Atlas of Genetics and Cytogenetics in Oncology and Haematology


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UGDH (UDP-glucose 6-dehydrogenase)

Identity

Alias_namesUDP-glucose dehydrogenase
Other aliasGDH
UDP-GlcDH
UDPGDH
UGD
HGNC (Hugo) UGDH
LocusID (NCBI) 7358
Atlas_Id 51337
Location 4p14  [Link to chromosome band 4p14]
Location_base_pair Starts at 39498755 and ends at 39527598 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CCDC69 (5q33.1) / UGDH (4p14)MAGT1 (Xq21.1) / UGDH (4p14)UGDH (4p14) / RPL7L1 (6p21.1)
UGDH (4p14) / SLC25A31 (4q28.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)UGDH   12525
Cards
Entrez_Gene (NCBI)UGDH  7358  UDP-glucose 6-dehydrogenase
AliasesGDH; UDP-GlcDH; UDPGDH; UGD
GeneCards (Weizmann)UGDH
Ensembl hg19 (Hinxton)ENSG00000109814 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000109814 [Gene_View]  chr4:39498755-39527598 [Contig_View]  UGDH [Vega]
ICGC DataPortalENSG00000109814
TCGA cBioPortalUGDH
AceView (NCBI)UGDH
Genatlas (Paris)UGDH
WikiGenes7358
SOURCE (Princeton)UGDH
Genetics Home Reference (NIH)UGDH
Genomic and cartography
GoldenPath hg38 (UCSC)UGDH  -     chr4:39498755-39527598 -  4p14   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)UGDH  -     4p14   [Description]    (hg19-Feb_2009)
EnsemblUGDH - 4p14 [CytoView hg19]  UGDH - 4p14 [CytoView hg38]
Mapping of homologs : NCBIUGDH [Mapview hg19]  UGDH [Mapview hg38]
OMIM603370   
Gene and transcription
Genbank (Entrez)AF049126 AF061016 AJ007702 AK097930 AK297737
RefSeq transcript (Entrez)NM_001184700 NM_001184701 NM_003359
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)UGDH
Cluster EST : UnigeneHs.572518 [ NCBI ]
CGAP (NCI)Hs.572518
Alternative Splicing GalleryENSG00000109814
Gene ExpressionUGDH [ NCBI-GEO ]   UGDH [ EBI - ARRAY_EXPRESS ]   UGDH [ SEEK ]   UGDH [ MEM ]
Gene Expression Viewer (FireBrowse)UGDH [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7358
GTEX Portal (Tissue expression)UGDH
Human Protein AtlasENSG00000109814-UGDH [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60701   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60701  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60701
Splice isoforms : SwissVarO60701
PhosPhoSitePlusO60701
Domains : Interpro (EBI)6-PGluconate_DH_C-like    NAD(P)-bd_dom    UDP-Glc/GDP-Man    UDP-Glc/GDP-Man_DH_C    UDP-Glc/GDP-Man_DH_dimer    UDP-Glc/GDP-Man_DH_N    UDPglc_DH_euk   
Domain families : Pfam (Sanger)UDPG_MGDP_dh (PF00984)    UDPG_MGDP_dh_C (PF03720)    UDPG_MGDP_dh_N (PF03721)   
Domain families : Pfam (NCBI)pfam00984    pfam03720    pfam03721   
Domain families : Smart (EMBL)UDPG_MGDP_dh_C (SM00984)  
Conserved Domain (NCBI)UGDH
DMDM Disease mutations7358
Blocks (Seattle)UGDH
PDB (SRS)2Q3E    2QG4    3ITK    3KHU    3PRJ    3PTZ    3TDK    3TF5    4EDF    4QEJ    4RJT    5TJH   
PDB (PDBSum)2Q3E    2QG4    3ITK    3KHU    3PRJ    3PTZ    3TDK    3TF5    4EDF    4QEJ    4RJT    5TJH   
PDB (IMB)2Q3E    2QG4    3ITK    3KHU    3PRJ    3PTZ    3TDK    3TF5    4EDF    4QEJ    4RJT    5TJH   
PDB (RSDB)2Q3E    2QG4    3ITK    3KHU    3PRJ    3PTZ    3TDK    3TF5    4EDF    4QEJ    4RJT    5TJH   
Structural Biology KnowledgeBase2Q3E    2QG4    3ITK    3KHU    3PRJ    3PTZ    3TDK    3TF5    4EDF    4QEJ    4RJT    5TJH   
SCOP (Structural Classification of Proteins)2Q3E    2QG4    3ITK    3KHU    3PRJ    3PTZ    3TDK    3TF5    4EDF    4QEJ    4RJT    5TJH   
CATH (Classification of proteins structures)2Q3E    2QG4    3ITK    3KHU    3PRJ    3PTZ    3TDK    3TF5    4EDF    4QEJ    4RJT    5TJH   
SuperfamilyO60701
Human Protein Atlas [tissue]ENSG00000109814-UGDH [tissue]
Peptide AtlasO60701
HPRD04535
IPIIPI00031420   IPI00964927   IPI00956601   IPI00965344   IPI00967433   IPI00966999   IPI00966697   IPI00968010   IPI00966385   
Protein Interaction databases
DIP (DOE-UCLA)O60701
IntAct (EBI)O60701
FunCoupENSG00000109814
BioGRIDUGDH
STRING (EMBL)UGDH
ZODIACUGDH
Ontologies - Pathways
QuickGOO60701
Ontology : AmiGOgastrulation with mouth forming second  UDP-glucose 6-dehydrogenase activity  nucleoplasm  cytosol  UDP-glucose metabolic process  glycosaminoglycan biosynthetic process  UDP-glucuronate biosynthetic process  UDP-glucuronate biosynthetic process  electron carrier activity  NAD binding  oxidation-reduction process  extracellular exosome  
Ontology : EGO-EBIgastrulation with mouth forming second  UDP-glucose 6-dehydrogenase activity  nucleoplasm  cytosol  UDP-glucose metabolic process  glycosaminoglycan biosynthetic process  UDP-glucuronate biosynthetic process  UDP-glucuronate biosynthetic process  electron carrier activity  NAD binding  oxidation-reduction process  extracellular exosome  
Pathways : KEGGPentose and glucuronate interconversions    Ascorbate and aldarate metabolism    Starch and sucrose metabolism    Amino sugar and nucleotide sugar metabolism   
NDEx NetworkUGDH
Atlas of Cancer Signalling NetworkUGDH
Wikipedia pathwaysUGDH
Orthology - Evolution
OrthoDB7358
GeneTree (enSembl)ENSG00000109814
Phylogenetic Trees/Animal Genes : TreeFamUGDH
HOVERGENO60701
HOGENOMO60701
Homologs : HomoloGeneUGDH
Homology/Alignments : Family Browser (UCSC)UGDH
Gene fusions - Rearrangements
Fusion : MitelmanUGDH/SLC25A31 [4p14/4q28.1]  
Tumor Fusion PortalUGDH
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUGDH [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UGDH
dbVarUGDH
ClinVarUGDH
1000_GenomesUGDH 
Exome Variant ServerUGDH
ExAC (Exome Aggregation Consortium)ENSG00000109814
GNOMAD BrowserENSG00000109814
Genetic variants : HAPMAP7358
Genomic Variants (DGV)UGDH [DGVbeta]
DECIPHERUGDH [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUGDH 
Mutations
ICGC Data PortalUGDH 
TCGA Data PortalUGDH 
Broad Tumor PortalUGDH
OASIS PortalUGDH [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUGDH  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUGDH
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch UGDH
DgiDB (Drug Gene Interaction Database)UGDH
DoCM (Curated mutations)UGDH (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UGDH (select a term)
intoGenUGDH
Cancer3DUGDH(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603370   
Orphanet
DisGeNETUGDH
MedgenUGDH
Genetic Testing Registry UGDH
NextProtO60701 [Medical]
TSGene7358
GENETestsUGDH
Target ValidationUGDH
Huge Navigator UGDH [HugePedia]
snp3D : Map Gene to Disease7358
BioCentury BCIQUGDH
ClinGenUGDH
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7358
Chemical/Pharm GKB GenePA37170
Clinical trialUGDH
Miscellaneous
canSAR (ICR)UGDH (select the gene name)
Probes
Litterature
PubMed52 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUGDH
EVEXUGDH
GoPubMedUGDH
iHOPUGDH
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:40:43 CET 2017

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