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UCHL3 (ubiquitin C-terminal hydrolase L3)

Identity

Alias_namesubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
HGNC (Hugo) UCHL3
LocusID (NCBI) 7347
Atlas_Id 42762
Location 13q22.2  [Link to chromosome band 13q22]
Location_base_pair Starts at 76123616 and ends at 76180156 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
FARP1 (13q32.2) / UCHL3 (13q22.2)LMO7 (13q22.2) / UCHL3 (13q22.2)FARP1 13q32.2 / UCHL3 13q22.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)UCHL3   12515
Cards
Entrez_Gene (NCBI)UCHL3  7347  ubiquitin C-terminal hydrolase L3
AliasesUCH-L3
GeneCards (Weizmann)UCHL3
Ensembl hg19 (Hinxton)ENSG00000118939 [Gene_View]  chr13:76123616-76180156 [Contig_View]  UCHL3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000118939 [Gene_View]  chr13:76123616-76180156 [Contig_View]  UCHL3 [Vega]
ICGC DataPortalENSG00000118939
TCGA cBioPortalUCHL3
AceView (NCBI)UCHL3
Genatlas (Paris)UCHL3
WikiGenes7347
SOURCE (Princeton)UCHL3
Genetics Home Reference (NIH)UCHL3
Genomic and cartography
GoldenPath hg19 (UCSC)UCHL3  -     chr13:76123616-76180156 +  13q22.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)UCHL3  -     13q22.2   [Description]    (hg38-Dec_2013)
EnsemblUCHL3 - 13q22.2 [CytoView hg19]  UCHL3 - 13q22.2 [CytoView hg38]
Mapping of homologs : NCBIUCHL3 [Mapview hg19]  UCHL3 [Mapview hg38]
OMIM603090   
Gene and transcription
Genbank (Entrez)AA234624 AK313665 BC018125 BQ427804 BT019359
RefSeq transcript (Entrez)NM_001270952 NM_006002
RefSeq genomic (Entrez)NC_000013 NC_018924 NT_024524 NW_004929388
Consensus coding sequences : CCDS (NCBI)UCHL3
Cluster EST : UnigeneHs.162241 [ NCBI ]
CGAP (NCI)Hs.162241
Alternative Splicing GalleryENSG00000118939
Gene ExpressionUCHL3 [ NCBI-GEO ]   UCHL3 [ EBI - ARRAY_EXPRESS ]   UCHL3 [ SEEK ]   UCHL3 [ MEM ]
Gene Expression Viewer (FireBrowse)UCHL3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7347
GTEX Portal (Tissue expression)UCHL3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP15374   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP15374  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP15374
Splice isoforms : SwissVarP15374
Catalytic activity : Enzyme3.4.19.12 [ Enzyme-Expasy ]   3.4.19.123.4.19.12 [ IntEnz-EBI ]   3.4.19.12 [ BRENDA ]   3.4.19.12 [ KEGG ]   
PhosPhoSitePlusP15374
Domaine pattern : Prosite (Expaxy)UCH_1 (PS00140)   
Domains : Interpro (EBI)Peptidase_C12_UCH   
Domain families : Pfam (Sanger)Peptidase_C12 (PF01088)   
Domain families : Pfam (NCBI)pfam01088   
Conserved Domain (NCBI)UCHL3
DMDM Disease mutations7347
Blocks (Seattle)UCHL3
PDB (SRS)1UCH    1XD3   
PDB (PDBSum)1UCH    1XD3   
PDB (IMB)1UCH    1XD3   
PDB (RSDB)1UCH    1XD3   
Structural Biology KnowledgeBase1UCH    1XD3   
SCOP (Structural Classification of Proteins)1UCH    1XD3   
CATH (Classification of proteins structures)1UCH    1XD3   
SuperfamilyP15374
Human Protein AtlasENSG00000118939
Peptide AtlasP15374
HPRD04367
IPIIPI00011250   IPI00514154   
Protein Interaction databases
DIP (DOE-UCLA)P15374
IntAct (EBI)P15374
FunCoupENSG00000118939
BioGRIDUCHL3
STRING (EMBL)UCHL3
ZODIACUCHL3
Ontologies - Pathways
QuickGOP15374
Ontology : AmiGOthiol-dependent ubiquitin-specific protease activity  protein binding  nucleus  cytoplasm  cytoplasm  ubiquitin-dependent protein catabolic process  peptidase activity  protein deubiquitination  protein catabolic process  ubiquitin binding  extracellular exosome  
Ontology : EGO-EBIthiol-dependent ubiquitin-specific protease activity  protein binding  nucleus  cytoplasm  cytoplasm  ubiquitin-dependent protein catabolic process  peptidase activity  protein deubiquitination  protein catabolic process  ubiquitin binding  extracellular exosome  
NDEx NetworkUCHL3
Atlas of Cancer Signalling NetworkUCHL3
Wikipedia pathwaysUCHL3
Orthology - Evolution
OrthoDB7347
GeneTree (enSembl)ENSG00000118939
Phylogenetic Trees/Animal Genes : TreeFamUCHL3
HOVERGENP15374
HOGENOMP15374
Homologs : HomoloGeneUCHL3
Homology/Alignments : Family Browser (UCSC)UCHL3
Gene fusions - Rearrangements
Fusion : MitelmanFARP1/UCHL3 [13q32.2/13q22.2]  [t(13;13)(q22;q32)]  
Fusion: TCGAFARP1 13q32.2 UCHL3 13q22.2 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUCHL3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UCHL3
dbVarUCHL3
ClinVarUCHL3
1000_GenomesUCHL3 
Exome Variant ServerUCHL3
ExAC (Exome Aggregation Consortium)UCHL3 (select the gene name)
Genetic variants : HAPMAP7347
Genomic Variants (DGV)UCHL3 [DGVbeta]
DECIPHER (Syndromes)13:76123616-76180156  ENSG00000118939
CONAN: Copy Number AnalysisUCHL3 
Mutations
ICGC Data PortalUCHL3 
TCGA Data PortalUCHL3 
Broad Tumor PortalUCHL3
OASIS PortalUCHL3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUCHL3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUCHL3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch UCHL3
DgiDB (Drug Gene Interaction Database)UCHL3
DoCM (Curated mutations)UCHL3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UCHL3 (select a term)
intoGenUCHL3
Cancer3DUCHL3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603090   
Orphanet
MedgenUCHL3
Genetic Testing Registry UCHL3
NextProtP15374 [Medical]
TSGene7347
GENETestsUCHL3
Huge Navigator UCHL3 [HugePedia]
snp3D : Map Gene to Disease7347
BioCentury BCIQUCHL3
ClinGenUCHL3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7347
Chemical/Pharm GKB GenePA37162
Clinical trialUCHL3
Miscellaneous
canSAR (ICR)UCHL3 (select the gene name)
Probes
Litterature
PubMed48 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUCHL3
EVEXUCHL3
GoPubMedUCHL3
iHOPUCHL3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Nov 18 19:55:10 CET 2016

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