UGT1A5 (UDP glucuronosyltransferase family 1 member A5)

2014-11-01 Affiliation

Identity

HGNC

UGT1A5

LOCATION

2q37.1

LOCUSID

54579

ALIAS

UDPGT,UDPGT 1-5,UGT1E

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 54579
MIM: 606430
HGNC: 12537
Ensembl: ENSG00000240224

Variants:

dbSNP: 54579
ClinVar: 54579
TCGA: ENSG00000240224
COSMIC: UGT1A5

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000240224	ENST00000373414	P35504
ENSG00000240224	ENST00000373414	Q5DSZ9

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Pentose and glucuronate interconversions	KEGG	ko00040
Ascorbate and aldarate metabolism	KEGG	ko00053
Steroid hormone biosynthesis	KEGG	ko00140
Retinol metabolism	KEGG	ko00830
Porphyrin and chlorophyll metabolism	KEGG	ko00860
Metabolism of xenobiotics by cytochrome P450	KEGG	ko00980
Drug metabolism - cytochrome P450	KEGG	ko00982
Drug metabolism - other enzymes	KEGG	ko00983
Pentose and glucuronate interconversions	KEGG	hsa00040
Ascorbate and aldarate metabolism	KEGG	hsa00053
Steroid hormone biosynthesis	KEGG	hsa00140
Retinol metabolism	KEGG	hsa00830
Porphyrin and chlorophyll metabolism	KEGG	hsa00860
Metabolism of xenobiotics by cytochrome P450	KEGG	hsa00980
Drug metabolism - cytochrome P450	KEGG	hsa00982
Drug metabolism - other enzymes	KEGG	hsa00983
Metabolic pathways	KEGG	hsa01100
Glucuronate pathway (uronate pathway)	KEGG	M00014
Chemical carcinogenesis	KEGG	hsa05204
Chemical carcinogenesis	KEGG	ko05204
Glucuronate pathway (uronate pathway)	KEGG	hsa_M00014
Metabolism	REACTOME	R-HSA-1430728
Biological oxidations	REACTOME	R-HSA-211859
Phase II conjugation	REACTOME	R-HSA-156580
Glucuronidation	REACTOME	R-HSA-156588

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA165958521	febuxostat	Chemical	ClinicalAnnotation	associated		PD	27798726
PA420	UGT1A1	Gene	VipGene	associated			15179404, 18004212, 18491077, 18518849, 19794410, 19997083, 8467709, 11434514
PA444065	Epilepsy	Disease	ClinicalAnnotation	associated	PK		28763744
PA444318	Gout	Disease	ClinicalAnnotation	associated		PD	27798726
PA445601	Osteosarcoma	Disease	ClinicalAnnotation	associated	PK		29791011
PA447216	Schizophrenia	Disease	ClinicalAnnotation	associated		PD
PA448320	allopurinol	Chemical	ClinicalAnnotation	associated		PD	27798726
PA450428	methotrexate	Chemical	ClinicalAnnotation	associated	PK		29791011
PA451257	risperidone	Chemical	ClinicalAnnotation	associated		PD
PA451846	valproic acid	Chemical	ClinicalAnnotation	associated	PK		28763744

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
19898482	2009	Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.	84
20628086	2010	Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.	11
18223459	2008	Genetic variations and haplotypes of UDP-glucuronosyltransferase 1A locus in a Korean population.	8
29710432	2018	A common polymorphic variant of UGT1A5 displays increased activity due to optimized cofactor binding.	1

Citation

Dessen P

UGT1A5 (UDP glucuronosyltransferase family 1 member A5)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/75469/ugt1a5