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UFD1 (ubiquitin recognition factor in ER associated degradation 1)

Identity

Alias (NCBI)UFD1L
HGNC (Hugo) UFD1
HGNC Previous nameUFD1L
HGNC Previous nameubiquitin fusion degradation 1-like
 ubiquitin fusion degradation 1 like (yeast)
LocusID (NCBI) 7353
Atlas_Id 56823
Location 22q11.21  [Link to chromosome band 22q11]
Location_base_pair Starts at 19449911 and ends at 19479193 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

Nomenclature
HGNC (Hugo)UFD1   12520
Cards
Entrez_Gene (NCBI)UFD1    ubiquitin recognition factor in ER associated degradation 1
AliasesUFD1L
GeneCards (Weizmann)UFD1
Ensembl hg19 (Hinxton)ENSG00000070010 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000070010 [Gene_View]  ENSG00000070010 [Sequence]  chr22:19449911-19479193 [Contig_View]  UFD1 [Vega]
ICGC DataPortalENSG00000070010
TCGA cBioPortalUFD1
AceView (NCBI)UFD1
Genatlas (Paris)UFD1
SOURCE (Princeton)UFD1
Genetics Home Reference (NIH)UFD1
Genomic and cartography
GoldenPath hg38 (UCSC)UFD1  -     chr22:19449911-19479193 -  22q11.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)UFD1  -     22q11.21   [Description]    (hg19-Feb_2009)
GoldenPathUFD1 - 22q11.21 [CytoView hg19]  UFD1 - 22q11.21 [CytoView hg38]
ImmunoBaseENSG00000070010
genome Data Viewer NCBIUFD1 [Mapview hg19]  
OMIM601754   
Gene and transcription
Genbank (Entrez)AF141201 AJ239058 AK128120 AK225877 AK304734
RefSeq transcript (Entrez)NM_001035247 NM_001362910 NM_005659
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)UFD1
Alternative Splicing GalleryENSG00000070010
Gene ExpressionUFD1 [ NCBI-GEO ]   UFD1 [ EBI - ARRAY_EXPRESS ]   UFD1 [ SEEK ]   UFD1 [ MEM ]
Gene Expression Viewer (FireBrowse)UFD1 [ Firebrowse - Broad ]
GenevisibleExpression of UFD1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7353
GTEX Portal (Tissue expression)UFD1
Human Protein AtlasENSG00000070010-UFD1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92890   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92890  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92890
Splice isoforms : SwissVarQ92890
PhosPhoSitePlusQ92890
Domains : Interpro (EBI)Ufd1-like    Ufd1-like_Nn   
Domain families : Pfam (Sanger)UFD1 (PF03152)   
Domain families : Pfam (NCBI)pfam03152   
Conserved Domain (NCBI)UFD1
Blocks (Seattle)UFD1
PDB (RSDB)2YUJ    5B6C    5C1B   
PDB Europe2YUJ    5B6C    5C1B   
PDB (PDBSum)2YUJ    5B6C    5C1B   
PDB (IMB)2YUJ    5B6C    5C1B   
Structural Biology KnowledgeBase2YUJ    5B6C    5C1B   
SCOP (Structural Classification of Proteins)2YUJ    5B6C    5C1B   
CATH (Classification of proteins structures)2YUJ    5B6C    5C1B   
SuperfamilyQ92890
Human Protein Atlas [tissue]ENSG00000070010-UFD1 [tissue]
Peptide AtlasQ92890
IPIIPI00655754   IPI00218292   IPI00654779   IPI00910767   IPI00873326   IPI00852988   IPI01011883   IPI00945833   IPI01010945   
Protein Interaction databases
DIP (DOE-UCLA)Q92890
IntAct (EBI)Q92890
BioGRIDUFD1
STRING (EMBL)UFD1
ZODIACUFD1
Ontologies - Pathways
QuickGOQ92890
Ontology : AmiGOskeletal system development  thiol-dependent ubiquitin-specific protease activity  signaling receptor binding  protein binding  nucleus  nucleoplasm  cytosol  ubiquitin-dependent protein catabolic process  protein deubiquitination  protein phosphopantetheinylation  ubiquitin-dependent ERAD pathway  retrograde protein transport, ER to cytosol  polyubiquitin modification-dependent protein binding  negative regulation of type I interferon production  VCP-NPL4-UFD1 AAA ATPase complex  VCP-NPL4-UFD1 AAA ATPase complex  VCP-NPL4-UFD1 AAA ATPase complex  K48-linked polyubiquitin modification-dependent protein binding  UFD1-NPL4 complex  negative regulation of RIG-I signaling pathway  protein-containing complex binding  ATPase binding  error-free translesion synthesis  ER-associated misfolded protein catabolic process  ER-associated misfolded protein catabolic process  
Ontology : EGO-EBIskeletal system development  thiol-dependent ubiquitin-specific protease activity  signaling receptor binding  protein binding  nucleus  nucleoplasm  cytosol  ubiquitin-dependent protein catabolic process  protein deubiquitination  protein phosphopantetheinylation  ubiquitin-dependent ERAD pathway  retrograde protein transport, ER to cytosol  polyubiquitin modification-dependent protein binding  negative regulation of type I interferon production  VCP-NPL4-UFD1 AAA ATPase complex  VCP-NPL4-UFD1 AAA ATPase complex  VCP-NPL4-UFD1 AAA ATPase complex  K48-linked polyubiquitin modification-dependent protein binding  UFD1-NPL4 complex  negative regulation of RIG-I signaling pathway  protein-containing complex binding  ATPase binding  error-free translesion synthesis  ER-associated misfolded protein catabolic process  ER-associated misfolded protein catabolic process  
NDEx NetworkUFD1
Atlas of Cancer Signalling NetworkUFD1
Wikipedia pathwaysUFD1
Orthology - Evolution
OrthoDB7353
GeneTree (enSembl)ENSG00000070010
Phylogenetic Trees/Animal Genes : TreeFamUFD1
HOGENOMQ92890
Homologs : HomoloGeneUFD1
Homology/Alignments : Family Browser (UCSC)UFD1
Gene fusions - Rearrangements
Fusion : QuiverUFD1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUFD1 [hg38]
dbVarUFD1
ClinVarUFD1
MonarchUFD1
1000_GenomesUFD1 
Exome Variant ServerUFD1
GNOMAD BrowserENSG00000070010
Varsome BrowserUFD1
Genomic Variants (DGV)UFD1 [DGVbeta]
DECIPHERUFD1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUFD1 
Mutations
ICGC Data PortalUFD1 
TCGA Data PortalUFD1 
Broad Tumor PortalUFD1
OASIS PortalUFD1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUFD1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DUFD1
Mutations and Diseases : HGMDUFD1
BioMutasearch UFD1
DgiDB (Drug Gene Interaction Database)UFD1
DoCM (Curated mutations)UFD1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UFD1 (select a term)
intoGenUFD1
Cancer3DUFD1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601754   
Orphanet
DisGeNETUFD1
MedgenUFD1
Genetic Testing Registry UFD1
NextProtQ92890 [Medical]
GENETestsUFD1
Target ValidationUFD1
Huge Navigator UFD1 [HugePedia]
ClinGenUFD1
Clinical trials, drugs, therapy
MyCancerGenomeUFD1
Protein Interactions : CTD
Pharm GKB GenePA37167
PharosQ92890
Clinical trialUFD1
Miscellaneous
canSAR (ICR)UFD1 (select the gene name)
HarmonizomeUFD1
DataMed IndexUFD1
Probes
Litterature
PubMed113 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXUFD1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Mar 25 19:51:54 CET 2021

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