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UCP1 (uncoupling protein 1)

Identity

Alias_namesUCP
uncoupling protein 1 (mitochondrial, proton carrier)
Alias_symbol (synonym)SLC25A7
Other alias
HGNC (Hugo) UCP1
LocusID (NCBI) 7350
Atlas_Id 75459
Location 4q31.1  [Link to chromosome band 4q31]
Location_base_pair Starts at 140559896 and ends at 140568805 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)UCP1   12517
Cards
Entrez_Gene (NCBI)UCP1  7350  uncoupling protein 1
AliasesSLC25A7; UCP
GeneCards (Weizmann)UCP1
Ensembl hg19 (Hinxton)ENSG00000109424 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000109424 [Gene_View]  chr4:140559896-140568805 [Contig_View]  UCP1 [Vega]
ICGC DataPortalENSG00000109424
TCGA cBioPortalUCP1
AceView (NCBI)UCP1
Genatlas (Paris)UCP1
WikiGenes7350
SOURCE (Princeton)UCP1
Genetics Home Reference (NIH)UCP1
Genomic and cartography
GoldenPath hg38 (UCSC)UCP1  -     chr4:140559896-140568805 -  4q31.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)UCP1  -     4q31.1   [Description]    (hg19-Feb_2009)
EnsemblUCP1 - 4q31.1 [CytoView hg19]  UCP1 - 4q31.1 [CytoView hg38]
Mapping of homologs : NCBIUCP1 [Mapview hg19]  UCP1 [Mapview hg38]
OMIM113730   601665   
Gene and transcription
Genbank (Entrez)BC069556 BC096736 BC098168 BC098258 BC098352
RefSeq transcript (Entrez)NM_021833
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)UCP1
Cluster EST : UnigeneHs.249211 [ NCBI ]
CGAP (NCI)Hs.249211
Alternative Splicing GalleryENSG00000109424
Gene ExpressionUCP1 [ NCBI-GEO ]   UCP1 [ EBI - ARRAY_EXPRESS ]   UCP1 [ SEEK ]   UCP1 [ MEM ]
Gene Expression Viewer (FireBrowse)UCP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7350
GTEX Portal (Tissue expression)UCP1
Human Protein AtlasENSG00000109424-UCP1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP25874   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP25874  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP25874
Splice isoforms : SwissVarP25874
PhosPhoSitePlusP25874
Domaine pattern : Prosite (Expaxy)SOLCAR (PS50920)   
Domains : Interpro (EBI)Mit_uncoupling    Mitochondrial_sb/sol_carrier    Mt_carrier_dom   
Domain families : Pfam (Sanger)Mito_carr (PF00153)   
Domain families : Pfam (NCBI)pfam00153   
Conserved Domain (NCBI)UCP1
DMDM Disease mutations7350
Blocks (Seattle)UCP1
SuperfamilyP25874
Human Protein Atlas [tissue]ENSG00000109424-UCP1 [tissue]
Peptide AtlasP25874
HPRD00221
IPIIPI00299306   
Protein Interaction databases
DIP (DOE-UCLA)P25874
IntAct (EBI)P25874
FunCoupENSG00000109424
BioGRIDUCP1
STRING (EMBL)UCP1
ZODIACUCP1
Ontologies - Pathways
QuickGOP25874
Ontology : AmiGOdiet induced thermogenesis  mitochondrion  mitochondrial inner membrane  mitochondrial inner membrane  mitochondrial inner membrane  regulation of transcription from RNA polymerase II promoter  response to temperature stimulus  response to cold  proton transport  proton transport  integral component of membrane  oxidative phosphorylation uncoupler activity  oxidative phosphorylation uncoupler activity  transmembrane transporter activity  response to nutrient levels  purine ribonucleotide binding  cellular response to hormone stimulus  cellular response to reactive oxygen species  long-chain fatty acid binding  brown fat cell differentiation  cellular response to fatty acid  cardiolipin binding  regulation of reactive oxygen species biosynthetic process  mitochondrial transmembrane transport  mitochondrial transmembrane transport  adaptive thermogenesis  adaptive thermogenesis  
Ontology : EGO-EBIdiet induced thermogenesis  mitochondrion  mitochondrial inner membrane  mitochondrial inner membrane  mitochondrial inner membrane  regulation of transcription from RNA polymerase II promoter  response to temperature stimulus  response to cold  proton transport  proton transport  integral component of membrane  oxidative phosphorylation uncoupler activity  oxidative phosphorylation uncoupler activity  transmembrane transporter activity  response to nutrient levels  purine ribonucleotide binding  cellular response to hormone stimulus  cellular response to reactive oxygen species  long-chain fatty acid binding  brown fat cell differentiation  cellular response to fatty acid  cardiolipin binding  regulation of reactive oxygen species biosynthetic process  mitochondrial transmembrane transport  mitochondrial transmembrane transport  adaptive thermogenesis  adaptive thermogenesis  
Pathways : KEGGPPAR signaling pathway    Huntington's disease   
NDEx NetworkUCP1
Atlas of Cancer Signalling NetworkUCP1
Wikipedia pathwaysUCP1
Orthology - Evolution
OrthoDB7350
GeneTree (enSembl)ENSG00000109424
Phylogenetic Trees/Animal Genes : TreeFamUCP1
HOVERGENP25874
HOGENOMP25874
Homologs : HomoloGeneUCP1
Homology/Alignments : Family Brogser USC)UCP1
Gene fusions - Rearrangements
Fusion: Tumor Portal UCP1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUCP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UCP1
dbVarUCP1
ClinVarUCP1
1000_GenomesUCP1 
Exome Variant ServerUCP1
ExAC (Exome Aggregation Consortium)ENSG00000109424
GNOMAD BrowserENSG00000109424
Genetic variants : HAPMAP7350
Genomic Variants (DGV)UCP1 [DGVbeta]
DECIPHERUCP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUCP1 
Mutations
ICGC Data PortalUCP1 
TCGA Data PortalUCP1 
Broad Tumor PortalUCP1
OASIS PortalUCP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUCP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUCP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch UCP1
DgiDB (Drug Gene Interaction Database)UCP1
DoCM (Curated mutations)UCP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UCP1 (select a term)
intoGenUCP1
Cancer3DUCP1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM113730    601665   
Orphanet
MedgenUCP1
Genetic Testing Registry UCP1
NextProtP25874 [Medical]
TSGene7350
GENETestsUCP1
Target ValidationUCP1
Huge Navigator UCP1 [HugePedia]
snp3D : Map Gene to Disease7350
BioCentury BCIQUCP1
ClinGenUCP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7350
Chemical/Pharm GKB GenePA37164
Clinical trialUCP1
Miscellaneous
canSAR (ICR)UCP1 (select the gene name)
Probes
Litterature
PubMed131 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUCP1
EVEXUCP1
GoPubMedUCP1
iHOPUCP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Nov 9 12:34:57 CET 2017

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