Atlas of Genetics and Cytogenetics in Oncology and Haematology


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UCN (urocortin)

Identity

Alias_symbol (synonym)UROC
UI
Other alias
HGNC (Hugo) UCN
LocusID (NCBI) 7349
Atlas_Id 43729
Location 2p23.3  [Link to chromosome band 2p23]
Location_base_pair Starts at 27530268 and ends at 27531313 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)UCN   12516
Cards
Entrez_Gene (NCBI)UCN  7349  urocortin
AliasesUI; UROC
GeneCards (Weizmann)UCN
Ensembl hg19 (Hinxton)ENSG00000163794 [Gene_View]  chr2:27530268-27531313 [Contig_View]  UCN [Vega]
Ensembl hg38 (Hinxton)ENSG00000163794 [Gene_View]  chr2:27530268-27531313 [Contig_View]  UCN [Vega]
ICGC DataPortalENSG00000163794
TCGA cBioPortalUCN
AceView (NCBI)UCN
Genatlas (Paris)UCN
WikiGenes7349
SOURCE (Princeton)UCN
Genetics Home Reference (NIH)UCN
Genomic and cartography
GoldenPath hg19 (UCSC)UCN  -     chr2:27530268-27531313 -  2p23.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)UCN  -     2p23.3   [Description]    (hg38-Dec_2013)
EnsemblUCN - 2p23.3 [CytoView hg19]  UCN - 2p23.3 [CytoView hg38]
Mapping of homologs : NCBIUCN [Mapview hg19]  UCN [Mapview hg38]
OMIM600945   
Gene and transcription
Genbank (Entrez)AI857458 BC104470 BC104471 BU619919 CR542244
RefSeq transcript (Entrez)NM_003353
RefSeq genomic (Entrez)NC_000002 NC_018913 NG_033055 NT_022184 NW_004929300
Consensus coding sequences : CCDS (NCBI)UCN
Cluster EST : UnigeneHs.534363 [ NCBI ]
CGAP (NCI)Hs.534363
Alternative Splicing GalleryENSG00000163794
Gene ExpressionUCN [ NCBI-GEO ]   UCN [ EBI - ARRAY_EXPRESS ]   UCN [ SEEK ]   UCN [ MEM ]
Gene Expression Viewer (FireBrowse)UCN [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7349
GTEX Portal (Tissue expression)UCN
Protein : pattern, domain, 3D structure
UniProt/SwissProtP55089   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP55089  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP55089
Splice isoforms : SwissVarP55089
PhosPhoSitePlusP55089
Domaine pattern : Prosite (Expaxy)CRF (PS00511)   
Domains : Interpro (EBI)Corticotropin-releasing_fac_CS    CRF    Urocortin_CRF   
Domain families : Pfam (Sanger)CRF (PF00473)   
Domain families : Pfam (NCBI)pfam00473   
Domain families : Smart (EMBL)CRF (SM00039)  
Conserved Domain (NCBI)UCN
DMDM Disease mutations7349
Blocks (Seattle)UCN
PDB (SRS)2RMF    3N96   
PDB (PDBSum)2RMF    3N96   
PDB (IMB)2RMF    3N96   
PDB (RSDB)2RMF    3N96   
Structural Biology KnowledgeBase2RMF    3N96   
SCOP (Structural Classification of Proteins)2RMF    3N96   
CATH (Classification of proteins structures)2RMF    3N96   
SuperfamilyP55089
Human Protein AtlasENSG00000163794
Peptide AtlasP55089
HPRD02970
IPIIPI00022801   IPI00981474   
Protein Interaction databases
DIP (DOE-UCLA)P55089
IntAct (EBI)P55089
FunCoupENSG00000163794
BioGRIDUCN
STRING (EMBL)UCN
ZODIACUCN
Ontologies - Pathways
QuickGOP55089
Ontology : AmiGOstartle response  neuropeptide hormone activity  protein binding  extracellular region  inflammatory response  response to oxidative stress  G-protein coupled receptor signaling pathway  neuropeptide signaling pathway  female pregnancy  sensory perception of sound  associative learning  aerobic respiration  negative regulation of gene expression  response to auditory stimulus  pancreatic juice secretion  positive regulation of cell growth  dendrite  positive regulation of cAMP biosynthetic process  negative regulation of histone deacetylation  neuron projection development  negative regulation of appetite  response to estradiol  positive regulation of interleukin-6 production  positive regulation of collagen biosynthetic process  positive regulation of peptidyl-serine phosphorylation  activation of protein kinase A activity  social behavior  gastric emptying  drinking behavior  negative regulation of apoptotic process  positive regulation of vascular permeability  varicosity  perikaryon  axon terminus  positive regulation of translation  positive regulation of DNA replication  negative regulation of blood pressure  negative regulation of cell size  positive regulation of vasodilation  positive regulation of transcription from RNA polymerase II promoter  histone deacetylase inhibitor activity  negative regulation of hormone secretion  response to pain  response to glucocorticoid  corticotropin-releasing hormone receptor 1 binding  corticotropin-releasing hormone receptor 2 binding  positive regulation of corticotropin secretion  regulation of synaptic transmission, glutamatergic  positive regulation of cardiac muscle contraction  negative regulation of gastric acid secretion  negative regulation of necrotic cell death  positive regulation of calcium ion import  negative regulation of neuron death  negative regulation of feeding behavior  positive regulation of behavioral fear response  
Ontology : EGO-EBIstartle response  neuropeptide hormone activity  protein binding  extracellular region  inflammatory response  response to oxidative stress  G-protein coupled receptor signaling pathway  neuropeptide signaling pathway  female pregnancy  sensory perception of sound  associative learning  aerobic respiration  negative regulation of gene expression  response to auditory stimulus  pancreatic juice secretion  positive regulation of cell growth  dendrite  positive regulation of cAMP biosynthetic process  negative regulation of histone deacetylation  neuron projection development  negative regulation of appetite  response to estradiol  positive regulation of interleukin-6 production  positive regulation of collagen biosynthetic process  positive regulation of peptidyl-serine phosphorylation  activation of protein kinase A activity  social behavior  gastric emptying  drinking behavior  negative regulation of apoptotic process  positive regulation of vascular permeability  varicosity  perikaryon  axon terminus  positive regulation of translation  positive regulation of DNA replication  negative regulation of blood pressure  negative regulation of cell size  positive regulation of vasodilation  positive regulation of transcription from RNA polymerase II promoter  histone deacetylase inhibitor activity  negative regulation of hormone secretion  response to pain  response to glucocorticoid  corticotropin-releasing hormone receptor 1 binding  corticotropin-releasing hormone receptor 2 binding  positive regulation of corticotropin secretion  regulation of synaptic transmission, glutamatergic  positive regulation of cardiac muscle contraction  negative regulation of gastric acid secretion  negative regulation of necrotic cell death  positive regulation of calcium ion import  negative regulation of neuron death  negative regulation of feeding behavior  positive regulation of behavioral fear response  
NDEx NetworkUCN
Atlas of Cancer Signalling NetworkUCN
Wikipedia pathwaysUCN
Orthology - Evolution
OrthoDB7349
GeneTree (enSembl)ENSG00000163794
Phylogenetic Trees/Animal Genes : TreeFamUCN
HOVERGENP55089
HOGENOMP55089
Homologs : HomoloGeneUCN
Homology/Alignments : Family Browser (UCSC)UCN
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUCN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UCN
dbVarUCN
ClinVarUCN
1000_GenomesUCN 
Exome Variant ServerUCN
ExAC (Exome Aggregation Consortium)UCN (select the gene name)
Genetic variants : HAPMAP7349
Genomic Variants (DGV)UCN [DGVbeta]
DECIPHER (Syndromes)2:27530268-27531313  ENSG00000163794
CONAN: Copy Number AnalysisUCN 
Mutations
ICGC Data PortalUCN 
TCGA Data PortalUCN 
Broad Tumor PortalUCN
OASIS PortalUCN [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUCN  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUCN
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch UCN
DgiDB (Drug Gene Interaction Database)UCN
DoCM (Curated mutations)UCN (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UCN (select a term)
intoGenUCN
Cancer3DUCN(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600945   
Orphanet
MedgenUCN
Genetic Testing Registry UCN
NextProtP55089 [Medical]
TSGene7349
GENETestsUCN
Huge Navigator UCN [HugePedia]
snp3D : Map Gene to Disease7349
BioCentury BCIQUCN
ClinGenUCN
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7349
Chemical/Pharm GKB GenePA37163
Clinical trialUCN
Miscellaneous
canSAR (ICR)UCN (select the gene name)
Probes
Litterature
PubMed73 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUCN
EVEXUCN
GoPubMedUCN
iHOPUCN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 15:24:14 CEST 2017

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