UCN2 (urocortin 2)

2016-10-01  

Identity

HGNC
UCN2
LOCATION
3p21.31
LOCUSID
90226
ALIAS
SRP,UCN-II,UCNI,UR,URP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 90226
MIM: 605902
HGNC: 18414
Ensembl: ENSG00000145040

Variants:

dbSNP: 90226
ClinVar: 90226
TCGA: ENSG00000145040
COSMIC: UCN2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145040ENST00000273610Q96RP3

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class B/2 (Secretin family receptors)REACTOMER-HSA-373080

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
203685122010Association of polymorphisms in genes regulating the corticotropin-releasing factor system with antidepressant treatment response.30
162239462006Urocortin 2 acts centrally to delay gastric emptying through sympathetic pathways while CRF and urocortin 1 inhibitory actions are vagal dependent in rats.22
272758432016Cardiovascular effects of urocortin 2 and urocortin 3 in patients with chronic heart failure.14
145194392003Protective effects of the urocortin homologues stresscopin (SCP) and stresscopin-related peptide (SRP) against hypoxia/reoxygenation injury in rat neonatal cardiomyocytes.13
145929502004Urocortin II is expressed in human pregnant myometrial cells and regulates myosin light chain phosphorylation: potential role of the type-2 corticotropin-releasing hormone receptor in the control of myometrial contractility.10
166266082006Urocortin 2 and urocortin 3 are expressed by the human placenta, deciduas, and fetal membranes.10
206163672010Hypoxia and preeclampsia: increased expression of urocortin 2 and urocortin 3.10
214543162011Urocortin 2 and urocortin 3 in endometriosis: evidence for a possible role in inflammatory response.8
213605272011Mapping the CRF-urocortins system in human osteoarthritic and rheumatoid synovial fibroblasts: effect of vasoactive intestinal peptide.7
220004742011Effects of urocortin 2 and urocortin 3 on IL-10 and TNF-α expression and secretion from human trophoblast explants.7

Citation

Dessen P

UCN2 (urocortin 2)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/55968/ucn2