UBQLN4 (ubiquilin 4)

2014-08-01  

Identity

HGNC
UBQLN4
LOCATION
1q22
LOCUSID
56893
ALIAS
A1U,A1Up,C1orf6,CIP75,UBIN
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 56893
MIM: 605440
HGNC: 1237
Ensembl: ENSG00000160803

Variants:

dbSNP: 56893
ClinVar: 56893
TCGA: ENSG00000160803
COSMIC: UBQLN4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160803ENST00000368309Q9NRR5

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
180791092008A novel connexin43-interacting protein, CIP75, which belongs to the UbL-UBA protein family, regulates the turnover of connexin43.28
209403042010Ubiquitin-independent proteasomal degradation of endoplasmic reticulum-localized connexin43 mediated by CIP75.24
234592052013Ubiquilin4 is an adaptor protein that recruits Ubiquilin1 to the autophagy machinery.23
271137552016UBQLN4 recognizes mislocalized transmembrane domain proteins and targets these to proteasomal degradation.21
306127382019UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors.10
284631122017A novel ALS-associated variant in UBQLN4 regulates motor axon morphogenesis.9
298993802019The UbL-UBA Ubiquilin4 protein functions as a tumor suppressor in gastric cancer by p53-dependent and p53-independent regulation of p21.8
207026502010Mumps virus small hydrophobic protein targets ataxin-1 ubiquitin-like interacting protein (ubiquilin 4).7
242561202014CIP75 (connexin43-interacting protein of 75 kDa) mediates the endoplasmic reticulum dislocation of connexin43.7
287960602017Candidate genes investigation for severe nonalcoholic fatty liver disease based on bioinformatics analysis.5

Citation

Dessen P

UBQLN4 (ubiquilin 4)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54746/ubqln4