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UHRF2 (ubiquitin like with PHD and ring finger domains 2)

Identity

Alias (NCBI)NIRF
RNF107
TDRD23
URF2
HGNC (Hugo) UHRF2
HGNC Alias symbRNF107
NIRF
URF2
MGC33463
TDRD23
HGNC Alias nameNp95-like ring finger protein
HGNC Previous nameubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase
LocusID (NCBI) 115426
Atlas_Id 42765
Location 9p24.1  [Link to chromosome band 9p24]
Location_base_pair Starts at 6413199 and ends at 6507051 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADAMTSL1 (9p22.2) / UHRF2 (9p24.1)KANK1 (9p24.3) / UHRF2 (9p24.1)PFDN6 (6p21.32) / UHRF2 (9p24.1)
TRIO (5p15.2) / UHRF2 (9p24.1)UHRF2 (9p24.1) / ADAMTSL1 (9p22.2)UHRF2 (9p24.1) / PUM2 (2p24.1)
KANK1 9p24.3 / UHRF2 9p24.1TRIO 5p15.2 / UHRF2 9p24.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

 

Nomenclature
HGNC (Hugo)UHRF2   12557
Cards
Entrez_Gene (NCBI)UHRF2    ubiquitin like with PHD and ring finger domains 2
AliasesNIRF; RNF107; TDRD23; URF2
GeneCards (Weizmann)UHRF2
Ensembl hg19 (Hinxton)ENSG00000147854 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000147854 [Gene_View]  ENSG00000147854 [Sequence]  chr9:6413199-6507051 [Contig_View]  UHRF2 [Vega]
ICGC DataPortalENSG00000147854
TCGA cBioPortalUHRF2
AceView (NCBI)UHRF2
Genatlas (Paris)UHRF2
SOURCE (Princeton)UHRF2
Genetics Home Reference (NIH)UHRF2
Genomic and cartography
GoldenPath hg38 (UCSC)UHRF2  -     chr9:6413199-6507051 +  9p24.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)UHRF2  -     9p24.1   [Description]    (hg19-Feb_2009)
GoldenPathUHRF2 - 9p24.1 [CytoView hg19]  UHRF2 - 9p24.1 [CytoView hg38]
ImmunoBaseENSG00000147854
Genome Data Viewer NCBIUHRF2 [Mapview hg19]  
OMIM615211   
Gene and transcription
Genbank (Entrez)AB071698 AF274049 AK122730 AK308433 AL137728
RefSeq transcript (Entrez)NM_152896
Consensus coding sequences : CCDS (NCBI)UHRF2
Gene ExpressionUHRF2 [ NCBI-GEO ]   UHRF2 [ EBI - ARRAY_EXPRESS ]   UHRF2 [ SEEK ]   UHRF2 [ MEM ]
Gene Expression Viewer (FireBrowse)UHRF2 [ Firebrowse - Broad ]
GenevisibleExpression of UHRF2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)115426
GTEX Portal (Tissue expression)UHRF2
Human Protein AtlasENSG00000147854-UHRF2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96PU4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96PU4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96PU4
Catalytic activity : Enzyme2.3.2.27 [ Enzyme-Expasy ]   2.3.2.272.3.2.27 [ IntEnz-EBI ]   2.3.2.27 [ BRENDA ]   2.3.2.27 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ96PU4
Domaine pattern : Prosite (Expaxy)UBIQUITIN_2 (PS50053)    YDG (PS51015)    ZF_PHD_1 (PS01359)    ZF_PHD_2 (PS50016)    ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)PUA-like_sf    SRA-YDG_sf    SRA_YDG    TTD_dom    Ubiquitin-like_dom    Ubiquitin-like_domsf    Znf_FYVE_PHD    Znf_PHD    Znf_PHD-finger    Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS   
Domain families : Pfam (Sanger)PHD (PF00628)    SAD_SRA (PF02182)    TTD (PF12148)    ubiquitin (PF00240)   
Domain families : Pfam (NCBI)pfam00628    pfam02182    pfam12148    pfam00240   
Domain families : Smart (EMBL)PHD (SM00249)  RING (SM00184)  SRA (SM00466)  UBQ (SM00213)  
Conserved Domain (NCBI)UHRF2
PDB (RSDB)1WY8    1Z6U    2E6S    3OLN    4PW5    4PW6    4PW7    4TVR    5YCO   
PDB Europe1WY8    1Z6U    2E6S    3OLN    4PW5    4PW6    4PW7    4TVR    5YCO   
PDB (PDBSum)1WY8    1Z6U    2E6S    3OLN    4PW5    4PW6    4PW7    4TVR    5YCO   
PDB (IMB)1WY8    1Z6U    2E6S    3OLN    4PW5    4PW6    4PW7    4TVR    5YCO   
Structural Biology KnowledgeBase1WY8    1Z6U    2E6S    3OLN    4PW5    4PW6    4PW7    4TVR    5YCO   
SCOP (Structural Classification of Proteins)1WY8    1Z6U    2E6S    3OLN    4PW5    4PW6    4PW7    4TVR    5YCO   
CATH (Classification of proteins structures)1WY8    1Z6U    2E6S    3OLN    4PW5    4PW6    4PW7    4TVR    5YCO   
SuperfamilyQ96PU4
AlphaFold pdb e-kbQ96PU4   
Human Protein Atlas [tissue]ENSG00000147854-UHRF2 [tissue]
HPRD18257
Protein Interaction databases
DIP (DOE-UCLA)Q96PU4
IntAct (EBI)Q96PU4
BioGRIDUHRF2
STRING (EMBL)UHRF2
ZODIACUHRF2
Ontologies - Pathways
QuickGOQ96PU4
Ontology : AmiGOheterochromatin  DNA binding  ubiquitin-protein transferase activity  protein binding  nucleus  nucleoplasm  nucleoplasm  pericentric heterochromatin  cell cycle  transcription factor binding  maintenance of DNA methylation  protein ubiquitination  protein ubiquitination  cell differentiation  histone binding  metal ion binding  regulation of cell cycle  regulation of cell cycle  protein autoubiquitination  ubiquitin protein ligase activity  ubiquitin protein ligase activity  
Ontology : EGO-EBIheterochromatin  DNA binding  ubiquitin-protein transferase activity  protein binding  nucleus  nucleoplasm  nucleoplasm  pericentric heterochromatin  cell cycle  transcription factor binding  maintenance of DNA methylation  protein ubiquitination  protein ubiquitination  cell differentiation  histone binding  metal ion binding  regulation of cell cycle  regulation of cell cycle  protein autoubiquitination  ubiquitin protein ligase activity  ubiquitin protein ligase activity  
NDEx NetworkUHRF2
Atlas of Cancer Signalling NetworkUHRF2
Wikipedia pathwaysUHRF2
Orthology - Evolution
OrthoDB115426
GeneTree (enSembl)ENSG00000147854
Phylogenetic Trees/Animal Genes : TreeFamUHRF2
Homologs : HomoloGeneUHRF2
Homology/Alignments : Family Browser (UCSC)UHRF2
Gene fusions - Rearrangements
Fusion : MitelmanADAMTSL1/UHRF2 [9p22.2/9p24.1]  
Fusion : MitelmanKANK1/UHRF2 [9p24.3/9p24.1]  
Fusion : MitelmanTRIO/UHRF2 [5p15.2/9p24.1]  
Fusion : MitelmanUHRF2/ADAMTSL1 [9p24.1/9p22.2]  
Fusion : QuiverUHRF2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUHRF2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UHRF2
dbVarUHRF2
ClinVarUHRF2
MonarchUHRF2
1000_GenomesUHRF2 
Exome Variant ServerUHRF2
GNOMAD BrowserENSG00000147854
Varsome BrowserUHRF2
ACMGUHRF2 variants
VarityQ96PU4
Genomic Variants (DGV)UHRF2 [DGVbeta]
DECIPHERUHRF2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUHRF2 
Mutations
ICGC Data PortalUHRF2 
TCGA Data PortalUHRF2 
Broad Tumor PortalUHRF2
OASIS PortalUHRF2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUHRF2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DUHRF2
Mutations and Diseases : HGMDUHRF2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaUHRF2
DgiDB (Drug Gene Interaction Database)UHRF2
DoCM (Curated mutations)UHRF2
CIViC (Clinical Interpretations of Variants in Cancer)UHRF2
Cancer3DUHRF2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615211   
Orphanet
DisGeNETUHRF2
MedgenUHRF2
Genetic Testing Registry UHRF2
NextProtQ96PU4 [Medical]
GENETestsUHRF2
Target ValidationUHRF2
Huge Navigator UHRF2 [HugePedia]
ClinGenUHRF2
Clinical trials, drugs, therapy
MyCancerGenomeUHRF2
Protein Interactions : CTDUHRF2
Pharm GKB GenePA37197
PharosQ96PU4
Clinical trialUHRF2
Miscellaneous
canSAR (ICR)UHRF2
HarmonizomeUHRF2
DataMed IndexUHRF2
Probes
Litterature
PubMed56 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXUHRF2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:37:25 CEST 2021
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