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UBQLN2 (ubiquilin 2)

Identity

Alias (NCBI)ALS15
CHAP1
DSK2
HRIHFB2157
N4BP4
PLIC2
HGNC (Hugo) UBQLN2
HGNC Alias symbChap1
Dsk2
RIHFB2157
LIC-2
CHAP1/DSK2
PLIC-2
N4BP4
PLIC2
HGNC Alias nameNEDD4 binding protein 4
LocusID (NCBI) 29978
Atlas_Id 55631
Location Xp11.21  [Link to chromosome band Xp11]
Location_base_pair Starts at 56563593 and ends at 56567010 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
UBQLN2 (Xp11.21) / UBQLN2 (Xp11.21)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)UBQLN2   12509
LRG (Locus Reference Genomic)LRG_665
Cards
Entrez_Gene (NCBI)UBQLN2    ubiquilin 2
AliasesALS15; CHAP1; DSK2; HRIHFB2157; 
N4BP4; PLIC2
GeneCards (Weizmann)UBQLN2
Ensembl hg19 (Hinxton)ENSG00000188021 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000188021 [Gene_View]  ENSG00000188021 [Sequence]  chrX:56563593-56567010 [Contig_View]  UBQLN2 [Vega]
ICGC DataPortalENSG00000188021
TCGA cBioPortalUBQLN2
AceView (NCBI)UBQLN2
Genatlas (Paris)UBQLN2
SOURCE (Princeton)UBQLN2
Genetics Home Reference (NIH)UBQLN2
Genomic and cartography
GoldenPath hg38 (UCSC)UBQLN2  -     chrX:56563593-56567010 +  Xp11.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)UBQLN2  -     Xp11.21   [Description]    (hg19-Feb_2009)
GoldenPathUBQLN2 - Xp11.21 [CytoView hg19]  UBQLN2 - Xp11.21 [CytoView hg38]
ImmunoBaseENSG00000188021
Genome Data Viewer NCBIUBQLN2 [Mapview hg19]  
OMIM300264   300857   
Gene and transcription
Genbank (Entrez)AB015344 AF189009 AF293385 AK001029 AK297252
RefSeq transcript (Entrez)NM_013444
Consensus coding sequences : CCDS (NCBI)UBQLN2
Gene ExpressionUBQLN2 [ NCBI-GEO ]   UBQLN2 [ EBI - ARRAY_EXPRESS ]   UBQLN2 [ SEEK ]   UBQLN2 [ MEM ]
Gene Expression Viewer (FireBrowse)UBQLN2 [ Firebrowse - Broad ]
GenevisibleExpression of UBQLN2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)29978
GTEX Portal (Tissue expression)UBQLN2
Human Protein AtlasENSG00000188021-UBQLN2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UHD9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UHD9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UHD9
PhosPhoSitePlusQ9UHD9
Domaine pattern : Prosite (Expaxy)UBA (PS50030)    UBIQUITIN_2 (PS50053)   
Domains : Interpro (EBI)ARM-type_fold    STI1_HS-bd    UBA    UBA-like_sf    Ubiquilin-1/2    Ubiquitin-like_dom    Ubiquitin-like_domsf   
Domain families : Pfam (Sanger)UBA (PF00627)    ubiquitin (PF00240)   
Domain families : Pfam (NCBI)pfam00627    pfam00240   
Domain families : Smart (EMBL)STI1 (SM00727)  UBA (SM00165)  UBQ (SM00213)  
Conserved Domain (NCBI)UBQLN2
PDB (RSDB)1J8C    2NBV    6MUN   
PDB Europe1J8C    2NBV    6MUN   
PDB (PDBSum)1J8C    2NBV    6MUN   
PDB (IMB)1J8C    2NBV    6MUN   
Structural Biology KnowledgeBase1J8C    2NBV    6MUN   
SCOP (Structural Classification of Proteins)1J8C    2NBV    6MUN   
CATH (Classification of proteins structures)1J8C    2NBV    6MUN   
SuperfamilyQ9UHD9
AlphaFold pdb e-kbQ9UHD9   
Human Protein Atlas [tissue]ENSG00000188021-UBQLN2 [tissue]
HPRD02224
Protein Interaction databases
DIP (DOE-UCLA)Q9UHD9
IntAct (EBI)Q9UHD9
BioGRIDUBQLN2
STRING (EMBL)UBQLN2
ZODIACUBQLN2
Ontologies - Pathways
QuickGOQ9UHD9
Ontology : AmiGOautophagosome assembly  protein binding  nucleus  cytoplasm  autophagosome  cytosol  cytosol  cytosol  plasma membrane  ubiquitin-dependent protein catabolic process  regulation of macroautophagy  regulation of macroautophagy  ubiquitin-dependent ERAD pathway  ubiquitin-dependent ERAD pathway  cytoplasmic vesicle  polyubiquitin modification-dependent protein binding  identical protein binding  negative regulation of clathrin-dependent endocytosis  positive regulation of ER-associated ubiquitin-dependent protein catabolic process  negative regulation of G protein-coupled receptor internalization  regulation of autophagosome assembly  
Ontology : EGO-EBIautophagosome assembly  protein binding  nucleus  cytoplasm  autophagosome  cytosol  cytosol  cytosol  plasma membrane  ubiquitin-dependent protein catabolic process  regulation of macroautophagy  regulation of macroautophagy  ubiquitin-dependent ERAD pathway  ubiquitin-dependent ERAD pathway  cytoplasmic vesicle  polyubiquitin modification-dependent protein binding  identical protein binding  negative regulation of clathrin-dependent endocytosis  positive regulation of ER-associated ubiquitin-dependent protein catabolic process  negative regulation of G protein-coupled receptor internalization  regulation of autophagosome assembly  
Pathways : KEGGProtein processing in endoplasmic reticulum   
NDEx NetworkUBQLN2
Atlas of Cancer Signalling NetworkUBQLN2
Wikipedia pathwaysUBQLN2
Orthology - Evolution
OrthoDB29978
GeneTree (enSembl)ENSG00000188021
Phylogenetic Trees/Animal Genes : TreeFamUBQLN2
Homologs : HomoloGeneUBQLN2
Homology/Alignments : Family Browser (UCSC)UBQLN2
Gene fusions - Rearrangements
Fusion : QuiverUBQLN2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUBQLN2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UBQLN2
dbVarUBQLN2
ClinVarUBQLN2
MonarchUBQLN2
1000_GenomesUBQLN2 
Exome Variant ServerUBQLN2
GNOMAD BrowserENSG00000188021
Varsome BrowserUBQLN2
ACMGUBQLN2 variants
VarityQ9UHD9
Genomic Variants (DGV)UBQLN2 [DGVbeta]
DECIPHERUBQLN2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUBQLN2 
Mutations
ICGC Data PortalUBQLN2 
TCGA Data PortalUBQLN2 
Broad Tumor PortalUBQLN2
OASIS PortalUBQLN2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUBQLN2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DUBQLN2
Mutations and Diseases : HGMDUBQLN2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaUBQLN2
DgiDB (Drug Gene Interaction Database)UBQLN2
DoCM (Curated mutations)UBQLN2
CIViC (Clinical Interpretations of Variants in Cancer)UBQLN2
Cancer3DUBQLN2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300264    300857   
Orphanet106   
DisGeNETUBQLN2
MedgenUBQLN2
Genetic Testing Registry UBQLN2
NextProtQ9UHD9 [Medical]
GENETestsUBQLN2
Target ValidationUBQLN2
Huge Navigator UBQLN2 [HugePedia]
ClinGenUBQLN2
Clinical trials, drugs, therapy
MyCancerGenomeUBQLN2
Protein Interactions : CTDUBQLN2
Pharm GKB GenePA37156
PharosQ9UHD9
Clinical trialUBQLN2
Miscellaneous
canSAR (ICR)UBQLN2
HarmonizomeUBQLN2
DataMed IndexUBQLN2
Probes
Litterature
PubMed111 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXUBQLN2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:37:14 CEST 2021

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