UGT2B7 (UDP glucuronosyltransferase family 2 member B7)

2008-08-01 Affiliation

Identity

HGNC

UGT2B7

LOCATION

4q13.2

LOCUSID

7364

ALIAS

UDPGT

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 7364
MIM: 600068
HGNC: 12554
Ensembl: ENSG00000171234

Variants:

dbSNP: 7364
ClinVar: 7364
TCGA: ENSG00000171234
COSMIC: UGT2B7

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000171234	ENST00000305231	P16662
ENSG00000171234	ENST00000502942	D6RH08
ENSG00000171234	ENST00000508661	E9PBP8
ENSG00000171234	ENST00000622664	A0A087X084

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Pentose and glucuronate interconversions	KEGG	ko00040
Ascorbate and aldarate metabolism	KEGG	ko00053
Steroid hormone biosynthesis	KEGG	ko00140
Retinol metabolism	KEGG	ko00830
Porphyrin and chlorophyll metabolism	KEGG	ko00860
Metabolism of xenobiotics by cytochrome P450	KEGG	ko00980
Drug metabolism - cytochrome P450	KEGG	ko00982
Drug metabolism - other enzymes	KEGG	ko00983
Pentose and glucuronate interconversions	KEGG	hsa00040
Ascorbate and aldarate metabolism	KEGG	hsa00053
Steroid hormone biosynthesis	KEGG	hsa00140
Retinol metabolism	KEGG	hsa00830
Porphyrin and chlorophyll metabolism	KEGG	hsa00860
Metabolism of xenobiotics by cytochrome P450	KEGG	hsa00980
Drug metabolism - cytochrome P450	KEGG	hsa00982
Drug metabolism - other enzymes	KEGG	hsa00983
Metabolic pathways	KEGG	hsa01100
Glucuronate pathway (uronate pathway)	KEGG	M00014
Chemical carcinogenesis	KEGG	hsa05204
Chemical carcinogenesis	KEGG	ko05204
Glucuronate pathway (uronate pathway)	KEGG	hsa_M00014
Metabolism	REACTOME	R-HSA-1430728
Biological oxidations	REACTOME	R-HSA-211859
Phase II conjugation	REACTOME	R-HSA-156580
Glucuronidation	REACTOME	R-HSA-156588

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA133950441	hmg coa reductase inhibitors	Chemical	Pathway	associated
PA156	ESR1	Gene	Literature, MultilinkAnnotation	associated			24879639
PA164747039	aprepitant	Chemical	MultilinkAnnotation	associated			26053558
PA164748728	mycophenolic acid	Chemical	Pathway	associated			24220207
PA165108401	Acute coronary syndrome	Disease	ClinicalAnnotation	associated	PK		25935875
PA165374673	ticagrelor	Chemical	ClinicalAnnotation	associated	PK		25935875
PA165817016	Kidney Transplantation	Disease	ClinicalAnnotation	associated		PD	24681964
PA166131338	tamoxifen-n-glucuronide	Chemical	MultilinkAnnotation	not associated			27098059
PA166163692	diclofenac acyl glucuronide	Chemical	VariantAnnotation	associated	PK		29203276
PA166177606	(S)-methadone	Chemical	ClinicalAnnotation	associated	PK		17178267
PA166178312	(R)-methadone	Chemical	ClinicalAnnotation	associated	PK		17178267
PA443355	Anemia, Sickle Cell	Disease	ClinicalAnnotation	associated	PK		17724700
PA443560	Breast Neoplasms	Disease	VariantAnnotation	not associated		PD
PA444065	Epilepsy	Disease	ClinicalAnnotation	associated	PK	PD	21806385, 23099353, 23263737, 25823783, 27406852, 28837897, 29243113
PA445043	Opioid-Related Disorders	Disease	ClinicalAnnotation	associated	PK	PD	17178267, 22676193
PA445208	Pain	Disease	ClinicalAnnotation, VariantAnnotation	associated		PD	24256307, 29502154, 31607718
PA445210	Pain, Postoperative	Disease	ClinicalAnnotation	associated		PD	32401749
PA445506	Recurrence	Disease	VariantAnnotation	not associated		PD
PA447230	HIV	Disease	ClinicalAnnotation	associated	PK		19779319, 20860463, 23172109, 24080498, 24729586, 26774523
PA448500	atorvastatin	Chemical	Pathway	associated
PA448685	buprenorphine	Chemical	VariantAnnotation	associated		PD	24256307
PA448785	carbamazepine	Chemical	ClinicalAnnotation, Pathway	associated	PK		21738081
PA449088	codeine	Chemical	ClinicalAnnotation	associated		PD	25752520
PA449441	efavirenz	Chemical	ClinicalAnnotation, MultilinkAnnotation	associated	PK		19487252, 19779319, 20860463, 23172109, 24080498, 24729586, 26774523
PA449599	fentanyl	Chemical	ClinicalAnnotation	associated		PD	32401749
PA449683	flurbiprofen	Chemical	VariantAnnotation	associated	PK		21856293
PA449688	fluvastatin	Chemical	Pathway	associated
PA449957	ibuprofen	Chemical	Pathway	associated			25502615
PA450164	lamotrigine	Chemical	ClinicalAnnotation	associated	PK	PD	23263737, 26213157, 26790665, 27096250
PA450268	losartan	Chemical	Pathway	associated
PA450272	lovastatin	Chemical	Pathway	associated
PA450401	methadone	Chemical	ClinicalAnnotation	associated	PK	PD	17178267, 22676193
PA450550	morphine	Chemical	ClinicalAnnotation	associated	PK	PD	12185559, 16580900, 17724700, 24703092, 25340733, 28063968, 31607718
PA450566	mycophenolate mofetil	Chemical	ClinicalAnnotation	associated		PD	24681964
PA450731	oxazepam	Chemical	Pathway	associated
PA450732	oxcarbazepine	Chemical	ClinicalAnnotation	associated	PK	PD	25823783, 28837897
PA450741	oxycodone	Chemical	ClinicalAnnotation	associated		PD	29502154
PA451363	simvastatin	Chemical	Pathway	associated
PA451581	tamoxifen	Chemical	VariantAnnotation	not associated		PD
PA451846	valproic acid	Chemical	ClinicalAnnotation, VariantAnnotation	associated	PK	PD	17687269, 21806385, 23099353, 27406852, 29243113
PA451954	zidovudine	Chemical	ClinicalAnnotation, Pathway	associated	PK		22960662

References

Pubmed ID	Year	Title	Citations
19898482	2009	Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.	84
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
17178267	2006	ABCB1 and cytochrome P450 genotypes and phenotypes: influence on methadone plasma levels and response to treatment.	61
18719619	2009	Pharmacogenetics of neonatal opioid toxicity following maternal use of codeine during breastfeeding: a case-control study.	54
16580900	2006	Environmental and genetic factors associated with morphine response in the postoperative period.	50
17241877	2007	Genetic susceptibility to diclofenac-induced hepatotoxicity: contribution of UGT2B7, CYP2C8, and ABCC2 genotypes.	49
17241877	2007	Genetic susceptibility to diclofenac-induced hepatotoxicity: contribution of UGT2B7, CYP2C8, and ABCC2 genotypes.	49
19779319	2009	CYP2B6, CYP2A6 and UGT2B7 genetic polymorphisms are predictors of efavirenz mid-dose concentration in HIV-infected patients.	44
19779319	2009	CYP2B6, CYP2A6 and UGT2B7 genetic polymorphisms are predictors of efavirenz mid-dose concentration in HIV-infected patients.	44
14871856	2004	Correlation between UDP-glucuronosyltransferase genotypes and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone glucuronidation phenotype in human liver microsomes.	41

Citation

Dessen P

UGT2B7 (UDP glucuronosyltransferase family 2 member B7)

Atlas Genet Cytogenet Oncol Haematol. 2008-08-01

Online version: http://atlasgeneticsoncology.org/gene/50279/ugt2b7