Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 7366
MIM: 600069
HGNC: 12546
Ensembl: ENSG00000196620
Variants:
dbSNP: 7366
ClinVar: 7366
TCGA: ENSG00000196620
COSMIC: UGT2B15
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000196620 | ENST00000338206 | P54855 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA156 | ESR1 | Gene | Literature, MultilinkAnnotation | associated | 24879639 | ||
| PA166114434 | sipoglitazar | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PK | PD | 22960998, 23444281 |
| PA166123026 | progression-free survival | Disease | VariantAnnotation | not associated | PD | 15952058 | |
| PA166123207 | overall survival | Disease | VariantAnnotation | not associated | PD | 15952058 | |
| PA166123366 | event-free survival | Disease | VariantAnnotation | associated | PD | 23842856 | |
| PA166127658 | Recurrence free survival | Disease | VariantAnnotation | not associated | PD | ||
| PA166131338 | tamoxifen-n-glucuronide | Chemical | MultilinkAnnotation | not associated | 27098059 | ||
| PA443560 | Breast Neoplasms | Disease | VariantAnnotation | ambiguous | PD | 15952058, 23842856 | |
| PA445208 | Pain | Disease | ClinicalAnnotation | associated | PD | 30908574 | |
| PA448015 | acetaminophen | Chemical | ClinicalAnnotation, Literature, MultilinkAnnotation, Pathway, VariantAnnotation | associated | PK | PD | 16696573, 26049587, 30908574 |
| PA450267 | lorazepam | Chemical | ClinicalAnnotation, Pathway | associated | PK | 15961980 | |
| PA450731 | oxazepam | Chemical | ClinicalAnnotation, Pathway | associated | PK | 15044558, 29737521 | |
| PA450911 | phenobarbital | Chemical | Pathway | associated | 26049587 | ||
| PA450947 | phenytoin | Chemical | Pathway | associated | 26049587 | ||
| PA451581 | tamoxifen | Chemical | VariantAnnotation | ambiguous | PD | 15952058, 23842856 | |
| PA452621 | antineoplastic agents | Chemical | VariantAnnotation | ambiguous | PD | 15952058, 23842856 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35626664 | 2022 | Identification of UDP-Glucuronosyltransferase 2B15 (UGT2B15) as a Target for IGF1 and Insulin Action. | 1 |
| 35626664 | 2022 | Identification of UDP-Glucuronosyltransferase 2B15 (UGT2B15) as a Target for IGF1 and Insulin Action. | 1 |
| 32660355 | 2021 | Expression of UDP Glucuronosyltransferases 2B15 and 2B17 is associated with methylation status in prostate cancer cells. | 3 |
| 32660355 | 2021 | Expression of UDP Glucuronosyltransferases 2B15 and 2B17 is associated with methylation status in prostate cancer cells. | 3 |
| 32086297 | 2020 | Coordinated Regulation of UGT2B15 Expression by Long Noncoding RNA LINC00574 and hsa-miR-129-5p in HepaRG Cells. | 5 |
| 32176075 | 2020 | The correlation between UDP-glucuronosyltransferase polymorphisms and environmental endocrine disruptors levels in polycystic ovary syndrome patients. | 4 |
| 32086297 | 2020 | Coordinated Regulation of UGT2B15 Expression by Long Noncoding RNA LINC00574 and hsa-miR-129-5p in HepaRG Cells. | 5 |
| 32176075 | 2020 | The correlation between UDP-glucuronosyltransferase polymorphisms and environmental endocrine disruptors levels in polycystic ovary syndrome patients. | 4 |
| 29367276 | 2018 | Regulation of UDP-Glucuronosyltransferase 2B15 by miR-331-5p in Prostate Cancer Cells Involves Canonical and Noncanonical Target Sites. | 7 |
| 30066917 | 2018 | Bioinformatic analysis suggests that UGT2B15 activates the Hippo‑YAP signaling pathway leading to the pathogenesis of gastric cancer. | 7 |
| 29367276 | 2018 | Regulation of UDP-Glucuronosyltransferase 2B15 by miR-331-5p in Prostate Cancer Cells Involves Canonical and Noncanonical Target Sites. | 7 |
| 30066917 | 2018 | Bioinformatic analysis suggests that UGT2B15 activates the Hippo‑YAP signaling pathway leading to the pathogenesis of gastric cancer. | 7 |
| 28882566 | 2017 | Genetic variations in UGT2B28, UGT2B17, UGT2B15 genes and the risk of prostate cancer: A case-control study. | 3 |
| 28962835 | 2017 | Identification and validation of the microRNA response elements in the 3'-untranslated region of the UDP glucuronosyltransferase (UGT) 2B7 and 2B15 genes by a functional genomics approach. | 14 |
| 28882566 | 2017 | Genetic variations in UGT2B28, UGT2B17, UGT2B15 genes and the risk of prostate cancer: A case-control study. | 3 |
Citation
Dessen P
UGT2B15 (UDP glucuronosyltransferase family 2 member B15)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/46029/ugt2b15
