UCN3 (urocortin 3)

2009-03-01 Affiliation

Identity

HGNC

UCN3

LOCATION

10p15.1

LOCUSID

114131

ALIAS

SCP,SPC,UCNIII

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 114131
MIM: 605901
HGNC: 17781
Ensembl: ENSG00000178473

Variants:

dbSNP: 114131
ClinVar: 114131
TCGA: ENSG00000178473
COSMIC: UCN3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000178473	ENST00000380433	Q969E3

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class B/2 (Secretin family receptors)	REACTOME	R-HSA-373080

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
18504423	2008	Polymorphisms in inflammation-related genes are associated with susceptibility to major depression and antidepressant response.	73
26076035	2015	Urocortin3 mediates somatostatin-dependent negative feedback control of insulin secretion.	67
20368512	2010	Association of polymorphisms in genes regulating the corticotropin-releasing factor system with antidepressant treatment response.	30
14764822	2004	Corticotropin-releasing hormone system in human adipose tissue.	20
15949638	2005	Urocortin 3/stresscopin in human colon: possible modulators of gastrointestinal function during stressful conditions.	15
27275843	2016	Cardiovascular effects of urocortin 2 and urocortin 3 in patients with chronic heart failure.	14
14519439	2003	Protective effects of the urocortin homologues stresscopin (SCP) and stresscopin-related peptide (SRP) against hypoxia/reoxygenation injury in rat neonatal cardiomyocytes.	13
15070962	2004	Expression of urocortin III/stresscopin in human heart and kidney.	12
25148370	2014	Maturation of stem cell-derived beta-cells guided by the expression of urocortin 3.	11
16626608	2006	Urocortin 2 and urocortin 3 are expressed by the human placenta, deciduas, and fetal membranes.	10

Citation

Dessen P

UCN3 (urocortin 3)

Atlas Genet Cytogenet Oncol Haematol. 2009-03-01

Online version: http://atlasgeneticsoncology.org/gene/50793/ucn3