UGCG (UDP-glucose ceramide glucosyltransferase)

2003-08-01  

Identity

HGNC
LOCATION
9q31.3
LOCUSID
ALIAS
GCS,GLCT1
FUSION GENES

Other Information

Locus ID:

NCBI: 7357
MIM: 602874
HGNC: 12524
Ensembl: ENSG00000148154

Variants:

dbSNP: 7357
ClinVar: 7357
TCGA: ENSG00000148154
COSMIC: UGCG

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000148154ENST00000374279Q16739
ENSG00000148154ENST00000374279A0A024R157

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Sphingolipid metabolismKEGGko00600
Sphingolipid metabolismKEGGhsa00600
Metabolic pathwaysKEGGhsa01100
Lactosylceramide biosynthesisKEGGhsa_M00066
Lactosylceramide biosynthesisKEGGM00066
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Sphingolipid metabolismREACTOMER-HSA-428157
Glycosphingolipid metabolismREACTOMER-HSA-1660662

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
205407462010Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and beta-catenin signaling.55
212782352011Suppression of glucosylceramide synthase restores p53-dependent apoptosis in mutant p53 cancer cells.29
216178562011Glucosylceramide synthase, a factor in modulating drug resistance, is overexpressed in metastatic breast carcinoma.29
229368062012Ceramide glycosylation by glucosylceramide synthase selectively maintains the properties of breast cancer stem cells.26
177091372008Overexpression of glucosylceramide synthase in associated with multidrug resistance of leukemia cells.23
185608902009Prognostic relevance of glucosylceramide synthase (GCS) expression in breast cancer.12
147668992004Cytoprotective effect of glucosylceramide synthase inhibition against daunorubicin-induced apoptosis in human leukemic cell lines.11
152630082004Inhibition of glucosylceramide synthase does not reverse drug resistance in cancer cells.11
268114972016Targeting glucosylceramide synthase upregulation reverts sorafenib resistance in experimental hepatocellular carcinoma.11
128739732003Glucosylceramide synthase and its functional interaction with RTN-1C regulate chemotherapeutic-induced apoptosis in neuroepithelioma cells.9

Citation

Dessen P

UGCG (UDP-glucose ceramide glucosyltransferase)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/42763/ugcg