ULK2 (unc-51 like autophagy activating kinase 2)

2006-10-01  

Identity

HGNC
ULK2
LOCATION
17p11.2
LOCUSID
9706
ALIAS
ATG1B,Unc51.2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9706
MIM: 608650
HGNC: 13480
Ensembl: ENSG00000083290

Variants:

dbSNP: 9706
ClinVar: 9706
TCGA: ENSG00000083290
COSMIC: ULK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000083290ENST00000361658Q8IYT8
ENSG00000083290ENST00000395544Q8IYT8
ENSG00000083290ENST00000574732K7EKK9
ENSG00000083290ENST00000575432K7EIU2
ENSG00000083290ENST00000580118K7EP89

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
mTOR signaling pathwayKEGGko04150
Autophagy - animalKEGGhsa04140
mTOR signaling pathwayKEGGhsa04150
Autophagy - otherKEGGko04136
Autophagy - otherKEGGhsa04136

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
124712432002The protein kinase complement of the human genome.2088
192251512009ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery.679
214753062011Upregulation of human autophagy-initiation kinase ULK1 by tumor suppressor p53 contributes to DNA-damage-induced cell death.63
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
259256682015Phosphorylation of the exchange factor DENND3 by ULK in response to starvation activates Rab12 and induces autophagy.25
271535342016ULK1/2 Constitute a Bifurcate Node Controlling Glucose Metabolic Fluxes in Addition to Autophagy.23
249234412014Methylation silencing of ULK2, an autophagy gene, is essential for astrocyte transformation and tumor growth.19
269200492016MiR-26b inhibits autophagy by targeting ULK2 in prostate cancer cells.15
270622952016Uncoordinated 51-like kinase 2 signaling pathway regulates epithelial-mesenchymal transition in A549 lung cancer cells.7
282308602017CARMA2sh and ULK2 control pathogen-associated molecular patterns recognition in human keratinocytes: psoriasis-linked CARMA2sh mutants escape ULK2 censorship.3

Citation

Dessen P

ULK2 (unc-51 like autophagy activating kinase 2)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43552/ulk2