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UGT1A4 (UDP glucuronosyltransferase family 1 member A4)

Identity

Alias_namesUDP glycosyltransferase 1 family
Alias_symbol (synonym)HUG-BR2
UGT1D
Other aliasUDPGT
UDPGT 1-4
UGT-1D
UGT1-04
UGT1.4
UGT1A4S
HGNC (Hugo) UGT1A4
LocusID (NCBI) 54657
Atlas_Id 55625
Location 2q37.1  [Link to chromosome band 2q37]
Location_base_pair Starts at 233718792 and ends at 233773299 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)UGT1A4   12536
Cards
Entrez_Gene (NCBI)UGT1A4  54657  UDP glucuronosyltransferase family 1 member A4
AliasesHUG-BR2; UDPGT; UDPGT; UGT-1D; 
UGT1-04; UGT1.4; UGT1A4S; UGT1D
GeneCards (Weizmann)UGT1A4
Ensembl hg19 (Hinxton)ENSG00000244474 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000244474 [Gene_View]  ENSG00000244474 [Sequence]  chr2:233718792-233773299 [Contig_View]  UGT1A4 [Vega]
ICGC DataPortalENSG00000244474
TCGA cBioPortalUGT1A4
AceView (NCBI)UGT1A4
Genatlas (Paris)UGT1A4
WikiGenes54657
SOURCE (Princeton)UGT1A4
Genetics Home Reference (NIH)UGT1A4
Genomic and cartography
GoldenPath hg38 (UCSC)UGT1A4  -     chr2:233718792-233773299 +  2q37.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)UGT1A4  -     2q37.1   [Description]    (hg19-Feb_2009)
EnsemblUGT1A4 - 2q37.1 [CytoView hg19]  UGT1A4 - 2q37.1 [CytoView hg38]
Mapping of homologs : NCBIUGT1A4 [Mapview hg19]  UGT1A4 [Mapview hg38]
OMIM606429   
Gene and transcription
Genbank (Entrez)AK313623 AY435139 BC121036 BC131623 BC139784
RefSeq transcript (Entrez)NM_007120
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)UGT1A4
Cluster EST : UnigeneHs.554822 [ NCBI ]
CGAP (NCI)Hs.554822
Alternative Splicing GalleryENSG00000244474
Gene ExpressionUGT1A4 [ NCBI-GEO ]   UGT1A4 [ EBI - ARRAY_EXPRESS ]   UGT1A4 [ SEEK ]   UGT1A4 [ MEM ]
Gene Expression Viewer (FireBrowse)UGT1A4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54657
GTEX Portal (Tissue expression)UGT1A4
Human Protein AtlasENSG00000244474-UGT1A4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP22310   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP22310  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP22310
Splice isoforms : SwissVarP22310
Catalytic activity : Enzyme2.4.1.17 [ Enzyme-Expasy ]   2.4.1.172.4.1.17 [ IntEnz-EBI ]   2.4.1.17 [ BRENDA ]   2.4.1.17 [ KEGG ]   
PhosPhoSitePlusP22310
Domaine pattern : Prosite (Expaxy)UDPGT (PS00375)   
Domains : Interpro (EBI)UDP_glucos_trans   
Domain families : Pfam (Sanger)UDPGT (PF00201)   
Domain families : Pfam (NCBI)pfam00201   
Conserved Domain (NCBI)UGT1A4
DMDM Disease mutations54657
Blocks (Seattle)UGT1A4
SuperfamilyP22310
Human Protein Atlas [tissue]ENSG00000244474-UGT1A4 [tissue]
Peptide AtlasP22310
HPRD08402
IPIIPI00439935   IPI01025461   IPI00893254   
Protein Interaction databases
DIP (DOE-UCLA)P22310
IntAct (EBI)P22310
FunCoupENSG00000244474
BioGRIDUGT1A4
STRING (EMBL)UGT1A4
ZODIACUGT1A4
Ontologies - Pathways
QuickGOP22310
Ontology : AmiGOretinoic acid binding  endoplasmic reticulum  endoplasmic reticulum membrane  bilirubin conjugation  glucuronosyltransferase activity  glucuronosyltransferase activity  integral component of membrane  heme catabolic process  protein homodimerization activity  protein heterodimerization activity  cellular glucuronidation  cellular glucuronidation  flavonoid glucuronidation  xenobiotic glucuronidation  
Ontology : EGO-EBIretinoic acid binding  endoplasmic reticulum  endoplasmic reticulum membrane  bilirubin conjugation  glucuronosyltransferase activity  glucuronosyltransferase activity  integral component of membrane  heme catabolic process  protein homodimerization activity  protein heterodimerization activity  cellular glucuronidation  cellular glucuronidation  flavonoid glucuronidation  xenobiotic glucuronidation  
NDEx NetworkUGT1A4
Atlas of Cancer Signalling NetworkUGT1A4
Wikipedia pathwaysUGT1A4
Orthology - Evolution
OrthoDB54657
GeneTree (enSembl)ENSG00000244474
Phylogenetic Trees/Animal Genes : TreeFamUGT1A4
HOVERGENP22310
HOGENOMP22310
Homologs : HomoloGeneUGT1A4
Homology/Alignments : Family Browser (UCSC)UGT1A4
Gene fusions - Rearrangements
Fusion : QuiverUGT1A4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUGT1A4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UGT1A4
dbVarUGT1A4
ClinVarUGT1A4
1000_GenomesUGT1A4 
Exome Variant ServerUGT1A4
ExAC (Exome Aggregation Consortium)ENSG00000244474
GNOMAD BrowserENSG00000244474
Genetic variants : HAPMAP54657
Genomic Variants (DGV)UGT1A4 [DGVbeta]
DECIPHERUGT1A4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUGT1A4 
Mutations
ICGC Data PortalUGT1A4 
TCGA Data PortalUGT1A4 
Broad Tumor PortalUGT1A4
OASIS PortalUGT1A4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUGT1A4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUGT1A4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch UGT1A4
DgiDB (Drug Gene Interaction Database)UGT1A4
DoCM (Curated mutations)UGT1A4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UGT1A4 (select a term)
intoGenUGT1A4
Cancer3DUGT1A4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606429   
Orphanet
DisGeNETUGT1A4
MedgenUGT1A4
Genetic Testing Registry UGT1A4
NextProtP22310 [Medical]
TSGene54657
GENETestsUGT1A4
Target ValidationUGT1A4
Huge Navigator UGT1A4 [HugePedia]
snp3D : Map Gene to Disease54657
BioCentury BCIQUGT1A4
ClinGenUGT1A4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD54657
Chemical/Pharm GKB GenePA37179
Clinical trialUGT1A4
Miscellaneous
canSAR (ICR)UGT1A4 (select the gene name)
Probes
Litterature
PubMed78 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUGT1A4
EVEXUGT1A4
GoPubMedUGT1A4
iHOPUGT1A4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jun 22 16:56:29 CEST 2018

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