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ULK2 (unc-51 like autophagy activating kinase 2)

Identity

Alias_namesunc-51 (C. elegans)-like kinase 2
unc-51-like kinase 2 (C. elegans)
Alias_symbol (synonym)KIAA0623
Unc51.2
ATG1B
Other alias
HGNC (Hugo) ULK2
LocusID (NCBI) 9706
Atlas_Id 43552
Location 17p11.2  [Link to chromosome band 17p11]
Location_base_pair Starts at 19770830 and ends at 19867926 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
APOL2 (22q12.3) / ULK2 (17p11.2)OAZ1 (19p13.3) / ULK2 (17p11.2)TOM1L2 (17p11.2) / ULK2 (17p11.2)
ULK2 (17p11.2) / DOCK6 (19p13.2)ULK2 (17p11.2) / HSPH1 (13q12.3)ULK2 (17p11.2) / MBD3 (19p13.3)
APOL2 22q12.3 / ULK2 17p11.2TOM1L2 17p11.2 / ULK2 17p11.2ULK2 17p11.2 / DOCK6 19p13.2
ULK2 17p11.2 / MBD3 19p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ULK2   13480
Cards
Entrez_Gene (NCBI)ULK2  9706  unc-51 like autophagy activating kinase 2
AliasesATG1B; Unc51.2
GeneCards (Weizmann)ULK2
Ensembl hg19 (Hinxton)ENSG00000083290 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000083290 [Gene_View]  chr17:19770830-19867926 [Contig_View]  ULK2 [Vega]
ICGC DataPortalENSG00000083290
TCGA cBioPortalULK2
AceView (NCBI)ULK2
Genatlas (Paris)ULK2
WikiGenes9706
SOURCE (Princeton)ULK2
Genetics Home Reference (NIH)ULK2
Genomic and cartography
GoldenPath hg38 (UCSC)ULK2  -     chr17:19770830-19867926 -  17p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ULK2  -     17p11.2   [Description]    (hg19-Feb_2009)
EnsemblULK2 - 17p11.2 [CytoView hg19]  ULK2 - 17p11.2 [CytoView hg38]
Mapping of homologs : NCBIULK2 [Mapview hg19]  ULK2 [Mapview hg38]
OMIM608650   
Gene and transcription
Genbank (Entrez)AB014523 AK098316 AK314345 AL080134 BC034988
RefSeq transcript (Entrez)NM_001142610 NM_014683
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ULK2
Cluster EST : UnigeneHs.168762 [ NCBI ]
CGAP (NCI)Hs.168762
Alternative Splicing GalleryENSG00000083290
Gene ExpressionULK2 [ NCBI-GEO ]   ULK2 [ EBI - ARRAY_EXPRESS ]   ULK2 [ SEEK ]   ULK2 [ MEM ]
Gene Expression Viewer (FireBrowse)ULK2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9706
GTEX Portal (Tissue expression)ULK2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IYT8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IYT8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IYT8
Splice isoforms : SwissVarQ8IYT8
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ8IYT8
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kin_STPK_Ulk-1/2    Ser/Thr_kinase_AS    Ser/Thr_kinase_C   
Domain families : Pfam (Sanger)DUF3543 (PF12063)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam12063    pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)ULK2
DMDM Disease mutations9706
Blocks (Seattle)ULK2
SuperfamilyQ8IYT8
Human Protein AtlasENSG00000083290
Peptide AtlasQ8IYT8
HPRD10556
IPIIPI00479399   
Protein Interaction databases
DIP (DOE-UCLA)Q8IYT8
IntAct (EBI)Q8IYT8
FunCoupENSG00000083290
BioGRIDULK2
STRING (EMBL)ULK2
ZODIACULK2
Ontologies - Pathways
QuickGOQ8IYT8
Ontology : AmiGOprotein serine/threonine kinase activity  protein binding  ATP binding  autophagy  signal transduction  cytoplasmic vesicle membrane  pre-autophagosomal structure membrane  response to starvation  protein autophosphorylation  negative regulation of collateral sprouting  axon extension  
Ontology : EGO-EBIprotein serine/threonine kinase activity  protein binding  ATP binding  autophagy  signal transduction  cytoplasmic vesicle membrane  pre-autophagosomal structure membrane  response to starvation  protein autophosphorylation  negative regulation of collateral sprouting  axon extension  
Pathways : KEGGRegulation of autophagy    mTOR signaling pathway   
NDEx NetworkULK2
Atlas of Cancer Signalling NetworkULK2
Wikipedia pathwaysULK2
Orthology - Evolution
OrthoDB9706
GeneTree (enSembl)ENSG00000083290
Phylogenetic Trees/Animal Genes : TreeFamULK2
HOVERGENQ8IYT8
HOGENOMQ8IYT8
Homologs : HomoloGeneULK2
Homology/Alignments : Family Browser (UCSC)ULK2
Gene fusions - Rearrangements
Fusion : MitelmanAPOL2/ULK2 [22q12.3/17p11.2]  [t(17;22)(p11;q12)]  
Fusion : MitelmanTOM1L2/ULK2 [17p11.2/17p11.2]  [t(17;17)(p11;p11)]  
Fusion : MitelmanULK2/DOCK6 [17p11.2/19p13.2]  [t(17;19)(p11;p13)]  
Fusion : MitelmanULK2/MBD3 [17p11.2/19p13.3]  [t(17;19)(p11;p13)]  
Fusion: TCGAAPOL2 22q12.3 ULK2 17p11.2 LUSC
Fusion: TCGATOM1L2 17p11.2 ULK2 17p11.2 BRCA
Fusion: TCGAULK2 17p11.2 DOCK6 19p13.2 BRCA
Fusion: TCGAULK2 17p11.2 MBD3 19p13.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerULK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ULK2
dbVarULK2
ClinVarULK2
1000_GenomesULK2 
Exome Variant ServerULK2
ExAC (Exome Aggregation Consortium)ULK2 (select the gene name)
Genetic variants : HAPMAP9706
Genomic Variants (DGV)ULK2 [DGVbeta]
DECIPHERULK2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisULK2 
Mutations
ICGC Data PortalULK2 
TCGA Data PortalULK2 
Broad Tumor PortalULK2
OASIS PortalULK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICULK2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDULK2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ULK2
DgiDB (Drug Gene Interaction Database)ULK2
DoCM (Curated mutations)ULK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ULK2 (select a term)
intoGenULK2
Cancer3DULK2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608650   
Orphanet
MedgenULK2
Genetic Testing Registry ULK2
NextProtQ8IYT8 [Medical]
TSGene9706
GENETestsULK2
Target ValidationULK2
Huge Navigator ULK2 [HugePedia]
snp3D : Map Gene to Disease9706
BioCentury BCIQULK2
ClinGenULK2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9706
Chemical/Pharm GKB GenePA37780
Clinical trialULK2
Miscellaneous
canSAR (ICR)ULK2 (select the gene name)
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineULK2
EVEXULK2
GoPubMedULK2
iHOPULK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 14:11:11 CEST 2017

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