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UBE4A (ubiquitination factor E4A)

Identity

Alias_namesubiquitination factor E4A (homologous to yeast UFD2)
ubiquitination factor E4A (UFD2 homolog, yeast)
Alias_symbol (synonym)UBOX2
UFD2
KIAA0126
E4
Other alias
HGNC (Hugo) UBE4A
LocusID (NCBI) 9354
Atlas_Id 47051
Location 11q23.3  [Link to chromosome band 11q23]
Location_base_pair Starts at 118359581 and ends at 118399211 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ENO1 (1p36.23) / UBE4A (11q23.3)TUBGCP2 (10q26.3) / UBE4A (11q23.3)UBE4A (11q23.3) / HIPK1 (1p13.2)
UBE4A (11q23.3) / UBE4A (11q23.3)TUBGCP2 10q26.3 / UBE4A 11q23.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)UBE4A   12499
Cards
Entrez_Gene (NCBI)UBE4A  9354  ubiquitination factor E4A
AliasesE4; UBOX2; UFD2
GeneCards (Weizmann)UBE4A
Ensembl hg19 (Hinxton)ENSG00000110344 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000110344 [Gene_View]  chr11:118359581-118399211 [Contig_View]  UBE4A [Vega]
ICGC DataPortalENSG00000110344
TCGA cBioPortalUBE4A
AceView (NCBI)UBE4A
Genatlas (Paris)UBE4A
WikiGenes9354
SOURCE (Princeton)UBE4A
Genetics Home Reference (NIH)UBE4A
Genomic and cartography
GoldenPath hg38 (UCSC)UBE4A  -     chr11:118359581-118399211 +  11q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)UBE4A  -     11q23.3   [Description]    (hg19-Feb_2009)
EnsemblUBE4A - 11q23.3 [CytoView hg19]  UBE4A - 11q23.3 [CytoView hg38]
Mapping of homologs : NCBIUBE4A [Mapview hg19]  UBE4A [Mapview hg38]
OMIM603753   
Gene and transcription
Genbank (Entrez)AF087968 AK296369 AK302328 AK307737 AL713515
RefSeq transcript (Entrez)NM_001204077 NM_004788
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)UBE4A
Cluster EST : UnigeneHs.602967 [ NCBI ]
CGAP (NCI)Hs.602967
Alternative Splicing GalleryENSG00000110344
Gene ExpressionUBE4A [ NCBI-GEO ]   UBE4A [ EBI - ARRAY_EXPRESS ]   UBE4A [ SEEK ]   UBE4A [ MEM ]
Gene Expression Viewer (FireBrowse)UBE4A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9354
GTEX Portal (Tissue expression)UBE4A
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14139   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14139  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14139
Splice isoforms : SwissVarQ14139
PhosPhoSitePlusQ14139
Domaine pattern : Prosite (Expaxy)U_BOX (PS51698)   
Domains : Interpro (EBI)Ub_conjug_fac_E4_core    Ubox_domain    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)U-box (PF04564)    Ufd2P_core (PF10408)   
Domain families : Pfam (NCBI)pfam04564    pfam10408   
Domain families : Smart (EMBL)Ubox (SM00504)  
Conserved Domain (NCBI)UBE4A
DMDM Disease mutations9354
Blocks (Seattle)UBE4A
PDB (SRS)1WGM   
PDB (PDBSum)1WGM   
PDB (IMB)1WGM   
PDB (RSDB)1WGM   
Structural Biology KnowledgeBase1WGM   
SCOP (Structural Classification of Proteins)1WGM   
CATH (Classification of proteins structures)1WGM   
SuperfamilyQ14139
Human Protein AtlasENSG00000110344
Peptide AtlasQ14139
HPRD06793
IPIIPI00556075   IPI00028957   IPI00807340   IPI01012808   
Protein Interaction databases
DIP (DOE-UCLA)Q14139
IntAct (EBI)Q14139
FunCoupENSG00000110344
BioGRIDUBE4A
STRING (EMBL)UBE4A
ZODIACUBE4A
Ontologies - Pathways
QuickGOQ14139
Ontology : AmiGOubiquitin ligase complex  protein polyubiquitination  protein binding  nucleus  cytoplasm  ubiquitin-dependent protein catabolic process  ubiquitin-dependent ERAD pathway  ubiquitin-ubiquitin ligase activity  
Ontology : EGO-EBIubiquitin ligase complex  protein polyubiquitination  protein binding  nucleus  cytoplasm  ubiquitin-dependent protein catabolic process  ubiquitin-dependent ERAD pathway  ubiquitin-ubiquitin ligase activity  
Pathways : KEGGUbiquitin mediated proteolysis   
NDEx NetworkUBE4A
Atlas of Cancer Signalling NetworkUBE4A
Wikipedia pathwaysUBE4A
Orthology - Evolution
OrthoDB9354
GeneTree (enSembl)ENSG00000110344
Phylogenetic Trees/Animal Genes : TreeFamUBE4A
HOVERGENQ14139
HOGENOMQ14139
Homologs : HomoloGeneUBE4A
Homology/Alignments : Family Browser (UCSC)UBE4A
Gene fusions - Rearrangements
Fusion : MitelmanTUBGCP2/UBE4A [10q26.3/11q23.3]  [t(10;11)(q26;q23)]  
Fusion: TCGATUBGCP2 10q26.3 UBE4A 11q23.3 PRAD
Fusion Cancer (Beijing)ENO1 [1p36.23]  -  UBE4A [11q23.3]  [FUSC001354]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUBE4A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UBE4A
dbVarUBE4A
ClinVarUBE4A
1000_GenomesUBE4A 
Exome Variant ServerUBE4A
ExAC (Exome Aggregation Consortium)UBE4A (select the gene name)
Genetic variants : HAPMAP9354
Genomic Variants (DGV)UBE4A [DGVbeta]
DECIPHERUBE4A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUBE4A 
Mutations
ICGC Data PortalUBE4A 
TCGA Data PortalUBE4A 
Broad Tumor PortalUBE4A
OASIS PortalUBE4A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUBE4A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUBE4A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch UBE4A
DgiDB (Drug Gene Interaction Database)UBE4A
DoCM (Curated mutations)UBE4A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UBE4A (select a term)
intoGenUBE4A
Cancer3DUBE4A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603753   
Orphanet
MedgenUBE4A
Genetic Testing Registry UBE4A
NextProtQ14139 [Medical]
TSGene9354
GENETestsUBE4A
Huge Navigator UBE4A [HugePedia]
snp3D : Map Gene to Disease9354
BioCentury BCIQUBE4A
ClinGenUBE4A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9354
Chemical/Pharm GKB GenePA37147
Clinical trialUBE4A
Miscellaneous
canSAR (ICR)UBE4A (select the gene name)
Probes
Litterature
PubMed26 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUBE4A
EVEXUBE4A
GoPubMedUBE4A
iHOPUBE4A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:43:07 CEST 2017

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