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ULK1 (unc-51 like autophagy activating kinase 1)

Identity

Other namesATG1
ATG1A
UNC51
Unc51.1
hATG1
HGNC (Hugo) ULK1
LocusID (NCBI) 8408
Location 12q24.33
Location_base_pair Starts at 132379279 and ends at 132407707 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ULK1   12558
Cards
Entrez_Gene (NCBI)ULK1  8408  unc-51 like autophagy activating kinase 1
GeneCards (Weizmann)ULK1
Ensembl (Hinxton)ENSG00000177169 [Gene_View]  chr12:132379279-132407707 [Contig_View]  ULK1 [Vega]
ICGC DataPortalENSG00000177169
cBioPortalULK1
AceView (NCBI)ULK1
Genatlas (Paris)ULK1
WikiGenes8408
SOURCE (Princeton)NM_003565
Genomic and cartography
GoldenPath (UCSC)ULK1  -  12q24.33   chr12:132379279-132407707 +  12q24.33   [Description]    (hg19-Feb_2009)
EnsemblULK1 - 12q24.33 [CytoView]
Mapping of homologs : NCBIULK1 [Mapview]
OMIM603168   
Gene and transcription
Genbank (Entrez)AB018265 AF045458 AK095774 AK128333 BC111603
RefSeq transcript (Entrez)NM_003565
RefSeq genomic (Entrez)AC_000144 NC_000012 NC_018923 NT_029419 NW_001838066 NW_004929386
Consensus coding sequences : CCDS (NCBI)ULK1
Cluster EST : UnigeneHs.47061 [ NCBI ]
CGAP (NCI)Hs.47061
Alternative Splicing : Fast-db (Paris)GSHG0007140
Alternative Splicing GalleryENSG00000177169
Gene ExpressionULK1 [ NCBI-GEO ]     ULK1 [ SEEK ]   ULK1 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75385 (Uniprot)
NextProtO75385  [Medical]
With graphics : InterProO75385
Splice isoforms : SwissVarO75385 (Swissvar)
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom [organisation]   Prot_kinase_dom [organisation]   Protein_kinase_ATP_BS [organisation]   Ser/Thr_dual-sp_kinase_dom [organisation]   Ser/Thr_kin_STPK_Ulk-1/2 [organisation]   Ser/Thr_kinase_AS [organisation]   Ser/Thr_kinase_C [organisation]  
Related proteins : CluSTrO75385
Domain families : Pfam (Sanger)DUF3543 (PF12063)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam12063    pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
DMDM Disease mutations8408
Blocks (Seattle)O75385
Human Protein AtlasENSG00000177169 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasO75385
HPRD11933
IPIIPI00289357   IPI01009875   IPI01012014   IPI01010149   IPI01009408   IPI01015003   IPI01010208   
Protein Interaction databases
DIP (DOE-UCLA)O75385
IntAct (EBI)O75385
FunCoupENSG00000177169
BioGRIDULK1
InParanoidO75385
Interologous Interaction database O75385
IntegromeDBULK1
STRING (EMBL)ULK1
Ontologies - Pathways
Ontology : AmiGOautophagic vacuole assembly  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  autophagic vacuole  cytosol  protein phosphorylation  Ras protein signal transduction  protein localization  regulation of autophagy  regulation of autophagy  positive regulation of autophagy  positive regulation of macroautophagy  Rab GTPase binding  protein kinase binding  cerebellar granule cell differentiation  radial glia guided migration of cerebellar granule cell  cytoplasmic vesicle membrane  neuron projection regeneration  neuron projection development  receptor internalization  cellular response to nutrient levels  protein complex binding  pre-autophagosomal structure membrane  Atg1p signaling complex  response to starvation  neuron projection  neuronal cell body  protein autophosphorylation  negative regulation of collateral sprouting  axon extension  regulation of neurotrophin TRK receptor signaling pathway  ULK1-ATG13-FIP200 complex  
Ontology : EGO-EBIautophagic vacuole assembly  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  autophagic vacuole  cytosol  protein phosphorylation  Ras protein signal transduction  protein localization  regulation of autophagy  regulation of autophagy  positive regulation of autophagy  positive regulation of macroautophagy  Rab GTPase binding  protein kinase binding  cerebellar granule cell differentiation  radial glia guided migration of cerebellar granule cell  cytoplasmic vesicle membrane  neuron projection regeneration  neuron projection development  receptor internalization  cellular response to nutrient levels  protein complex binding  pre-autophagosomal structure membrane  Atg1p signaling complex  response to starvation  neuron projection  neuronal cell body  protein autophosphorylation  negative regulation of collateral sprouting  axon extension  regulation of neurotrophin TRK receptor signaling pathway  ULK1-ATG13-FIP200 complex  
Pathways : KEGGRegulation of autophagy    mTOR signaling pathway   
Protein Interaction DatabaseULK1
Wikipedia pathwaysULK1
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)ULK1
snp3D : Map Gene to Disease8408
SNP (GeneSNP Utah)ULK1
SNP : HGBaseULK1
Genetic variants : HAPMAPULK1
Exome VariantULK1
1000_GenomesULK1 
ICGC programENSG00000177169 
Somatic Mutations in Cancer : COSMICULK1 
CONAN: Copy Number AnalysisULK1 
Mutations and Diseases : HGMDULK1
Mutations and Diseases : intOGenULK1
Genomic VariantsULK1  ULK1 [DGVbeta]
dbVarULK1
ClinVarULK1
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM603168   
MedgenULK1
GENETestsULK1
Disease Genetic AssociationULK1
Huge Navigator ULK1 [HugePedia]  ULK1 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneULK1
Homology/Alignments : Family Browser (UCSC)ULK1
Phylogenetic Trees/Animal Genes : TreeFamULK1
Chemical/Protein Interactions : CTD8408
Chemical/Pharm GKB GenePA37198
Clinical trialULK1
Cancer Resource (Charite)ENSG00000177169
Other databases
Probes
Litterature
PubMed48 Pubmed reference(s) in Entrez
CoreMineULK1
iHOPULK1
OncoSearchULK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 26 17:09:36 CEST 2014

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