UCP1 (uncoupling protein 1)

2014-11-01 Affiliation

Identity

HGNC

UCP1

LOCATION

4q31.1

LOCUSID

7350

ALIAS

SLC25A7,UCP

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 7350
MIM: 113730
HGNC: 12517
Ensembl: ENSG00000109424

Variants:

dbSNP: 7350
ClinVar: 7350
TCGA: ENSG00000109424
COSMIC: UCP1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000109424	ENST00000262999	P25874

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
PPAR signaling pathway	KEGG	ko03320
Huntington's disease	KEGG	ko05016
PPAR signaling pathway	KEGG	hsa03320
Huntington's disease	KEGG	hsa05016
Metabolism	REACTOME	R-HSA-1430728
The citric acid (TCA) cycle and respiratory electron transport	REACTOME	R-HSA-1428517
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	REACTOME	R-HSA-163200
Mitochondrial Uncoupling Proteins	REACTOME	R-HSA-166187
The fatty acid cycling model	REACTOME	R-HSA-167826
The proton buffering model	REACTOME	R-HSA-167827
Apelin signaling pathway	KEGG	hsa04371

References

Pubmed ID	Year	Title	Citations
23266187	2013	The mitochondrial transporter family SLC25: identification, properties and physiopathology.	159
22277967	2012	Molecular diagnosis of infantile mitochondrial disease with targeted next-generation sequencing.	141
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
19567523	2009	Uncoupling protein-1 and related messenger ribonucleic acids in human epicardial and other adipose tissues: epicardial fat functioning as brown fat.	72
23454374	2013	White-to-brown transdifferentiation of omental adipocytes in patients affected by pheochromocytoma.	64
19730683	2009	The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.	59
22075692	2012	Triiodothyronine induces UCP-1 expression and mitochondrial biogenesis in human adipocytes.	50
19056576	2009	Effects of novel capsinoid treatment on fatness and energy metabolism in humans: possible pharmacogenetic implications.	49
25135951	2014	Taking control over intracellular fatty acid levels is essential for the analysis of thermogenic function in cultured primary brown and brite/beige adipocytes.	42
23824424	2013	Adult epicardial fat exhibits beige features.	40

Citation

Dessen P

UCP1 (uncoupling protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/75459/ucp1