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UBE4B (ubiquitination factor E4B)

Identity

Alias_namesubiquitination factor E4B (homologous to yeast UFD2)
ubiquitination factor E4B (UFD2 homolog, yeast)
Alias_symbol (synonym)UBOX3
E4
UFD2
KIAA0684
Other aliasHDNB1
UFD2A
HGNC (Hugo) UBE4B
LocusID (NCBI) 10277
Atlas_Id 42757
Location 1p36.22  [Link to chromosome band 1p36]
Location_base_pair Starts at 10032983 and ends at 10181238 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
KIF1B (1p36.22) / UBE4B (1p36.22)PIEZO1 (16q24.3) / UBE4B (1p36.22)SELENBP1 (1q21.3) / UBE4B (1p36.22)
SNORA73A () / UBE4B (1p36.22)UBE4B (1p36.22) / KIF1B (1p36.22)UBE4B (1p36.22) / MED18 (1p35.3)
UBE4B (1p36.22) / NMNAT1 (1p36.22)UBE4B (1p36.22) / RBP7 (1p36.22)UBE4B (1p36.22) / TBCB (19q13.12)
UBE4B (1p36.22) / USP40 (2q37.1)KIF1B 1p36.22 / UBE4B 1p36.22UBE4B 1p36.22 / MED18 1p35.3
UBE4B 1p36.22 / NMNAT1 1p36.22UBE4B 1p36.22 / RBP7 1p36.22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Small Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)UBE4B   12500
Cards
Entrez_Gene (NCBI)UBE4B  10277  ubiquitination factor E4B
AliasesE4; HDNB1; UBOX3; UFD2; 
UFD2A
GeneCards (Weizmann)UBE4B
Ensembl hg19 (Hinxton)ENSG00000130939 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000130939 [Gene_View]  chr1:10032983-10181238 [Contig_View]  UBE4B [Vega]
ICGC DataPortalENSG00000130939
TCGA cBioPortalUBE4B
AceView (NCBI)UBE4B
Genatlas (Paris)UBE4B
WikiGenes10277
SOURCE (Princeton)UBE4B
Genetics Home Reference (NIH)UBE4B
Genomic and cartography
GoldenPath hg38 (UCSC)UBE4B  -     chr1:10032983-10181238 +  1p36.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)UBE4B  -     1p36.22   [Description]    (hg19-Feb_2009)
EnsemblUBE4B - 1p36.22 [CytoView hg19]  UBE4B - 1p36.22 [CytoView hg38]
Mapping of homologs : NCBIUBE4B [Mapview hg19]  UBE4B [Mapview hg38]
OMIM613565   
Gene and transcription
Genbank (Entrez)AB014584 AB028839 AF043117 AF091093 AF331520
RefSeq transcript (Entrez)NM_001105562 NM_006048
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)UBE4B
Cluster EST : UnigeneHs.593974 [ NCBI ]
CGAP (NCI)Hs.593974
Alternative Splicing GalleryENSG00000130939
Gene ExpressionUBE4B [ NCBI-GEO ]   UBE4B [ EBI - ARRAY_EXPRESS ]   UBE4B [ SEEK ]   UBE4B [ MEM ]
Gene Expression Viewer (FireBrowse)UBE4B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10277
GTEX Portal (Tissue expression)UBE4B
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95155   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95155  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95155
Splice isoforms : SwissVarO95155
PhosPhoSitePlusO95155
Domaine pattern : Prosite (Expaxy)U_BOX (PS51698)   
Domains : Interpro (EBI)Ub_conjug_fac_E4_core    Ubox_domain    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)U-box (PF04564)    Ufd2P_core (PF10408)   
Domain families : Pfam (NCBI)pfam04564    pfam10408   
Domain families : Smart (EMBL)Ubox (SM00504)  
Conserved Domain (NCBI)UBE4B
DMDM Disease mutations10277
Blocks (Seattle)UBE4B
PDB (SRS)2KRE    3L1X    3L1Z   
PDB (PDBSum)2KRE    3L1X    3L1Z   
PDB (IMB)2KRE    3L1X    3L1Z   
PDB (RSDB)2KRE    3L1X    3L1Z   
Structural Biology KnowledgeBase2KRE    3L1X    3L1Z   
SCOP (Structural Classification of Proteins)2KRE    3L1X    3L1Z   
CATH (Classification of proteins structures)2KRE    3L1X    3L1Z   
SuperfamilyO95155
Human Protein AtlasENSG00000130939
Peptide AtlasO95155
HPRD11659
IPIIPI00005715   IPI00555735   IPI00655534   IPI00217042   
Protein Interaction databases
DIP (DOE-UCLA)O95155
IntAct (EBI)O95155
FunCoupENSG00000130939
BioGRIDUBE4B
STRING (EMBL)UBE4B
ZODIACUBE4B
Ontologies - Pathways
QuickGOO95155
Ontology : AmiGOubiquitin ligase complex  protein polyubiquitination  ventricular trabecula myocardium morphogenesis  ATP binding  nucleus  cytoplasm  cytoplasm  protein monoubiquitination  granzyme-mediated apoptotic signaling pathway  response to UV  enzyme binding  ubiquitin-dependent ERAD pathway  neuron projection development  ubiquitin-ubiquitin ligase activity  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  proteasome-mediated ubiquitin-dependent protein catabolic process  ATPase binding  protein autoubiquitination  
Ontology : EGO-EBIubiquitin ligase complex  protein polyubiquitination  ventricular trabecula myocardium morphogenesis  ATP binding  nucleus  cytoplasm  cytoplasm  protein monoubiquitination  granzyme-mediated apoptotic signaling pathway  response to UV  enzyme binding  ubiquitin-dependent ERAD pathway  neuron projection development  ubiquitin-ubiquitin ligase activity  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  proteasome-mediated ubiquitin-dependent protein catabolic process  ATPase binding  protein autoubiquitination  
Pathways : KEGGUbiquitin mediated proteolysis    Protein processing in endoplasmic reticulum   
NDEx NetworkUBE4B
Atlas of Cancer Signalling NetworkUBE4B
Wikipedia pathwaysUBE4B
Orthology - Evolution
OrthoDB10277
GeneTree (enSembl)ENSG00000130939
Phylogenetic Trees/Animal Genes : TreeFamUBE4B
HOVERGENO95155
HOGENOMO95155
Homologs : HomoloGeneUBE4B
Homology/Alignments : Family Browser (UCSC)UBE4B
Gene fusions - Rearrangements
Fusion : MitelmanKIF1B/UBE4B [1p36.22/1p36.22]  [t(1;1)(p36;p36)]  
Fusion : MitelmanUBE4B/MED18 [1p36.22/1p35.3]  [t(1;1)(p35;p36)]  
Fusion : MitelmanUBE4B/NMNAT1 [1p36.22/1p36.22]  [t(1;1)(p36;p36)]  
Fusion : MitelmanUBE4B/RBP7 [1p36.22/1p36.22]  [t(1;1)(p36;p36)]  
Fusion : MitelmanUBE4B/TBCB [1p36.22/19q13.12]  [t(1;19)(p36;q13)]  
Fusion: TCGAKIF1B 1p36.22 UBE4B 1p36.22 GBM KIRC
Fusion: TCGAUBE4B 1p36.22 MED18 1p35.3 GBM
Fusion: TCGAUBE4B 1p36.22 NMNAT1 1p36.22 BRCA
Fusion: TCGAUBE4B 1p36.22 RBP7 1p36.22 OV
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUBE4B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UBE4B
dbVarUBE4B
ClinVarUBE4B
1000_GenomesUBE4B 
Exome Variant ServerUBE4B
ExAC (Exome Aggregation Consortium)UBE4B (select the gene name)
Genetic variants : HAPMAP10277
Genomic Variants (DGV)UBE4B [DGVbeta]
DECIPHERUBE4B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUBE4B 
Mutations
ICGC Data PortalUBE4B 
TCGA Data PortalUBE4B 
Broad Tumor PortalUBE4B
OASIS PortalUBE4B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUBE4B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUBE4B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch UBE4B
DgiDB (Drug Gene Interaction Database)UBE4B
DoCM (Curated mutations)UBE4B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UBE4B (select a term)
intoGenUBE4B
Cancer3DUBE4B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613565   
Orphanet
MedgenUBE4B
Genetic Testing Registry UBE4B
NextProtO95155 [Medical]
TSGene10277
GENETestsUBE4B
Target ValidationUBE4B
Huge Navigator UBE4B [HugePedia]
snp3D : Map Gene to Disease10277
BioCentury BCIQUBE4B
ClinGenUBE4B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10277
Chemical/Pharm GKB GenePA37148
Clinical trialUBE4B
Miscellaneous
canSAR (ICR)UBE4B (select the gene name)
Probes
Litterature
PubMed59 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUBE4B
EVEXUBE4B
GoPubMedUBE4B
iHOPUBE4B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 1 17:18:13 CEST 2017

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