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UCK2 (uridine-cytidine kinase 2)

Identity

Alias_namesUMPK
uridine monophosphate kinase
Other aliasTSA903
UK
HGNC (Hugo) UCK2
LocusID (NCBI) 7371
Atlas_Id 46207
Location 1q24.1  [Link to chromosome band 1q24]
Location_base_pair Starts at 165796732 and ends at 165880855 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
FNDC3B (3q26.31) / UCK2 (1q24.1)MPZL1 (1q24.2) / UCK2 (1q24.1)UCK2 (1q24.1) / DARS2 (1q25.1)
UCK2 (1q24.1) / PBX1 (1q23.3)UCK2 (1q24.1) / PID1 (2q36.3)UCK2 (1q24.1) / SELL (1q24.2)
UCK2 (1q24.1) / SNX27 (1q21.3)UCK2 (1q24.1) / UCK2 (1q24.1)FNDC3B 3q26.31 / UCK2 1q24.1
UCK2 1q24.1 / DARS2 1q25.1UCK2 1q24.1 / PBX1 1q23.3UCK2 1q24.1 / SNX27 1q21.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)UCK2   12562
Cards
Entrez_Gene (NCBI)UCK2  7371  uridine-cytidine kinase 2
AliasesTSA903; UK; UMPK
GeneCards (Weizmann)UCK2
Ensembl hg19 (Hinxton)ENSG00000143179 [Gene_View]  chr1:165796732-165880855 [Contig_View]  UCK2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000143179 [Gene_View]  chr1:165796732-165880855 [Contig_View]  UCK2 [Vega]
ICGC DataPortalENSG00000143179
TCGA cBioPortalUCK2
AceView (NCBI)UCK2
Genatlas (Paris)UCK2
WikiGenes7371
SOURCE (Princeton)UCK2
Genetics Home Reference (NIH)UCK2
Genomic and cartography
GoldenPath hg19 (UCSC)UCK2  -     chr1:165796732-165880855 +  1q24.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)UCK2  -     1q24.1   [Description]    (hg38-Dec_2013)
EnsemblUCK2 - 1q24.1 [CytoView hg19]  UCK2 - 1q24.1 [CytoView hg38]
Mapping of homologs : NCBIUCK2 [Mapview hg19]  UCK2 [Mapview hg38]
OMIM609329   
Gene and transcription
Genbank (Entrez)AB062451 AF236637 AK294537 AK309739 BC002906
RefSeq transcript (Entrez)NM_012474
RefSeq genomic (Entrez)NC_000001 NC_018912 NT_004487 NW_004929293
Consensus coding sequences : CCDS (NCBI)UCK2
Cluster EST : UnigeneHs.458360 [ NCBI ]
CGAP (NCI)Hs.458360
Alternative Splicing GalleryENSG00000143179
Gene ExpressionUCK2 [ NCBI-GEO ]   UCK2 [ EBI - ARRAY_EXPRESS ]   UCK2 [ SEEK ]   UCK2 [ MEM ]
Gene Expression Viewer (FireBrowse)UCK2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7371
GTEX Portal (Tissue expression)UCK2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BZX2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BZX2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BZX2
Splice isoforms : SwissVarQ9BZX2
Catalytic activity : Enzyme2.7.1.48 [ Enzyme-Expasy ]   2.7.1.482.7.1.48 [ IntEnz-EBI ]   2.7.1.48 [ BRENDA ]   2.7.1.48 [ KEGG ]   
PhosPhoSitePlusQ9BZX2
Domains : Interpro (EBI)P-loop_NTPase    PRK/URK    UCK-2    Uridine_kinase-like   
Domain families : Pfam (Sanger)PRK (PF00485)   
Domain families : Pfam (NCBI)pfam00485   
Conserved Domain (NCBI)UCK2
DMDM Disease mutations7371
Blocks (Seattle)UCK2
PDB (SRS)1UDW    1UEI    1UEJ    1UFQ    1UJ2    1XRJ   
PDB (PDBSum)1UDW    1UEI    1UEJ    1UFQ    1UJ2    1XRJ   
PDB (IMB)1UDW    1UEI    1UEJ    1UFQ    1UJ2    1XRJ   
PDB (RSDB)1UDW    1UEI    1UEJ    1UFQ    1UJ2    1XRJ   
Structural Biology KnowledgeBase1UDW    1UEI    1UEJ    1UFQ    1UJ2    1XRJ   
SCOP (Structural Classification of Proteins)1UDW    1UEI    1UEJ    1UFQ    1UJ2    1XRJ   
CATH (Classification of proteins structures)1UDW    1UEI    1UEJ    1UFQ    1UJ2    1XRJ   
SuperfamilyQ9BZX2
Human Protein AtlasENSG00000143179
Peptide AtlasQ9BZX2
HPRD01882
IPIIPI00065671   IPI00607810   IPI00908603   
Protein Interaction databases
DIP (DOE-UCLA)Q9BZX2
IntAct (EBI)Q9BZX2
FunCoupENSG00000143179
BioGRIDUCK2
STRING (EMBL)UCK2
ZODIACUCK2
Ontologies - Pathways
QuickGOQ9BZX2
Ontology : AmiGOuridine kinase activity  ATP binding  cellular_component  cytosol  cytosol  pyrimidine nucleobase metabolic process  CMP salvage  phosphorylation  nucleoside kinase activity  pyrimidine nucleoside salvage  pyrimidine nucleoside salvage  UMP salvage  CTP salvage  
Ontology : EGO-EBIuridine kinase activity  ATP binding  cellular_component  cytosol  cytosol  pyrimidine nucleobase metabolic process  CMP salvage  phosphorylation  nucleoside kinase activity  pyrimidine nucleoside salvage  pyrimidine nucleoside salvage  UMP salvage  CTP salvage  
Pathways : KEGGPyrimidine metabolism    Drug metabolism - other enzymes   
NDEx NetworkUCK2
Atlas of Cancer Signalling NetworkUCK2
Wikipedia pathwaysUCK2
Orthology - Evolution
OrthoDB7371
GeneTree (enSembl)ENSG00000143179
Phylogenetic Trees/Animal Genes : TreeFamUCK2
HOVERGENQ9BZX2
HOGENOMQ9BZX2
Homologs : HomoloGeneUCK2
Homology/Alignments : Family Browser (UCSC)UCK2
Gene fusions - Rearrangements
Fusion : MitelmanFNDC3B/UCK2 [3q26.31/1q24.1]  [t(1;3)(q24;q26)]  
Fusion : MitelmanUCK2/DARS2 [1q24.1/1q25.1]  [t(1;1)(q24;q25)]  
Fusion : MitelmanUCK2/PBX1 [1q24.1/1q23.3]  [t(1;1)(q23;q24)]  
Fusion : MitelmanUCK2/SNX27 [1q24.1/1q21.3]  [t(1;1)(q21;q24)]  
Fusion: TCGAFNDC3B 3q26.31 UCK2 1q24.1 BRCA
Fusion: TCGAUCK2 1q24.1 DARS2 1q25.1 BLCA
Fusion: TCGAUCK2 1q24.1 PBX1 1q23.3 OV
Fusion: TCGAUCK2 1q24.1 SNX27 1q21.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUCK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UCK2
dbVarUCK2
ClinVarUCK2
1000_GenomesUCK2 
Exome Variant ServerUCK2
ExAC (Exome Aggregation Consortium)UCK2 (select the gene name)
Genetic variants : HAPMAP7371
Genomic Variants (DGV)UCK2 [DGVbeta]
DECIPHER (Syndromes)1:165796732-165880855  ENSG00000143179
CONAN: Copy Number AnalysisUCK2 
Mutations
ICGC Data PortalUCK2 
TCGA Data PortalUCK2 
Broad Tumor PortalUCK2
OASIS PortalUCK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUCK2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUCK2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch UCK2
DgiDB (Drug Gene Interaction Database)UCK2
DoCM (Curated mutations)UCK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UCK2 (select a term)
intoGenUCK2
Cancer3DUCK2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609329   
Orphanet
MedgenUCK2
Genetic Testing Registry UCK2
NextProtQ9BZX2 [Medical]
TSGene7371
GENETestsUCK2
Huge Navigator UCK2 [HugePedia]
snp3D : Map Gene to Disease7371
BioCentury BCIQUCK2
ClinGenUCK2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7371
Chemical/Pharm GKB GenePA362
Clinical trialUCK2
Miscellaneous
canSAR (ICR)UCK2 (select the gene name)
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUCK2
EVEXUCK2
GoPubMedUCK2
iHOPUCK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:33:15 CET 2017

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