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UHRF1 (ubiquitin like with PHD and ring finger domains 1)

Identity

Alias (NCBI)ICBP90
Np95
RNF106
TDRD22
hNP95
hUHRF1
huNp95
HGNC (Hugo) UHRF1
HGNC Alias symbICBP90
Np95
FLJ21925
RNF106
TDRD22
LocusID (NCBI) 29128
Atlas_Id 43071
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 4910367 and ends at 4962154 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ATG4D (19p13.2) / UHRF1 (19p13.3)KDM4B (19p13.3) / UHRF1 (19p13.3)MAPKAP1 (9q33.3) / UHRF1 (19p13.3)
NRIP1 (21q11.2) / UHRF1 (19p13.3)UHRF1 (19p13.3) / PIAS4 (19p13.3)ATG4D 19p13.2 / UHRF1 19p13.3
KDM4B 19p13.3 / UHRF1 19p13.3MAPKAP1 9q33.3 / UHRF1 19p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)UHRF1   12556
Cards
Entrez_Gene (NCBI)UHRF1    ubiquitin like with PHD and ring finger domains 1
AliasesICBP90; Np95; RNF106; TDRD22; 
hNP95; hUHRF1; huNp95
GeneCards (Weizmann)UHRF1
Ensembl hg19 (Hinxton)ENSG00000276043 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000276043 [Gene_View]  ENSG00000276043 [Sequence]  chr19:4910367-4962154 [Contig_View]  UHRF1 [Vega]
ICGC DataPortalENSG00000276043
TCGA cBioPortalUHRF1
AceView (NCBI)UHRF1
Genatlas (Paris)UHRF1
SOURCE (Princeton)UHRF1
Genetics Home Reference (NIH)UHRF1
Genomic and cartography
GoldenPath hg38 (UCSC)UHRF1  -     chr19:4910367-4962154 +  19p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)UHRF1  -     19p13.3   [Description]    (hg19-Feb_2009)
GoldenPathUHRF1 - 19p13.3 [CytoView hg19]  UHRF1 - 19p13.3 [CytoView hg38]
ImmunoBaseENSG00000276043
Genome Data Viewer NCBIUHRF1 [Mapview hg19]  
OMIM607990   
Gene and transcription
Genbank (Entrez)AA026356 AB177623 AB177624 AF129507 AF274048
RefSeq transcript (Entrez)NM_001048201 NM_001290050 NM_001290051 NM_001290052 NM_013282
Consensus coding sequences : CCDS (NCBI)UHRF1
Gene ExpressionUHRF1 [ NCBI-GEO ]   UHRF1 [ EBI - ARRAY_EXPRESS ]   UHRF1 [ SEEK ]   UHRF1 [ MEM ]
Gene Expression Viewer (FireBrowse)UHRF1 [ Firebrowse - Broad ]
GenevisibleExpression of UHRF1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)29128
GTEX Portal (Tissue expression)UHRF1
Human Protein AtlasENSG00000276043-UHRF1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96T88   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96T88  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96T88
Catalytic activity : Enzyme2.3.2.27 [ Enzyme-Expasy ]   2.3.2.272.3.2.27 [ IntEnz-EBI ]   2.3.2.27 [ BRENDA ]   2.3.2.27 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ96T88
Domaine pattern : Prosite (Expaxy)UBIQUITIN_2 (PS50053)    YDG (PS51015)    ZF_PHD_1 (PS01359)    ZF_PHD_2 (PS50016)    ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)PUA-like_sf    SRA-YDG_sf    SRA_YDG    TTD_dom    Ubiquitin-like_dom    Ubiquitin-like_domsf    Znf_FYVE_PHD    Znf_PHD    Znf_PHD-finger    Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS   
Domain families : Pfam (Sanger)PHD (PF00628)    SAD_SRA (PF02182)    TTD (PF12148)    ubiquitin (PF00240)   
Domain families : Pfam (NCBI)pfam00628    pfam02182    pfam12148    pfam00240   
Domain families : Smart (EMBL)PHD (SM00249)  RING (SM00184)  SRA (SM00466)  UBQ (SM00213)  
Conserved Domain (NCBI)UHRF1
PDB (RSDB)2FAZ    2L3R    2LGG    2LGK    2LGL    2PB7    3ASK    3ASL    3BI7    3CLZ    3DB3    3DB4    3DWH    3FL2    3SHB    3SOU    3SOW    3SOX    3T6R    3ZVY    3ZVZ    4GY5    4QQD    5C6D    5IAY    5XPI    5YY9    5YYA    6B9M    6IIW    6VCS    6VED   
PDB Europe2FAZ    2L3R    2LGG    2LGK    2LGL    2PB7    3ASK    3ASL    3BI7    3CLZ    3DB3    3DB4    3DWH    3FL2    3SHB    3SOU    3SOW    3SOX    3T6R    3ZVY    3ZVZ    4GY5    4QQD    5C6D    5IAY    5XPI    5YY9    5YYA    6B9M    6IIW    6VCS    6VED   
PDB (PDBSum)2FAZ    2L3R    2LGG    2LGK    2LGL    2PB7    3ASK    3ASL    3BI7    3CLZ    3DB3    3DB4    3DWH    3FL2    3SHB    3SOU    3SOW    3SOX    3T6R    3ZVY    3ZVZ    4GY5    4QQD    5C6D    5IAY    5XPI    5YY9    5YYA    6B9M    6IIW    6VCS    6VED   
PDB (IMB)2FAZ    2L3R    2LGG    2LGK    2LGL    2PB7    3ASK    3ASL    3BI7    3CLZ    3DB3    3DB4    3DWH    3FL2    3SHB    3SOU    3SOW    3SOX    3T6R    3ZVY    3ZVZ    4GY5    4QQD    5C6D    5IAY    5XPI    5YY9    5YYA    6B9M    6IIW    6VCS    6VED   
Structural Biology KnowledgeBase2FAZ    2L3R    2LGG    2LGK    2LGL    2PB7    3ASK    3ASL    3BI7    3CLZ    3DB3    3DB4    3DWH    3FL2    3SHB    3SOU    3SOW    3SOX    3T6R    3ZVY    3ZVZ    4GY5    4QQD    5C6D    5IAY    5XPI    5YY9    5YYA    6B9M    6IIW    6VCS    6VED   
SCOP (Structural Classification of Proteins)2FAZ    2L3R    2LGG    2LGK    2LGL    2PB7    3ASK    3ASL    3BI7    3CLZ    3DB3    3DB4    3DWH    3FL2    3SHB    3SOU    3SOW    3SOX    3T6R    3ZVY    3ZVZ    4GY5    4QQD    5C6D    5IAY    5XPI    5YY9    5YYA    6B9M    6IIW    6VCS    6VED   
CATH (Classification of proteins structures)2FAZ    2L3R    2LGG    2LGK    2LGL    2PB7    3ASK    3ASL    3BI7    3CLZ    3DB3    3DB4    3DWH    3FL2    3SHB    3SOU    3SOW    3SOX    3T6R    3ZVY    3ZVZ    4GY5    4QQD    5C6D    5IAY    5XPI    5YY9    5YYA    6B9M    6IIW    6VCS    6VED   
SuperfamilyQ96T88
AlphaFold pdb e-kbQ96T88   
Human Protein Atlas [tissue]ENSG00000276043-UHRF1 [tissue]
HPRD06992
Protein Interaction databases
DIP (DOE-UCLA)Q96T88
IntAct (EBI)Q96T88
BioGRIDUHRF1
STRING (EMBL)UHRF1
ZODIACUHRF1
Ontologies - Pathways
QuickGOQ96T88
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  chromatin  chromatin  euchromatin  heterochromatin  cis-regulatory region sequence-specific DNA binding  ubiquitin-protein transferase activity  protein binding  nucleus  nucleoplasm  replication fork  DNA repair  ubiquitin-dependent protein catabolic process  cell cycle  zinc ion binding  methyl-CpG binding  maintenance of DNA methylation  maintenance of DNA methylation  histone monoubiquitination  histone monoubiquitination  nuclear matrix  protein ubiquitination  histone ubiquitination  nucleosomal histone binding  positive regulation of cellular protein metabolic process  methylated histone binding  histone binding  identical protein binding  hemi-methylated DNA-binding  positive regulation of transcription by RNA polymerase II  regulation of epithelial cell proliferation  protein autoubiquitination  ubiquitin protein ligase activity  ubiquitin protein ligase activity  positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  chromatin  chromatin  euchromatin  heterochromatin  cis-regulatory region sequence-specific DNA binding  ubiquitin-protein transferase activity  protein binding  nucleus  nucleoplasm  replication fork  DNA repair  ubiquitin-dependent protein catabolic process  cell cycle  zinc ion binding  methyl-CpG binding  maintenance of DNA methylation  maintenance of DNA methylation  histone monoubiquitination  histone monoubiquitination  nuclear matrix  protein ubiquitination  histone ubiquitination  nucleosomal histone binding  positive regulation of cellular protein metabolic process  methylated histone binding  histone binding  identical protein binding  hemi-methylated DNA-binding  positive regulation of transcription by RNA polymerase II  regulation of epithelial cell proliferation  protein autoubiquitination  ubiquitin protein ligase activity  ubiquitin protein ligase activity  positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity  
NDEx NetworkUHRF1
Atlas of Cancer Signalling NetworkUHRF1
Wikipedia pathwaysUHRF1
Orthology - Evolution
OrthoDB29128
GeneTree (enSembl)ENSG00000276043
Phylogenetic Trees/Animal Genes : TreeFamUHRF1
Homologs : HomoloGeneUHRF1
Homology/Alignments : Family Browser (UCSC)UHRF1
Gene fusions - Rearrangements
Fusion : MitelmanATG4D/UHRF1 [19p13.2/19p13.3]  
Fusion : MitelmanKDM4B/UHRF1 [19p13.3/19p13.3]  
Fusion : MitelmanMAPKAP1/UHRF1 [9q33.3/19p13.3]  
Fusion : QuiverUHRF1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUHRF1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UHRF1
dbVarUHRF1
ClinVarUHRF1
MonarchUHRF1
1000_GenomesUHRF1 
Exome Variant ServerUHRF1
GNOMAD BrowserENSG00000276043
Varsome BrowserUHRF1
ACMGUHRF1 variants
VarityQ96T88
Genomic Variants (DGV)UHRF1 [DGVbeta]
DECIPHERUHRF1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUHRF1 
Mutations
ICGC Data PortalUHRF1 
TCGA Data PortalUHRF1 
Broad Tumor PortalUHRF1
OASIS PortalUHRF1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUHRF1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DUHRF1
Mutations and Diseases : HGMDUHRF1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaUHRF1
DgiDB (Drug Gene Interaction Database)UHRF1
DoCM (Curated mutations)UHRF1
CIViC (Clinical Interpretations of Variants in Cancer)UHRF1
Cancer3DUHRF1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607990   
Orphanet
DisGeNETUHRF1
MedgenUHRF1
Genetic Testing Registry UHRF1
NextProtQ96T88 [Medical]
GENETestsUHRF1
Target ValidationUHRF1
Huge Navigator UHRF1 [HugePedia]
ClinGenUHRF1
Clinical trials, drugs, therapy
MyCancerGenomeUHRF1
Protein Interactions : CTDUHRF1
Pharm GKB GenePA37196
PharosQ96T88
Clinical trialUHRF1
Miscellaneous
canSAR (ICR)UHRF1
HarmonizomeUHRF1
DataMed IndexUHRF1
Probes
Litterature
PubMed238 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXUHRF1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:37:24 CEST 2021

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