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UFL1 (UFM1 specific ligase 1)

Identity

Alias_namesKIAA0776
KIAA0776
UFM1-specific ligase 1
Alias_symbol (synonym)NLBP
Maxer
RCAD
Other alias
HGNC (Hugo) UFL1
LocusID (NCBI) 23376
Atlas_Id 53895
Location 6q16.1  [Link to chromosome band 6q16]
Location_base_pair Starts at 96521826 and ends at 96555275 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)UFL1   23039
Cards
Entrez_Gene (NCBI)UFL1  23376  UFM1 specific ligase 1
AliasesKIAA0776; Maxer; NLBP; RCAD
GeneCards (Weizmann)UFL1
Ensembl hg19 (Hinxton)ENSG00000014123 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000014123 [Gene_View]  ENSG00000014123 [Sequence]  chr6:96521826-96555275 [Contig_View]  UFL1 [Vega]
ICGC DataPortalENSG00000014123
TCGA cBioPortalUFL1
AceView (NCBI)UFL1
Genatlas (Paris)UFL1
WikiGenes23376
SOURCE (Princeton)UFL1
Genetics Home Reference (NIH)UFL1
Genomic and cartography
GoldenPath hg38 (UCSC)UFL1  -     chr6:96521826-96555275 +  6q16.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)UFL1  -     6q16.1   [Description]    (hg19-Feb_2009)
EnsemblUFL1 - 6q16.1 [CytoView hg19]  UFL1 - 6q16.1 [CytoView hg38]
Mapping of homologs : NCBIUFL1 [Mapview hg19]  UFL1 [Mapview hg38]
OMIM613372   
Gene and transcription
Genbank (Entrez)AB018319 AJ420579 AK295934 AK307651 AK316453
RefSeq transcript (Entrez)NM_015323
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)UFL1
Cluster EST : UnigeneHs.149367 [ NCBI ]
CGAP (NCI)Hs.149367
Alternative Splicing GalleryENSG00000014123
Gene ExpressionUFL1 [ NCBI-GEO ]   UFL1 [ EBI - ARRAY_EXPRESS ]   UFL1 [ SEEK ]   UFL1 [ MEM ]
Gene Expression Viewer (FireBrowse)UFL1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23376
GTEX Portal (Tissue expression)UFL1
Human Protein AtlasENSG00000014123-UFL1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO94874   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO94874  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO94874
Splice isoforms : SwissVarO94874
PhosPhoSitePlusO94874
Domains : Interpro (EBI)E3_UFM1_ligase_1   
Domain families : Pfam (Sanger)DUF2042 (PF09743)   
Domain families : Pfam (NCBI)pfam09743   
Conserved Domain (NCBI)UFL1
DMDM Disease mutations23376
Blocks (Seattle)UFL1
SuperfamilyO94874
Human Protein Atlas [tissue]ENSG00000014123-UFL1 [tissue]
Peptide AtlasO94874
HPRD11109
IPIIPI00844000   IPI00955456   IPI00955462   
Protein Interaction databases
DIP (DOE-UCLA)O94874
IntAct (EBI)O94874
FunCoupENSG00000014123
BioGRIDUFL1
STRING (EMBL)UFL1
ZODIACUFL1
Ontologies - Pathways
QuickGOO94874
Ontology : AmiGOosteoblast differentiation  protein binding  cytoplasm  endoplasmic reticulum  endoplasmic reticulum membrane  cytosol  positive regulation of cell proliferation  membrane  ligase activity  negative regulation of protein ubiquitination  negative regulation of NF-kappaB transcription factor activity  regulation of proteasomal ubiquitin-dependent protein catabolic process  regulation of protein localization  regulation of intracellular estrogen receptor signaling pathway  response to endoplasmic reticulum stress  neuron projection  negative regulation of apoptotic process  protein complex  positive regulation of glial cell proliferation  UFM1 transferase activity  protein ufmylation  protein ufmylation  response to L-glutamate  protein K69-linked ufmylation  
Ontology : EGO-EBIosteoblast differentiation  protein binding  cytoplasm  endoplasmic reticulum  endoplasmic reticulum membrane  cytosol  positive regulation of cell proliferation  membrane  ligase activity  negative regulation of protein ubiquitination  negative regulation of NF-kappaB transcription factor activity  regulation of proteasomal ubiquitin-dependent protein catabolic process  regulation of protein localization  regulation of intracellular estrogen receptor signaling pathway  response to endoplasmic reticulum stress  neuron projection  negative regulation of apoptotic process  protein complex  positive regulation of glial cell proliferation  UFM1 transferase activity  protein ufmylation  protein ufmylation  response to L-glutamate  protein K69-linked ufmylation  
NDEx NetworkUFL1
Atlas of Cancer Signalling NetworkUFL1
Wikipedia pathwaysUFL1
Orthology - Evolution
OrthoDB23376
GeneTree (enSembl)ENSG00000014123
Phylogenetic Trees/Animal Genes : TreeFamUFL1
HOVERGENO94874
HOGENOMO94874
Homologs : HomoloGeneUFL1
Homology/Alignments : Family Browser (UCSC)UFL1
Gene fusions - Rearrangements
Fusion : QuiverUFL1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUFL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UFL1
dbVarUFL1
ClinVarUFL1
1000_GenomesUFL1 
Exome Variant ServerUFL1
ExAC (Exome Aggregation Consortium)ENSG00000014123
GNOMAD BrowserENSG00000014123
Genetic variants : HAPMAP23376
Genomic Variants (DGV)UFL1 [DGVbeta]
DECIPHERUFL1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUFL1 
Mutations
ICGC Data PortalUFL1 
TCGA Data PortalUFL1 
Broad Tumor PortalUFL1
OASIS PortalUFL1 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDUFL1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch UFL1
DgiDB (Drug Gene Interaction Database)UFL1
DoCM (Curated mutations)UFL1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UFL1 (select a term)
intoGenUFL1
Cancer3DUFL1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613372   
Orphanet
DisGeNETUFL1
MedgenUFL1
Genetic Testing Registry UFL1
NextProtO94874 [Medical]
TSGene23376
GENETestsUFL1
Target ValidationUFL1
Huge Navigator UFL1 [HugePedia]
snp3D : Map Gene to Disease23376
BioCentury BCIQUFL1
ClinGenUFL1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23376
Chemical/Pharm GKB GenePA134937763
Clinical trialUFL1
Miscellaneous
canSAR (ICR)UFL1 (select the gene name)
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUFL1
EVEXUFL1
GoPubMedUFL1
iHOPUFL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jun 22 16:56:27 CEST 2018

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