Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 7365
MIM: 600070
HGNC: 12544
Ensembl: ENSG00000109181
Variants:
dbSNP: 7365
ClinVar: 7365
TCGA: ENSG00000109181
COSMIC: UGT2B10
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000109181 | ENST00000265403 | P36537 |
| ENSG00000109181 | ENST00000458688 | P36537 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA156 | ESR1 | Gene | Literature, MultilinkAnnotation | associated | 24879639 | ||
| PA166114414 | cotinine | Chemical | ClinicalAnnotation | associated | PK | ||
| PA445876 | Tobacco Use Disorder | Disease | ClinicalAnnotation | associated | PK | ||
| PA450626 | nicotine | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PK | PD | 17909004, 18300939, 24192532 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 32532831 | 2020 | UGT2B10 Genotype Influences Serum Cotinine Levels and Is a Primary Determinant of Higher Cotinine in African American Smokers. | 5 |
| 32532831 | 2020 | UGT2B10 Genotype Influences Serum Cotinine Levels and Is a Primary Determinant of Higher Cotinine in African American Smokers. | 5 |
| 29431853 | 2018 | rs294775 is a cis-regulatory SNP for human UGT2B10. | 0 |
| 29438977 | 2018 | Post-transcriptional Regulation of UGT2B10 Hepatic Expression and Activity by Alternative Splicing. | 0 |
| 29460622 | 2018 | Influence of UGT2B10 Genotype on Urinary Excretion of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol- N-glucuronide by African American Smokers. | 2 |
| 29691239 | 2018 | Disposition of Mianserin and Cyclizine in UGT2B10-Overexpressing Human Embryonic Kidney 293 Cells: Identification of UGT2B10 as a Novel N-Glucosidation Enzyme and Breast Cancer Resistance Protein as an N-Glucoside Transporter. | 0 |
| 29431853 | 2018 | rs294775 is a cis-regulatory SNP for human UGT2B10. | 0 |
| 29438977 | 2018 | Post-transcriptional Regulation of UGT2B10 Hepatic Expression and Activity by Alternative Splicing. | 0 |
| 29460622 | 2018 | Influence of UGT2B10 Genotype on Urinary Excretion of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol- N-glucuronide by African American Smokers. | 2 |
| 29691239 | 2018 | Disposition of Mianserin and Cyclizine in UGT2B10-Overexpressing Human Embryonic Kidney 293 Cells: Identification of UGT2B10 as a Novel N-Glucosidation Enzyme and Breast Cancer Resistance Protein as an N-Glucoside Transporter. | 0 |
| 28264876 | 2017 | Low Cotinine Glucuronidation Results in Higher Serum and Saliva Cotinine in African American Compared to White Smokers. | 18 |
| 28264876 | 2017 | Low Cotinine Glucuronidation Results in Higher Serum and Saliva Cotinine in African American Compared to White Smokers. | 18 |
| 26669329 | 2016 | Human UDP-Glucuronosyltransferase (UGT) 2B10: Validation of Cotinine as a Selective Probe Substrate, Inhibition by UGT Enzyme-Selective Inhibitors and Antidepressant and Antipsychotic Drugs, and Structural Determinants of Enzyme Inhibition. | 5 |
| 26669329 | 2016 | Human UDP-Glucuronosyltransferase (UGT) 2B10: Validation of Cotinine as a Selective Probe Substrate, Inhibition by UGT Enzyme-Selective Inhibitors and Antidepressant and Antipsychotic Drugs, and Structural Determinants of Enzyme Inhibition. | 5 |
| 25233931 | 2014 | Nicotine N-glucuronidation relative to N-oxidation and C-oxidation and UGT2B10 genotype in five ethnic/racial groups. | 107 |
Citation
Dessen P
UGT2B10 (UDP glucuronosyltransferase family 2 member B10)
Atlas Genet Cytogenet Oncol Haematol. 2008-05-01
Online version: http://atlasgeneticsoncology.org/gene/50141/ugt2b10
