UGT1A9 (UDP glucuronosyltransferase family 1 member A9)

2003-08-01  

Identity

HGNC
LOCATION
2q37.1
LOCUSID
ALIAS
HLUGP4,LUGP4,UDPGT,UDPGT

Other Information

Locus ID:

NCBI: 54600
MIM: 606434
HGNC: 12541
Ensembl: ENSG00000241119

Variants:

dbSNP: 54600
ClinVar: 54600
TCGA: ENSG00000241119
COSMIC: UGT1A9

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000241119ENST00000354728O60656
ENSG00000241119ENST00000354728Q5DSZ5

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Pentose and glucuronate interconversionsKEGGko00040
Ascorbate and aldarate metabolismKEGGko00053
Steroid hormone biosynthesisKEGGko00140
Retinol metabolismKEGGko00830
Porphyrin and chlorophyll metabolismKEGGko00860
Metabolism of xenobiotics by cytochrome P450KEGGko00980
Drug metabolism - cytochrome P450KEGGko00982
Drug metabolism - other enzymesKEGGko00983
Pentose and glucuronate interconversionsKEGGhsa00040
Ascorbate and aldarate metabolismKEGGhsa00053
Steroid hormone biosynthesisKEGGhsa00140
Retinol metabolismKEGGhsa00830
Porphyrin and chlorophyll metabolismKEGGhsa00860
Metabolism of xenobiotics by cytochrome P450KEGGhsa00980
Drug metabolism - cytochrome P450KEGGhsa00982
Drug metabolism - other enzymesKEGGhsa00983
Metabolic pathwaysKEGGhsa01100
Glucuronate pathway (uronate pathway)KEGGM00014
Chemical carcinogenesisKEGGhsa05204
Chemical carcinogenesisKEGGko05204
Glucuronate pathway (uronate pathway)KEGGhsa_M00014
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
GlucuronidationREACTOMER-HSA-156588

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164748728mycophenolic acidChemicalClinicalAnnotation, MultilinkAnnotation, PathwayassociatedPK24220207, 25163792
PA164888966raltegravirChemicalVariantAnnotationassociatedPK
PA165110775SN-38ChemicalClinicalAnnotation, PathwayassociatedPKPD12181437, 16636344, 18221820, 24897286
PA165817016Kidney TransplantationDiseaseClinicalAnnotationassociatedPKPD16198654, 18946804, 20565459, 22210424, 22765258, 25163792
PA165958521febuxostatChemicalClinicalAnnotationassociatedPD27798726
PA166119041drug-induced liver injuryDiseaseMultilinkAnnotationassociated25446781
PA420UGT1A1GeneVipGeneassociated11037804, 11434514, 12019197, 12181437, 12969965, 14647407, 15179404, 1651156, 17058217, 17728214, 18004212, 18349289, 18466101, 18491077, 18518849, 19364970, 19390945, 19794410, 19852077, 19997083, 20562211, 8467709, 10381366
PA443622Carcinoma, Non-Small-Cell LungDiseaseClinicalAnnotationassociatedPKPD16636344, 18221820
PA444065EpilepsyDiseaseClinicalAnnotationassociatedPKPD15761113, 21806385, 27900402, 28763744
PA444318GoutDiseaseClinicalAnnotationassociatedPD27798726
PA445062NeoplasmsDiseaseClinicalAnnotationassociatedPD22912756
PA445601OsteosarcomaDiseaseClinicalAnnotationassociatedPK29791011
PA445629SeizuresDiseaseClinicalAnnotationassociatedPD27900402
PA446108Colorectal NeoplasmsDiseaseClinicalAnnotationassociatedPKPD12181437, 23386248
PA446443Liver Failure, AcuteDiseaseClinicalAnnotationassociatedPD
PA447216SchizophreniaDiseaseClinicalAnnotationassociatedPD
PA447230HIVDiseaseVariantAnnotationassociatedPK
PA448015acetaminophenChemicalClinicalAnnotation, Literature, MultilinkAnnotation, PathwayassociatedPD11714888, 16696573, 23279026, 26049587
PA448320allopurinolChemicalClinicalAnnotationassociatedPD27798726
PA449957ibuprofenChemicalPathwayassociated25502615
PA450085irinotecanChemicalClinicalAnnotationassociatedPKPD12181437, 16636344, 18221820, 23386248
PA450428methotrexateChemicalClinicalAnnotationassociatedPK29791011
PA450566mycophenolate mofetilChemicalClinicalAnnotationassociatedPKPD16198654, 18946804, 20565459, 22210424, 22765258
PA450731oxazepamChemicalPathwayassociated
PA450732oxcarbazepineChemicalClinicalAnnotationassociatedPD27900402
PA450911phenobarbitalChemicalPathwayassociated26049587
PA450947phenytoinChemicalPathwayassociated26049587
PA451141propofolChemicalClinicalAnnotation, VariantAnnotationassociatedPKPD18816295
PA451257risperidoneChemicalClinicalAnnotationassociatedPD
PA451363simvastatinChemicalClinicalAnnotationassociatedPD25493567
PA451550sulfinpyrazoneChemicalClinicalAnnotationassociatedPK22981363
PA451846valproic acidChemicalClinicalAnnotation, VariantAnnotationassociatedPKPD15761113, 21806385, 28763744
PA7000sorafenibChemicalClinicalAnnotation, PathwayassociatedPD22912756, 28362716

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
198984822009Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.84
193495402009Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics.74
166363442006Comprehensive analysis of UGT1A polymorphisms predictive for pharmacokinetics and treatment outcome in patients with non-small-cell lung cancer treated with irinotecan and cisplatin.67
193649702009Predictive role of the UGT1A1, UGT1A7, and UGT1A9 genetic variants and their haplotypes on the outcome of metastatic colorectal cancer patients treated with fluorouracil, leucovorin, and irinotecan.65
193649702009Predictive role of the UGT1A1, UGT1A7, and UGT1A9 genetic variants and their haplotypes on the outcome of metastatic colorectal cancer patients treated with fluorouracil, leucovorin, and irinotecan.65
175583052007Irinotecan pharmacokinetics/pharmacodynamics and UGT1A genetic polymorphisms in Japanese: roles of UGT1A1*6 and *28.63
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
157091932005UGT1A7 and UGT1A9 polymorphisms predict response and toxicity in colorectal cancer patients treated with capecitabine/irinotecan.46
152580992004The main role of UGT1A9 in the hepatic metabolism of mycophenolic acid and the effects of naturally occurring variants.38

Citation

Dessen P

UGT1A9 (UDP glucuronosyltransferase family 1 member A9)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/42764/ugt1a9