UGT2B28 (UDP glucuronosyltransferase family 2 member B28)

2017-01-01  

Identity

HGNC
LOCATION
4q13.2
LOCUSID
ALIAS
-

Other Information

Locus ID:

NCBI: 54490
MIM: 606497
HGNC: 13479
Ensembl: ENSG00000135226

Variants:

dbSNP: 54490
ClinVar: 54490
TCGA: ENSG00000135226
COSMIC: UGT2B28

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135226ENST00000335568Q9BY64
ENSG00000135226ENST00000511240Q9BY64

Expression (GTEx)

0
1

Pathways

PathwaySourceExternal ID
Pentose and glucuronate interconversionsKEGGko00040
Ascorbate and aldarate metabolismKEGGko00053
Steroid hormone biosynthesisKEGGko00140
Retinol metabolismKEGGko00830
Porphyrin and chlorophyll metabolismKEGGko00860
Metabolism of xenobiotics by cytochrome P450KEGGko00980
Drug metabolism - cytochrome P450KEGGko00982
Drug metabolism - other enzymesKEGGko00983
Pentose and glucuronate interconversionsKEGGhsa00040
Ascorbate and aldarate metabolismKEGGhsa00053
Steroid hormone biosynthesisKEGGhsa00140
Retinol metabolismKEGGhsa00830
Porphyrin and chlorophyll metabolismKEGGhsa00860
Metabolism of xenobiotics by cytochrome P450KEGGhsa00980
Drug metabolism - cytochrome P450KEGGhsa00982
Drug metabolism - other enzymesKEGGhsa00983
Metabolic pathwaysKEGGhsa01100
Glucuronate pathway (uronate pathway)KEGGM00014
Chemical carcinogenesisKEGGhsa05204
Chemical carcinogenesisKEGGko05204
Glucuronate pathway (uronate pathway)KEGGhsa_M00014
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
GlucuronidationREACTOMER-HSA-156588

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
198984822009Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.84
195723762009Copy-number variations (CNVs) of the human sex steroid metabolizing genes UGT2B17 and UGT2B28 and their associations with a UGT2B15 functional polymorphism.19
200566422010Genetic variation of genes involved in dihydrotestosterone metabolism and the risk of prostate cancer.14
262156102016The UGT2B28 Sex-steroid Inactivation Pathway Is a Regulator of Steroidogenesis and Modifies the Risk of Prostate Cancer Progression.10
216791492011Quantitative analysis of UGT2B28 mRNA expression by real-time RT-PCR and application to human tissue distribution study.2
288825662017Genetic variations in UGT2B28, UGT2B17, UGT2B15 genes and the risk of prostate cancer: A case-control study.2
293571082018rs142362919 and rs7681187 Are cis-Regulatory Variations for Human UGT2B28 in Breast.0
306286802019Whole exome sequencing identifies hemizygous deletions in the UGT2B28 and USP17L2 genes in a three‑generation family with endometriosis.0
318059792019Ages of hepatocellular carcinoma occurrence and life expectancy are associated with a UGT2B28 genomic variation.0

Citation

Dessen P

UGT2B28 (UDP glucuronosyltransferase family 2 member B28)

Atlas Genet Cytogenet Oncol Haematol. 2017-01-01

Online version: http://atlasgeneticsoncology.org/gene/56693/ugt2b28