UGT2B17 (UDP glucuronosyltransferase family 2 member B17)

2007-02-01  

Identity

HGNC
LOCATION
4q13.2
LOCUSID
ALIAS
BMND12,UDPGT2B17

Other Information

Locus ID:

NCBI: 7367
MIM: 601903
HGNC: 12547
Ensembl: ENSG00000197888

Variants:

dbSNP: 7367
ClinVar: 7367
TCGA: ENSG00000197888
COSMIC: UGT2B17

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197888ENST00000317746O75795

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Pentose and glucuronate interconversionsKEGGko00040
Ascorbate and aldarate metabolismKEGGko00053
Steroid hormone biosynthesisKEGGko00140
Retinol metabolismKEGGko00830
Porphyrin and chlorophyll metabolismKEGGko00860
Metabolism of xenobiotics by cytochrome P450KEGGko00980
Drug metabolism - cytochrome P450KEGGko00982
Drug metabolism - other enzymesKEGGko00983
Pentose and glucuronate interconversionsKEGGhsa00040
Ascorbate and aldarate metabolismKEGGhsa00053
Steroid hormone biosynthesisKEGGhsa00140
Retinol metabolismKEGGhsa00830
Porphyrin and chlorophyll metabolismKEGGhsa00860
Metabolism of xenobiotics by cytochrome P450KEGGhsa00980
Drug metabolism - cytochrome P450KEGGhsa00982
Drug metabolism - other enzymesKEGGhsa00983
Metabolic pathwaysKEGGhsa01100
Glucuronate pathway (uronate pathway)KEGGM00014
Chemical carcinogenesisKEGGhsa05204
Chemical carcinogenesisKEGGko05204
Glucuronate pathway (uronate pathway)KEGGhsa_M00014
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
GlucuronidationREACTOMER-HSA-156588

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA449957ibuprofenChemicalPathwayassociated25502615

References

Pubmed IDYearTitleCitations
381986662024Promiscuity and Quantitative Contribution of UGT2B17 in Drug and Steroid Metabolism Determined by Experimental and Computational Approaches.0
381986662024Promiscuity and Quantitative Contribution of UGT2B17 in Drug and Steroid Metabolism Determined by Experimental and Computational Approaches.0
363479652023Extensive metabolic consequences of human glycosyltransferase gene knockouts in prostate cancer.2
371746952023A Non-Canonical Role for the Glycosyltransferase Enzyme UGT2B17 as a Novel Constituent of the B Cell Receptor Signalosome.1
363479652023Extensive metabolic consequences of human glycosyltransferase gene knockouts in prostate cancer.2
371746952023A Non-Canonical Role for the Glycosyltransferase Enzyme UGT2B17 as a Novel Constituent of the B Cell Receptor Signalosome.1
361095182022Pangenomic analysis of Chinese gastric cancer.7
361095182022Pangenomic analysis of Chinese gastric cancer.7
326603552021Expression of UDP Glucuronosyltransferases 2B15 and 2B17 is associated with methylation status in prostate cancer cells.3
343615612021Potential Assessment of UGT2B17 Inhibition by Salicylic Acid in Human Supersomes In Vitro.2
326603552021Expression of UDP Glucuronosyltransferases 2B15 and 2B17 is associated with methylation status in prostate cancer cells.3
343615612021Potential Assessment of UGT2B17 Inhibition by Salicylic Acid in Human Supersomes In Vitro.2
309675972020Prognostic impact of genetic variants of CYP19A1 and UGT2B17 in a randomized trial for endocrine-responsive postmenopausal breast cancer.7
320472962020Alternative promoters control UGT2B17-dependent androgen catabolism in prostate cancer and its influence on progression.11
324189952020UGT2B17 modifies drug response in chronic lymphocytic leukaemia.13

Citation

Dessen P

UGT2B17 (UDP glucuronosyltransferase family 2 member B17)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45518/ugt2b17