UGT2B15 (UDP glucuronosyltransferase family 2 member B15)

2007-02-01 Affiliation

Identity

HGNC

UGT2B15

LOCATION

4q13.2

LOCUSID

7366

ALIAS

HLUG4,UDPGT

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 7366
MIM: 600069
HGNC: 12546
Ensembl: ENSG00000196620

Variants:

dbSNP: 7366
ClinVar: 7366
TCGA: ENSG00000196620
COSMIC: UGT2B15

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000196620	ENST00000338206	P54855

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Pentose and glucuronate interconversions	KEGG	ko00040
Ascorbate and aldarate metabolism	KEGG	ko00053
Steroid hormone biosynthesis	KEGG	ko00140
Retinol metabolism	KEGG	ko00830
Porphyrin and chlorophyll metabolism	KEGG	ko00860
Metabolism of xenobiotics by cytochrome P450	KEGG	ko00980
Drug metabolism - cytochrome P450	KEGG	ko00982
Drug metabolism - other enzymes	KEGG	ko00983
Pentose and glucuronate interconversions	KEGG	hsa00040
Ascorbate and aldarate metabolism	KEGG	hsa00053
Steroid hormone biosynthesis	KEGG	hsa00140
Retinol metabolism	KEGG	hsa00830
Porphyrin and chlorophyll metabolism	KEGG	hsa00860
Metabolism of xenobiotics by cytochrome P450	KEGG	hsa00980
Drug metabolism - cytochrome P450	KEGG	hsa00982
Drug metabolism - other enzymes	KEGG	hsa00983
Metabolic pathways	KEGG	hsa01100
Glucuronate pathway (uronate pathway)	KEGG	M00014
Chemical carcinogenesis	KEGG	hsa05204
Chemical carcinogenesis	KEGG	ko05204
Glucuronate pathway (uronate pathway)	KEGG	hsa_M00014
Metabolism	REACTOME	R-HSA-1430728
Biological oxidations	REACTOME	R-HSA-211859
Phase II conjugation	REACTOME	R-HSA-156580
Glucuronidation	REACTOME	R-HSA-156588

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA156	ESR1	Gene	Literature, MultilinkAnnotation	associated			24879639
PA166114434	sipoglitazar	Chemical	ClinicalAnnotation, VariantAnnotation	associated	PK	PD	22960998, 23444281
PA166123026	progression-free survival	Disease	VariantAnnotation	not associated		PD	15952058
PA166123207	overall survival	Disease	VariantAnnotation	not associated		PD	15952058
PA166123366	event-free survival	Disease	VariantAnnotation	associated		PD	23842856
PA166127658	Recurrence free survival	Disease	VariantAnnotation	not associated		PD
PA166131338	tamoxifen-n-glucuronide	Chemical	MultilinkAnnotation	not associated			27098059
PA443560	Breast Neoplasms	Disease	VariantAnnotation	ambiguous		PD	15952058, 23842856
PA445208	Pain	Disease	ClinicalAnnotation	associated		PD	30908574
PA448015	acetaminophen	Chemical	ClinicalAnnotation, Literature, MultilinkAnnotation, Pathway, VariantAnnotation	associated	PK	PD	16696573, 26049587, 30908574
PA450267	lorazepam	Chemical	ClinicalAnnotation, Pathway	associated	PK		15961980
PA450731	oxazepam	Chemical	ClinicalAnnotation, Pathway	associated	PK		15044558, 29737521
PA450911	phenobarbital	Chemical	Pathway	associated			26049587
PA450947	phenytoin	Chemical	Pathway	associated			26049587
PA451581	tamoxifen	Chemical	VariantAnnotation	ambiguous		PD	15952058, 23842856
PA452621	antineoplastic agents	Chemical	VariantAnnotation	ambiguous		PD	15952058, 23842856

References

Pubmed ID	Year	Title	Citations
15952058	2005	Association of genetic variation in tamoxifen-metabolizing enzymes with overall survival and recurrence of disease in breast cancer patients.	87
15952058	2005	Association of genetic variation in tamoxifen-metabolizing enzymes with overall survival and recurrence of disease in breast cancer patients.	87
19898482	2009	Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.	84
17244352	2007	Genetic variants of CYP3A5, CYP2D6, SULT1A1, UGT2B15 and tamoxifen response in postmenopausal patients with breast cancer.	73
21365123	2011	Steroidogenic enzymes and stem cell markers are upregulated during androgen deprivation in prostate cancer.	38
17507624	2007	Evaluation of genetic variations in the androgen and estrogen metabolic pathways as risk factors for sporadic and familial prostate cancer.	37
17848572	2007	UDP-glucuronosyltransferase 2B15 (UGT2B15) and UGT2B17 enzymes are major determinants of the androgen response in prostate cancer LNCaP cells.	33
15044558	2004	UDP-glucuronosyltransferase (UGT) 2B15 pharmacogenetics: UGT2B15 D85Y genotype and gender are major determinants of oxazepam glucuronidation by human liver.	28
15044558	2004	UDP-glucuronosyltransferase (UGT) 2B15 pharmacogenetics: UGT2B15 D85Y genotype and gender are major determinants of oxazepam glucuronidation by human liver.	28
12386133	2002	Stereoselective conjugation of oxazepam by human UDP-glucuronosyltransferases (UGTs): S-oxazepam is glucuronidated by UGT2B15, while R-oxazepam is glucuronidated by UGT2B7 and UGT1A9.	27

Citation

Dessen P

UGT2B15 (UDP glucuronosyltransferase family 2 member B15)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46029/ugt2b15