Atlas of Genetics and Cytogenetics in Oncology and Haematology


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UHRF1 (ubiquitin like with PHD and ring finger domains 1)

Identity

Alias_symbol (synonym)ICBP90
Np95
FLJ21925
RNF106
TDRD22
Other aliashNP95
hUHRF1
huNp95
HGNC (Hugo) UHRF1
LocusID (NCBI) 29128
Atlas_Id 43071
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 4909442 and ends at 4962165 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ATG4D (19p13.2) / UHRF1 (19p13.3)KDM4B (19p13.3) / UHRF1 (19p13.3)MAPKAP1 (9q33.3) / UHRF1 (19p13.3)
NRIP1 (21q11.2) / UHRF1 (19p13.3)UHRF1 (19p13.3) / PIAS4 (19p13.3)ATG4D 19p13.2 / UHRF1 19p13.3
KDM4B 19p13.3 / UHRF1 19p13.3MAPKAP1 9q33.3 / UHRF1 19p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)UHRF1   12556
Cards
Entrez_Gene (NCBI)UHRF1  29128  ubiquitin like with PHD and ring finger domains 1
AliasesICBP90; Np95; RNF106; TDRD22; 
hNP95; hUHRF1; huNp95
GeneCards (Weizmann)UHRF1
Ensembl hg19 (Hinxton)ENSG00000276043 [Gene_View]  chr19:4909442-4962165 [Contig_View]  UHRF1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000276043 [Gene_View]  chr19:4909442-4962165 [Contig_View]  UHRF1 [Vega]
ICGC DataPortalENSG00000276043
TCGA cBioPortalUHRF1
AceView (NCBI)UHRF1
Genatlas (Paris)UHRF1
WikiGenes29128
SOURCE (Princeton)UHRF1
Genetics Home Reference (NIH)UHRF1
Genomic and cartography
GoldenPath hg19 (UCSC)UHRF1  -     chr19:4909442-4962165 +  19p13.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)UHRF1  -     19p13.3   [Description]    (hg38-Dec_2013)
EnsemblUHRF1 - 19p13.3 [CytoView hg19]  UHRF1 - 19p13.3 [CytoView hg38]
Mapping of homologs : NCBIUHRF1 [Mapview hg19]  UHRF1 [Mapview hg38]
OMIM607990   
Gene and transcription
Genbank (Entrez)AA026356 AB177623 AB177624 AF129507 AF274048
RefSeq transcript (Entrez)NM_001048201 NM_001290050 NM_001290051 NM_001290052 NM_013282
RefSeq genomic (Entrez)NC_000019 NC_018930 NG_033256 NT_011295 NW_004929412
Consensus coding sequences : CCDS (NCBI)UHRF1
Cluster EST : UnigeneHs.108106 [ NCBI ]
CGAP (NCI)Hs.108106
Alternative Splicing GalleryENSG00000276043
Gene ExpressionUHRF1 [ NCBI-GEO ]   UHRF1 [ EBI - ARRAY_EXPRESS ]   UHRF1 [ SEEK ]   UHRF1 [ MEM ]
Gene Expression Viewer (FireBrowse)UHRF1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)29128
GTEX Portal (Tissue expression)UHRF1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96T88   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96T88  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96T88
Splice isoforms : SwissVarQ96T88
Catalytic activity : Enzyme6.3.2.- [ Enzyme-Expasy ]   6.3.2.-6.3.2.- [ IntEnz-EBI ]   6.3.2.- [ BRENDA ]   6.3.2.- [ KEGG ]   
PhosPhoSitePlusQ96T88
Domaine pattern : Prosite (Expaxy)UBIQUITIN_2 (PS50053)    YDG (PS51015)    ZF_PHD_1 (PS01359)    ZF_PHD_2 (PS50016)    ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)PUA-like_domain    Rib_L2_dom2    SRA_YDG    TTD_dom    Ubiquitin-rel_dom    Ubiquitin_dom    Znf_FYVE_PHD    Znf_PHD    Znf_PHD-finger    Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS   
Domain families : Pfam (Sanger)PHD (PF00628)    SAD_SRA (PF02182)    TTD (PF12148)    ubiquitin (PF00240)   
Domain families : Pfam (NCBI)pfam00628    pfam02182    pfam12148    pfam00240   
Domain families : Smart (EMBL)PHD (SM00249)  RING (SM00184)  SRA (SM00466)  UBQ (SM00213)  
Conserved Domain (NCBI)UHRF1
DMDM Disease mutations29128
Blocks (Seattle)UHRF1
PDB (SRS)2FAZ    2L3R    2LGG    2LGK    2LGL    2PB7    3ASK    3ASL    3BI7    3CLZ    3DB3    3DB4    3DWH    3FL2    3SHB    3SOU    3SOW    3SOX    3T6R    3ZVY    3ZVZ    4GY5    4QQD    5C6D   
PDB (PDBSum)2FAZ    2L3R    2LGG    2LGK    2LGL    2PB7    3ASK    3ASL    3BI7    3CLZ    3DB3    3DB4    3DWH    3FL2    3SHB    3SOU    3SOW    3SOX    3T6R    3ZVY    3ZVZ    4GY5    4QQD    5C6D   
PDB (IMB)2FAZ    2L3R    2LGG    2LGK    2LGL    2PB7    3ASK    3ASL    3BI7    3CLZ    3DB3    3DB4    3DWH    3FL2    3SHB    3SOU    3SOW    3SOX    3T6R    3ZVY    3ZVZ    4GY5    4QQD    5C6D   
PDB (RSDB)2FAZ    2L3R    2LGG    2LGK    2LGL    2PB7    3ASK    3ASL    3BI7    3CLZ    3DB3    3DB4    3DWH    3FL2    3SHB    3SOU    3SOW    3SOX    3T6R    3ZVY    3ZVZ    4GY5    4QQD    5C6D   
Structural Biology KnowledgeBase2FAZ    2L3R    2LGG    2LGK    2LGL    2PB7    3ASK    3ASL    3BI7    3CLZ    3DB3    3DB4    3DWH    3FL2    3SHB    3SOU    3SOW    3SOX    3T6R    3ZVY    3ZVZ    4GY5    4QQD    5C6D   
SCOP (Structural Classification of Proteins)2FAZ    2L3R    2LGG    2LGK    2LGL    2PB7    3ASK    3ASL    3BI7    3CLZ    3DB3    3DB4    3DWH    3FL2    3SHB    3SOU    3SOW    3SOX    3T6R    3ZVY    3ZVZ    4GY5    4QQD    5C6D   
CATH (Classification of proteins structures)2FAZ    2L3R    2LGG    2LGK    2LGL    2PB7    3ASK    3ASL    3BI7    3CLZ    3DB3    3DB4    3DWH    3FL2    3SHB    3SOU    3SOW    3SOX    3T6R    3ZVY    3ZVZ    4GY5    4QQD    5C6D   
SuperfamilyQ96T88
Human Protein AtlasENSG00000276043
Peptide AtlasQ96T88
HPRD06992
IPIIPI00797945   IPI00797279   
Protein Interaction databases
DIP (DOE-UCLA)Q96T88
IntAct (EBI)Q96T88
FunCoupENSG00000276043
BioGRIDUHRF1
STRING (EMBL)UHRF1
ZODIACUHRF1
Ontologies - Pathways
QuickGOQ96T88
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  nuclear chromatin  nuclear chromatin  euchromatin  heterochromatin  core promoter proximal region sequence-specific DNA binding  transcription factor activity, sequence-specific DNA binding  ubiquitin-protein transferase activity  protein binding  nucleus  replication fork  nuclear heterochromatin  DNA repair  transcription, DNA-templated  cell cycle  zinc ion binding  cell proliferation  methyl-CpG binding  maintenance of DNA methylation  histone monoubiquitination  histone monoubiquitination  nuclear matrix  histone ubiquitination  ligase activity  nucleosomal histone binding  positive regulation of cellular protein metabolic process  methylated histone binding  histone binding  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  identical protein binding  hemi-methylated DNA-binding  positive regulation of transcription from RNA polymerase II promoter  protein autoubiquitination  ubiquitin protein ligase activity  ubiquitin protein ligase activity  regulation of methylation-dependent chromatin silencing  positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  nuclear chromatin  nuclear chromatin  euchromatin  heterochromatin  core promoter proximal region sequence-specific DNA binding  transcription factor activity, sequence-specific DNA binding  ubiquitin-protein transferase activity  protein binding  nucleus  replication fork  nuclear heterochromatin  DNA repair  transcription, DNA-templated  cell cycle  zinc ion binding  cell proliferation  methyl-CpG binding  maintenance of DNA methylation  histone monoubiquitination  histone monoubiquitination  nuclear matrix  histone ubiquitination  ligase activity  nucleosomal histone binding  positive regulation of cellular protein metabolic process  methylated histone binding  histone binding  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  identical protein binding  hemi-methylated DNA-binding  positive regulation of transcription from RNA polymerase II promoter  protein autoubiquitination  ubiquitin protein ligase activity  ubiquitin protein ligase activity  regulation of methylation-dependent chromatin silencing  positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity  
NDEx NetworkUHRF1
Atlas of Cancer Signalling NetworkUHRF1
Wikipedia pathwaysUHRF1
Orthology - Evolution
OrthoDB29128
GeneTree (enSembl)ENSG00000276043
Phylogenetic Trees/Animal Genes : TreeFamUHRF1
HOVERGENQ96T88
HOGENOMQ96T88
Homologs : HomoloGeneUHRF1
Homology/Alignments : Family Browser (UCSC)UHRF1
Gene fusions - Rearrangements
Fusion : MitelmanATG4D/UHRF1 [19p13.2/19p13.3]  [t(19;19)(p13;p13)]  
Fusion : MitelmanKDM4B/UHRF1 [19p13.3/19p13.3]  [t(19;19)(p13;p13)]  
Fusion : MitelmanMAPKAP1/UHRF1 [9q33.3/19p13.3]  [t(9;19)(q33;p13)]  
Fusion: TCGAATG4D 19p13.2 UHRF1 19p13.3 OV
Fusion: TCGAKDM4B 19p13.3 UHRF1 19p13.3 BRCA
Fusion: TCGAMAPKAP1 9q33.3 UHRF1 19p13.3 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUHRF1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UHRF1
dbVarUHRF1
ClinVarUHRF1
1000_GenomesUHRF1 
Exome Variant ServerUHRF1
ExAC (Exome Aggregation Consortium)UHRF1 (select the gene name)
Genetic variants : HAPMAP29128
Genomic Variants (DGV)UHRF1 [DGVbeta]
DECIPHER (Syndromes)19:4909442-4962165  ENSG00000276043
CONAN: Copy Number AnalysisUHRF1 
Mutations
ICGC Data PortalUHRF1 
TCGA Data PortalUHRF1 
Broad Tumor PortalUHRF1
OASIS PortalUHRF1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUHRF1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUHRF1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch UHRF1
DgiDB (Drug Gene Interaction Database)UHRF1
DoCM (Curated mutations)UHRF1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UHRF1 (select a term)
intoGenUHRF1
Cancer3DUHRF1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607990   
Orphanet
MedgenUHRF1
Genetic Testing Registry UHRF1
NextProtQ96T88 [Medical]
TSGene29128
GENETestsUHRF1
Huge Navigator UHRF1 [HugePedia]
snp3D : Map Gene to Disease29128
BioCentury BCIQUHRF1
ClinGenUHRF1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD29128
Chemical/Pharm GKB GenePA37196
Clinical trialUHRF1
Miscellaneous
canSAR (ICR)UHRF1 (select the gene name)
Probes
Litterature
PubMed123 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUHRF1
EVEXUHRF1
GoPubMedUHRF1
iHOPUHRF1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:24:20 CEST 2017

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