Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 7364
MIM: 600068
HGNC: 12554
Ensembl: ENSG00000171234
Variants:
dbSNP: 7364
ClinVar: 7364
TCGA: ENSG00000171234
COSMIC: UGT2B7
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000171234 | ENST00000305231 | P16662 |
| ENSG00000171234 | ENST00000502942 | D6RH08 |
| ENSG00000171234 | ENST00000508661 | E9PBP8 |
| ENSG00000171234 | ENST00000622664 | A0A087X084 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA133950441 | hmg coa reductase inhibitors | Chemical | Pathway | associated | |||
| PA156 | ESR1 | Gene | Literature, MultilinkAnnotation | associated | 24879639 | ||
| PA164747039 | aprepitant | Chemical | MultilinkAnnotation | associated | 26053558 | ||
| PA164748728 | mycophenolic acid | Chemical | Pathway | associated | 24220207 | ||
| PA165108401 | Acute coronary syndrome | Disease | ClinicalAnnotation | associated | PK | 25935875 | |
| PA165374673 | ticagrelor | Chemical | ClinicalAnnotation | associated | PK | 25935875 | |
| PA165817016 | Kidney Transplantation | Disease | ClinicalAnnotation | associated | PD | 24681964 | |
| PA166131338 | tamoxifen-n-glucuronide | Chemical | MultilinkAnnotation | not associated | 27098059 | ||
| PA166163692 | diclofenac acyl glucuronide | Chemical | VariantAnnotation | associated | PK | 29203276 | |
| PA166177606 | (S)-methadone | Chemical | ClinicalAnnotation | associated | PK | 17178267 | |
| PA166178312 | (R)-methadone | Chemical | ClinicalAnnotation | associated | PK | 17178267 | |
| PA443355 | Anemia, Sickle Cell | Disease | ClinicalAnnotation | associated | PK | 17724700 | |
| PA443560 | Breast Neoplasms | Disease | VariantAnnotation | not associated | PD | ||
| PA444065 | Epilepsy | Disease | ClinicalAnnotation | associated | PK | PD | 21806385, 23099353, 23263737, 25823783, 27406852, 28837897, 29243113 |
| PA445043 | Opioid-Related Disorders | Disease | ClinicalAnnotation | associated | PK | PD | 17178267, 22676193 |
| PA445208 | Pain | Disease | ClinicalAnnotation, VariantAnnotation | associated | PD | 24256307, 29502154, 31607718 | |
| PA445210 | Pain, Postoperative | Disease | ClinicalAnnotation | associated | PD | 32401749 | |
| PA445506 | Recurrence | Disease | VariantAnnotation | not associated | PD | ||
| PA447230 | HIV | Disease | ClinicalAnnotation | associated | PK | 19779319, 20860463, 23172109, 24080498, 24729586, 26774523 | |
| PA448500 | atorvastatin | Chemical | Pathway | associated | |||
| PA448685 | buprenorphine | Chemical | VariantAnnotation | associated | PD | 24256307 | |
| PA448785 | carbamazepine | Chemical | ClinicalAnnotation, Pathway | associated | PK | 21738081 | |
| PA449088 | codeine | Chemical | ClinicalAnnotation | associated | PD | 25752520 | |
| PA449441 | efavirenz | Chemical | ClinicalAnnotation, MultilinkAnnotation | associated | PK | 19487252, 19779319, 20860463, 23172109, 24080498, 24729586, 26774523 | |
| PA449599 | fentanyl | Chemical | ClinicalAnnotation | associated | PD | 32401749 | |
| PA449683 | flurbiprofen | Chemical | VariantAnnotation | associated | PK | 21856293 | |
| PA449688 | fluvastatin | Chemical | Pathway | associated | |||
| PA449957 | ibuprofen | Chemical | Pathway | associated | 25502615 | ||
| PA450164 | lamotrigine | Chemical | ClinicalAnnotation | associated | PK | PD | 23263737, 26213157, 26790665, 27096250 |
| PA450268 | losartan | Chemical | Pathway | associated | |||
| PA450272 | lovastatin | Chemical | Pathway | associated | |||
| PA450401 | methadone | Chemical | ClinicalAnnotation | associated | PK | PD | 17178267, 22676193 |
| PA450550 | morphine | Chemical | ClinicalAnnotation | associated | PK | PD | 12185559, 16580900, 17724700, 24703092, 25340733, 28063968, 31607718 |
| PA450566 | mycophenolate mofetil | Chemical | ClinicalAnnotation | associated | PD | 24681964 | |
| PA450731 | oxazepam | Chemical | Pathway | associated | |||
| PA450732 | oxcarbazepine | Chemical | ClinicalAnnotation | associated | PK | PD | 25823783, 28837897 |
| PA450741 | oxycodone | Chemical | ClinicalAnnotation | associated | PD | 29502154 | |
| PA451363 | simvastatin | Chemical | Pathway | associated | |||
| PA451581 | tamoxifen | Chemical | VariantAnnotation | not associated | PD | ||
| PA451846 | valproic acid | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PK | PD | 17687269, 21806385, 23099353, 27406852, 29243113 |
| PA451954 | zidovudine | Chemical | ClinicalAnnotation, Pathway | associated | PK | 22960662 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36571650 | 2023 | Significance of UGT1A6, UGT1A9, and UGT2B7 genetic variants and their mRNA expression in the clinical outcome of renal cell carcinoma. | 0 |
| 37340142 | 2023 | Bearing variant alleles at uridine glucuronosyltransferase polymorphisms UGT2B7 -161C > T (rs7668258) or UGT1A4*3 c.142 T > G (rs2011425) has no relevant consequences for lamotrigine troughs in adults with epilepsy. | 1 |
| 36571650 | 2023 | Significance of UGT1A6, UGT1A9, and UGT2B7 genetic variants and their mRNA expression in the clinical outcome of renal cell carcinoma. | 0 |
| 37340142 | 2023 | Bearing variant alleles at uridine glucuronosyltransferase polymorphisms UGT2B7 -161C > T (rs7668258) or UGT1A4*3 c.142 T > G (rs2011425) has no relevant consequences for lamotrigine troughs in adults with epilepsy. | 1 |
| 36250837 | 2022 | Impact of MDR1 and UGT Gene Polymorphisms on Sodium Valproate Plasma Concentration in Patients with Epilepsy. | 2 |
| 36250837 | 2022 | Impact of MDR1 and UGT Gene Polymorphisms on Sodium Valproate Plasma Concentration in Patients with Epilepsy. | 2 |
| 33387482 | 2021 | The N(6)-methyladenosine modification posttranscriptionally regulates hepatic UGT2B7 expression. | 8 |
| 33400134 | 2021 | UGT1A6 and UGT2B7 Gene Polymorphism and its Effect in Pediatric Epileptic Patients on Sodium Valproate Monotherapy. | 3 |
| 33595913 | 2021 | Association between sex hormones regulation-related SNP rs12233719 and lung cancer risk among never-smoking Chinese women. | 4 |
| 34000957 | 2021 | Influence of UGT2B7 and UGT1A6 polymorphisms on plasma concentration to dose ratio of valproic acid in Chinese epileptic children. | 2 |
| 33387482 | 2021 | The N(6)-methyladenosine modification posttranscriptionally regulates hepatic UGT2B7 expression. | 8 |
| 33400134 | 2021 | UGT1A6 and UGT2B7 Gene Polymorphism and its Effect in Pediatric Epileptic Patients on Sodium Valproate Monotherapy. | 3 |
| 33595913 | 2021 | Association between sex hormones regulation-related SNP rs12233719 and lung cancer risk among never-smoking Chinese women. | 4 |
| 34000957 | 2021 | Influence of UGT2B7 and UGT1A6 polymorphisms on plasma concentration to dose ratio of valproic acid in Chinese epileptic children. | 2 |
| 31892527 | 2020 | The Human UGT2B7 Nanodisc. | 2 |
Citation
Dessen P
UGT2B7 (UDP glucuronosyltransferase family 2 member B7)
Atlas Genet Cytogenet Oncol Haematol. 2008-08-01
Online version: http://atlasgeneticsoncology.org/gene/50279/ugt2b7
