UCP3 (uncoupling protein 3)

2007-02-01  

Identity

HGNC
LOCATION
11q13.4
LOCUSID
ALIAS
SLC25A9

Other Information

Locus ID:

NCBI: 7352
MIM: 602044
HGNC: 12519
Ensembl: ENSG00000175564

Variants:

dbSNP: 7352
ClinVar: 7352
TCGA: ENSG00000175564
COSMIC: UCP3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000175564ENST00000314032P55916
ENSG00000175564ENST00000314032A0A0S2Z4G5
ENSG00000175564ENST00000426995P55916
ENSG00000175564ENST00000544614F5H3N5

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
The citric acid (TCA) cycle and respiratory electron transportREACTOMER-HSA-1428517
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.REACTOMER-HSA-163200
Mitochondrial Uncoupling ProteinsREACTOMER-HSA-166187
The fatty acid cycling modelREACTOMER-HSA-167826
The proton buffering modelREACTOMER-HSA-167827

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
193693662009Plasma acylcarnitine profiles suggest incomplete long-chain fatty acid beta-oxidation and altered tricarboxylic acid cycle activity in type 2 diabetic African-American women.191
232661872013The mitochondrial transporter family SLC25: identification, properties and physiopathology.159
173516412007Uncoupling proteins 2 and 3 are fundamental for mitochondrial Ca2+ uniport.121
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
175711652007Overexpression of uncoupling protein 3 in skeletal muscle protects against fat-induced insulin resistance.69
160463002005Physiological increases in uncoupling protein 3 augment fatty acid oxidation and decrease reactive oxygen species production without uncoupling respiration in muscle cells.53
190565762009Effects of novel capsinoid treatment on fatness and energy metabolism in humans: possible pharmacogenetic implications.49
216132212011Leucine zipper EF hand-containing transmembrane protein 1 (Letm1) and uncoupling proteins 2 and 3 (UCP2/3) contribute to two distinct mitochondrial Ca2+ uptake pathways.45
207340642010A large-scale candidate gene association study of age at menarche and age at natural menopause.38
121454752002Downregulation of metabolic gene expression in failing human heart before and after mechanical unloading.36

Citation

Dessen P

UCP3 (uncoupling protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43772/ucp3