UBR3 (ubiquitin protein ligase E3 component n-recognin 3)

2014-08-01  

Identity

HGNC
UBR3
LOCATION
2q31.1
LOCUSID
130507
ALIAS
ZNF650
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 130507
MIM: 613831
HGNC: 30467
Ensembl: ENSG00000144357

Variants:

dbSNP: 130507
ClinVar: 130507
TCGA: ENSG00000144357
COSMIC: UBR3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000144357ENST00000272793Q6ZT12
ENSG00000144357ENST00000392632H0Y3K2
ENSG00000144357ENST00000418381Q6ZT12
ENSG00000144357ENST00000430321H7C481
ENSG00000144357ENST00000439681H7BZD8
ENSG00000144357ENST00000444475F8WEB7

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
219338132012Ubiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stability.29
199105432010Confirmation of genomewide association signals in Chinese Han population reveals risk loci for ischemic stroke.6
260595632015Cardiac Nav 1.5 is modulated by ubiquitin protein ligase E3 component n-recognin UBR3 and 6.4

Citation

Dessen P

UBR3 (ubiquitin protein ligase E3 component n-recognin 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54748/ubr3