UGT1A (UDP glucuronosyltransferase family 1 member A complex locus)

2010-03-01 Affiliation

Identity

HGNC

UGT1A

LOCATION

2q37.1

LOCUSID

7361

ALIAS

GNT1,UGT,UGT1,UGT1A@

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 7361
HGNC: 12529

Variants:

dbSNP: 7361
ClinVar: 7361
COSMIC: UGT1A

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA166123346	bilirubin	Chemical	ClinicalAnnotation	associated	PK		25778466
PA446108	Colorectal Neoplasms	Disease	ClinicalAnnotation	associated	PK	PD	25778466
PA446443	Liver Failure, Acute	Disease	ClinicalAnnotation	associated		PD
PA448015	acetaminophen	Chemical	ClinicalAnnotation	associated	PK	PD
PA450085	irinotecan	Chemical	ClinicalAnnotation	associated		PD	25778466

References

Pubmed ID	Year	Title	Citations
20972438	2010	A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.	188
18480185	2008	Expression of UGT1A and UGT2B mRNA in human normal tissues and various cell lines.	91
11325819	2001	CYP2C9 and UGT1A6 genotypes modulate the protective effect of aspirin on colon adenoma risk.	33
20053997	2010	Interaction between oxidative stress sensor Nrf2 and xenobiotic-activated aryl hydrocarbon receptor in the regulation of the human phase II detoxifying UDP-glucuronosyltransferase 1A10.	29
22558097	2012	A genome-wide association study of total bilirubin and cholelithiasis risk in sickle cell anemia.	26
23408116	2013	The UDP-glucuronosyltransferase (UGT) 1A polymorphism c.2042C>G (rs8330) is associated with increased human liver acetaminophen glucuronidation, increased UGT1A exon 5a/5b splice variant mRNA ratio, and decreased risk of unintentional acetaminophen-induced acute liver failure.	26
22086872	2013	Androgen receptor signals regulate UDP-glucuronosyltransferases in the urinary bladder: a potential mechanism of androgen-induced bladder carcinogenesis.	25
23052946	2013	Comprehensive candidate gene study highlights UGT1A and BNC2 as new genes determining continuous skin color variation in Europeans.	23
18004212	2007	Genetic diversity at the UGT1 locus is amplified by a novel 3' alternative splicing mechanism leading to nine additional UGT1A proteins that act as regulators of glucuronidation activity.	20
15643497	2005	UDP-glucuronosyltransferases 1A expression in human urinary bladder and colon cancer by immunohistochemistry.	17

Citation

Dessen P

UGT1A (UDP glucuronosyltransferase family 1 member A complex locus)

Atlas Genet Cytogenet Oncol Haematol. 2010-03-01

Online version: http://atlasgeneticsoncology.org/gene/51398/ugt1a