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ULK1 (unc-51 like autophagy activating kinase 1)

Identity

Other namesATG1
ATG1A
UNC51
Unc51.1
hATG1
HGNC (Hugo) ULK1
LocusID (NCBI) 8408
Atlas_Id 43551
Location 12q24.33  [Link to chromosome band 12q24]
Location_base_pair Starts at 132379279 and ends at 132407707 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
PRR4 (12p13.2) / ULK1 (12q24.33)PUS1 (12q24.33) / ULK1 (12q24.33)SUN2 (22q13.1) / ULK1 (12q24.33)
ULK1 (12q24.33) / ETHE1 (19q13.31)ULK1 (12q24.33) / FBXW8 (12q24.22)ULK1 (12q24.33) / NLGN2 (17p13.1)
ULK1 (12q24.33) / PPP1R12C (19q13.42)ULK1 (12q24.33) / PRKAR1B (7p22.3)ULK1 (12q24.33) / ULK1 (12q24.33)
ULK1 12q24.33 / ETHE1 19q13.31ULK1 12q24.33 / FBXW8 12q24.22ULK1 12q24.33 / PPP1R12C 19q13.42
ULK1 12q24.33 / PRKAR1B 7p22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ULK1   12558
Cards
Entrez_Gene (NCBI)ULK1  8408  unc-51 like autophagy activating kinase 1
AliasesATG1; ATG1A; UNC51; Unc51.1; 
hATG1
GeneCards (Weizmann)ULK1
Ensembl hg19 (Hinxton)ENSG00000177169 [Gene_View]  chr12:132379279-132407707 [Contig_View]  ULK1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000177169 [Gene_View]  chr12:132379279-132407707 [Contig_View]  ULK1 [Vega]
ICGC DataPortalENSG00000177169
TCGA cBioPortalULK1
AceView (NCBI)ULK1
Genatlas (Paris)ULK1
WikiGenes8408
SOURCE (Princeton)ULK1
Genomic and cartography
GoldenPath hg19 (UCSC)ULK1  -     chr12:132379279-132407707 +  12q24.33   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ULK1  -     12q24.33   [Description]    (hg38-Dec_2013)
EnsemblULK1 - 12q24.33 [CytoView hg19]  ULK1 - 12q24.33 [CytoView hg38]
Mapping of homologs : NCBIULK1 [Mapview hg19]  ULK1 [Mapview hg38]
OMIM603168   
Gene and transcription
Genbank (Entrez)AB018265 AF045458 AK095774 AK128333 BC111603
RefSeq transcript (Entrez)NM_003565
RefSeq genomic (Entrez)NC_000012 NC_018923 NT_029419 NW_004929386
Consensus coding sequences : CCDS (NCBI)ULK1
Cluster EST : UnigeneHs.47061 [ NCBI ]
CGAP (NCI)Hs.47061
Alternative Splicing GalleryENSG00000177169
Gene ExpressionULK1 [ NCBI-GEO ]   ULK1 [ EBI - ARRAY_EXPRESS ]   ULK1 [ SEEK ]   ULK1 [ MEM ]
Gene Expression Viewer (FireBrowse)ULK1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8408
GTEX Portal (Tissue expression)ULK1
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75385 (Uniprot)
NextProtO75385  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75385
Splice isoforms : SwissVarO75385 (Swissvar)
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusO75385
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase    Ser/Thr_kin_STPK_Ulk-1/2    Ser/Thr_kinase_AS    Ser/Thr_kinase_C   
Domain families : Pfam (Sanger)DUF3543 (PF12063)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam12063    pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
DMDM Disease mutations8408
Blocks (Seattle)ULK1
PDB (SRS)4WNO    4WNP    5CI7   
PDB (PDBSum)4WNO    4WNP    5CI7   
PDB (IMB)4WNO    4WNP    5CI7   
PDB (RSDB)4WNO    4WNP    5CI7   
Structural Biology KnowledgeBase4WNO    4WNP    5CI7   
SCOP (Structural Classification of Proteins)4WNO    4WNP    5CI7   
CATH (Classification of proteins structures)4WNO    4WNP    5CI7   
SuperfamilyO75385
Human Protein AtlasENSG00000177169
Peptide AtlasO75385
HPRD11933
IPIIPI00289357   IPI01009875   IPI01012014   IPI01010149   IPI01009408   IPI01015003   IPI01010208   
Protein Interaction databases
DIP (DOE-UCLA)O75385
IntAct (EBI)O75385
FunCoupENSG00000177169
BioGRIDULK1
STRING (EMBL)ULK1
ZODIACULK1
Ontologies - Pathways
QuickGOO75385
Ontology : AmiGOprotein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  autophagosome  cytosol  cytosol  protein phosphorylation  signal transduction  protein localization  regulation of autophagy  regulation of autophagy  positive regulation of autophagy  macroautophagy  positive regulation of macroautophagy  Rab GTPase binding  peptidyl-serine phosphorylation  neuron projection regeneration  neuron projection development  negative regulation of protein complex assembly  cellular response to nutrient levels  protein complex binding  pre-autophagosomal structure membrane  response to starvation  protein autophosphorylation  axon extension  extrinsic component of omegasome membrane  extrinsic component of pre-autophagosomal structure membrane  extrinsic component of autophagosome membrane  ATG1/ULK1 kinase complex  
Ontology : EGO-EBIprotein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  autophagosome  cytosol  cytosol  protein phosphorylation  signal transduction  protein localization  regulation of autophagy  regulation of autophagy  positive regulation of autophagy  macroautophagy  positive regulation of macroautophagy  Rab GTPase binding  peptidyl-serine phosphorylation  neuron projection regeneration  neuron projection development  negative regulation of protein complex assembly  cellular response to nutrient levels  protein complex binding  pre-autophagosomal structure membrane  response to starvation  protein autophosphorylation  axon extension  extrinsic component of omegasome membrane  extrinsic component of pre-autophagosomal structure membrane  extrinsic component of autophagosome membrane  ATG1/ULK1 kinase complex  
Pathways : KEGGRegulation of autophagy    mTOR signaling pathway   
NDEx Network
Atlas of Cancer Signalling NetworkULK1
Wikipedia pathwaysULK1
Orthology - Evolution
OrthoDB8408
GeneTree (enSembl)ENSG00000177169
Phylogenetic Trees/Animal Genes : TreeFamULK1
Homologs : HomoloGeneULK1
Homology/Alignments : Family Browser (UCSC)ULK1
Gene fusions - Rearrangements
Fusion: TCGAULK1 12q24.33 ETHE1 19q13.31 BRCA
Fusion: TCGAULK1 12q24.33 FBXW8 12q24.22 LUSC
Fusion: TCGAULK1 12q24.33 PPP1R12C 19q13.42 BRCA
Fusion: TCGAULK1 12q24.33 PRKAR1B 7p22.3 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerULK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ULK1
dbVarULK1
ClinVarULK1
1000_GenomesULK1 
Exome Variant ServerULK1
ExAC (Exome Aggregation Consortium)ULK1 (select the gene name)
Genetic variants : HAPMAP8408
Genomic Variants (DGV)ULK1 [DGVbeta]
Mutations
ICGC Data PortalULK1 
TCGA Data PortalULK1 
Broad Tumor PortalULK1
OASIS PortalULK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICULK1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ULK1
DgiDB (Drug Gene Interaction Database)ULK1
DoCM (Curated mutations)ULK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ULK1 (select a term)
intoGenULK1
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)12:132379279-132407707  ENSG00000177169
CONAN: Copy Number AnalysisULK1 
Mutations and Diseases : HGMDULK1
OMIM603168   
MedgenULK1
Genetic Testing Registry ULK1
NextProtO75385 [Medical]
TSGene8408
GENETestsULK1
Huge Navigator ULK1 [HugePedia]
snp3D : Map Gene to Disease8408
BioCentury BCIQULK1
ClinGenULK1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8408
Chemical/Pharm GKB GenePA37198
Clinical trialULK1
Miscellaneous
canSAR (ICR)ULK1 (select the gene name)
Probes
Litterature
PubMed81 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineULK1
EVEXULK1
GoPubMedULK1
iHOPULK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 9 19:12:09 CEST 2016

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