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UBR3 (ubiquitin protein ligase E3 component n-recognin 3 (putative))

Identity

Alias_namesZNF650
zinc finger protein 650
Alias_symbol (synonym)KIAA2024
DKFZp434P117
FLJ37422
Other alias
HGNC (Hugo) UBR3
LocusID (NCBI) 130507
Atlas_Id 54748
Location 2q31.1  [Link to chromosome band 2q31]
Location_base_pair Starts at 169827508 and ends at 170084129 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
BDH1 (3q29) / UBR3 (2q31.1)CASP8 (2q33.1) / UBR3 (2q31.1)FXYD2 (11q23.3) / UBR3 (2q31.1)
G2E3 (14q12) / UBR3 (2q31.1)UBR3 (2q31.1) / CDK14 (7q21.13)UBR3 (2q31.1) / MEOX2 (7p21.2)
UBR3 (2q31.1) / SYT7 (11q12.2)CASP8 2q33.1 / UBR3 2q31.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)UBR3   30467
Cards
Entrez_Gene (NCBI)UBR3  130507  ubiquitin protein ligase E3 component n-recognin 3 (putative)
AliasesZNF650
GeneCards (Weizmann)UBR3
Ensembl hg19 (Hinxton)ENSG00000144357 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000144357 [Gene_View]  chr2:169827508-170084129 [Contig_View]  UBR3 [Vega]
ICGC DataPortalENSG00000144357
TCGA cBioPortalUBR3
AceView (NCBI)UBR3
Genatlas (Paris)UBR3
WikiGenes130507
SOURCE (Princeton)UBR3
Genetics Home Reference (NIH)UBR3
Genomic and cartography
GoldenPath hg38 (UCSC)UBR3  -     chr2:169827508-170084129 +  2q31.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)UBR3  -     2q31.1   [Description]    (hg19-Feb_2009)
EnsemblUBR3 - 2q31.1 [CytoView hg19]  UBR3 - 2q31.1 [CytoView hg38]
Mapping of homologs : NCBIUBR3 [Mapview hg19]  UBR3 [Mapview hg38]
OMIM613831   
Gene and transcription
Genbank (Entrez)AB095944 AI142128 AK094741 AK126998 AK127553
RefSeq transcript (Entrez)NM_172070
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)UBR3
Cluster EST : UnigeneHs.379548 [ NCBI ]
CGAP (NCI)Hs.379548
Alternative Splicing GalleryENSG00000144357
Gene ExpressionUBR3 [ NCBI-GEO ]   UBR3 [ EBI - ARRAY_EXPRESS ]   UBR3 [ SEEK ]   UBR3 [ MEM ]
Gene Expression Viewer (FireBrowse)UBR3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)130507
GTEX Portal (Tissue expression)UBR3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6ZT12   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6ZT12  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6ZT12
Splice isoforms : SwissVarQ6ZT12
Catalytic activity : Enzyme2.3.2.27 [ Enzyme-Expasy ]   2.3.2.272.3.2.27 [ IntEnz-EBI ]   2.3.2.27 [ BRENDA ]   2.3.2.27 [ KEGG ]   
PhosPhoSitePlusQ6ZT12
Domaine pattern : Prosite (Expaxy)ZF_UBR (PS51157)   
Domains : Interpro (EBI)Znf_RING/FYVE/PHD    Znf_UBR   
Domain families : Pfam (Sanger)zf-UBR (PF02207)   
Domain families : Pfam (NCBI)pfam02207   
Domain families : Smart (EMBL)ZnF_UBR1 (SM00396)  
Conserved Domain (NCBI)UBR3
DMDM Disease mutations130507
Blocks (Seattle)UBR3
SuperfamilyQ6ZT12
Human Protein AtlasENSG00000144357
Peptide AtlasQ6ZT12
HPRD15887
IPIIPI00335581   IPI00796748   IPI00915334   IPI00827533   IPI00894102   IPI00893873   
Protein Interaction databases
DIP (DOE-UCLA)Q6ZT12
IntAct (EBI)Q6ZT12
FunCoupENSG00000144357
BioGRIDUBR3
STRING (EMBL)UBR3
ZODIACUBR3
Ontologies - Pathways
QuickGOQ6ZT12
Ontology : AmiGOubiquitin ligase complex  in utero embryonic development  suckling behavior  ubiquitin-protein transferase activity  cytoplasm  ubiquitin-dependent protein catabolic process  sensory perception of smell  zinc ion binding  embryo development  integral component of membrane  protein ubiquitination  olfactory behavior  ubiquitin protein ligase activity  ubiquitin-dependent protein catabolic process via the N-end rule pathway  
Ontology : EGO-EBIubiquitin ligase complex  in utero embryonic development  suckling behavior  ubiquitin-protein transferase activity  cytoplasm  ubiquitin-dependent protein catabolic process  sensory perception of smell  zinc ion binding  embryo development  integral component of membrane  protein ubiquitination  olfactory behavior  ubiquitin protein ligase activity  ubiquitin-dependent protein catabolic process via the N-end rule pathway  
NDEx NetworkUBR3
Atlas of Cancer Signalling NetworkUBR3
Wikipedia pathwaysUBR3
Orthology - Evolution
OrthoDB130507
GeneTree (enSembl)ENSG00000144357
Phylogenetic Trees/Animal Genes : TreeFamUBR3
HOVERGENQ6ZT12
HOGENOMQ6ZT12
Homologs : HomoloGeneUBR3
Homology/Alignments : Family Browser (UCSC)UBR3
Gene fusions - Rearrangements
Fusion : MitelmanCASP8/UBR3 [2q33.1/2q31.1]  [t(2;2)(q31;q33)]  
Fusion : MitelmanUBR3/CDK14 [2q31.1/7q21.13]  [t(2;7)(q31;q21)]  
Fusion: TCGACASP8 2q33.1 UBR3 2q31.1 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUBR3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UBR3
dbVarUBR3
ClinVarUBR3
1000_GenomesUBR3 
Exome Variant ServerUBR3
ExAC (Exome Aggregation Consortium)UBR3 (select the gene name)
Genetic variants : HAPMAP130507
Genomic Variants (DGV)UBR3 [DGVbeta]
DECIPHERUBR3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUBR3 
Mutations
ICGC Data PortalUBR3 
TCGA Data PortalUBR3 
Broad Tumor PortalUBR3
OASIS PortalUBR3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUBR3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUBR3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch UBR3
DgiDB (Drug Gene Interaction Database)UBR3
DoCM (Curated mutations)UBR3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UBR3 (select a term)
intoGenUBR3
Cancer3DUBR3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613831   
Orphanet
MedgenUBR3
Genetic Testing Registry UBR3
NextProtQ6ZT12 [Medical]
TSGene130507
GENETestsUBR3
Target ValidationUBR3
Huge Navigator UBR3 [HugePedia]
snp3D : Map Gene to Disease130507
BioCentury BCIQUBR3
ClinGenUBR3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD130507
Chemical/Pharm GKB GenePA162407919
Clinical trialUBR3
Miscellaneous
canSAR (ICR)UBR3 (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUBR3
EVEXUBR3
GoPubMedUBR3
iHOPUBR3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:18:15 CEST 2017

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