UHRF2 (ubiquitin like with PHD and ring finger domains 2)

2003-06-01  

Identity

HGNC
LOCATION
9p24.1
LOCUSID
ALIAS
NIRF,RNF107,TDRD23,URF2
FUSION GENES

Other Information

Locus ID:

NCBI: 115426
MIM: 615211
HGNC: 12557
Ensembl: ENSG00000147854

Variants:

dbSNP: 115426
ClinVar: 115426
TCGA: ENSG00000147854
COSMIC: UHRF2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000147854ENST00000276893Q96PU4
ENSG00000147854ENST00000381373B1AL33
ENSG00000147854ENST00000450508A0A0A0MSQ3
ENSG00000147854ENST00000468435Q96PU4

Expression (GTEx)

0
5
10
15
20
25
30
35

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
248139442014Structural basis for hydroxymethylcytosine recognition by the SRA domain of UHRF2.45
192182382009Intranuclear degradation of polyglutamine aggregates by the ubiquitin-proteasome system.37
215983012011Cooperative DNA and histone binding by Uhrf2 links the two major repressive epigenetic pathways.31
121760132002NIRF, a novel RING finger protein, is involved in cell-cycle regulation.23
198187752009Let-7a elevates p21(WAF1) levels by targeting of NIRF and suppresses the growth of A549 lung cancer cells.23
147413692004NIRF is a ubiquitin ligase that is capable of ubiquitinating PCNP, a PEST-containing nuclear protein.21
147413692004NIRF is a ubiquitin ligase that is capable of ubiquitinating PCNP, a PEST-containing nuclear protein.21
220189862012NIRF is frequently upregulated in colorectal cancer and its oncogenicity can be suppressed by let-7a microRNA.18
219526392011NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor.14

Citation

Dessen P

UHRF2 (ubiquitin like with PHD and ring finger domains 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42765/uhrf2