Atlas of Genetics and Cytogenetics in Oncology and Haematology

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UHRF2 (ubiquitin like with PHD and ring finger domains 2)

Identity

Alias_namesubiquitin-like with PHD and ring finger domains 2
Alias_symbol (synonym)RNF107
NIRF
URF2
MGC33463
TDRD23
Other alias
HGNC (Hugo) UHRF2
LocusID (NCBI) 115426
Atlas_Id 42765
Location 12q23.1  [Link to chromosome band 12q23]
Location_base_pair Starts at 6413151 and ends at 6507051 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADAMTSL1 (9p22.2) / UHRF2 (9p24.1)KANK1 (9p24.3) / UHRF2 (9p24.1)PFDN6 (6p21.32) / UHRF2 (9p24.1)
TRIO (5p15.2) / UHRF2 (9p24.1)UHRF2 (9p24.1) / ADAMTSL1 (9p22.2)UHRF2 (9p24.1) / PUM2 (2p24.1)
KANK1 9p24.3 / UHRF2 9p24.1TRIO 5p15.2 / UHRF2 9p24.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]
  t(5;9)(p15;p24) TRIO/UHRF2
t(9;9)(p22;p24) ADAMTSL1/UHRF2
t(9;9)(p22;p24) UHRF2/ADAMTSL1
KANK1/UHRF2 (9p24)

External links

Nomenclature
HGNC (Hugo)UHRF2   12557
Cards
Entrez_Gene (NCBI)UHRF2  115426  ubiquitin like with PHD and ring finger domains 2
AliasesNIRF; RNF107; TDRD23; URF2
GeneCards (Weizmann)UHRF2
Ensembl hg19 (Hinxton)ENSG00000147854 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000147854 [Gene_View]  ENSG00000147854 [Sequence]  chr9:6413151-6507051 [Contig_View]  UHRF2 [Vega]
ICGC DataPortalENSG00000147854
TCGA cBioPortalUHRF2
AceView (NCBI)UHRF2
Genatlas (Paris)UHRF2
WikiGenes115426
SOURCE (Princeton)UHRF2
Genetics Home Reference (NIH)UHRF2
Genomic and cartography
GoldenPath hg38 (UCSC)UHRF2  -     chr9:6413151-6507051 +  12q23.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)UHRF2  -     12q23.1   [Description]    (hg19-Feb_2009)
EnsemblUHRF2 - 12q23.1 [CytoView hg19]  UHRF2 - 12q23.1 [CytoView hg38]
Mapping of homologs : NCBIUHRF2 [Mapview hg19]  UHRF2 [Mapview hg38]
OMIM615211   
Gene and transcription
Genbank (Entrez)AB071698 AF274049 AK122730 AK308433 AL137728
RefSeq transcript (Entrez)NM_152896
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)UHRF2
Cluster EST : UnigeneHs.493401 [ NCBI ]
CGAP (NCI)Hs.493401
Alternative Splicing GalleryENSG00000147854
Gene ExpressionUHRF2 [ NCBI-GEO ]   UHRF2 [ EBI - ARRAY_EXPRESS ]   UHRF2 [ SEEK ]   UHRF2 [ MEM ]
Gene Expression Viewer (FireBrowse)UHRF2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)115426
GTEX Portal (Tissue expression)UHRF2
Human Protein AtlasENSG00000147854-UHRF2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96PU4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96PU4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96PU4
Splice isoforms : SwissVarQ96PU4
Catalytic activity : Enzyme2.3.2.27 [ Enzyme-Expasy ]   2.3.2.272.3.2.27 [ IntEnz-EBI ]   2.3.2.27 [ BRENDA ]   2.3.2.27 [ KEGG ]   
PhosPhoSitePlusQ96PU4
Domaine pattern : Prosite (Expaxy)UBIQUITIN_2 (PS50053)    YDG (PS51015)    ZF_PHD_1 (PS01359)    ZF_PHD_2 (PS50016)    ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)PUA-like_sf    SRA-YDG_sf    SRA_YDG    TTD_dom    Ubiquitin-like_domsf    Ubiquitin_dom    Znf_FYVE_PHD    Znf_PHD    Znf_PHD-finger    Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS   
Domain families : Pfam (Sanger)PHD (PF00628)    SAD_SRA (PF02182)    TTD (PF12148)    ubiquitin (PF00240)   
Domain families : Pfam (NCBI)pfam00628    pfam02182    pfam12148    pfam00240   
Domain families : Smart (EMBL)PHD (SM00249)  RING (SM00184)  SRA (SM00466)  UBQ (SM00213)  
Conserved Domain (NCBI)UHRF2
DMDM Disease mutations115426
Blocks (Seattle)UHRF2
PDB (SRS)1WY8    1Z6U    2E6S    3OLN    4PW5    4PW6    4PW7    4TVR    5YCO   
PDB (PDBSum)1WY8    1Z6U    2E6S    3OLN    4PW5    4PW6    4PW7    4TVR    5YCO   
PDB (IMB)1WY8    1Z6U    2E6S    3OLN    4PW5    4PW6    4PW7    4TVR    5YCO   
PDB (RSDB)1WY8    1Z6U    2E6S    3OLN    4PW5    4PW6    4PW7    4TVR    5YCO   
Structural Biology KnowledgeBase1WY8    1Z6U    2E6S    3OLN    4PW5    4PW6    4PW7    4TVR    5YCO   
SCOP (Structural Classification of Proteins)1WY8    1Z6U    2E6S    3OLN    4PW5    4PW6    4PW7    4TVR    5YCO   
CATH (Classification of proteins structures)1WY8    1Z6U    2E6S    3OLN    4PW5    4PW6    4PW7    4TVR    5YCO   
SuperfamilyQ96PU4
Human Protein Atlas [tissue]ENSG00000147854-UHRF2 [tissue]
Peptide AtlasQ96PU4
HPRD18257
IPIIPI00044681   IPI00395464   IPI00514651   IPI01009542   
Protein Interaction databases
DIP (DOE-UCLA)Q96PU4
IntAct (EBI)Q96PU4
FunCoupENSG00000147854
BioGRIDUHRF2
STRING (EMBL)UHRF2
ZODIACUHRF2
Ontologies - Pathways
QuickGOQ96PU4
Ontology : AmiGODNA binding  ubiquitin-protein transferase activity  protein binding  nucleus  nucleoplasm  nuclear heterochromatin  nuclear heterochromatin  cell cycle  cell proliferation  maintenance of DNA methylation  protein ubiquitination  protein ubiquitination  cell differentiation  histone binding  metal ion binding  regulation of cell cycle  protein autoubiquitination  ubiquitin protein ligase activity  ubiquitin protein ligase activity  positive regulation of cell cycle arrest  
Ontology : EGO-EBIDNA binding  ubiquitin-protein transferase activity  protein binding  nucleus  nucleoplasm  nuclear heterochromatin  nuclear heterochromatin  cell cycle  cell proliferation  maintenance of DNA methylation  protein ubiquitination  protein ubiquitination  cell differentiation  histone binding  metal ion binding  regulation of cell cycle  protein autoubiquitination  ubiquitin protein ligase activity  ubiquitin protein ligase activity  positive regulation of cell cycle arrest  
NDEx NetworkUHRF2
Atlas of Cancer Signalling NetworkUHRF2
Wikipedia pathwaysUHRF2
Orthology - Evolution
OrthoDB115426
GeneTree (enSembl)ENSG00000147854
Phylogenetic Trees/Animal Genes : TreeFamUHRF2
HOVERGENQ96PU4
HOGENOMQ96PU4
Homologs : HomoloGeneUHRF2
Homology/Alignments : Family Browser (UCSC)UHRF2
Gene fusions - Rearrangements
Fusion : MitelmanADAMTSL1/UHRF2 [9p22.2/9p24.1]  [t(9;9)(p22;p24)]  
Fusion : MitelmanKANK1/UHRF2 [9p24.3/9p24.1]  [t(9;9)(p24;p24)]  
Fusion : MitelmanTRIO/UHRF2 [5p15.2/9p24.1]  [t(5;9)(p15;p24)]  
Fusion : MitelmanUHRF2/ADAMTSL1 [9p24.1/9p22.2]  [t(9;9)(p22;p24)]  
Fusion PortalKANK1 9p24.3 UHRF2 9p24.1 KIRC
Fusion PortalTRIO 5p15.2 UHRF2 9p24.1 LUAD
Fusion : QuiverUHRF2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUHRF2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UHRF2
dbVarUHRF2
ClinVarUHRF2
1000_GenomesUHRF2 
Exome Variant ServerUHRF2
ExAC (Exome Aggregation Consortium)ENSG00000147854
GNOMAD BrowserENSG00000147854
Varsome BrowserUHRF2
Genetic variants : HAPMAP115426
Genomic Variants (DGV)UHRF2 [DGVbeta]
DECIPHERUHRF2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUHRF2 
Mutations
ICGC Data PortalUHRF2 
TCGA Data PortalUHRF2 
Broad Tumor PortalUHRF2
OASIS PortalUHRF2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUHRF2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUHRF2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch UHRF2
DgiDB (Drug Gene Interaction Database)UHRF2
DoCM (Curated mutations)UHRF2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UHRF2 (select a term)
intoGenUHRF2
Cancer3DUHRF2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615211   
Orphanet
DisGeNETUHRF2
MedgenUHRF2
Genetic Testing Registry UHRF2
NextProtQ96PU4 [Medical]
TSGene115426
GENETestsUHRF2
Target ValidationUHRF2
Huge Navigator UHRF2 [HugePedia]
snp3D : Map Gene to Disease115426
BioCentury BCIQUHRF2
ClinGenUHRF2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD115426
Chemical/Pharm GKB GenePA37197
Clinical trialUHRF2
Miscellaneous
canSAR (ICR)UHRF2 (select the gene name)
Probes
Litterature
PubMed43 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUHRF2
EVEXUHRF2
GoPubMedUHRF2
iHOPUHRF2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Aug 16 11:40:21 CEST 2018
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