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UCK2 (uridine-cytidine kinase 2)

Identity

Alias (NCBI)TSA903
UK
UMPK
HGNC (Hugo) UCK2
HGNC Previous nameUMPK
HGNC Previous nameuridine monophosphate kinase
LocusID (NCBI) 7371
Atlas_Id 46207
Location 1q24.1  [Link to chromosome band 1q24]
Location_base_pair Starts at 165827614 and ends at 165911618 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FNDC3B (3q26.31) / UCK2 (1q24.1)MPZL1 (1q24.2) / UCK2 (1q24.1)UCK2 (1q24.1) / DARS2 (1q25.1)
UCK2 (1q24.1) / PBX1 (1q23.3)UCK2 (1q24.1) / PID1 (2q36.3)UCK2 (1q24.1) / SELL (1q24.2)
UCK2 (1q24.1) / SNX27 (1q21.3)UCK2 (1q24.1) / UCK2 (1q24.1)FNDC3B 3q26.31 / UCK2 1q24.1
UCK2 1q24.1 / DARS2 1q25.1UCK2 1q24.1 / PBX1 1q23.3UCK2 1q24.1 / SNX27 1q21.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  dup(1q) in ALL


External links

 

Nomenclature
HGNC (Hugo)UCK2   12562
Cards
Entrez_Gene (NCBI)UCK2    uridine-cytidine kinase 2
AliasesTSA903; UK; UMPK
GeneCards (Weizmann)UCK2
Ensembl hg19 (Hinxton)ENSG00000143179 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000143179 [Gene_View]  ENSG00000143179 [Sequence]  chr1:165827614-165911618 [Contig_View]  UCK2 [Vega]
ICGC DataPortalENSG00000143179
TCGA cBioPortalUCK2
AceView (NCBI)UCK2
Genatlas (Paris)UCK2
SOURCE (Princeton)UCK2
Genetics Home Reference (NIH)UCK2
Genomic and cartography
GoldenPath hg38 (UCSC)UCK2  -     chr1:165827614-165911618 +  1q24.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)UCK2  -     1q24.1   [Description]    (hg19-Feb_2009)
GoldenPathUCK2 - 1q24.1 [CytoView hg19]  UCK2 - 1q24.1 [CytoView hg38]
ImmunoBaseENSG00000143179
Genome Data Viewer NCBIUCK2 [Mapview hg19]  
OMIM609329   
Gene and transcription
Genbank (Entrez)AB062451 AF236637 AK294537 AK309739 BC002906
RefSeq transcript (Entrez)NM_001363568 NM_012474
Consensus coding sequences : CCDS (NCBI)UCK2
Gene ExpressionUCK2 [ NCBI-GEO ]   UCK2 [ EBI - ARRAY_EXPRESS ]   UCK2 [ SEEK ]   UCK2 [ MEM ]
Gene Expression Viewer (FireBrowse)UCK2 [ Firebrowse - Broad ]
GenevisibleExpression of UCK2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7371
GTEX Portal (Tissue expression)UCK2
Human Protein AtlasENSG00000143179-UCK2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BZX2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BZX2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BZX2
Catalytic activity : Enzyme2.7.1.48 [ Enzyme-Expasy ]   2.7.1.482.7.1.48 [ IntEnz-EBI ]   2.7.1.48 [ BRENDA ]   2.7.1.48 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9BZX2
Domains : Interpro (EBI)P-loop_NTPase    PRK/URK    UCK-2    Uridine_kinase-like   
Domain families : Pfam (Sanger)PRK (PF00485)   
Domain families : Pfam (NCBI)pfam00485   
Conserved Domain (NCBI)UCK2
PDB (RSDB)1UDW    1UEI    1UEJ    1UFQ    1UJ2    1XRJ    6N53    6N54    6N55    6PWZ   
PDB Europe1UDW    1UEI    1UEJ    1UFQ    1UJ2    1XRJ    6N53    6N54    6N55    6PWZ   
PDB (PDBSum)1UDW    1UEI    1UEJ    1UFQ    1UJ2    1XRJ    6N53    6N54    6N55    6PWZ   
PDB (IMB)1UDW    1UEI    1UEJ    1UFQ    1UJ2    1XRJ    6N53    6N54    6N55    6PWZ   
Structural Biology KnowledgeBase1UDW    1UEI    1UEJ    1UFQ    1UJ2    1XRJ    6N53    6N54    6N55    6PWZ   
SCOP (Structural Classification of Proteins)1UDW    1UEI    1UEJ    1UFQ    1UJ2    1XRJ    6N53    6N54    6N55    6PWZ   
CATH (Classification of proteins structures)1UDW    1UEI    1UEJ    1UFQ    1UJ2    1XRJ    6N53    6N54    6N55    6PWZ   
SuperfamilyQ9BZX2
AlphaFold pdb e-kbQ9BZX2   
Human Protein Atlas [tissue]ENSG00000143179-UCK2 [tissue]
HPRD01882
Protein Interaction databases
DIP (DOE-UCLA)Q9BZX2
IntAct (EBI)Q9BZX2
BioGRIDUCK2
STRING (EMBL)UCK2
ZODIACUCK2
Ontologies - Pathways
QuickGOQ9BZX2
Ontology : AmiGOuridine kinase activity  ATP binding  cellular_component  cytoplasm  cytosol  cytosol  phosphorylation  identical protein binding  pyrimidine nucleoside salvage  UMP salvage  CTP salvage  
Ontology : EGO-EBIuridine kinase activity  ATP binding  cellular_component  cytoplasm  cytosol  cytosol  phosphorylation  identical protein binding  pyrimidine nucleoside salvage  UMP salvage  CTP salvage  
Pathways : KEGGPyrimidine metabolism    Drug metabolism - other enzymes   
NDEx NetworkUCK2
Atlas of Cancer Signalling NetworkUCK2
Wikipedia pathwaysUCK2
Orthology - Evolution
OrthoDB7371
GeneTree (enSembl)ENSG00000143179
Phylogenetic Trees/Animal Genes : TreeFamUCK2
Homologs : HomoloGeneUCK2
Homology/Alignments : Family Browser (UCSC)UCK2
Gene fusions - Rearrangements
Fusion : MitelmanFNDC3B/UCK2 [3q26.31/1q24.1]  
Fusion : MitelmanUCK2/DARS2 [1q24.1/1q25.1]  
Fusion : MitelmanUCK2/PBX1 [1q24.1/1q23.3]  
Fusion : MitelmanUCK2/SNX27 [1q24.1/1q21.3]  
Fusion : QuiverUCK2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUCK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UCK2
dbVarUCK2
ClinVarUCK2
MonarchUCK2
1000_GenomesUCK2 
Exome Variant ServerUCK2
GNOMAD BrowserENSG00000143179
Varsome BrowserUCK2
ACMGUCK2 variants
VarityQ9BZX2
Genomic Variants (DGV)UCK2 [DGVbeta]
DECIPHERUCK2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUCK2 
Mutations
ICGC Data PortalUCK2 
TCGA Data PortalUCK2 
Broad Tumor PortalUCK2
OASIS PortalUCK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUCK2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DUCK2
Mutations and Diseases : HGMDUCK2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaUCK2
DgiDB (Drug Gene Interaction Database)UCK2
DoCM (Curated mutations)UCK2
CIViC (Clinical Interpretations of Variants in Cancer)UCK2
Cancer3DUCK2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609329   
Orphanet
DisGeNETUCK2
MedgenUCK2
Genetic Testing Registry UCK2
NextProtQ9BZX2 [Medical]
GENETestsUCK2
Target ValidationUCK2
Huge Navigator UCK2 [HugePedia]
ClinGenUCK2
Clinical trials, drugs, therapy
MyCancerGenomeUCK2
Protein Interactions : CTDUCK2
Pharm GKB GenePA362
Pharm GKB PathwaysPA150653776   
PharosQ9BZX2
Clinical trialUCK2
Miscellaneous
canSAR (ICR)UCK2
HarmonizomeUCK2
DataMed IndexUCK2
Probes
Litterature
PubMed61 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXUCK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:37:18 CEST 2021

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