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UBQLN4 (ubiquilin 4)

Identity

Alias (NCBI)A1U
A1Up
C1orf6
CIP75
UBIN
HGNC (Hugo) UBQLN4
HGNC Alias symbA1U
UBIN
HGNC Alias nameataxin-1 ubiquitin-like interacting protein
HGNC Previous nameC1orf6
HGNC Previous namechromosome 1 open reading frame 6
LocusID (NCBI) 56893
Atlas_Id 54746
Location 1q22  [Link to chromosome band 1q22]
Location_base_pair Starts at 156035299 and ends at 156053798 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GAPDH (12p13.31)::UBQLN4 (1q22)STT3A (11q24.2)::UBQLN4 (1q22)UBQLN4 (1q22)::ITPR3 (6p21.31)
ZSWIM4 (19p13.13)::UBQLN4 (1q22)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)UBQLN4   1237
Cards
Entrez_Gene (NCBI)UBQLN4    ubiquilin 4
AliasesA1U; A1Up; C1orf6; CIP75; 
UBIN
GeneCards (Weizmann)UBQLN4
Ensembl hg19 (Hinxton)ENSG00000160803 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000160803 [Gene_View]  ENSG00000160803 [Sequence]  chr1:156035299-156053798 [Contig_View]  UBQLN4 [Vega]
ICGC DataPortalENSG00000160803
TCGA cBioPortalUBQLN4
AceView (NCBI)UBQLN4
Genatlas (Paris)UBQLN4
SOURCE (Princeton)UBQLN4
Genetics Home Reference (NIH)UBQLN4
Genomic and cartography
GoldenPath hg38 (UCSC)UBQLN4  -     chr1:156035299-156053798 -  1q22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)UBQLN4  -     1q22   [Description]    (hg19-Feb_2009)
GoldenPathUBQLN4 - 1q22 [CytoView hg19]  UBQLN4 - 1q22 [CytoView hg38]
ImmunoBaseENSG00000160803
Genome Data Viewer NCBIUBQLN4 [Mapview hg19]  
OMIM605440   
Gene and transcription
Genbank (Entrez)AB209566 AF113544 AF188240 AI074831 AK098368
RefSeq transcript (Entrez)NM_001304342 NM_020131
Consensus coding sequences : CCDS (NCBI)UBQLN4
Gene ExpressionUBQLN4 [ NCBI-GEO ]   UBQLN4 [ EBI - ARRAY_EXPRESS ]   UBQLN4 [ SEEK ]   UBQLN4 [ MEM ]
Gene Expression Viewer (FireBrowse)UBQLN4 [ Firebrowse - Broad ]
GenevisibleExpression of UBQLN4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)56893
GTEX Portal (Tissue expression)UBQLN4
Human Protein AtlasENSG00000160803-UBQLN4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NRR5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NRR5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NRR5
PhosPhoSitePlusQ9NRR5
Domaine pattern : Prosite (Expaxy)UBA (PS50030)    UBIQUITIN_2 (PS50053)   
Domains : Interpro (EBI)STI1_HS-bd    UBA    UBA-like_sf    Ubiquitin-like_dom    Ubiquitin-like_domsf   
Domain families : Pfam (Sanger)UBA (PF00627)    ubiquitin (PF00240)   
Domain families : Pfam (NCBI)pfam00627    pfam00240   
Domain families : Smart (EMBL)STI1 (SM00727)  UBA (SM00165)  UBQ (SM00213)  
Conserved Domain (NCBI)UBQLN4
SuperfamilyQ9NRR5
AlphaFold pdb e-kbQ9NRR5   
Human Protein Atlas [tissue]ENSG00000160803-UBQLN4 [tissue]
HPRD05670
Protein Interaction databases
DIP (DOE-UCLA)Q9NRR5
IntAct (EBI)Q9NRR5
BioGRIDUBQLN4
STRING (EMBL)UBQLN4
ZODIACUBQLN4
Ontologies - Pathways
QuickGOQ9NRR5
Ontology : AmiGOprotein binding  nucleus  nucleoplasm  cytoplasm  autophagosome  endoplasmic reticulum membrane  cytosol  cytosol  cytosol  DNA repair  ubiquitin-dependent protein catabolic process  autophagy  cellular response to DNA damage stimulus  cytoplasmic vesicle  polyubiquitin modification-dependent protein binding  polyubiquitin modification-dependent protein binding  polyubiquitin modification-dependent protein binding  regulation of proteasomal ubiquitin-dependent protein catabolic process  regulation of proteasomal ubiquitin-dependent protein catabolic process  protein-containing complex  K48-linked polyubiquitin modification-dependent protein binding  identical protein binding  perinuclear region of cytoplasm  site of DNA damage  negative regulation of autophagosome maturation  negative regulation of double-strand break repair via homologous recombination  
Ontology : EGO-EBIprotein binding  nucleus  nucleoplasm  cytoplasm  autophagosome  endoplasmic reticulum membrane  cytosol  cytosol  cytosol  DNA repair  ubiquitin-dependent protein catabolic process  autophagy  cellular response to DNA damage stimulus  cytoplasmic vesicle  polyubiquitin modification-dependent protein binding  polyubiquitin modification-dependent protein binding  polyubiquitin modification-dependent protein binding  regulation of proteasomal ubiquitin-dependent protein catabolic process  regulation of proteasomal ubiquitin-dependent protein catabolic process  protein-containing complex  K48-linked polyubiquitin modification-dependent protein binding  identical protein binding  perinuclear region of cytoplasm  site of DNA damage  negative regulation of autophagosome maturation  negative regulation of double-strand break repair via homologous recombination  
NDEx NetworkUBQLN4
Atlas of Cancer Signalling NetworkUBQLN4
Wikipedia pathwaysUBQLN4
Orthology - Evolution
OrthoDB56893
GeneTree (enSembl)ENSG00000160803
Phylogenetic Trees/Animal Genes : TreeFamUBQLN4
Homologs : HomoloGeneUBQLN4
Homology/Alignments : Family Browser (UCSC)UBQLN4
Gene fusions - Rearrangements
Fusion : MitelmanZSWIM4::UBQLN4 [19p13.13/1q22]  
Fusion : QuiverUBQLN4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUBQLN4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UBQLN4
dbVarUBQLN4
ClinVarUBQLN4
MonarchUBQLN4
1000_GenomesUBQLN4 
Exome Variant ServerUBQLN4
GNOMAD BrowserENSG00000160803
Varsome BrowserUBQLN4
ACMGUBQLN4 variants
VarityQ9NRR5
Genomic Variants (DGV)UBQLN4 [DGVbeta]
DECIPHERUBQLN4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUBQLN4 
Mutations
ICGC Data PortalUBQLN4 
TCGA Data PortalUBQLN4 
Broad Tumor PortalUBQLN4
OASIS PortalUBQLN4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUBQLN4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DUBQLN4
Mutations and Diseases : HGMDUBQLN4
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaUBQLN4
DgiDB (Drug Gene Interaction Database)UBQLN4
DoCM (Curated mutations)UBQLN4
CIViC (Clinical Interpretations of Variants in Cancer)UBQLN4
Cancer3DUBQLN4
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605440   
Orphanet
DisGeNETUBQLN4
MedgenUBQLN4
Genetic Testing Registry UBQLN4
NextProtQ9NRR5 [Medical]
GENETestsUBQLN4
Target ValidationUBQLN4
Huge Navigator UBQLN4 [HugePedia]
ClinGenUBQLN4
Clinical trials, drugs, therapy
MyCancerGenomeUBQLN4
Protein Interactions : CTDUBQLN4
Pharm GKB GenePA25619
PharosQ9NRR5
Clinical trialUBQLN4
Miscellaneous
canSAR (ICR)UBQLN4
HarmonizomeUBQLN4
ARCHS4UBQLN4
DataMed IndexUBQLN4
Probes
Litterature
PubMed51 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXUBQLN4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 20 13:05:17 CET 2022

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