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UGT1A3 (UDP glucuronosyltransferase family 1 member A3)

Identity

Alias_namesUDP glycosyltransferase 1 family
Alias_symbol (synonym)UGT1C
Other aliasUDPGT
UDPGT 1-3
UGT-1C
UGT1-03
UGT1.3
UGT1A3S
HGNC (Hugo) UGT1A3
LocusID (NCBI) 54659
Atlas_Id 55580
Location 2q37.1  [Link to chromosome band 2q37]
Location_base_pair Starts at 234637773 and ends at 234681945 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)UGT1A3   12535
Cards
Entrez_Gene (NCBI)UGT1A3  54659  UDP glucuronosyltransferase family 1 member A3
AliasesUDPGT; UDPGT; UGT-1C; UGT1-03; 
UGT1.3; UGT1A3S; UGT1C
GeneCards (Weizmann)UGT1A3
Ensembl hg19 (Hinxton)ENSG00000243135 [Gene_View]  chr2:234637773-234681945 [Contig_View]  UGT1A3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000243135 [Gene_View]  chr2:234637773-234681945 [Contig_View]  UGT1A3 [Vega]
ICGC DataPortalENSG00000243135
TCGA cBioPortalUGT1A3
AceView (NCBI)UGT1A3
Genatlas (Paris)UGT1A3
WikiGenes54659
SOURCE (Princeton)UGT1A3
Genetics Home Reference (NIH)UGT1A3
Genomic and cartography
GoldenPath hg19 (UCSC)UGT1A3  -     chr2:234637773-234681945 +  2q37.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)UGT1A3  -     2q37.1   [Description]    (hg38-Dec_2013)
EnsemblUGT1A3 - 2q37.1 [CytoView hg19]  UGT1A3 - 2q37.1 [CytoView hg38]
Mapping of homologs : NCBIUGT1A3 [Mapview hg19]  UGT1A3 [Mapview hg38]
OMIM606428   
Gene and transcription
Genbank (Entrez)AY435138 BC166641 DQ364248
RefSeq transcript (Entrez)NM_019093
RefSeq genomic (Entrez)NC_000002 NC_018913 NG_002601 NT_005403 NW_004929306
Consensus coding sequences : CCDS (NCBI)UGT1A3
Cluster EST : UnigeneHs.554822 [ NCBI ]
CGAP (NCI)Hs.554822
Alternative Splicing GalleryENSG00000243135
Gene ExpressionUGT1A3 [ NCBI-GEO ]   UGT1A3 [ EBI - ARRAY_EXPRESS ]   UGT1A3 [ SEEK ]   UGT1A3 [ MEM ]
Gene Expression Viewer (FireBrowse)UGT1A3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54659
GTEX Portal (Tissue expression)UGT1A3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP35503   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP35503  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP35503
Splice isoforms : SwissVarP35503
Catalytic activity : Enzyme2.4.1.17 [ Enzyme-Expasy ]   2.4.1.172.4.1.17 [ IntEnz-EBI ]   2.4.1.17 [ BRENDA ]   2.4.1.17 [ KEGG ]   
PhosPhoSitePlusP35503
Domaine pattern : Prosite (Expaxy)UDPGT (PS00375)   
Domains : Interpro (EBI)UDP_glucos_trans   
Domain families : Pfam (Sanger)UDPGT (PF00201)   
Domain families : Pfam (NCBI)pfam00201   
Conserved Domain (NCBI)UGT1A3
DMDM Disease mutations54659
Blocks (Seattle)UGT1A3
SuperfamilyP35503
Human Protein AtlasENSG00000243135
Peptide AtlasP35503
HPRD07566
IPIIPI00473079   
Protein Interaction databases
DIP (DOE-UCLA)P35503
IntAct (EBI)P35503
FunCoupENSG00000243135
BioGRIDUGT1A3
STRING (EMBL)UGT1A3
ZODIACUGT1A3
Ontologies - Pathways
QuickGOP35503
Ontology : AmiGOretinoic acid binding  endoplasmic reticulum  endoplasmic reticulum  endoplasmic reticulum membrane  endoplasmic reticulum membrane  endoplasmic reticulum membrane  metabolic process  flavonoid biosynthetic process  glucuronosyltransferase activity  glucuronosyltransferase activity  glucuronosyltransferase activity  integral component of membrane  drug metabolic process  enzyme binding  retinoic acid metabolic process  protein homodimerization activity  negative regulation of fatty acid metabolic process  protein heterodimerization activity  protein heterodimerization activity  cellular glucuronidation  cellular glucuronidation  flavonoid glucuronidation  xenobiotic glucuronidation  negative regulation of glucuronosyltransferase activity  negative regulation of cellular glucuronidation  
Ontology : EGO-EBIretinoic acid binding  endoplasmic reticulum  endoplasmic reticulum  endoplasmic reticulum membrane  endoplasmic reticulum membrane  endoplasmic reticulum membrane  metabolic process  flavonoid biosynthetic process  glucuronosyltransferase activity  glucuronosyltransferase activity  glucuronosyltransferase activity  integral component of membrane  drug metabolic process  enzyme binding  retinoic acid metabolic process  protein homodimerization activity  negative regulation of fatty acid metabolic process  protein heterodimerization activity  protein heterodimerization activity  cellular glucuronidation  cellular glucuronidation  flavonoid glucuronidation  xenobiotic glucuronidation  negative regulation of glucuronosyltransferase activity  negative regulation of cellular glucuronidation  
Pathways : KEGGPentose and glucuronate interconversions    Ascorbate and aldarate metabolism    Steroid hormone biosynthesis    Starch and sucrose metabolism    Retinol metabolism    Porphyrin and chlorophyll metabolism    Metabolism of xenobiotics by cytochrome P450    Drug metabolism - cytochrome P450    Drug metabolism - other enzymes    Chemical carcinogenesis   
NDEx NetworkUGT1A3
Atlas of Cancer Signalling NetworkUGT1A3
Wikipedia pathwaysUGT1A3
Orthology - Evolution
OrthoDB54659
GeneTree (enSembl)ENSG00000243135
Phylogenetic Trees/Animal Genes : TreeFamUGT1A3
HOVERGENP35503
HOGENOMP35503
Homologs : HomoloGeneUGT1A3
Homology/Alignments : Family Browser (UCSC)UGT1A3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUGT1A3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UGT1A3
dbVarUGT1A3
ClinVarUGT1A3
1000_GenomesUGT1A3 
Exome Variant ServerUGT1A3
ExAC (Exome Aggregation Consortium)UGT1A3 (select the gene name)
Genetic variants : HAPMAP54659
Genomic Variants (DGV)UGT1A3 [DGVbeta]
DECIPHER (Syndromes)2:234637773-234681945  ENSG00000243135
CONAN: Copy Number AnalysisUGT1A3 
Mutations
ICGC Data PortalUGT1A3 
TCGA Data PortalUGT1A3 
Broad Tumor PortalUGT1A3
OASIS PortalUGT1A3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUGT1A3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUGT1A3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch UGT1A3
DgiDB (Drug Gene Interaction Database)UGT1A3
DoCM (Curated mutations)UGT1A3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UGT1A3 (select a term)
intoGenUGT1A3
Cancer3DUGT1A3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606428   
Orphanet
MedgenUGT1A3
Genetic Testing Registry UGT1A3
NextProtP35503 [Medical]
TSGene54659
GENETestsUGT1A3
Huge Navigator UGT1A3 [HugePedia]
snp3D : Map Gene to Disease54659
BioCentury BCIQUGT1A3
ClinGenUGT1A3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD54659
Chemical/Pharm GKB GenePA37178
Clinical trialUGT1A3
Miscellaneous
canSAR (ICR)UGT1A3 (select the gene name)
Probes
Litterature
PubMed60 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUGT1A3
EVEXUGT1A3
GoPubMedUGT1A3
iHOPUGT1A3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:24:17 CEST 2017

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