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UBXN2A (UBX domain protein 2A)

Identity

Alias_namesUBXD4
UBX domain containing 4
Other alias
HGNC (Hugo) UBXN2A
LocusID (NCBI) 165324
Atlas_Id 54947
Location 2p23.3  [Link to chromosome band 2p23]
Location_base_pair Starts at 23940506 and ends at 24000823 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CENPO (2p23.3) / UBXN2A (2p23.3)MTBP (8q24.12) / UBXN2A (2p23.3)UBXN2A (2p23.3) / HORMAD1 (1q21.3)
CENPO 2p23.3 / UBXN2A 2p23.3MTBP 8q24.12 / UBXN2A 2p23.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(2;2)(p23;p23) CENPO/UBXN2A
t(2;8)(p23;q24) MTBP/UBXN2A

External links

Nomenclature
HGNC (Hugo)UBXN2A   27265
Cards
Entrez_Gene (NCBI)UBXN2A  165324  UBX domain protein 2A
AliasesUBXD4
GeneCards (Weizmann)UBXN2A
Ensembl hg19 (Hinxton)ENSG00000173960 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000173960 [Gene_View]  ENSG00000173960 [Sequence]  chr2:23940506-24000823 [Contig_View]  UBXN2A [Vega]
ICGC DataPortalENSG00000173960
TCGA cBioPortalUBXN2A
AceView (NCBI)UBXN2A
Genatlas (Paris)UBXN2A
WikiGenes165324
SOURCE (Princeton)UBXN2A
Genetics Home Reference (NIH)UBXN2A
Genomic and cartography
GoldenPath hg38 (UCSC)UBXN2A  -     chr2:23940506-24000823 +  2p23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)UBXN2A  -     2p23.3   [Description]    (hg19-Feb_2009)
EnsemblUBXN2A - 2p23.3 [CytoView hg19]  UBXN2A - 2p23.3 [CytoView hg38]
Mapping of homologs : NCBIUBXN2A [Mapview hg19]  UBXN2A [Mapview hg38]
Gene and transcription
Genbank (Entrez)AK291192 AL832079 BC016364 BC037901 BC092484
RefSeq transcript (Entrez)NM_181713
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)UBXN2A
Cluster EST : UnigeneHs.591576 [ NCBI ]
CGAP (NCI)Hs.591576
Alternative Splicing GalleryENSG00000173960
Gene ExpressionUBXN2A [ NCBI-GEO ]   UBXN2A [ EBI - ARRAY_EXPRESS ]   UBXN2A [ SEEK ]   UBXN2A [ MEM ]
Gene Expression Viewer (FireBrowse)UBXN2A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)165324
GTEX Portal (Tissue expression)UBXN2A
Human Protein AtlasENSG00000173960-UBXN2A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP68543   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP68543  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP68543
Splice isoforms : SwissVarP68543
PhosPhoSitePlusP68543
Domaine pattern : Prosite (Expaxy)SEP (PS51399)    UBX (PS50033)   
Domains : Interpro (EBI)SEP_domain    Ubiquitin-rel_dom    UBX_dom   
Domain families : Pfam (Sanger)SEP (PF08059)    UBX (PF00789)   
Domain families : Pfam (NCBI)pfam08059    pfam00789   
Domain families : Smart (EMBL)SEP (SM00553)  UBX (SM00166)  
Conserved Domain (NCBI)UBXN2A
DMDM Disease mutations165324
Blocks (Seattle)UBXN2A
SuperfamilyP68543
Human Protein Atlas [tissue]ENSG00000173960-UBXN2A [tissue]
Peptide AtlasP68543
HPRD10292
IPIIPI00094507   IPI00922237   
Protein Interaction databases
DIP (DOE-UCLA)P68543
IntAct (EBI)P68543
FunCoupENSG00000173960
BioGRIDUBXN2A
STRING (EMBL)UBXN2A
ZODIACUBXN2A
Ontologies - Pathways
QuickGOP68543
Ontology : AmiGOautophagosome assembly  protein binding  nucleus  endoplasmic reticulum  cis-Golgi network  cytosol  Golgi organization  regulation of gene expression  protein phosphatase regulator activity  regulation of protein ubiquitination  nuclear envelope reassembly  acetylcholine receptor binding  regulation of protein catabolic process  ubiquitin binding  proteasome-mediated ubiquitin-dependent protein catabolic process  regulation of phosphoprotein phosphatase activity  membrane fusion  cellular response to leukemia inhibitory factor  
Ontology : EGO-EBIautophagosome assembly  protein binding  nucleus  endoplasmic reticulum  cis-Golgi network  cytosol  Golgi organization  regulation of gene expression  protein phosphatase regulator activity  regulation of protein ubiquitination  nuclear envelope reassembly  acetylcholine receptor binding  regulation of protein catabolic process  ubiquitin binding  proteasome-mediated ubiquitin-dependent protein catabolic process  regulation of phosphoprotein phosphatase activity  membrane fusion  cellular response to leukemia inhibitory factor  
NDEx NetworkUBXN2A
Atlas of Cancer Signalling NetworkUBXN2A
Wikipedia pathwaysUBXN2A
Orthology - Evolution
OrthoDB165324
GeneTree (enSembl)ENSG00000173960
Phylogenetic Trees/Animal Genes : TreeFamUBXN2A
HOVERGENP68543
HOGENOMP68543
Homologs : HomoloGeneUBXN2A
Homology/Alignments : Family Browser (UCSC)UBXN2A
Gene fusions - Rearrangements
Fusion : MitelmanCENPO/UBXN2A [2p23.3/2p23.3]  [t(2;2)(p23;p23)]  
Fusion : MitelmanMTBP/UBXN2A [8q24.12/2p23.3]  [t(2;8)(p23;q24)]  
Fusion PortalCENPO 2p23.3 UBXN2A 2p23.3 BRCA LGG
Fusion PortalMTBP 8q24.12 UBXN2A 2p23.3 BRCA
Fusion : QuiverUBXN2A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUBXN2A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UBXN2A
dbVarUBXN2A
ClinVarUBXN2A
1000_GenomesUBXN2A 
Exome Variant ServerUBXN2A
ExAC (Exome Aggregation Consortium)ENSG00000173960
GNOMAD BrowserENSG00000173960
Genetic variants : HAPMAP165324
Genomic Variants (DGV)UBXN2A [DGVbeta]
DECIPHERUBXN2A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUBXN2A 
Mutations
ICGC Data PortalUBXN2A 
TCGA Data PortalUBXN2A 
Broad Tumor PortalUBXN2A
OASIS PortalUBXN2A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUBXN2A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUBXN2A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch UBXN2A
DgiDB (Drug Gene Interaction Database)UBXN2A
DoCM (Curated mutations)UBXN2A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UBXN2A (select a term)
intoGenUBXN2A
Cancer3DUBXN2A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETUBXN2A
MedgenUBXN2A
Genetic Testing Registry UBXN2A
NextProtP68543 [Medical]
TSGene165324
GENETestsUBXN2A
Target ValidationUBXN2A
Huge Navigator UBXN2A [HugePedia]
snp3D : Map Gene to Disease165324
BioCentury BCIQUBXN2A
ClinGenUBXN2A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD165324
Chemical/Pharm GKB GenePA162408375
Clinical trialUBXN2A
Miscellaneous
canSAR (ICR)UBXN2A (select the gene name)
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUBXN2A
EVEXUBXN2A
GoPubMedUBXN2A
iHOPUBXN2A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 22 16:56:23 CEST 2018
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