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UGT1A8 (UDP glucuronosyltransferase family 1 member A8)

Identity

Alias_namesUDP glycosyltransferase 1 family
Alias_symbol (synonym)UGT1H
Other aliasUDPGT
UDPGT 1-8
UGT-1H
UGT1-08
UGT1.8
UGT1A8S
HGNC (Hugo) UGT1A8
LocusID (NCBI) 54576
Atlas_Id 52824
Location 2q37.1  [Link to chromosome band 2q37]
Location_base_pair Starts at 233617645 and ends at 233773299 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
KMT2A (11q23.3) / UGT1A8 (2q37.1)UGT1A8 (2q37.1) / UGT1A8 (2q37.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)UGT1A8   12540
Cards
Entrez_Gene (NCBI)UGT1A8  54576  UDP glucuronosyltransferase family 1 member A8
AliasesUDPGT; UDPGT; UGT-1H; UGT1-08; 
UGT1.8; UGT1A8S; UGT1H
GeneCards (Weizmann)UGT1A8
Ensembl hg19 (Hinxton)ENSG00000242366 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000242366 [Gene_View]  chr2:233617645-233773299 [Contig_View]  UGT1A8 [Vega]
ICGC DataPortalENSG00000242366
TCGA cBioPortalUGT1A8
AceView (NCBI)UGT1A8
Genatlas (Paris)UGT1A8
WikiGenes54576
SOURCE (Princeton)UGT1A8
Genetics Home Reference (NIH)UGT1A8
Genomic and cartography
GoldenPath hg38 (UCSC)UGT1A8  -     chr2:233617645-233773299 +  2q37.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)UGT1A8  -     2q37.1   [Description]    (hg19-Feb_2009)
EnsemblUGT1A8 - 2q37.1 [CytoView hg19]  UGT1A8 - 2q37.1 [CytoView hg38]
Mapping of homologs : NCBIUGT1A8 [Mapview hg19]  UGT1A8 [Mapview hg38]
OMIM606433   
Gene and transcription
Genbank (Entrez)AF030310 AF462267 AF462268 AK313488 AY435143
RefSeq transcript (Entrez)NM_019076
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)UGT1A8
Cluster EST : UnigeneHs.554822 [ NCBI ]
CGAP (NCI)Hs.554822
Alternative Splicing GalleryENSG00000242366
Gene ExpressionUGT1A8 [ NCBI-GEO ]   UGT1A8 [ EBI - ARRAY_EXPRESS ]   UGT1A8 [ SEEK ]   UGT1A8 [ MEM ]
Gene Expression Viewer (FireBrowse)UGT1A8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54576
GTEX Portal (Tissue expression)UGT1A8
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HAW9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HAW9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HAW9
Splice isoforms : SwissVarQ9HAW9
Catalytic activity : Enzyme2.4.1.17 [ Enzyme-Expasy ]   2.4.1.172.4.1.17 [ IntEnz-EBI ]   2.4.1.17 [ BRENDA ]   2.4.1.17 [ KEGG ]   
PhosPhoSitePlusQ9HAW9
Domaine pattern : Prosite (Expaxy)UDPGT (PS00375)   
Domains : Interpro (EBI)UDP_glucos_trans   
Domain families : Pfam (Sanger)UDPGT (PF00201)   
Domain families : Pfam (NCBI)pfam00201   
Conserved Domain (NCBI)UGT1A8
DMDM Disease mutations54576
Blocks (Seattle)UGT1A8
SuperfamilyQ9HAW9
Human Protein AtlasENSG00000242366
Peptide AtlasQ9HAW9
HPRD07072
IPIIPI00039666   
Protein Interaction databases
DIP (DOE-UCLA)Q9HAW9
IntAct (EBI)Q9HAW9
FunCoupENSG00000242366
BioGRIDUGT1A8
STRING (EMBL)UGT1A8
ZODIACUGT1A8
Ontologies - Pathways
QuickGOQ9HAW9
Ontology : AmiGOretinoic acid binding  enzyme inhibitor activity  steroid binding  fatty acid binding  endoplasmic reticulum  endoplasmic reticulum membrane  fatty acid metabolic process  steroid metabolic process  coumarin metabolic process  glucuronosyltransferase activity  integral component of membrane  retinoic acid metabolic process  protein homodimerization activity  negative regulation of catalytic activity  negative regulation of fatty acid metabolic process  negative regulation of steroid metabolic process  protein heterodimerization activity  flavone metabolic process  flavonoid glucuronidation  xenobiotic glucuronidation  
Ontology : EGO-EBIretinoic acid binding  enzyme inhibitor activity  steroid binding  fatty acid binding  endoplasmic reticulum  endoplasmic reticulum membrane  fatty acid metabolic process  steroid metabolic process  coumarin metabolic process  glucuronosyltransferase activity  integral component of membrane  retinoic acid metabolic process  protein homodimerization activity  negative regulation of catalytic activity  negative regulation of fatty acid metabolic process  negative regulation of steroid metabolic process  protein heterodimerization activity  flavone metabolic process  flavonoid glucuronidation  xenobiotic glucuronidation  
Pathways : KEGG   
NDEx NetworkUGT1A8
Atlas of Cancer Signalling NetworkUGT1A8
Wikipedia pathwaysUGT1A8
Orthology - Evolution
OrthoDB54576
GeneTree (enSembl)ENSG00000242366
Phylogenetic Trees/Animal Genes : TreeFamUGT1A8
HOVERGENQ9HAW9
HOGENOMQ9HAW9
Homologs : HomoloGeneUGT1A8
Homology/Alignments : Family Browser (UCSC)UGT1A8
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUGT1A8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UGT1A8
dbVarUGT1A8
ClinVarUGT1A8
1000_GenomesUGT1A8 
Exome Variant ServerUGT1A8
ExAC (Exome Aggregation Consortium)UGT1A8 (select the gene name)
Genetic variants : HAPMAP54576
Genomic Variants (DGV)UGT1A8 [DGVbeta]
DECIPHERUGT1A8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUGT1A8 
Mutations
ICGC Data PortalUGT1A8 
TCGA Data PortalUGT1A8 
Broad Tumor PortalUGT1A8
OASIS PortalUGT1A8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUGT1A8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUGT1A8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch UGT1A8
DgiDB (Drug Gene Interaction Database)UGT1A8
DoCM (Curated mutations)UGT1A8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UGT1A8 (select a term)
intoGenUGT1A8
Cancer3DUGT1A8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606433   
Orphanet
MedgenUGT1A8
Genetic Testing Registry UGT1A8
NextProtQ9HAW9 [Medical]
TSGene54576
GENETestsUGT1A8
Target ValidationUGT1A8
Huge Navigator UGT1A8 [HugePedia]
snp3D : Map Gene to Disease54576
BioCentury BCIQUGT1A8
ClinGenUGT1A8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD54576
Chemical/Pharm GKB GenePA37183
Clinical trialUGT1A8
Miscellaneous
canSAR (ICR)UGT1A8 (select the gene name)
Probes
Litterature
PubMed69 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUGT1A8
EVEXUGT1A8
GoPubMedUGT1A8
iHOPUGT1A8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 13:01:52 CEST 2017

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