Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   
X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

ULK1 (unc-51-like kinase 1 (C. elegans))

Identity

Other namesATG1
ATG1A
UNC51
Unc51.1
hATG1
HGNC (Hugo) ULK1
LocusID (NCBI) 8408
Location 12q24.33
Location_base_pair Starts at 132379279 and ends at 132407707 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ULK1   12558
Entrez_Gene (NCBI)ULK1  8408  unc-51-like kinase 1 (C. elegans)
Cards
GeneCards (Weizmann)ULK1
Ensembl (Hinxton)ENSG00000177169 [Gene_View]  chr12:132379279-132407707 [Contig_View]  ULK1 [Vega]
AceView (NCBI)ULK1
Genatlas (Paris)ULK1
SOURCE (Stanford)NM_003565
Genomic and cartography
GoldenPath (UCSC)ULK1  -  12q24.33   chr12:132379279-132407707 +  12q24.33   [Description]    (hg19-Feb_2009)
EnsemblULK1 - 12q24.33 [CytoView]
Mapping of homologs : NCBIULK1 [Mapview]
OMIM603168   
Gene and transcription
Genbank (Entrez)AB018265 AF045458 AK095774 AK128333 BC111603
RefSeq transcript (SRS)NM_003565
RefSeq transcript (Entrez)NM_003565
RefSeq genomic (SRS)AC_000144 NC_000012 NC_018923 NT_009755 NW_001838066 NW_004078075
RefSeq genomic (Entrez)AC_000144 NC_000012 NC_018923 NT_009755 NW_001838066 NW_004078075
Consensus coding sequences : CCDS (NCBI)ULK1
Cluster EST : UnigeneHs.47061 [ SRS ] Hs.47061 [ NCBI ]
CGAP (NCI)Hs.47061
Alternative Splicing : Fast-db (Paris)GSHG0007140
Alternative Splicing GalleryENSG00000177169
Gene ExpressionULK1 [ NCBI-GEO ]   ULK1 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75385 (SRS) O75385 (Uniprot)
NextProtO75385
With graphics : InterProO75385
Splice isoforms : SwissVarO75385(Swissvar)
Domaine pattern : Prosite (SRS)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (SRS)Kinase-like_dom    Prot_kinase_cat_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase_dom    Ser/Thr_kin_STPK_Ulk-1/2    Ser/Thr_kinase_AS    Ser/Thr_kinase_C   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_cat_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase_dom    Ser/Thr_kin_STPK_Ulk-1/2    Ser/Thr_kinase_AS    Ser/Thr_kinase_C   
Related proteins : CluSTrO75385
Domain families : Pfam (SRS)DUF3543 (PF12063)    Pkinase (PF00069)   
Domain families : Pfam (Sanger)DUF3543 (PF12063)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam12063    pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
DMDM8408
Blocks (Seattle)O75385
Human Protein AtlasENSG00000177169
HPRD11933
IPIIPI00289357   IPI01009875   IPI01012014   IPI01010149   IPI01009408   IPI01015003   IPI01010208   
Protein Interaction databases
DIP (DOE-UCLA)O75385
IntAct (EBI)O75385
FunCoupENSG00000177169
REACTOMEULK1
Protein Interaction Database8408
BioGRIDULK1
InParanoidO75385
Interologous Interaction database O75385
IntegromeDBULK1
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)ULK1
SNP (GeneSNP Utah)ULK1
SNP : HGBaseULK1
Genetic variants : HAPMAPULK1
Somatic Mutations in Cancer : COSMICULK1 
CONAN: Copy Number AnalysisULK1 
Mutations and Diseases : HGMDULK1
OMIM603168   
GENETests603168   
Disease Genetic AssociationULK1
Huge Navigator ULK1 [HugePedia]  ULK1 [HugeCancerGEM]
Genomic VariantsULK1  ULK1 [DGVbeta]
snp3D : Map Gene to Disease8408
General knowledge
Homologs : HomoloGeneULK1
Homology/Alignments : Family Browser (UCSC)ULK1
Phylogenetic Trees/Animal Genes : TreeFamULK1
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.1 [ Enzyme-SRS ]   2.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
Chemical/Protein Interactions : CTD8408
Chemical/Pharm GKB GenePA37198
Clinical trialULK1
Cancer Resource (Charite)ENSG00000177169
Ontology : AmiGOautophagic vacuole assembly  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  autophagic vacuole  cytosol  protein phosphorylation  Ras protein signal transduction  protein localization  regulation of autophagy  regulation of autophagy  positive regulation of autophagy  positive regulation of macroautophagy  Rab GTPase binding  protein kinase binding  cerebellar granule cell differentiation  radial glia guided migration of cerebellar granule cell  cytoplasmic vesicle membrane  neuron projection regeneration  neuron projection development  receptor internalization  cellular response to nutrient levels  protein complex binding  pre-autophagosomal structure membrane  response to starvation  neuron projection  neuronal cell body  protein autophosphorylation  negative regulation of collateral sprouting  axon extension  regulation of nerve growth factor receptor signaling pathway  ULK1-ATG13-FIP200 complex  
Ontology : EGO-EBIautophagic vacuole assembly  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  autophagic vacuole  cytosol  protein phosphorylation  Ras protein signal transduction  protein localization  regulation of autophagy  regulation of autophagy  positive regulation of autophagy  positive regulation of macroautophagy  Rab GTPase binding  protein kinase binding  cerebellar granule cell differentiation  radial glia guided migration of cerebellar granule cell  cytoplasmic vesicle membrane  neuron projection regeneration  neuron projection development  receptor internalization  cellular response to nutrient levels  protein complex binding  pre-autophagosomal structure membrane  response to starvation  neuron projection  neuronal cell body  protein autophosphorylation  negative regulation of collateral sprouting  axon extension  regulation of nerve growth factor receptor signaling pathway  ULK1-ATG13-FIP200 complex  
Pathways : KEGGmTOR signaling pathwayRegulation of autophagy
Other databases
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
PubGeneULK1
iHOPULK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:39:05 CEST 2013
Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.