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ULK1 (unc-51 like autophagy activating kinase 1)

Identity

Other namesATG1
ATG1A
UNC51
Unc51.1
hATG1
HGNC (Hugo) ULK1
LocusID (NCBI) 8408
Atlas_Id 43551
Location 12q24.33
Location_base_pair Starts at 132379279 and ends at 132407707 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ULK1   12558
Cards
Entrez_Gene (NCBI)ULK1  8408  unc-51 like autophagy activating kinase 1
GeneCards (Weizmann)ULK1
Ensembl hg19 (Hinxton)ENSG00000177169 [Gene_View]  chr12:132379279-132407707 [Contig_View]  ULK1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000177169 [Gene_View]  chr12:132379279-132407707 [Contig_View]  ULK1 [Vega]
ICGC DataPortalENSG00000177169
TCGA cBioPortalULK1
AceView (NCBI)ULK1
Genatlas (Paris)ULK1
WikiGenes8408
SOURCE (Princeton)ULK1
Genomic and cartography
GoldenPath hg19 (UCSC)ULK1  -     chr12:132379279-132407707 +  12q24.33   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ULK1  -     12q24.33   [Description]    (hg38-Dec_2013)
EnsemblULK1 - 12q24.33 [CytoView hg19]  ULK1 - 12q24.33 [CytoView hg38]
Mapping of homologs : NCBIULK1 [Mapview hg19]  ULK1 [Mapview hg38]
OMIM603168   
Gene and transcription
Genbank (Entrez)AB018265 AF045458 AK095774 AK128333 BC111603
RefSeq transcript (Entrez)NM_003565
RefSeq genomic (Entrez)NC_000012 NC_018923 NT_029419 NW_004929386
Consensus coding sequences : CCDS (NCBI)ULK1
Cluster EST : UnigeneHs.47061 [ NCBI ]
CGAP (NCI)Hs.47061
Alternative Splicing : Fast-db (Paris)GSHG0007140
Alternative Splicing GalleryENSG00000177169
Gene ExpressionULK1 [ NCBI-GEO ]     ULK1 [ SEEK ]   ULK1 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75385 (Uniprot)
NextProtO75385  [Medical]
With graphics : InterProO75385
Splice isoforms : SwissVarO75385 (Swissvar)
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase    Ser/Thr_kin_STPK_Ulk-1/2    Ser/Thr_kinase_AS    Ser/Thr_kinase_C   
Related proteins : CluSTrO75385
Domain families : Pfam (Sanger)DUF3543 (PF12063)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam12063    pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
DMDM Disease mutations8408
Blocks (Seattle)O75385
Human Protein AtlasENSG00000177169
Peptide AtlasO75385
HPRD11933
IPIIPI00289357   IPI01009875   IPI01012014   IPI01010149   IPI01009408   IPI01015003   IPI01010208   
Protein Interaction databases
DIP (DOE-UCLA)O75385
IntAct (EBI)O75385
FunCoupENSG00000177169
BioGRIDULK1
IntegromeDBULK1
STRING (EMBL)ULK1
Ontologies - Pathways
QuickGOO75385
Ontology : AmiGOautophagic vacuole assembly  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  autophagic vacuole  cytosol  protein phosphorylation  Ras protein signal transduction  protein localization  regulation of autophagy  regulation of autophagy  positive regulation of autophagy  positive regulation of macroautophagy  Rab GTPase binding  protein kinase binding  cerebellar granule cell differentiation  radial glia guided migration of cerebellar granule cell  cytoplasmic vesicle membrane  neuron projection regeneration  neuron projection development  receptor internalization  cellular response to nutrient levels  protein complex binding  pre-autophagosomal structure membrane  ATG1/UKL1 signaling complex  response to starvation  neuron projection  neuronal cell body  protein autophosphorylation  negative regulation of collateral sprouting  axon extension  regulation of neurotrophin TRK receptor signaling pathway  ULK1-ATG13-FIP200 complex  extrinsic component of omegasome membrane  extrinsic component of pre-autophagosomal structure membrane  extrinsic component of autophagic vacuole membrane  
Ontology : EGO-EBIautophagic vacuole assembly  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  autophagic vacuole  cytosol  protein phosphorylation  Ras protein signal transduction  protein localization  regulation of autophagy  regulation of autophagy  positive regulation of autophagy  positive regulation of macroautophagy  Rab GTPase binding  protein kinase binding  cerebellar granule cell differentiation  radial glia guided migration of cerebellar granule cell  cytoplasmic vesicle membrane  neuron projection regeneration  neuron projection development  receptor internalization  cellular response to nutrient levels  protein complex binding  pre-autophagosomal structure membrane  ATG1/UKL1 signaling complex  response to starvation  neuron projection  neuronal cell body  protein autophosphorylation  negative regulation of collateral sprouting  axon extension  regulation of neurotrophin TRK receptor signaling pathway  ULK1-ATG13-FIP200 complex  extrinsic component of omegasome membrane  extrinsic component of pre-autophagosomal structure membrane  extrinsic component of autophagic vacuole membrane  
Pathways : KEGGRegulation of autophagy    mTOR signaling pathway   
Protein Interaction DatabaseULK1
DoCM (Curated mutations)ULK1
Wikipedia pathwaysULK1
Gene fusion - Rearrangements
Gene fusion: TCGA
Polymorphisms : SNP, variants
NCBI Variation ViewerULK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ULK1
dbVarULK1
ClinVarULK1
1000_GenomesULK1 
Exome Variant ServerULK1
SNP (GeneSNP Utah)ULK1
SNP : HGBaseULK1
Genetic variants : HAPMAPULK1
Genomic Variants (DGV)ULK1 [DGVbeta]
Mutations
ICGC Data PortalULK1 
TCGA Data PortalULK1 
Tumor PortalULK1
Somatic Mutations in Cancer : COSMICULK1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)12:132379279-132407707
CONAN: Copy Number AnalysisULK1 
Mutations and Diseases : HGMDULK1
OMIM603168   
MedgenULK1
NextProtO75385 [Medical]
GENETestsULK1
Disease Genetic AssociationULK1
Huge Navigator ULK1 [HugePedia]  ULK1 [HugeCancerGEM]
snp3D : Map Gene to Disease8408
DGIdb (Drug Gene Interaction db)ULK1
General knowledge
Homologs : HomoloGeneULK1
Homology/Alignments : Family Browser (UCSC)ULK1
Phylogenetic Trees/Animal Genes : TreeFamULK1
Chemical/Protein Interactions : CTD8408
Chemical/Pharm GKB GenePA37198
Clinical trialULK1
Cancer Resource (Charite)ENSG00000177169
Other databases
Probes
Litterature
PubMed56 Pubmed reference(s) in Entrez
CoreMineULK1
GoPubMedULK1
iHOPULK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 20 20:18:38 CEST 2015

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