumor PortalUBE3D
OASIS PortalUBE3D [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDUBE3D
BioMutasearch UBE3D
DgiDB (Drug Gene Interaction Database)UBE3D
DoCM (Curated mutations)UBE3D (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UBE3D (select a term)
intoGenUBE3D
Cancer3DUBE3D(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612495   
Orphanet
DisGeNETUBE3D
MedgenUBE3D
Genetic Testing Registry UBE3D
NextProtQ7Z6J8 [Medical]
TSGene90025
GENETestsUBE3D
Target ValidationUBE3D
Huge Navigator UBE3D [HugePedia]
snp3D : Map Gene to Disease90025
BioCentury BCIQUBE3D
ClinGenUBE3D
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD90025
Chemical/Pharm GKB GenePA162407873
Clinical trialUBE3D
Miscellaneous
canSAR (ICR)UBE3D (select the gene name)
Probes
Litterature
PubMed5 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUBE3D
EVEXUBE3D
GoPubMedUBE3D
iHOPUBE3D
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Feb 23 18:57:31 CET 2018

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